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It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These intrinsically disordered proteins (IDPs) or regions (IDRs) have peculiar features due to their plasticity such as the capacity to bind their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. A correlation between intrinsic disorder and various human diseases such as cancer, diabetes, amyloidoses and neurodegenerative diseases is now evident, highlighting the great importance of the topic. In this volume, we have collected recent high-quality research about IDPs and human diseases. We have selected nine papers which deal with a wide range of topics, from neurodegenerative disease to cancer, from IDR-mediated interactions to bioinformatics tools, all related to IDP peculiar features. Recent advances in the IDPs/IDRs issue are here presented, contributing to the progress of knowledge of the intrinsic disorder field in human disease.

Research & information: general --- Biology, life sciences --- alpha-synuclein --- NMR --- secondary structure propensity --- pre-structured motifs (PreSMos) --- intrinsically disordered protein --- ubiquitin-proteasome system --- intrinsically disordered proteins --- protein misfolding --- molecular recognition features --- cancer --- neurodegenerative diseases --- protein degradation --- EPR spectroscopy --- isothermal titration calorimetry --- protein-ligand interaction --- site-directed spin labeling --- protein structural dynamics --- WASp interacting protein --- protein-protein interactions --- actin --- cytoskeleton remodeling --- SH3 domain --- proline-rich motif --- single nucleotide variants --- interface core and rim --- human disease --- intrinsically disordered regions --- linear motifs --- gene duplications --- de novo --- evolutionary origin --- circular dichroism --- flexibility --- fluorescence --- importin --- isothermal titration calorimetry (ITC) --- molecular docking --- nuclear magnetic resonance (NMR) --- nuclear protein 1 (NPR1) --- peptide --- Methyl-CpG-binding protein 2 (MeCP2) --- Rett syndrome --- intrinsically disordered protein (IDP) --- protein stability --- protein-DNA interaction --- proteostasis --- ubiquitin independent degradation --- NADH-26S proteasome --- alpha-synuclein --- NMR --- secondary structure propensity --- pre-structured motifs (PreSMos) --- intrinsically disordered protein --- ubiquitin-proteasome system --- intrinsically disordered proteins --- protein misfolding --- molecular recognition features --- cancer --- neurodegenerative diseases --- protein degradation --- EPR spectroscopy --- isothermal titration calorimetry --- protein-ligand interaction --- site-directed spin labeling --- protein structural dynamics --- WASp interacting protein --- protein-protein interactions --- actin --- cytoskeleton remodeling --- SH3 domain --- proline-rich motif --- single nucleotide variants --- interface core and rim --- human disease --- intrinsically disordered regions --- linear motifs --- gene duplications --- de novo --- evolutionary origin --- circular dichroism --- flexibility --- fluorescence --- importin --- isothermal titration calorimetry (ITC) --- molecular docking --- nuclear magnetic resonance (NMR) --- nuclear protein 1 (NPR1) --- peptide --- Methyl-CpG-binding protein 2 (MeCP2) --- Rett syndrome --- intrinsically disordered protein (IDP) --- protein stability --- protein-DNA interaction --- proteostasis --- ubiquitin independent degradation --- NADH-26S proteasome

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The regulation of imports and exports by customs authorities profoundly affects the activity of economic operators in international trade. This is (one of) the first book(s) in English to critically assess the legal instruments of the European Union's trade and customs policy--namely the Union Customs Code and its regulatory instruments--taking account of doctrinal contributions and the jurisprudential acquis of the Court of Justice of the European Union.

