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Stereochemistry --- Indole alkaloids

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Indole Alkaloids: Spirooxindole details the multistep synthesis of natural products using schematic diagrams, providing a quick-and-easy way to review and understand new and novel synthetic strategies to construct structural frameworks of natural products. As a volume in the Visual Guides to Natural Product Synthesis series, this book presents the schematic total syntheses of natural products containing a “spirooxindole” core structure. It covers spirooxindole molecules through visual diagrams, highlighting key steps involved in total, formal and semi-syntheses. Sections cover Brevianamide A and B, Citrinadin A and B, Coerulescine and Horsfiline, Elacomine and Isoelacomine, Gelsemine, Paraherquamide A and B, Rynchophylline, Isorynchophylline, and more.

Indole alkaloids. --- Indole alkaloids --- Natural products. --- Spiro Compounds --- Indole Alkaloids --- Biological Products --- Synthesis. --- chemical synthesis

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Indole alkaloids --- Saxton, J. Edwin --- Alkaloids --- Saxton, John Edwin, --- Indoliques (Composés). --- Indolverbindingen. --- Alcaloides indoliques

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Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment.

alga --- marine-derived fungus --- Penicillium chrysogenum --- polyketide --- hydroxyphenylacetic acid --- cytotoxicity --- flaccidoxide-13-acetate --- hepatocellular carcinoma --- invasion --- migration --- epithelial-mesenchymal transition --- prostate cancer --- astaxanthin --- STAT3 --- proliferation --- colony formation --- apoptosis --- Sarcophyton digitatum --- biscembranoid-type metabolites --- inflammatory factor production --- LPS-stimulated murine macrophage --- Ehlich’s tumor --- P. purpurogenum --- antitumor --- meroterpenoids --- inflammation --- T47D --- BT20 --- pontin --- mutp53 --- cancer stem cells --- Oct4 --- Nanog --- siRNA --- secondary metabolites --- epigenome --- epigenetic signaling --- bioactive compounds --- cancer therapy --- marine species --- environment --- total synthesis --- natural product --- nannocystin --- anti-cancer --- gram-scale --- aplysinopsin analogs --- indole alkaloids --- marine source --- chronic myeloid leukemia --- BH3 mimetics --- n/a --- Ehlich's tumor

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Plant alkaloids are critical components of modern medicine and pharmaceuticals. These compounds are also becoming increasingly important for industrial uses as part of the green chemistry revolution. This Special Issue will focus on the molecular advances being made in understanding how such a large and diverse class of compounds are made by plants and how metabolic engineering advances are increasing the overall yield of crucial precursors.

Research & information: general --- Biology, life sciences --- canthin-6-one --- Picrolemma huberi --- Simaroubaceae --- antiplasmodial activity --- Sarcococca hookeriana --- sarchookloides A–C --- steroidal alkaloid --- cytotoxicity --- Rhodophiala --- alkaloids --- molecular docking --- AChE --- BuChE --- GC-MS --- Mahonia imbricata --- Berberidaceae --- isoquinoline alkaloid --- mahimbrine A --- hedgehog signaling --- Veratrum californicum --- cyclopamine --- HPLC-MS --- Shh-Light II cells --- halogencyclopropane --- dichlorocarbene --- epoxidation --- vindoline --- catharanthine --- dimer alkaloids --- vindoline trimer --- Ruta graveolens --- photosystem II --- Chl a fluorescence --- Hill reaction inhibitors --- acridone alkaloids --- benzylisoquinoline alkaloids --- cytochrome P450 monooxygenase --- medicinal properties --- methyltransferase --- Nelumbo nucifera --- norcoclaurine synthase --- sacred lotus --- stereochemistry --- Aristotelia chilensis Molina Stuntz --- vascular activity --- endothelium-independent --- indole alkaloid --- 8-oxo-9-dihydromakomakine --- voltage-dependent calcium channels --- Catharanthus roseus --- cambial meristematic cells --- Aspergillus flavus --- terpenoid indole alkaloids --- biosynthesis --- Buxaceae --- Borago officinalis --- Crassocephalum --- Copper-dependent diamine oxidase --- Gynura bicolor --- Homospermidine synthase --- Lolium perenne --- Necic acids --- Necine bases --- Pyrrolizidine alkaloid biosynthesis --- Senecionine --- tropane alkaloids --- scopolamine --- cocaine --- calystegine --- chemistry --- pharmacology --- biotechnological production --- Erythroxylaceae --- Erythroxylum coca --- next generation sequencing --- traditional medicine --- bioprospecting --- tropane --- late-stage functionalization --- sulfinate --- DiversinateTM --- natural product --- medicinal chemistry --- papaverine --- scaffold --- library --- biodiscovery --- Swinglea glutinosa --- dereplication --- acridones --- phenylacrylamides --- canthin-6-one --- Picrolemma huberi --- Simaroubaceae --- antiplasmodial activity --- Sarcococca hookeriana --- sarchookloides A–C --- steroidal alkaloid --- cytotoxicity --- Rhodophiala --- alkaloids --- molecular docking --- AChE --- BuChE --- GC-MS --- Mahonia imbricata --- Berberidaceae --- isoquinoline alkaloid --- mahimbrine A --- hedgehog signaling --- Veratrum californicum --- cyclopamine --- HPLC-MS --- Shh-Light II cells --- halogencyclopropane --- dichlorocarbene --- epoxidation --- vindoline --- catharanthine --- dimer alkaloids --- vindoline trimer --- Ruta graveolens --- photosystem II --- Chl a fluorescence --- Hill reaction inhibitors --- acridone alkaloids --- benzylisoquinoline alkaloids --- cytochrome P450 monooxygenase --- medicinal properties --- methyltransferase --- Nelumbo nucifera --- norcoclaurine synthase --- sacred lotus --- stereochemistry --- Aristotelia chilensis Molina Stuntz --- vascular activity --- endothelium-independent --- indole alkaloid --- 8-oxo-9-dihydromakomakine --- voltage-dependent calcium channels --- Catharanthus roseus --- cambial meristematic cells --- Aspergillus flavus --- terpenoid indole alkaloids --- biosynthesis --- Buxaceae --- Borago officinalis --- Crassocephalum --- Copper-dependent diamine oxidase --- Gynura bicolor --- Homospermidine synthase --- Lolium perenne --- Necic acids --- Necine bases --- Pyrrolizidine alkaloid biosynthesis --- Senecionine --- tropane alkaloids --- scopolamine --- cocaine --- calystegine --- chemistry --- pharmacology --- biotechnological production --- Erythroxylaceae --- Erythroxylum coca --- next generation sequencing --- traditional medicine --- bioprospecting --- tropane --- late-stage functionalization --- sulfinate --- DiversinateTM --- natural product --- medicinal chemistry --- papaverine --- scaffold --- library --- biodiscovery --- Swinglea glutinosa --- dereplication --- acridones --- phenylacrylamides