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Few recent advances in science have generated as much excitement and controversy as human embryonic stem cells. The potential of these cells to replace diseased or damaged cells in virtually every tissue of the body heralds the advent of an extraordinary new field of medicine. Controversy arises, however, because current techniques required to harvest stem cells involve the destruction of the human blastocyst. This even-handed, lucidly written volume is an essential tool for understanding the complex issues-scientific, religious, ethical, and political-that currently fuel public debate about stem cell research. One of the few books to provide a comprehensive overview for a wide audience, the volume brings together leading scientists, ethicists, political scientists, and doctors to explain this new scientific development and explore its ramifications.

Embryonic stem cells --- Embryonal stem cells --- Stem cells --- Research --- Moral and ethical aspects --- Religious aspects. --- Political aspects --- american government. --- american politics. --- biomedical ethics. --- bone marrow. --- california. --- cell lineage. --- controversy. --- damaged cells. --- diseased cells. --- embryonic organisms. --- ethical debate. --- ethical issues. --- gonads. --- human blastocyst. --- human embryonic stem cells. --- medical. --- medicine. --- political debate. --- political. --- politics. --- religious debate. --- science. --- scientific debate. --- scientists. --- stem cell lines. --- stem cell research. --- stem cells. --- theoretical. --- therapeutic uses.

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Even today, cardiovascular diseases are the main cause of death worldwide, and therapeutic approaches are very restricted. Due to the limited regenerative capabilities of terminally differentiated cardiomyocytes post injury, new strategies to treat cardiac patients are urgently needed. Post myocardial injury, resident fibroblasts begin to generate the extracellular matrix, resulting in fibrosis, and finally, cardiac failure. Recently, preclinical investigations and clinical trials raised hope in stem cell-based approaches, to be an effective therapy option for these diseases. So far, several types of stem cells have been identified to be promising candidates to be applied for treatment: cardiac progenitor cells, bone marrow derived stem cells, embryonic and induced pluripotent stem cells, as well as their descendants. Furthermore, the innovative techniques of direct cardiac reprogramming of cells offered promising options for cardiovascular research, in vitro and in vivo. Hereby, the investigation of underlying and associated mechanisms triggering the therapeutic effects of stem cell application is of particular importance to improve approaches for heart patients. This Special Issue of Cells provides the latest update in the rapidly developing field of regenerative medicine in cardiology.

Research & information: general --- Biology, life sciences --- Fabry disease --- human embryonic stem cells --- CRISPR/Cas9 genomic editing --- Mass spectrometry proteomic analysis --- hypertrophic cardiomyopathy --- disease model --- physical exercise --- cardiac cellular regeneration --- microRNA (miR) --- Akt signaling --- cardiomyocyte proliferation --- cardiac hypertrophy --- cardioprotection --- myocarditis --- inflammation --- leukocytes --- cardiomyocytes --- multi-electrode-array --- micro-electrode-array --- MEA --- drug/toxicity screening --- field potential --- arrhythmia --- electrocardiography --- cardiac regeneration --- stem cells --- iPSC --- PSC --- ESC --- cardiovascular disease --- regeneration --- cardiac progenitor cells --- induced pluripotent stem cells --- transdifferentiation --- direct reprogramming --- genetic engineering --- cardiac tissue engineering --- biomaterials --- 18F-FDG PET --- cardiac induced cells --- cardiac function --- non-invasive imaging --- human pluripotent stem cell --- ventricular --- maturation --- bone marrow stem cells --- angiogenesis --- myocardial infarction --- human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) --- iPS cells --- big conductance calcium activated potassium channel (BK) --- Maxi-K --- slo1 --- KCa1.1 --- iberiotoxin --- long QT syndrome --- mesenchymal stromal cells (MSC) --- mRNA --- miRNA --- cardiac reprogramming --- cardiac differentiation --- cardiovascular diseases --- adult stem cells --- myocardial infraction --- 3D printing --- 3D model --- bioprinting --- cardiovascular medicine --- heart --- myocardium --- heart valves --- vascular graft --- endothelialization --- tissue engineering --- decorin --- fibronectin --- electrospinning --- endothelial progenitor cells --- bioreactor --- biostable polyurethane --- MicroRNA --- Mir-133 --- coronary heart disease --- biomarker --- meta-analysis

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"Thousands of people from more than eighty countries have traveled to China since 2001 to undergo fetal cell transplantation. Galvanized by the potential of stem and fetal cells to regenerate damaged neurons and restore lost bodily functions, people grappling with paralysis and neurodegenerative disorders have ignored the warnings of doctors and scientists back home in order to stake their futures on a Chinese experiment. Biomedical Odysseys looks at why and how these individuals have entrusted their lives to Chinese neurosurgeons operating on the forefront of experimental medicine, in a world where technologies and risks move faster than laws can keep pace. Priscilla Song shows how cutting-edge medicine is not just about the latest advances in biomedical science but also encompasses transformations in online patient activism, surgical intervention, and borderline experiments in health care bureaucracy. Bringing together a decade of ethnographic research in hospital wards, laboratories, and online patient discussion forums, Song opens up important theoretical and methodological horizons in the anthropology of science, technology, and medicine. She illuminates how poignant journeys in search of fetal cell cures become tangled in complex webs of digital mediation, the entrepreneurial logics of postsocialist medicine, and fraught debates about the ethics of clinical experimentation. Using innovative methods to track the border-crossing quests of Chinese clinicians and their patients from around the world, Biomedical Odysseys is the first book to map the transnational life of fetal cell therapies."--

