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Immunogenetics --- Immunogenetics. --- Immunogenetica. --- Immungenetik. --- Immunogenetik --- Genetics --- Immunity --- Immunology --- Immunogenetic --- Immunological aspects --- Genetic aspects --- Immunbiologie --- Serology --- Genes, Immunoglobulin --- Immungenetik --- Man --- Serials

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This open access book explores techniques for working in the field of immunogenetics, i.e. fundamental and translational research into the adaptive immune receptor repertoire. Many chapters are dedicated to lab protocols, bioinformatics, and immunoinformatics analysis of high-resolution immunome analysis, exemplified by numerous applications. Additionally, the newest technological variations on these protocols are discussed, including non-amplicon, single-cell, and cell-free strategies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immunogenetics: Methods and Protocols covers a broad spectrum of methodologies for applications in research and clinical diagnostics to illustrate the impact that immunogenetics has achieved and will further expand in all fields of medicine, from infection and (auto)immunity, to vaccination, to lymphoid malignancy and tumor immunity.

Immunogenetics. --- Immunospecificity. --- Adaptive Immunity. --- Immunological specifics --- Serological specificity --- Specificity (Immunology) --- Antibody diversity --- Antigenic determinants --- Binding sites (Biochemistry) --- Immune recognition --- Genetics --- Immunity --- Immunology --- Serology --- Immunological aspects --- Genetic aspects --- The immunome --- Adaptive immune cells --- Antigen receptors --- Immunoinformatics --- T-cell receptors --- Lymphocytes --- Immunogenètica --- Receptors cel·lulars --- Manuals de laboratori

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Genetic / DNA immunization represents a novel approach to vaccine and immune therapeutic development. The direct injec­ tion of nucleic acid expression cassettes into a living host results in a limited number of its cells becoming factories for production of the introduced gene products. This host-inappropriate gene expression has important immunological consequences, resulting in the specific immune activation of the host against the gene­ delivered antigen. The recent demonstration by a number of laboratories that the induced immune responses are functional in experimental models against both specific infectious diseases and cancers is likely to have dramatic consequences for the develop­ ment of a new generation of experimental vaccines and immune therapies. This technology has the potential to enable the pro­ duction of vaccines and immune-based therapies that are not only effective immunologically but are accessible to the entire world (rather than just to the most developed nations). Vaccine Development Vaccination against pathogenic microorganisms represents one of the most important advances in the history of medicine. Vaccines, including those against polio, measles, mumps, rubella, hepatitis A, hepatitis B, pertussis and other diseases, have dramatically improved and protected more human lives than any other avenue of modern medicine. The vaccine against smallpox, for example, has been so successful that it is now widely believed that this malicious killer, responsible for more deaths in the twentieth century than World Wars I and II combined, has been removed from the face of the earth.

ADN [Vaccins à ] --- DNA vaccines --- DNA-vaccins --- Genetic vaccines --- Genetica [Immuno] --- Genetica--Immunologische aspecten --- Genetics--Immunological aspects --- Génétique--Aspects immunologiques --- Immunity--Genetic aspects --- Immunogenetica --- Immunogenetics --- Immunogénétique --- Immunologie--Aspects génétiques --- Immunologie--Genetische aspecten --- Immunology--Genetic aspects --- Vaccins [DNA-] --- Vaccins à ADN --- Vaccines --- Gentherapie --- DNA --- Vaccines. --- Gentherapie. --- DNA. --- Immunology. --- Virology. --- Cancer research. --- Molecular biology. --- Cancer Research. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Microbiology --- Immunobiology --- Life sciences --- Serology

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Molecular biology. --- Genetics. --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Microbiologia mèdica --- Genètica --- Biologia --- Lleis de Mendel --- Al·lelomorfisme --- Cariotips --- Citogenètica --- Epigènesi --- Epigenètica --- Farmacogenètica --- Fenotip --- Genètica animal --- Genètica de poblacions --- Genètica de la conducta --- Genètica del desenvolupament --- Genètica evolutiva --- Genètica forense --- Genètica humana --- Genètica microbiana --- Genètica molecular --- Genètica quantitativa --- Genètica vegetal --- Herència citoplasmàtica --- Herència i medi --- Immunogenètica --- Neurogenètica --- Recursos genètics --- Selecció natural --- Sexualitat --- Adaptació (Biologia) --- Cromosomes --- Evolució --- Herència (Biologia) --- Millora de les espècies --- Mutació (Biologia) --- Nutrigenòmica --- Variació (Biologia) --- Microbiologia clínica --- Ciències de la salut --- Microbiologia --- Bacteriologia mèdica --- Diagnòstic microbiològic --- Infeccions --- Malalties infeccioses --- Micologia mèdica --- Microbiologia oral --- Microbiologia sanitària --- Microbiologia veterinària --- Virologia mèdica --- Microorganismes patògens

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Human genetics --- Medical genetics --- Genetics --- Génétique humaine --- Génétique médicale --- Periodicals --- periodicals --- Périodiques --- Genetics. --- Medical genetics. --- Genetica. --- Genetic Processes --- Genetic Structures --- Genetic Phenomena --- Health Sciences --- Life Sciences --- Biology --- Health Sciences. --- Génétique humaine --- Génétique médicale --- Périodiques --- EJBIOLO EJBIOMO EJMEDEC ELSEVIER-E EPUB-ALPHA-A EPUB-PER-FT MDGENETI PUBMED-E --- Clinical genetics --- Diseases --- Heredity of disease --- Genetic aspects --- Medical sciences --- Pathology --- Genetic disorders --- periodicals. --- Menselijke genetica --- Genetics, Medical. --- Medical Genetics --- Anthropology, Physical --- Chromosome Disorders --- Sex Chromosome Disorders --- Genetic Diseases, Inborn --- Molecular Medicine --- Genetics, Medical --- genetics. --- Biological Sciences --- animal genetics --- cytogenetics --- gender --- genetic equilibrium --- genetic factors --- genetic relationships --- genetic selection --- genetic stability --- genetic structure --- genetic traits --- genetic vectors --- genomics --- human genetics --- immunogenetics --- inheritance (genetics) --- landscape genetics --- maternal effect --- metabolomics --- microbial genetics --- molecular genetics --- nutrigenomics --- paternal effect --- phenomics --- phenotype --- plant genetics --- population genetics --- proteomics --- quantitative genetics --- reproductive fitness --- sex determination --- transcriptomics --- biotechnology --- breeding --- genetic models --- genetic resources --- geneticists --- Genètica. --- Genètica humana. --- Antropologia física --- Biologia humana --- Genètica --- Herència humana --- Citogenètica humana --- Cromosomes humans --- Genètica de poblacions humanes --- Genètica mèdica --- Genètica molecular humana --- Psicologia genètica --- Genoma humà --- Biologia --- Lleis de Mendel --- Al·lelomorfisme --- Cariotips --- Citogenètica --- Epigènesi --- Epigenètica --- Farmacogenètica --- Fenotip --- Genètica animal --- Genètica de poblacions --- Genètica de la conducta --- Genètica del desenvolupament --- Genètica evolutiva --- Genètica forense --- Genètica humana --- Genètica microbiana --- Genètica molecular --- Genètica quantitativa --- Genètica vegetal --- Herència citoplasmàtica --- Herència i medi --- Immunogenètica --- Neurogenètica --- Recursos genètics --- Selecció natural --- Sexualitat --- Adaptació (Biologia) --- Cromosomes --- Evolució --- Herència (Biologia) --- Millora de les espècies --- Mutació (Biologia) --- Nutrigenòmica --- Variació (Biologia)