Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Our common knowledge on oxidative stress has evolved substantially over the years and has been mostly focused on the fundamental chemical reactions and the most relevant chemical species involved in the human pathophysiology of oxidative stress-associated diseases. Thus, reactive oxygen species and reactive nitrogen species (ROS and RNS) were identified as the key players initiating, mediating, and regulating the cellular and biochemical complexity of oxidative stress either as physiological (acting pro-hormetic) or as pathogenic (causing destructive vicious circle) process. The papers published in this particular Special Issue of the Cells demonstrate the impressive pathophysiological relevance of ROS and RNS in a range of contexts, including the relevance of second messengers of free radicals like 4-hydroxynonenal, allowing us to assume that even more detailed mechanisms of their positive and negative effects lie in wait, and should assist in better monitoring of the major modern diseases and the development of advanced integrative biomedicine treatments.

toxicity --- toll-like receptors --- acrolein --- hydroxyapatite-based biomaterials --- LC-MS/MS --- blood–brain barrier --- NADPH-oxidase --- human neuroblastoma SH-SY5Y cells --- NRF2-NQO1 axis --- granulocytes --- free radicals --- antioxidant --- plaque vulnerability --- bEnd.3 --- relaxation --- Ca2+ --- keratinocytes --- oxidative metabolism of the cells --- lipid peroxidation --- intermittent hypoxia --- osteoblast growth --- UV radiation --- ROS --- bEnd5 --- cyclopurines --- NF?B --- glucose deprivation --- antimicrobial --- endothelial cells --- 4-hydroxynonenal (4-HNE) --- histamine --- glutamine deprivation --- optical coherence tomography --- antioxidants --- DNA damage --- glutathione --- NQO1 transcript variants --- xeroderma pigmentosum --- cancer cells --- VAS2870 --- reactive oxygen species (ROS) --- TP53 mutation --- DNA and RNA polymerases --- viability --- oxidative burst --- macrophages --- inflammation --- Nrf2 --- von Willebrand factor --- reactive oxygen species --- growth control --- intracellular signaling --- MFN2 --- nuclear factor erythroid 2–related factor 2 --- fusion/fission --- IMR-90 --- calcium --- proliferation --- mitochondria --- pathophysiology of oxidative stress --- redox balance --- 4-hydroxynonenal --- cannabidiol --- oxidative homeostasis --- rs1800566 --- neuronal cell death --- heme-oxygenase-1 --- vitamins --- cell signaling --- TRPM2 channel --- aorta --- cancer --- growth --- cancer regression --- oxidative stress --- nucleotide excision repair

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This Special Issue, entitled "Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications", has included both reviews and original research contributions focused on the chemical design and biomedical applications of structurally modified bioactive peptides. The papers collected show how successful this class of molecules still is, both as model molecules for studying the structure of proteins and as potential therapeutics and diagnostics, and also as laboratory tools for advanced basic and applied studies. The large scientific community working in this field is in fact very active and productive, and is making the most of the potential and versatility of these molecules to generate increasingly interesting and innovative molecules of therapeutic interest and to understand the fundamental molecular mechanisms of life.

