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Antiviral agents are used for the treatment of viral diseases. Antiviral drugs have been successfully developed and used clinically for a limited number of important human viral diseases notably caused by human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), herpes, and influenza viruses. Despite the successes of these antiviral drugs, issues with drug resistance and toxicity remain challenging. These challenges are driving research to identify new drug candidates and to investigate novel drug targets to develop new mechanistic drug classes. Antiviral agents are not available against many viruses that cause human disease and economic burdens; in particular, the development of antiviral agents against emerging, re-emerging, and neglected viruses is increasingly becoming a priority. This book includes six review articles that discuss new antiviral strategies. The reviews either discuss advances relating to a specific virus or new therapeutic targets and approaches. The book includes 15 original research articles reporting new antiviral agents against a variety of clinically and economically important viruses and studies into the prevalence or acquisition of drug resistance. Overall, this book is an exciting collection of new research and ideas relating to the development of antiviral agents.

Zika virus --- nucleoside analogues --- antiviral agents --- NS5 --- prodrugs --- ProTides --- neural stem cells --- RNA-dependent RNA polymerase --- cytomegalovirus --- latent infection --- TALEN --- Surveyor nuclease mutation detection assay --- ie-1 gene --- quantitative real-time PCR --- Epstein–Barr virus --- herpes viruses --- lytic gene expression --- Burkitt lymphoma cells --- clozapine --- antipsychotic drug --- antiviral drug --- enteroviruses --- coxsackievirus B4 --- persistent infection --- fluoxetine --- resistance --- mutations --- herpes B virus --- macacine herpesvirus-1 --- genistein --- flavonoids --- acyclovir --- ganciclovir --- Plantago asiatica --- Clerodendrum trichotomum --- RSV --- therapeutic effects --- acteoside --- human antimicrobial peptides --- antiviral strategies --- defensins --- cathelicidins --- hepcidins --- transferrins --- influenza A virus --- brevilin A --- antiviral --- sesquiterpene lactone --- replication --- PRRSV --- polyethylenimine --- PEI --- virion internalization --- endocytosis --- HIV --- pediatrics --- Ethiopia --- pre-treatment drug resistance --- combination antiretroviral therapy (cART) --- dried plasma spots --- dried blood spots --- sphingolipids --- glycosphingolipids --- viruses --- lipid biosynthesis --- flavivirus --- Japanese encephalitis virus --- furin inhibitor --- precursor membrane protein --- measles virus --- central nervous system --- tropism --- treatments --- porcine reproductive and respiratory syndrome virus --- ginsenoside Rg1 --- antiviral activity --- pro-inflammatory factor --- NF-κB signaling pathway --- acute/latent infection --- congenital infection --- antiviral agent --- therapeutic strategies --- nucleic acid-based therapeutic approach --- HCMV vaccine --- adoptive cell therapy --- Rev response element --- chemical footprinting --- SHAPE --- drug discovery --- branched peptides --- herpesvirus --- immediate-early --- IE1 --- IE2 --- ribozyme --- RNA interference --- CRISPR/Cas --- small molecule --- orthohantavirus --- phenyl-benzotriazoles --- C-FRA --- Porcine circovirus type 2 --- epigallocatechin gallate --- heparan sulfate --- antiviral effect --- virus attachment --- microvirin --- lectin --- human immunodeficiency virus --- hepatitis C virus --- antiviral inhibitor --- non-immunogenic --- viral entry --- protein drugs --- LUMS1 --- oleanane-type derivatives --- influenza A virus (IAV) --- virus entry inhibitors --- hemagglutinin (HA) --- n/a --- Epstein-Barr virus

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In recent years, peptides have received increased interest from the pharmaceutical industry. The high potency, specificity, and safety profile are the main strengths of bioactive peptides as new and promising therapies that may fill the gap between small molecules and protein drugs. These positive attributes have renewed interest in the discovery, optimization, and development of peptides as pharmacological therapy. Among bioactive peptides, those released from food sources have acquired importance as nutraceutical and active components in functional foods because they possess regulatory functions that can lead to health benefits. This Special Issue covers a selection of recent research papers and reviews in the field of bioactive peptides. It covers all aspects of peptide research in relation to health promotion. In particular, it emphasizes current knowledge and research trends concerning bioactive peptides, including identification and quantification of peptides from new sources, methods for their production and purification, structure–function relationships, mechanisms of action, in vitro and in vivo assays for the evaluation of their bioactivity, physiological evidence to support health benefits, and peptide stability and bioavailability. Papers regarding the development of new drugs, functional foods, or nutraceuticals based on bioactive peptides were also considered.

