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This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.

Research & information: general --- Biology, life sciences --- nanoparticles --- fungi --- drug delivery systems --- marine --- biological synthesis --- myconanotechnology --- canesten --- clotrimazole --- vulvovaginal --- vaginitis --- mycosis --- candidosis --- yeast infection --- candida --- candida albicans --- vaginal health --- anticandidal activity --- indazole --- pyrazole --- 3-phenyl-1H-indazole --- drug design --- acetylsalicylic acid (ASA, aspirin) --- capsule --- CAP64 --- Cryptococcus --- membrane potential (ΔΨM) --- photodynamic treatment --- photosensitiser --- ultrastructure --- drug repurposing --- antifungals --- repositioning --- yeasts --- emerging fungi --- multidrug resistance --- therapeutic alternatives --- new targets --- Candida auris --- Aspergillus spp. --- antifungal --- beta-glucan --- polycations --- Galleria mellonella model --- retinoids --- Candida spp. --- onychomycosis --- Malassezia spp. --- dermatophytes --- microbiology --- mycology --- all-trans retinoic acid --- Acanthamoeba --- free-living ameba --- Acanthamoeba keratitis --- isavuconazonium sulfate --- cyst --- drug --- drug discovery --- drug targets --- invasive aspergillosis treatment --- invasive fungal infections --- fission yeast --- cell wall --- β(1,3)-D-glucan synthase --- antifungal drugs --- echinocandin drugs --- echinocandin resistance --- Fks resistance hot spots --- cytokinesis --- septation --- cell separation --- cell integrity --- cell lysis --- sporotrichosis --- Felis catus --- quinones --- hydrazones --- zoonoses --- host-directed drug therapy --- azoles --- polyenes --- echinocandins --- viral infections --- azole --- synergy --- resistance --- Candida --- natural products --- n/a

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This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.

nanoparticles --- fungi --- drug delivery systems --- marine --- biological synthesis --- myconanotechnology --- canesten --- clotrimazole --- vulvovaginal --- vaginitis --- mycosis --- candidosis --- yeast infection --- candida --- candida albicans --- vaginal health --- anticandidal activity --- indazole --- pyrazole --- 3-phenyl-1H-indazole --- drug design --- acetylsalicylic acid (ASA, aspirin) --- capsule --- CAP64 --- Cryptococcus --- membrane potential (ΔΨM) --- photodynamic treatment --- photosensitiser --- ultrastructure --- drug repurposing --- antifungals --- repositioning --- yeasts --- emerging fungi --- multidrug resistance --- therapeutic alternatives --- new targets --- Candida auris --- Aspergillus spp. --- antifungal --- beta-glucan --- polycations --- Galleria mellonella model --- retinoids --- Candida spp. --- onychomycosis --- Malassezia spp. --- dermatophytes --- microbiology --- mycology --- all-trans retinoic acid --- Acanthamoeba --- free-living ameba --- Acanthamoeba keratitis --- isavuconazonium sulfate --- cyst --- drug --- drug discovery --- drug targets --- invasive aspergillosis treatment --- invasive fungal infections --- fission yeast --- cell wall --- β(1,3)-D-glucan synthase --- antifungal drugs --- echinocandin drugs --- echinocandin resistance --- Fks resistance hot spots --- cytokinesis --- septation --- cell separation --- cell integrity --- cell lysis --- sporotrichosis --- Felis catus --- quinones --- hydrazones --- zoonoses --- host-directed drug therapy --- azoles --- polyenes --- echinocandins --- viral infections --- azole --- synergy --- resistance --- Candida --- natural products --- n/a

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The dynamic development of global industry and growing demand for new material technologies generate constantly increasing problems regarding premature material degradation and the requirement to determine corrosion mechanisms and to develop new protection/evaluation approaches. Corrosion resistance depends on numerous determinants, such as material structure, chemistry, and complex environmental factors. It is highly challenging to obtain consensus between high corrosion resistance and an economic approach. On the other hand, inadequate levels of corrosion control create serious hazards to life and the environment. This Special Issue, “Recent Advances in Corrosion Science”, brings together fourteen articles and one review, providing a snapshot of the recent activity and development in this field. The book contains studies related to the development of new corrosion-resistant alloys and the determination of microstructure-dependent properties; it also provides an insight into recent approaches towards anticorrosion technologies, such as corrosion inhibitors and composite and metal protective coatings.

Research & information: general --- corrosion inhibitor --- electrochemical --- AFM --- CO2 corrosion --- austempered gray cast iron --- austempering temperature --- microstructure --- potentiodynamic polarization --- electrochemical impedance spectroscopy --- titanium-based alloys --- passivity breakdown --- pitting corrosion --- carbon steel --- indazole derivatives --- electrochemistry --- DFT --- thermal diffusion coatings --- grade 10.9 bolts --- corrosion resistance --- thermal deformation parameters --- 35CrMoV steel --- grain size --- electrochemical corrosion --- aluminum alloys --- phase characterization --- de-alloying --- titanium aluminides --- oxidation --- non-isothermal --- mechanism --- internal oxidation --- pre-corrosion pits --- residual fatigue life --- 42CrMo steel --- stress intensity factor --- aluminum alloy --- alkaline environment --- impedance analysis --- adsorption --- dihydroxybenzene --- magnesium --- immersion test --- polarization --- cleaning --- bond coat --- PDC coatings --- fillers --- EC-AFM --- corrosion --- metallic materials --- metal coatings --- nickel --- composite coatings --- electrodeposition --- XPS --- electrochemical impedance spectroscopy (EIS) --- boron-doped diamond --- high-temperature treatment --- surface oxidation --- microstructure defects --- electrochemical activity --- n/a