Research & information: general --- Biology, life sciences --- polymers --- peptidomimetics --- AFM --- transfection --- molecular modelling --- peptide --- α-helix --- hydrocarbon stapling --- ring-closing metathesis --- i,i + 1 staple --- X-ray structure --- deferoxamine --- RGD peptides --- integrins --- radiodiagnostics --- PET imaging --- retro-inverso peptides --- anticancer peptides --- drug delivery --- peptide antigens --- Aβ --- IAPP --- antimicrobial peptides --- peptides --- diagnostic --- ELISA --- microarray --- PET --- SPECT --- imaging diagnostic --- non-imaging diagnostic --- amphiphilic peptides --- non-viral gene delivery --- nanocarrier --- peptide self-assemblies --- stimuli responsive --- SARS-CoV-2 --- FRET --- molecular docking --- molecular dynamics --- MM-GBSA --- drug repurposing --- antiviral --- cancer --- cyclic peptide --- integrin --- αvβ3 --- ALOS4 --- melanoma --- fluorescent peptide --- environment-sensitive fluorophore --- peptide labeling --- luciferin --- membrane-binding peptide --- antimicrobial peptide --- antitumor peptide --- RGD peptide --- antiproliferative activity --- chirality --- conformational analysis --- density functional theory (DFT) --- ferrocene --- hydrogen bonds --- peptidomimetic --- X-ray --- protein–protein interactions (PPIs) --- voltage-gated Na+ (Nav) channels --- fibroblast growth factor 14 (FGF14) --- medium spiny neurons (MSNs) --- nucleus accumbens (NAc) --- neurotherapeutics --- cyclophilin A (CypA) --- apoptosis-inducing factor (AIF) --- human neuroblastoma SH-SY5Y cells --- staurosporine-mediated cell death --- AIF(370-394) peptide --- caspase-3 --- PARP --- antifungal --- antibacterial --- peptide-based therapies --- synthetic peptides --- polymers --- peptidomimetics --- AFM --- transfection --- molecular modelling --- peptide --- α-helix --- hydrocarbon stapling --- ring-closing metathesis --- i,i + 1 staple --- X-ray structure --- deferoxamine --- RGD peptides --- integrins --- radiodiagnostics --- PET imaging --- retro-inverso peptides --- anticancer peptides --- drug delivery --- peptide antigens --- Aβ --- IAPP --- antimicrobial peptides --- peptides --- diagnostic --- ELISA --- microarray --- PET --- SPECT --- imaging diagnostic --- non-imaging diagnostic --- amphiphilic peptides --- non-viral gene delivery --- nanocarrier --- peptide self-assemblies --- stimuli responsive --- SARS-CoV-2 --- FRET --- molecular docking --- molecular dynamics --- MM-GBSA --- drug repurposing --- antiviral --- cancer --- cyclic peptide --- integrin --- αvβ3 --- ALOS4 --- melanoma --- fluorescent peptide --- environment-sensitive fluorophore --- peptide labeling --- luciferin --- membrane-binding peptide --- antimicrobial peptide --- antitumor peptide --- RGD peptide --- antiproliferative activity --- chirality --- conformational analysis --- density functional theory (DFT) --- ferrocene --- hydrogen bonds --- peptidomimetic --- X-ray --- protein–protein interactions (PPIs) --- voltage-gated Na+ (Nav) channels --- fibroblast growth factor 14 (FGF14) --- medium spiny neurons (MSNs) --- nucleus accumbens (NAc) --- neurotherapeutics --- cyclophilin A (CypA) --- apoptosis-inducing factor (AIF) --- human neuroblastoma SH-SY5Y cells --- staurosporine-mediated cell death --- AIF(370-394) peptide --- caspase-3 --- PARP --- antifungal --- antibacterial --- peptide-based therapies --- synthetic peptides

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This Special Issue, entitled "Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications", has included both reviews and original research contributions focused on the chemical design and biomedical applications of structurally modified bioactive peptides. The papers collected show how successful this class of molecules still is, both as model molecules for studying the structure of proteins and as potential therapeutics and diagnostics, and also as laboratory tools for advanced basic and applied studies. The large scientific community working in this field is in fact very active and productive, and is making the most of the potential and versatility of these molecules to generate increasingly interesting and innovative molecules of therapeutic interest and to understand the fundamental molecular mechanisms of life.

polymers --- peptidomimetics --- AFM --- transfection --- molecular modelling --- peptide --- α-helix --- hydrocarbon stapling --- ring-closing metathesis --- i,i + 1 staple --- X-ray structure --- deferoxamine --- RGD peptides --- integrins --- radiodiagnostics --- PET imaging --- retro-inverso peptides --- anticancer peptides --- drug delivery --- peptide antigens --- Aβ --- IAPP --- antimicrobial peptides --- peptides --- diagnostic --- ELISA --- microarray --- PET --- SPECT --- imaging diagnostic --- non-imaging diagnostic --- amphiphilic peptides --- non-viral gene delivery --- nanocarrier --- peptide self-assemblies --- stimuli responsive --- SARS-CoV-2 --- FRET --- molecular docking --- molecular dynamics --- MM-GBSA --- drug repurposing --- antiviral --- cancer --- cyclic peptide --- integrin --- αvβ3 --- ALOS4 --- melanoma --- fluorescent peptide --- environment-sensitive fluorophore --- peptide labeling --- luciferin --- membrane-binding peptide --- antimicrobial peptide --- antitumor peptide --- RGD peptide --- antiproliferative activity --- chirality --- conformational analysis --- density functional theory (DFT) --- ferrocene --- hydrogen bonds --- peptidomimetic --- X-ray --- protein–protein interactions (PPIs) --- voltage-gated Na+ (Nav) channels --- fibroblast growth factor 14 (FGF14) --- medium spiny neurons (MSNs) --- nucleus accumbens (NAc) --- neurotherapeutics --- cyclophilin A (CypA) --- apoptosis-inducing factor (AIF) --- human neuroblastoma SH-SY5Y cells --- staurosporine-mediated cell death --- AIF(370-394) peptide --- caspase-3 --- PARP --- antifungal --- antibacterial --- peptide-based therapies --- synthetic peptides