Research & information: general --- Biology, life sciences --- antihypertensive peptides --- functional food --- food-derived --- fermentation --- Chlorella sorokiniana --- in silico --- BIOPEP-UWM database --- proteomics --- bioactive peptides --- nano liquid chromatography tandem mass spectrometry (nanoLC–nanoESI MS/MS) --- apolipoprotein E --- amyloid fibrils --- Alzheimer’s disease --- Αβ oligomer --- amyloid --- Aβ peptide --- glioma --- platelets --- antiproliferative assay --- conjugation --- docetaxel --- doxorubicin --- extra domain B --- fibronectin --- Fmoc/tBu --- peptide–drug conjugate --- prostate cancer --- solid-phase synthesis --- targeting --- acrylamide --- enteric nervous system --- galanin --- pig --- stomach --- formyl peptide receptors --- ligands --- diseases --- polymicrobial biofilms --- intragenic antimicrobial peptide --- Hs02 --- Pseudomonas aeruginosa --- Staphylococcus aureus --- osteostatin --- arthritis --- inflammation --- immune response --- cartilage destruction --- bone erosion --- collagen --- hydrolysis --- enzyme --- molecular weight --- sheepskin --- NF-κB --- dry-cured pork ham --- angiotensin I converting enzyme --- endothelial dysfunction --- molecular blind docking --- Lactoferricin B (Lfcin B) --- Histatin-5 --- antimicrobial peptides (AMPs) --- antifungal activity --- proteome microarray --- synergy --- temporin --- MRSA --- antimicrobial peptide --- human keratinocytes --- pseudin-2 --- antisepsis, peptide antibiotics --- neurotensin --- asthma --- T cells --- In situ tetramer staining --- MHC tetramer --- antigen-specific --- confocal microscopy --- fresh tissue --- velvet antler --- alcalase hydrolysate --- antioxidant peptide --- protection ability --- oxidative stress --- Crassostrea angulata --- pidotimod --- CXCR3 --- monocyte --- migration --- PI3K/Akt pathway --- T cell --- immunomodulant --- host defense peptides --- membrane activity --- copper --- piscidins --- Clostridioides difficile --- prolactin-releasing peptide --- GPR10 --- RF-amide peptides --- food intake regulation --- energy expenditure --- neuroprotection --- signaling --- gender differences --- dyslipidemia --- obesity --- hyperglycemia --- pulmonary emphysema --- endothelial progenitor cells --- angiogenic precursor cells --- pegylated glucagon-like peptide 1 --- and endothelial regeneration --- miiuy croaker (Miichthys miiuy) --- swim bladder --- FPYLRH --- antioxidant activity --- cytoprotective effect --- antimicrobial peptides --- antimicrobial resistance --- AMP identification and design --- biosynthesis --- mode of action --- physico-chemical properties --- therapeutic potential --- insects --- Cecropins --- Cec-analogs --- MDR infectious diseases --- airway inflammation --- non-atopic asthma --- hybrid peptide --- pro-inflammatory cytokines --- sPLA2 --- MDA --- database --- proteolysis --- SMILES code --- foods --- nutrition --- chronic diseases --- nutraceuticals --- peptide vaccine --- immune checkpoint inhibitor --- humanized mouse --- cancer antigen --- immune suppression --- vasoactive intestinal peptide --- VPAC1 receptor --- VPAC2 receptor --- rheumatic diseases --- inflammatory bowel disease --- central nervous system diseases --- type 1 diabetes --- Sjögren’s syndrome --- biomarkers --- human antimicrobial peptides --- defensins --- cathelicidins --- anti-inflammatory --- pro-inflammatory --- peptide --- combinatorial library --- library design --- screening --- mutagenesis --- prolyl-hydroxyproline (Pro-Hyp) --- hydroxyprolyl-glycine (Hyp-Gly) --- collagen peptide --- fibroblasts --- fetal bovine serum (FBS) --- AMD --- CNV --- VEGFR1 --- multimeric peptides --- oral delivery --- colorectal cancer --- cancer stem cells --- chemoprevention --- bioactive peptide --- lunasin --- ACE-inhibitory activity --- whey peptides --- molecular docking --- hypertension --- antibiotic resistance --- cystic fibrosis --- cryptides --- anti-biofilm peptides --- synergistic effects --- n/a --- nano liquid chromatography tandem mass spectrometry (nanoLC-nanoESI MS/MS) --- Alzheimer's disease --- peptide-drug conjugate --- Sjögren's syndrome