export tax --- customs duties --- free movement of goods --- EU customs procedure --- import tax --- taksë importi --- gravamen sobre las importaciones --- порез на увоз --- taxe à l'importation --- dleacht allmhairiúcháin --- импортна такса --- imposta all'importazione --- importskatt --- tuontivero --- εισαγωγικός φόρος --- dovozní daň --- taxxa tal-importazzjoni --- данок на увоз --- Einfuhrabgabe --- imporditollimaks --- importa nodoklis --- dovozná daň --- importadó --- heffing bij invoer --- podatek importowy --- importo mokestis --- direitos de importação --- uvozna davščina --- porez na uvoz --- importskat --- taxă de import --- imposition à l'importation --- bijzondere heffing bij invoer --- pridėtinis importo mokestis --- särskild importskatt --- zvláštny poplatok z dovozov --- taxa à importação --- import surcharge --- tuonnin verotus --- mbitaksë importi --- impordi maksustamine --- behozatali adó --- увозна давачка --- importbeskattning --- impordi erimaks --- importbelasting --- zdanenie dovozov --- gravamen especial sobre las importaciones --- zdanění dovozu --- tatim i importeve --- særlig importafgift --- importo apmokestinimas --- impuesto especial a la importación --- oporezivanje uvoza --- posebna naknada na uvezenu robu --- special charge on imports --- ειδικός φόρος κατά την εισαγωγή --- ieveduma nodoklis --- impordi lisamaks --- imposizione all'importazione --- besondere Einfuhrabgabe --- taxe spéciale à l'importation --- suprataxă de import --- gravamen a la importación --- Abgabe bei der Einfuhr --- importbeskatning --- importná prirážka --- specialusis importo mokestis --- tuontiin kohdistuva lisämaksu --- taksë e veçantë mbi importin --- ylimääräinen tuontimaksu --- tassa speciale all'importazione --- invoerbelasting --- taxa especial à importação --- impuesto a la importación --- impuesto especial sobre las importaciones --- taxation of imports --- îtaxarea importurilor --- procedura celna UE --- царински поступак ЕУ --- colný režim EÚ --- celní režim EU --- uniós vámeljárás --- Zollverfahren der EU --- ES muitas procedūra --- carinski postopek EU --- regime aduaneiro da UE --- regim vamal al UE --- Bendrijos muitinės procedūra --- EU:n tullimenettely --- EU's toldordning --- ELi tolliprotseduur --- procedurë doganore e BE-së --- carinski postupak EU-a --- царинска постапка на ЕУ --- τελωνειακό καθεστώς της ΕΕ --- régimen aduanero de la UE --- skema doganali tal-UE --- EU:s tullförfarande --- nós imeachta custaim an Aontais Eorpaigh --- régime douanier de l'UE --- regime doganale dell'UE --- EU-douanestelsel --- митнически режим на ЕС --- procedurë doganore e Bashkimit Europian --- ühenduse tolliprotseduur --- közösségi vámeljárás --- regime doganale comunitario --- colný postup Spoločenstva --- Zollverfahren der Gemeinschaft --- Euroopan unionin tullimenettely --- celní režim Společenství --- colný režim Európskej únie --- celní režim Evropské unie --- European Union customs procedure --- procedură vamală comunitară --- gemeenschappelijke douaneregeling --- carinski postopek Skupnosti --- Kopienas muitas procedūra --- κοινοτικό τελωνειακό καθεστώς --- procedura celna Unii Europejskiej --- regimul vamal al Uniunii Europene --- митнически режим на Общността --- митнически режим на Европейския съюз --- Euroopa Liidu tolliprotseduur --- Bendrijos muitų tvarka --- gemenskapens tullförfarande --- régime douanier communautaire --- régimen aduanero comunitario --- régime douanier de l'Union européenne --- regime aduaneiro comunitário --- skema doganali tal-Unjoni Ewropea --- douanestelsel van de Europese Unie --- Eiropas Savienības muitas procedūra --- ES muitinės procedūra --- régimen aduanero de la Unión Europea --- Fællesskabets toldordning --- Европска царинска унија --- regime aduaneiro da União Europeia --- Zollverfahren der Europäischen Union --- yhteisön tullimenettely --- regime doganale dell'Unione europea --- unionin tullimenettely --- carinski postopek Evropske unije --- Community customs procedure --- царинска постапка во Европската Унија --- Europos Sąjungos muitinės procedūra --- царински поступак Заједнице --- carinski postupak Zajednice --- procedura celna WE --- τελωνειακό καθεστώς της Ευρωπαϊκής Ένωσης --- carinski postupak Europske unije --- európai uniós vámeljárás --- свободно движение на стоки --- kaupade vaba liikumine --- laisvas prekių judėjimas --- voľný pohyb tovaru --- ελεύθερη κυκλοφορία των εμπορευμάτων --- slobodno kretanje roba --- слободно движење на стоки --- moviment liberu tal-merkanzija --- lëvizja e lirë e mallrave --- áruk szabad mozgása --- слобода кретања робе --- livre circulação de mercadorias --- tavaroiden vapaa liikkuvuus --- swobodny przepływ towarów --- frie varebevægelser --- vrij verkeer van goederen --- fri rörlighet för varor --- freier Warenverkehr --- volný pohyb zboží --- libre circulación de mercancías --- brīva preču kustība --- prosti pretok blaga --- saorghluaiseacht earraí --- libera circulație a mărfurilor --- libre circulation des marchandises --- libera circolazione delle merci --- libre-échange --- слободна трговија --- librecambismo --- livre circulação de bens --- livre-troca --- fri rörlighet för produkter --- volný obchod --- libre circulación de productos --- vrij handelsverkeer --- voľný obchod --- ελεύθερη εμπορία --- ελεύθερη διακίνηση των εμπορευμάτων --- freier Handel --- libre cambio --- libre circulation des biens --- freier Güterverkehr --- volný obchod komodit --- vrijhandel --- libre commercialisation --- lëvizja e lirë e produkteve --- tregti e lirë --- comerț liber --- vapaakauppa --- fri vareudveksling --- free movement of products --- volný pohyb výrobků --- libre circulation des produits --- voľný pohyb výrobkov --- eliminazione delle barriere doganali --- vabakaubandus --- ελεύθερη διακίνηση των αγαθών --- szabad áruforgalom --- libera circulație a bunurilor --- libera commercializzazione --- libero scambio --- svobodný obchod --- free movement of commodities --- libera circolazione dei prodotti --- laisvas gaminių judėjimas --- livre comercialização --- Freihandel --- libre comercialización --- fri markedsføring --- szabad kereskedelem --- frihandel --- laisva prekių apyvarta --- libera circulație a produselor --- tuotteiden vapaa liikkuvuus --- slobodna trgovina --- abolizione delle restrizioni qualitative --- abolizione delle restrizioni quantitative --- voľný pohyb komodít --- toodete vaba liikumine --- libera circolazione dei beni --- brīvā tirdzniecība --- laisvoji prekyba --- ελεύθερες συναλλαγές --- vrije commercialisering --- ελεύθερη διακίνηση των προϊόντων --- libre circulación de bienes --- hyödykkeiden vapaa liikkuvuus --- slobodno kretanje proizvoda --- слободно движење на производи --- vrij verkeer van producten --- free trade --- lëvizja e lirë e mallrave bazë --- livre circulação de produtos --- fritt varuutbyte --- δασμός --- muitai --- douanerechten --- muitas nodokļi --- cla --- tollimaksud --- tullar --- dleachtanna custaim --- царинске дажбине --- direitos aduaneiros --- tullit --- Zollsatz --- carinska pristojba --- dazi doganali --- taksa doganore --- opłata celna --- droits de douane --- derechos de aduana --- dazji doganali --- taxă vamală --- carinske dajatve --- царински давачки --- митнически дългове --- toldafgifter --- colné poplatky --- vámtétel --- τελωνειακός δασμός --- muitas --- давачки за увоз --- diritti doganali --- carina --- Zölle --- акцизи --- vámok --- давачки за извоз --- celní poplatky --- diritti di confine --- taxa alfandegária --- cáin onnmhairíochta --- vývozní daň --- gravamen sobre las exportaciones --- eksporta nodoklis --- taxxa fuq l-esportazzjoni --- данок на извоз --- Ausfuhrabgabe --- taxe à l'exportation --- експортна такса --- порез на извоз --- taksë eksporti --- direitos de exportação --- podatek eksportowy --- eksporditollimaks --- eksportskat --- imposta all'esportazione --- εξαγωγικός φόρος --- porez na izvoz --- heffing bij uitvoer --- vývozná daň --- taxă de export --- exportadó --- exportskatt --- izvozna dajatev --- eksporto mokestis --- vientivero --- vientiin kohdistuva lisämaksu --- taxation of exports --- ekspordi erimaks --- zdanění vývozu --- besondere Ausfuhrabgabe --- særlig eksportafgift --- tatim i eksporteve --- zvláštny poplatok z vývozu --- taxa especial à exportação --- export surcharge --- zdanenie vývozov --- tassa speciale all'esportazione --- specialusis eksporto mokestis --- kiviteli adó --- taxe spéciale à l'exportation --- Abgabe bei der Ausfuhr --- oporezivanje izvoza --- bijzondere heffing bij uitvoer --- särskild exportskatt --- gravamen a la exportación --- taxa à exportação --- mbitaksë eksporti --- imposition à l'exportation --- извозна давачка --- ylimääräinen vientimaksu --- suprataxă de export --- přirážka k vývozu --- taksë e veçantë mbi eksportin --- eksportbeskatning --- ειδικός φόρος κατά την εξαγωγή --- taxarea exporturilor --- exportbelasting --- viennin verotus --- eksporto apmokestinimas --- ekspordi maksustamine --- exportná prirážka --- exportfelár --- special charge on exports --- imposizione all'esportazione --- exportbeskattning --- gravamen especial sobre las exportaciones --- uitvoerbelasting --- pridėtinis eksporto mokestis --- impuesto a la exportación --- ekspordi lisamaks --- European law --- Tax law --- European Union --- Douanes --- Customs administration --- Droit --- Law and legislation .