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This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design.

Medicine --- hydrochlorothiazide --- cyclodextrins --- sepiolite --- nanoclay --- dissolution rate --- tablet --- electrospinning --- chitosan --- chondroitin sulfate --- scaffolds --- montmorillonite --- halloysite --- fibroblasts proliferation --- immune response --- glycosaminoglycans --- antimicrobial properties --- palygorskite --- spring water --- hydrogel --- fibroblast --- biocompatibility --- wound healing --- mesoporous clay --- Neusilin --- aeroperl --- liquisolid technique --- glyburide --- dissolution improvement --- hydrotalcite --- ketoprofen --- hybrid --- photostability --- hydrogel film --- bioadhesion --- heavy metal --- hazardous element --- element mobility --- clay minerals --- toxicity --- palygorksite --- proliferation --- Franz cell --- bioactive elements --- praziquantel --- drug --- organic solvents --- in vitro dissolution tests --- cytotoxicity --- targeted drug delivery --- halloysite nanotube --- osteosarcoma --- methotrexate --- surface modification --- hydrochlorothiazide --- cyclodextrins --- sepiolite --- nanoclay --- dissolution rate --- tablet --- electrospinning --- chitosan --- chondroitin sulfate --- scaffolds --- montmorillonite --- halloysite --- fibroblasts proliferation --- immune response --- glycosaminoglycans --- antimicrobial properties --- palygorskite --- spring water --- hydrogel --- fibroblast --- biocompatibility --- wound healing --- mesoporous clay --- Neusilin --- aeroperl --- liquisolid technique --- glyburide --- dissolution improvement --- hydrotalcite --- ketoprofen --- hybrid --- photostability --- hydrogel film --- bioadhesion --- heavy metal --- hazardous element --- element mobility --- clay minerals --- toxicity --- palygorksite --- proliferation --- Franz cell --- bioactive elements --- praziquantel --- drug --- organic solvents --- in vitro dissolution tests --- cytotoxicity --- targeted drug delivery --- halloysite nanotube --- osteosarcoma --- methotrexate --- surface modification

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This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design.

hydrochlorothiazide --- cyclodextrins --- sepiolite --- nanoclay --- dissolution rate --- tablet --- electrospinning --- chitosan --- chondroitin sulfate --- scaffolds --- montmorillonite --- halloysite --- fibroblasts proliferation --- immune response --- glycosaminoglycans --- antimicrobial properties --- palygorskite --- spring water --- hydrogel --- fibroblast --- biocompatibility --- wound healing --- mesoporous clay --- Neusilin --- aeroperl --- liquisolid technique --- glyburide --- dissolution improvement --- hydrotalcite --- ketoprofen --- hybrid --- photostability --- hydrogel film --- bioadhesion --- heavy metal --- hazardous element --- element mobility --- clay minerals --- toxicity --- palygorksite --- proliferation --- Franz cell --- bioactive elements --- praziquantel --- drug --- organic solvents --- in vitro dissolution tests --- cytotoxicity --- targeted drug delivery --- halloysite nanotube --- osteosarcoma --- methotrexate --- surface modification --- n/a

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The purpose of this volume is to show how in this area the technology, creativity and inventiveness are the basis of new and encouraging results not only in the environmental field but also in the monitoring of xenobiotics of organic and inorganic origin in complex matrices. The final objective will always be on determining the fundamental parameters of interest to set up an analytical procedure, such as precision and trueness (that together give accuracy), the limits of detection and quantification, selectivity, and especially sensitivity, or attempting to increase this

azides --- screen-printed sensors --- poly (3-octylthiophene) --- solid contact potentiometric sensors --- iron-phthalocyanine --- nitron-azide complexes --- microwave-assisted aqueous two-phase extraction --- Solasodine --- alkaloid --- response surface methodology --- high-performance liquid chromatography --- pre-development process --- clotrimazole --- itraconazole --- stability --- method validation --- sporotrichosis --- differential pulse voltammetry --- hydrochlorothiazide --- pyridoxine --- chemometrics --- bioindication --- heavy metals --- urban soil --- Senecio vulgaris --- Poa annua --- Polygonum aviculare --- predictive models --- MIPs --- parabens --- biological matrix --- extraction procedure --- HPLC-PDA --- stationary phase characterization --- phenol --- 3-aminophenol --- wastewater --- SPMMTE --- capillary electrophoresis --- deoxynivalenol --- dcELISA kit --- performance measurement --- development --- grapevine --- bioaccumulation --- biomonitoring --- laser-induced breakdown spectroscopy --- surface pollution --- high voltage insulators --- quantitatively analysis

