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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

infant gut microbiota --- microbial colonization --- food impact --- functional food --- intestinal immunity

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Medical microbiology & virology --- Microbiology (non-medical) --- infant gut microbiota --- microbial colonization --- food impact --- functional food --- intestinal immunity

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We have entered a new era where some concepts of the complex community of microorganisms (microbiota comprising bacteria, fungi, viruses, bacteriophages and helminths) are being re-discovered and re-visited. Microbiota and human interaction is not new; they have shared a long history of co-existence. Nevertheless, the opportunities to understand the role of these microorganisms in human diseases and to design a potential treatment were limited. At present, thanks to development of innovative and cutting-edge molecular biological and microbiological technologies as well as clinical informatics and bioinformatics skills, microbiome application is moving into clinics. Approaches to therapy based on prebiotics, probiotics and lately on fecal microbiota transplantation has revolutionized medicine. Microbiota outnumbers our genes and is now regarded as another organ of the body. The gastrointestinal tract and gut microbiota display a well-documented symbiotic relationship. Disruption of intestinal microbiota homeostasis—called dysbiosis—has been associated with several diseases. Whether dysbiosis is a cause or consequence of disease initiation and progression still needs to be investigated in more depth. The aim of this book is to highlight recent advances in the field of microbiome research, which are now shaping medicine, and current approaches to microbiome-oriented therapy for gastrointestinal diseases. Dr. Rinaldo Pellicano Dr. Sharmila Fagoonee Guest Editors

Public health & preventive medicine --- Bacteroides ovatus --- Bifidobacterium adolescentis --- Dysbiosis --- Faecalibacterium prausnitzii --- Ruminococcus gnavus --- type 1 diabetes --- microbiota --- microbiome --- auto-immunity --- gut permeability --- gut --- IBS --- celiac disease --- enteropathy --- gluten --- therapy --- gut microbiota --- precision medicine --- Clostridium difficile --- inflammatory bowel disease --- ulcerative colitis --- irritable bowel disease --- metabolic syndrome --- gastric microbiota --- transient --- persistent --- culture --- sequencing --- Helicobacter pylori --- fecal microbiota transplantation --- feces donor --- fecal microbiota --- flow cytometry --- viability of bacteria --- next-generation sequencing --- culturing of fecal microbiota --- Alzheimer’s disease --- microbiota–gut–brain axis --- neurodegenerative disease --- intestinal flora --- necrotizing enterocolitis --- intestinal microbiology --- infant gut --- metabolomics --- IL-6 --- IL-8 --- IL-12p70 --- intestinal permeability --- zonulin --- gut virome --- steatosis --- cirrhosis --- hepatocellular carcinoma --- gastrointestinal --- technology --- high-throughput --- crohn’s disease --- mononuclear cells --- transient receptor potential channel --- pancreatic diseases --- acute pancreatitis --- chronic pancreatitis --- diabetes mellitus --- pancreatic ductal adenocarcinoma --- pancreatic cystic neoplasms

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

We have entered a new era where some concepts of the complex community of microorganisms (microbiota comprising bacteria, fungi, viruses, bacteriophages and helminths) are being re-discovered and re-visited. Microbiota and human interaction is not new; they have shared a long history of co-existence. Nevertheless, the opportunities to understand the role of these microorganisms in human diseases and to design a potential treatment were limited. At present, thanks to development of innovative and cutting-edge molecular biological and microbiological technologies as well as clinical informatics and bioinformatics skills, microbiome application is moving into clinics. Approaches to therapy based on prebiotics, probiotics and lately on fecal microbiota transplantation has revolutionized medicine. Microbiota outnumbers our genes and is now regarded as another organ of the body. The gastrointestinal tract and gut microbiota display a well-documented symbiotic relationship. Disruption of intestinal microbiota homeostasis—called dysbiosis—has been associated with several diseases. Whether dysbiosis is a cause or consequence of disease initiation and progression still needs to be investigated in more depth. The aim of this book is to highlight recent advances in the field of microbiome research, which are now shaping medicine, and current approaches to microbiome-oriented therapy for gastrointestinal diseases. Dr. Rinaldo Pellicano Dr. Sharmila Fagoonee Guest Editors

Public health & preventive medicine --- Bacteroides ovatus --- Bifidobacterium adolescentis --- Dysbiosis --- Faecalibacterium prausnitzii --- Ruminococcus gnavus --- type 1 diabetes --- microbiota --- microbiome --- auto-immunity --- gut permeability --- gut --- IBS --- celiac disease --- enteropathy --- gluten --- therapy --- gut microbiota --- precision medicine --- Clostridium difficile --- inflammatory bowel disease --- ulcerative colitis --- irritable bowel disease --- metabolic syndrome --- gastric microbiota --- transient --- persistent --- culture --- sequencing --- Helicobacter pylori --- fecal microbiota transplantation --- feces donor --- fecal microbiota --- flow cytometry --- viability of bacteria --- next-generation sequencing --- culturing of fecal microbiota --- Alzheimer’s disease --- microbiota–gut–brain axis --- neurodegenerative disease --- intestinal flora --- necrotizing enterocolitis --- intestinal microbiology --- infant gut --- metabolomics --- IL-6 --- IL-8 --- IL-12p70 --- intestinal permeability --- zonulin --- gut virome --- steatosis --- cirrhosis --- hepatocellular carcinoma --- gastrointestinal --- technology --- high-throughput --- crohn’s disease --- mononuclear cells --- transient receptor potential channel --- pancreatic diseases --- acute pancreatitis --- chronic pancreatitis --- diabetes mellitus --- pancreatic ductal adenocarcinoma --- pancreatic cystic neoplasms --- Bacteroides ovatus --- Bifidobacterium adolescentis --- Dysbiosis --- Faecalibacterium prausnitzii --- Ruminococcus gnavus --- type 1 diabetes --- microbiota --- microbiome --- auto-immunity --- gut permeability --- gut --- IBS --- celiac disease --- enteropathy --- gluten --- therapy --- gut microbiota --- precision medicine --- Clostridium difficile --- inflammatory bowel disease --- ulcerative colitis --- irritable bowel disease --- metabolic syndrome --- gastric microbiota --- transient --- persistent --- culture --- sequencing --- Helicobacter pylori --- fecal microbiota transplantation --- feces donor --- fecal microbiota --- flow cytometry --- viability of bacteria --- next-generation sequencing --- culturing of fecal microbiota --- Alzheimer’s disease --- microbiota–gut–brain axis --- neurodegenerative disease --- intestinal flora --- necrotizing enterocolitis --- intestinal microbiology --- infant gut --- metabolomics --- IL-6 --- IL-8 --- IL-12p70 --- intestinal permeability --- zonulin --- gut virome --- steatosis --- cirrhosis --- hepatocellular carcinoma --- gastrointestinal --- technology --- high-throughput --- crohn’s disease --- mononuclear cells --- transient receptor potential channel --- pancreatic diseases --- acute pancreatitis --- chronic pancreatitis --- diabetes mellitus --- pancreatic ductal adenocarcinoma --- pancreatic cystic neoplasms