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The dynamic development of global industry and growing demand for new material technologies generate constantly increasing problems regarding premature material degradation and the requirement to determine corrosion mechanisms and to develop new protection/evaluation approaches. Corrosion resistance depends on numerous determinants, such as material structure, chemistry, and complex environmental factors. It is highly challenging to obtain consensus between high corrosion resistance and an economic approach. On the other hand, inadequate levels of corrosion control create serious hazards to life and the environment. This Special Issue, “Recent Advances in Corrosion Science”, brings together fourteen articles and one review, providing a snapshot of the recent activity and development in this field. The book contains studies related to the development of new corrosion-resistant alloys and the determination of microstructure-dependent properties; it also provides an insight into recent approaches towards anticorrosion technologies, such as corrosion inhibitors and composite and metal protective coatings.

corrosion inhibitor --- electrochemical --- AFM --- CO2 corrosion --- austempered gray cast iron --- austempering temperature --- microstructure --- potentiodynamic polarization --- electrochemical impedance spectroscopy --- titanium-based alloys --- passivity breakdown --- pitting corrosion --- carbon steel --- indazole derivatives --- electrochemistry --- DFT --- thermal diffusion coatings --- grade 10.9 bolts --- corrosion resistance --- thermal deformation parameters --- 35CrMoV steel --- grain size --- electrochemical corrosion --- aluminum alloys --- phase characterization --- de-alloying --- titanium aluminides --- oxidation --- non-isothermal --- mechanism --- internal oxidation --- pre-corrosion pits --- residual fatigue life --- 42CrMo steel --- stress intensity factor --- aluminum alloy --- alkaline environment --- impedance analysis --- adsorption --- dihydroxybenzene --- magnesium --- immersion test --- polarization --- cleaning --- bond coat --- PDC coatings --- fillers --- EC-AFM --- corrosion --- metallic materials --- metal coatings --- nickel --- composite coatings --- electrodeposition --- XPS --- electrochemical impedance spectroscopy (EIS) --- boron-doped diamond --- high-temperature treatment --- surface oxidation --- microstructure defects --- electrochemical activity --- n/a

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The Special Issue "Anticancer Drugs 2021" of Pharmaceuticals is focused on recent significant advances in the design, synthesis, molecular mechanism of action and therapeutic applications of anticancer drugs. This collection of preclinical research papers and reviews includes designed chemotherapeutic agents, targeted therapies and biological agents. The rationalization for the biological activity of these drugs is presented, which helps to guide the design of more effective agents. Structure–activity relationships, together with the biological context in which targets are selected for oncology drug development, are also considered.

Research & information: general --- Chemistry --- thymidylate synthase --- cytotoxicity --- 1,2,3-triazole --- 1,3,4-oxadiazole --- 5-fluoruracil --- pemetrexed --- docking --- 3,4′-bis-guanidino --- 3-amino-4′-guanidino --- diphenyl ether --- phenyl pyridyl ether --- intramolecular hydrogen bond --- cancer cell viability --- HL-60 --- BRAF --- apoptosis --- thieno[2,3-d][1,2,3]triazine --- acetamide --- H1299 --- HER2 --- EGFR --- Bcl-2 inhibitors --- Indole-based analogues --- benzimidazole --- MTT cytotoxic assay --- cell cycle analysis --- DNA fragmentation --- ELISA --- solid/lipid nanoparticles --- phenstatin --- letrozole --- tubulin polymerisation inhibitor --- aromatase inhibitor --- breast cancer --- hybrid molecule --- dual-targeting molecule --- designed multiple ligand --- NaMSA --- cyclophosphamide --- histopathology --- testis --- urinary bladder --- anticancer agents --- enantioselective synthesis --- gastric adenocarcinoma --- tryptophanol --- concentration-guided dosing --- model informed dosing --- physiologically based pharmacokinetics --- sorafenib --- tyrosil-DNA-phosphodiesterase 1 --- adamantane --- resin acid --- TDP1 --- cytotoxic agents --- apoptosis induction --- HT-29 cells --- MDA-MB-231 cells --- mechanism prediction --- STAT inhibitors --- miR-21 --- hydrazide derivatives --- nitrogen scaffolds --- mitoxantrone --- cardiotoxicity --- inflammation --- oxidative stress --- age --- cumulative dose --- Trk --- NTRK --- tissue-agnostic --- larotrectinib --- entrectinib --- Trk fusion --- protein kinase inhibitors --- USFDA --- cancer --- patent review --- generic product --- doxazosin --- MD simulations --- combretastatin A-4 --- cytotoxic activity --- hybrid compounds --- indazole --- mucin --- MUC1 --- MUC16 --- immunotherapy --- cancer vaccine --- CAR (chimeric antigen receptor) --- ADC (antibody-drug conjugate) --- thiourea --- interleukin-6 --- trypan blue assay --- chalcones --- exportin-1 --- covalent binding --- CovDock --- anticancer activity --- xanthone --- in vitro --- in vivo --- isolation --- synthesis --- heterocyclic compound --- benzenesulfonamides --- imidazoles --- alkylated --- colony formation --- tumor spheroids --- HDAC inhibitors --- chalcone --- dual inhibitors --- carvedilol --- kidney --- toxicity --- 7-deaza-4′-thioadenosine derivatives --- multi-kinase inhibitor --- anticancer --- nucleoside --- Imiquimod --- drug efflux --- multidrug resistance --- Toll-Like Receptor --- n/a --- 3,4'-bis-guanidino --- 3-amino-4'-guanidino --- 7-deaza-4'-thioadenosine derivatives