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Pharmaceutical Preparations --- analysis --- Drugs --- Pharmaceutical chemistry --- Médicaments --- Chimie pharmaceutique --- Analysis --- Yearbooks. --- Analyse --- Pharmaceutical Preparations - analysis --- Atenolol --- Camphre --- Chloroquine --- Cholecalciferol --- Cimetidine --- Disopyramide (phosphate) --- Indomethacine --- Ketofifene --- Melphalan --- Moxalactam (disodium) --- Oxyphenbutazone --- Pentazocine --- Phenytoine --- Pyridoxine --- Reserpine --- Saccharine --- Salicylamide --- Sulfadadiazine argent --- Sulindac --- Tetracycline (chlorhydrate --- Tolbutamide --- Vitamine d3 --- CHLORTHALIDONE --- IMIPRAMINE HCl --- CISPLATIN --- ANALYTICAL PROFILE --- TRIPELENNAMINE HCl --- XYLOMETAZOLINE HCl --- MEFLOQUINE HCl --- ACIDE IOPOANOIQUE --- LIDOCAINE --- LIDOCAINE HCl --- BENPERIDOL --- HYDRATE DE TERPINE --- ATROPINE --- ISOPROTERENOL --- WARFARIN --- NALOXONE HCl --- DIFLUNISAL --- BACLOFEN --- ACETAMINOPHEN --- HALOTHANE --- Bacitracine --- Bretylium --- Carbamazepine --- Ccyproheptadine --- Cefaclor --- Cefamandole --- Dibenzepine --- Digoxine --- Doxorubicine --- Fluphenazine --- Gentamicine (sulfate) --- Griseofulvine --- Haloperidol --- Khellin --- Lorazepam --- Methadone --- Methoxsalen --- Monographies medicaments --- Nadolol --- Nitrazepam --- Nitroglycerin --- Trifluoroperazine --- Acide ascorbique --- Acide flufenamique --- Aminophylline --- Captopril --- Cefotaxime --- Cefoxitine sodium --- Clofibrate --- Clotrimazole --- Dopamine chlorhydrate --- Ergonovine maleate --- Hexestrol --- Mestranol --- Noscapine --- Penicilline-g benzathine --- Phenylbutazone --- Sulfadiazine --- Amantadine --- Amikacine sulfate --- Benzocaine --- Dibucaine --- Dibucaine chlorhydrate --- Dioctylsulfosuccinate de sodium --- Estrone --- Etomidate --- Heparine sodium --- Hydrocortisone --- Isopropamide --- Metoprolol tartrate --- Phenylpropanolamine chlorhydrate --- Pilocarpine --- Pyrazinamide --- Pyrimethamine --- Quinine chlorhydrate --- Quinine sulfate --- Rutine --- Trimipramine maleate --- AMILORIDE CHLORHYDRATE --- AMINOGLUTETHIMIDE --- CAFEINE --- COCAINE CHLORHYDRATE --- EPHEDRINE CHLORHYDRATE --- OESTRADIOL --- GUANABENZ ACETATE --- IODAMIDE --- LITHIUM CARBONATE --- MAPROTILINE CHLORHYDRATE --- PENICILLIN G --- POTASSIUM --- PIROXICAM --- RANITIDINE --- STRYCHNINE --- VIDARABINE --- ZOMEPIRAC --- SODIUM --- CHLORAMPHENICOL --- LIDOCAINE CHLORHYDRATE --- SODIUM NITROPRUSSIATE --- Acide aminosalicylique --- Azathioprine --- Benzoate de benzyle --- Chlorhydrate d'emetine --- Chlorhydrate de clindamycine --- Chlorhydrate de methylphenidate --- Colchicine --- Cyanocobalamine --- Glibenclamide --- Heroine --- Hydrochlorothiazide --- Ketoprofen --- Nabinole --- Natamycine --- Oxytocine --- Penicillamine --- Phosphate de codeine