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This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation, and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix, and skin as well as gastric cancer, sarcoma, lymphoma, leukemia, and multiple myeloma.

Cancer --- Inflammation --- Immunological aspects. --- Mediators. --- Inflammatory mediators --- Mediators of inflammation --- Biomolecules --- Carcinogenesis --- Immunological aspects --- Oncology. --- Immunology. --- Oncology  . --- Cancer Research. --- Tumors --- Immunobiology --- Life sciences --- Serology --- Cancer research. --- Cancer research

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Inflammation. --- Inflammation --- Inflammation (Pathologie) --- Mediators. --- Médiateurs --- -Inflammatory process --- Pathology --- Anti-inflammatory agents --- Inflammations --- Mediators --- -Mediators --- -Inflammations --- Inflammatory process --- Médiateurs --- Inflammatory mediators --- Mediators of inflammation --- Biomolecules --- Innate Inflammatory Response --- Inflammatory Response, Innate --- Innate Inflammatory Responses --- Immunity, Innate

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Interferon --- Cytokines --- Interférons --- Periodicals --- Périodiques --- Inflammation --- Interferons. --- Cytokines. --- Inflammation Mediators. --- Interferon. --- Mediators --- Mediators. --- Interferons --- Inflammatory mediators --- Mediators of inflammation --- Mediators of Inflammation --- Mediators, Inflammation --- Inflammatory process --- Antineoplastic agents --- Antiviral agents --- Glycoproteins --- Lymphokines --- Biomolecules --- Cellular immunity --- Immune response --- Inflammasomes --- Viral Interference --- Pathology --- Anti-inflammatory agents --- Regulation --- interferon --- Microbiology & Immunology --- Cytokine --- Interferó. --- Citocines. --- Inflammation Mediators --- Inflammation (Pathologie) --- Médiateurs

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Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appeared in 1850 [1]. However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were. Despite widespread use, it was not until 1878 that the selective action of capsaicin on the sensory nervous system was r- ognized [2]. In Chapter 1 of this volume, Janos Szolcsányi reviews this early research, which culminated with the seminal studies of Nicholas Jansco and his c- leagues in Hungary in the 1940s. Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema.

Nociceptors. --- Pain. --- Inflammation. --- Inflammation --- Mediators. --- Inflammatory mediators --- Mediators of inflammation --- Biomolecules --- Inflammatory process --- Pathology --- Anti-inflammatory agents --- Aches --- Emotions --- Pleasure --- Senses and sensation --- Symptoms --- Analgesia --- Suffering --- Pain receptors --- Sensory receptors --- Pain Medicine. --- Immunology. --- Neurosciences. --- Toxicology. --- Cytology. --- Pharmacology/Toxicology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Immunobiology --- Life sciences --- Serology --- Toxicology --- Algiatry --- Pain medicine. --- Pharmacology. --- Cell biology. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Angiogenesis is an essential component of inflammation and its resolution. This volume provides up-to-date information on the latest developments in the pathology, mechanisms and therapy of angiogenesis dependent inflammatory disease. Recent years have seen large advances in angiogenesis research, especially in oncology. Traditionally mechanisms in inflammation angiogenesis were inferred from tumour angiogenesis, however recent research has matured highlighting the similarities and dissimilarities between these processes. This volume relates the lessons learned from tumour biology applied to inflammation. This issue of Angiogenesis in Inflammation: Mechanisms and Clinical Correlates develops current knowledge on the mechanisms at the molecular and cellular levels as they relate to inflammation, including acute and chronic inflammation, neurogenic initiation, and the role of the multiple cellular components that comprise inflammation: granulocytes, macrophages, fibroblasts, dendritic cells and lymphocytes. This is related to inflammatory disease: not only the familiar angiogenesis dependent diseases of rheumatoid arthritis and psoriasis, but also loci such as the lung, gastric ulcers, the eye with uveitis, wound healing and periodontal disease and their therapy, how this knowledge may be used in the discovery of novel therapeutics. The volume brings together experts in each of these fields to link the molecular and cellular processes in angiogenesis to those of inflammation and disease, culminating in a discourse on areas for future therapies.

Neovascularization. --- Inflammation --- Mediators. --- Inflammatory mediators --- Mediators of inflammation --- Biomolecules --- Angiogenesis --- Blood-vessels --- Growth --- Immunology. --- Oncology. --- Internal medicine. --- Angiography. --- Cytology. --- Cancer Research. --- Internal Medicine. --- Angiology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Diagnosis, Radioscopic --- Radiography, Medical --- Medicine, Internal --- Medicine --- Tumors --- Immunobiology --- Life sciences --- Serology --- Radiography --- Cancer research. --- Cell biology. --- Cancer research --- Cancer. --- Cancer Biology. --- Diseases. --- Angiology --- Vascular diseases --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors