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Health Sciences --- Veterinary Science --- in vivo studies --- laboratory animal science --- model organisms

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Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.

chitosan --- intestinal epithelial cells --- ocular delivery --- amphiphilic polymers --- cornea --- tight junction modulator --- cyclodextrin --- permeability --- gemini surfactant --- transferrin --- compound 48/80 --- epithelial permeability --- cervicovaginal tumors --- nanoparticles --- confocal laser scanning microscopy --- safety --- formulation --- salcaprozate sodium --- intestinal absorption --- FITC-dextran --- curcumin --- block copolymers --- nasal vaccination --- whole leaf --- brush border --- ocular drug delivery --- vaccine adjuvant --- nanoparticle --- nasal delivery --- efflux --- permeation enhancers --- absorption enhancers --- nose to brain delivery --- small intestine --- epithelium --- CNS disorders --- absorption modifying excipients --- insulin --- absorption enhancer --- gel --- intestinal delivery --- thermogel system --- Caco-2 --- biocompatibility studies --- absorption enhancement --- man --- PN159 --- poorly absorbed drug --- tryptophan --- tight junction --- oral macromolecule delivery --- penetration enhancer --- intestinal permeation enhancers --- nanocrystals --- simvastatin --- nanomedicine --- enterocyte --- N-dodecyl-?-D-maltoside (DDM) --- cell-penetrating peptide --- quaternization --- KLAL --- nasal --- nasal permeability --- transmucosal drug delivery --- Caco-2 cells --- mast cell activator --- penetration enhancers --- drug delivery --- nose-to-brain --- bioenhancer --- polymeric micelles --- mucoadhesion --- cell-penetrating peptide (CPP) --- simulated intestinal fluid --- vaginal delivery --- nasal formulation --- pharmacokinetic interaction --- sodium caprate --- clinical trial --- transmucosal permeation --- drug absorption enhancer --- sugar-based surfactants --- nanocapsules --- imatinib --- teriparatide --- osteoporosis --- hydrophobization --- F-actin --- combined microsphere --- transepithelial electrical resistance --- oral delivery --- ocular conditions --- metabolism --- antimicrobial peptide --- permeation enhancer --- drug administration --- antiepileptic drug --- amino acid --- in vivo studies --- sodium cholate (NaC) --- epithelial transport --- preclinical --- nose to brain transport --- pharmacokinetics --- chitosan derivatives --- ophthalmology --- tight junctions --- sheep --- cationic functionalization --- GLP-1 --- pulmonary --- and liposome --- cytochrome P450 --- claudin --- P-glycoprotein --- in situ hydrogel --- mucoadhesiveness --- PTH 1-34 --- Aloe vera --- oral peptides

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The Special Issue, entitled “Forest, Food and Nutrition”, is focused on understanding of the intersection and linking existing between forests, food, and nutrition. Forest ecosystems are an important biodiversity environment resource for many species. Forests and trees play a key role in food production and have a relevant impact also on nutrition. Plants and animals in the forests enable nutrient-rich food sources to be available, and can provide important contributions to dietary diversity, quality, and quantity.

Research & information: general --- Biology, life sciences --- Food & society --- pteridophytes --- ferns --- antioxidant --- tyrosinase inhibition --- cosmetics --- Polypodiopsida --- heavy metal contamination --- herbal medicine --- historically polluted area --- wild food --- blackberry --- mangrove forest --- local communities --- Ayeyarwaddy region --- Myanmar --- economic --- livelihoods --- Chamaemelum fuscatum --- chamomile --- essential oil --- aliphatic esters --- methacrylate --- Compositae --- Mediterranean --- Cyclocarya paliurus --- seasonal dynamic --- phenolic acids --- flavonoids --- antioxidant activity --- structure-activity relationship --- flavonoid --- phenolics --- triterpenoid --- solvent --- natural population --- Ulmus pumila --- transcriptome analysis --- phytonutrients --- seed development --- phenylpropanoid biosynthesis --- ciwujia --- Siberian ginseng --- Acanthopanax --- secondary metabolite --- Changbai Mountains --- Khingan Mountains --- walnut (Juglans regia L.) --- electrochemical oxidation --- UV-VIS --- ABTS --- DPPH --- edible landscape --- food security --- urban horticulture --- community garden --- auxin --- biocontrol --- chitinase --- fruit --- fungal pathogen --- jujube --- Lysobacter antibioticus HS124 --- mineral concentration --- production --- Rhamnaceae --- ESCC (Esophageal squamous cell carcinoma) --- podophyllotoxin --- ROS (reactive oxygen species) --- p38 --- JNK (c-Jun N-terminal kinase) --- Vitellaria paradoxa --- Butyrospermum parkii --- agroforestry --- market --- non-wood forest product --- contingent valuation --- food --- gender --- Fulani --- wild edible tree species --- biodiversity --- ethnic groups --- conservation --- green coffee --- hawthorn --- bioactive compounds --- Crataegus --- biological activity --- nutraceuticals --- health benefits --- plant extracts --- assessment of wild food --- dimensions in science --- technology and innovation (STI) --- estimation of potential --- tropical forest areas --- food processing industry --- wild edible plants --- neglected and underutilized species (NUS) --- Africa --- urban consumers --- marketing --- product differentiation --- essential oils --- extracts --- Salvia Africana --- S. rutilans --- S. munzii --- S. mellifera --- S. greggii --- S. officinalis “Icterina” --- S. officinalis --- chaste tree --- Vitex agnus-castus L. --- in vitro studies --- in vivo studies --- health-promoting properties. --- mushroom --- Enguday --- ethnomycology --- folk taxonomy --- Amhara --- Agew and Sidama --- bioeconomy --- food and nutrition security --- forests and trees --- forest foods --- wild harvesting --- forest --- tree --- edible forest products --- non-edible forest products --- nutritional value --- biologically activecompounds --- food composition databases --- dedicated databases --- novel food --- sustainable agriculture --- pteridophytes --- ferns --- antioxidant --- tyrosinase inhibition --- cosmetics --- Polypodiopsida --- heavy metal contamination --- herbal medicine --- historically polluted area --- wild food --- blackberry --- mangrove forest --- local communities --- Ayeyarwaddy region --- Myanmar --- economic --- livelihoods --- Chamaemelum fuscatum --- chamomile --- essential oil --- aliphatic esters --- methacrylate --- Compositae --- Mediterranean --- Cyclocarya paliurus --- seasonal dynamic --- phenolic acids --- flavonoids --- antioxidant activity --- structure-activity relationship --- flavonoid --- phenolics --- triterpenoid --- solvent --- natural population --- Ulmus pumila --- transcriptome analysis --- phytonutrients --- seed development --- phenylpropanoid biosynthesis --- ciwujia --- Siberian ginseng --- Acanthopanax --- secondary metabolite --- Changbai Mountains --- Khingan Mountains --- walnut (Juglans regia L.) --- electrochemical oxidation --- UV-VIS --- ABTS --- DPPH --- edible landscape --- food security --- urban horticulture --- community garden --- auxin --- biocontrol --- chitinase --- fruit --- fungal pathogen --- jujube --- Lysobacter antibioticus HS124 --- mineral concentration --- production --- Rhamnaceae --- ESCC (Esophageal squamous cell carcinoma) --- podophyllotoxin --- ROS (reactive oxygen species) --- p38 --- JNK (c-Jun N-terminal kinase) --- Vitellaria paradoxa --- Butyrospermum parkii --- agroforestry --- market --- non-wood forest product --- contingent valuation --- food --- gender --- Fulani --- wild edible tree species --- biodiversity --- ethnic groups --- conservation --- green coffee --- hawthorn --- bioactive compounds --- Crataegus --- biological activity --- nutraceuticals --- health benefits --- plant extracts --- assessment of wild food --- dimensions in science --- technology and innovation (STI) --- estimation of potential --- tropical forest areas --- food processing industry --- wild edible plants --- neglected and underutilized species (NUS) --- Africa --- urban consumers --- marketing --- product differentiation --- essential oils --- extracts --- Salvia Africana --- S. rutilans --- S. munzii --- S. mellifera --- S. greggii --- S. officinalis “Icterina” --- S. officinalis --- chaste tree --- Vitex agnus-castus L. --- in vitro studies --- in vivo studies --- health-promoting properties. --- mushroom --- Enguday --- ethnomycology --- folk taxonomy --- Amhara --- Agew and Sidama --- bioeconomy --- food and nutrition security --- forests and trees --- forest foods --- wild harvesting --- forest --- tree --- edible forest products --- non-edible forest products --- nutritional value --- biologically activecompounds --- food composition databases --- dedicated databases --- novel food --- sustainable agriculture