Hematopoietic stem cells --- Medical ethics --- Stem cells --- Medizinische Ethik --- Periphere Stammzellentransplantation --- SOCIAL SCIENCE / Anthropology / General. --- Periphere Blutstammzellentransplantation --- Periphere Stammzellentransfusion --- Periphere Blutstammzellentransfusion --- PBST --- Peripheral stem cell transplantation --- Hematopoietic stem cell transplantation --- Peripheral stem cell transfusion --- PBSCT --- Peripheral blood progenitor cell transplantation --- Stammzellentransplantation --- Zelltransplantation --- Ärztliche Ethik --- Klinische Ethik --- Ärztliches Ethos --- Arzt --- Medizin --- Heilberuf --- Medizinethik --- Wissenschaftsethik --- Angewandte Ethik --- Bioethik --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Biomedical ethics --- Clinical ethics --- Ethics, Medical --- Health care ethics --- Medical care --- Medicine --- Bioethics --- Professional ethics --- Nursing ethics --- Social medicine --- HSCs (Hematopoietic stem cells) --- Blood cells --- Bone marrow cells --- Hematopoietic system --- Multipotent stem cells --- Transplantation --- Research --- Ethik --- Ethos --- Moral and ethical aspects --- Ärztliche Ethik --- Ärztliches Ethos --- Human Embryonic Stem Cells --- Medical Tourism --- Therapies, Investigational --- S21/0500 --- transplantation --- psychology --- ethics --- China: Medicine, public health and food--Public health, hospitals, medical schools, etc --- China. --- Mainland China --- Inner Mongolia --- Manchuria --- People's Republic of China --- Sinkiang --- Health Tourism --- Medical Tourists --- Surgical Tourism --- Medical Tourist --- Tourism, Health --- Tourism, Medical --- Tourism, Surgical --- Tourist, Medical --- Tourists, Medical --- 1949 --- -BNKhAU --- Bu̇gd Naĭramdakh Dundad Ard Uls --- Bu̇gu̇de Nayiramdaqu Dumdadu Arad Ulus --- Bu̇gu̇de Nayiramdaxu Dundadu Arad Ulus --- Catay --- Cathay --- Central Government of the People's Republic of China --- Central People's Government of Communist China --- China --- Chine --- Chinese National Government --- Chinese People's Republic --- Chūka Jinmin Kyōwakoku --- Chung-hua chung yang jen min kung ho kuo --- Chung-hua jen min kung ho kuo --- Chung-hua min kuo --- Chung-kuo --- Chung-kuo kuo min cheng fu --- Chung yang jen min cheng fu --- Cina --- Činská lidová republika --- Dumdad Uls --- Dumdadu Ulus --- Erets Sin --- Jhonggu --- Jumhūriyat al-Ṣīn al-Shaʻbīyah --- Khi͡atad --- Kínai Népköztársaság --- Kin --- Kitad --- Kita --- Kitaĭskai͡a Narodnai͡a Respublika --- Kitajska --- KNR --- Kytaĭsʹka Narodna Respublika --- National Government --- P.R.C. --- P.R. China --- PR China --- PRC --- Republic --- Republic of China --- República Popular China --- Republik Rakjat Tiongkok --- République Populaire de Chine --- RRC --- RRT --- Sāthāranarat Prachāchon Čhīn --- VR China --- VRChina --- Zhong guo --- Zhong hua ren min gong he guo --- Zhongguo --- Zhonghua Renmin Gongheguo --- Zhonghuaminguo --- ALS. --- CareCure. --- Chinese clinicians. --- Chinese medicine. --- Chinese neurosurgeons. --- Dr. Huang Hongyun. --- Huang Hongyun. --- amyotrophic lateral sclerosis. --- biomediation. --- biomedical practice. --- biomedical research protocols. --- biomedical science. --- biomedicine. --- chronicity. --- clinical experimentation. --- cybersociality. --- experimental medicine. --- experimental medicines. --- experimental surgery. --- experimental therapy. --- experimental treatment. --- fetal cell transplantation. --- foreign patients. --- hope. --- illness. --- institutional practice. --- market socialism. --- medical entrepreneurialism. --- medical entrepreneurs. --- medical practice. --- neurodegenerative condition. --- neurodegenerative disorders. --- neurosurgeon. --- olfactory ensheathing cells. --- olfactory ensheathing glia. --- online discussion forum. --- paralysis. --- patient activism. --- regenerative medicine. --- spinal cord injuries. --- spinal cord injury. --- surgical intervention. --- technonationalism. --- transplantation.