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In recent years, peptides have received increased interest from the pharmaceutical industry. The high potency, specificity, and safety profile are the main strengths of bioactive peptides as new and promising therapies that may fill the gap between small molecules and protein drugs. These positive attributes have renewed interest in the discovery, optimization, and development of peptides as pharmacological therapy. Among bioactive peptides, those released from food sources have acquired importance as nutraceutical and active components in functional foods because they possess regulatory functions that can lead to health benefits. This Special Issue covers a selection of recent research papers and reviews in the field of bioactive peptides. It covers all aspects of peptide research in relation to health promotion. In particular, it emphasizes current knowledge and research trends concerning bioactive peptides, including identification and quantification of peptides from new sources, methods for their production and purification, structure–function relationships, mechanisms of action, in vitro and in vivo assays for the evaluation of their bioactivity, physiological evidence to support health benefits, and peptide stability and bioavailability. Papers regarding the development of new drugs, functional foods, or nutraceuticals based on bioactive peptides were also considered.

antihypertensive peptides --- functional food --- food-derived --- fermentation --- Chlorella sorokiniana --- in silico --- BIOPEP-UWM database --- proteomics --- bioactive peptides --- nano liquid chromatography tandem mass spectrometry (nanoLC–nanoESI MS/MS) --- apolipoprotein E --- amyloid fibrils --- Alzheimer’s disease --- Αβ oligomer --- amyloid --- Aβ peptide --- glioma --- platelets --- antiproliferative assay --- conjugation --- docetaxel --- doxorubicin --- extra domain B --- fibronectin --- Fmoc/tBu --- peptide–drug conjugate --- prostate cancer --- solid-phase synthesis --- targeting --- acrylamide --- enteric nervous system --- galanin --- pig --- stomach --- formyl peptide receptors --- ligands --- diseases --- polymicrobial biofilms --- intragenic antimicrobial peptide --- Hs02 --- Pseudomonas aeruginosa --- Staphylococcus aureus --- osteostatin --- arthritis --- inflammation --- immune response --- cartilage destruction --- bone erosion --- collagen --- hydrolysis --- enzyme --- molecular weight --- sheepskin --- NF-κB --- dry-cured pork ham --- angiotensin I converting enzyme --- endothelial dysfunction --- molecular blind docking --- Lactoferricin B (Lfcin B) --- Histatin-5 --- antimicrobial peptides (AMPs) --- antifungal activity --- proteome microarray --- synergy --- temporin --- MRSA --- antimicrobial peptide --- human keratinocytes --- pseudin-2 --- antisepsis, peptide antibiotics --- neurotensin --- asthma --- T cells --- In situ tetramer staining --- MHC tetramer --- antigen-specific --- confocal microscopy --- fresh tissue --- velvet antler --- alcalase hydrolysate --- antioxidant peptide --- protection ability --- oxidative stress --- Crassostrea angulata --- pidotimod --- CXCR3 --- monocyte --- migration --- PI3K/Akt pathway --- T cell --- immunomodulant --- host defense peptides --- membrane activity --- copper --- piscidins --- Clostridioides difficile --- prolactin-releasing peptide --- GPR10 --- RF-amide peptides --- food intake regulation --- energy expenditure --- neuroprotection --- signaling --- gender differences --- dyslipidemia --- obesity --- hyperglycemia --- pulmonary emphysema --- endothelial progenitor cells --- angiogenic precursor cells --- pegylated glucagon-like peptide 1 --- and endothelial regeneration --- miiuy croaker (Miichthys miiuy) --- swim bladder --- FPYLRH --- antioxidant activity --- cytoprotective effect --- antimicrobial peptides --- antimicrobial resistance --- AMP identification and design --- biosynthesis --- mode of action --- physico-chemical properties --- therapeutic potential --- insects --- Cecropins --- Cec-analogs --- MDR infectious diseases --- airway inflammation --- non-atopic asthma --- hybrid peptide --- pro-inflammatory cytokines --- sPLA2 --- MDA --- database --- proteolysis --- SMILES code --- foods --- nutrition --- chronic diseases --- nutraceuticals --- peptide vaccine --- immune checkpoint inhibitor --- humanized mouse --- cancer antigen --- immune suppression --- vasoactive intestinal peptide --- VPAC1 receptor --- VPAC2 receptor --- rheumatic diseases --- inflammatory bowel disease --- central nervous system diseases --- type 1 diabetes --- Sjögren’s syndrome --- biomarkers --- human antimicrobial peptides --- defensins --- cathelicidins --- anti-inflammatory --- pro-inflammatory --- peptide --- combinatorial library --- library design --- screening --- mutagenesis --- prolyl-hydroxyproline (Pro-Hyp) --- hydroxyprolyl-glycine (Hyp-Gly) --- collagen peptide --- fibroblasts --- fetal bovine serum (FBS) --- AMD --- CNV --- VEGFR1 --- multimeric peptides --- oral delivery --- colorectal cancer --- cancer stem cells --- chemoprevention --- bioactive peptide --- lunasin --- ACE-inhibitory activity --- whey peptides --- molecular docking --- hypertension --- antibiotic resistance --- cystic fibrosis --- cryptides --- anti-biofilm peptides --- synergistic effects --- n/a --- nano liquid chromatography tandem mass spectrometry (nanoLC-nanoESI MS/MS) --- Alzheimer's disease --- peptide-drug conjugate --- Sjögren's syndrome

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

In recent years, peptides have received increased interest from the pharmaceutical industry. The high potency, specificity, and safety profile are the main strengths of bioactive peptides as new and promising therapies that may fill the gap between small molecules and protein drugs. These positive attributes have renewed interest in the discovery, optimization, and development of peptides as pharmacological therapy. Among bioactive peptides, those released from food sources have acquired importance as nutraceutical and active components in functional foods because they possess regulatory functions that can lead to health benefits. This Special Issue covers a selection of recent research papers and reviews in the field of bioactive peptides. It covers all aspects of peptide research in relation to health promotion. In particular, it emphasizes current knowledge and research trends concerning bioactive peptides, including identification and quantification of peptides from new sources, methods for their production and purification, structure–function relationships, mechanisms of action, in vitro and in vivo assays for the evaluation of their bioactivity, physiological evidence to support health benefits, and peptide stability and bioavailability. Papers regarding the development of new drugs, functional foods, or nutraceuticals based on bioactive peptides were also considered.

Research & information: general --- Biology, life sciences --- antihypertensive peptides --- functional food --- food-derived --- fermentation --- Chlorella sorokiniana --- in silico --- BIOPEP-UWM database --- proteomics --- bioactive peptides --- nano liquid chromatography tandem mass spectrometry (nanoLC-nanoESI MS/MS) --- apolipoprotein E --- amyloid fibrils --- Alzheimer's disease --- Αβ oligomer --- amyloid --- Aβ peptide --- glioma --- platelets --- antiproliferative assay --- conjugation --- docetaxel --- doxorubicin --- extra domain B --- fibronectin --- Fmoc/tBu --- peptide-drug conjugate --- prostate cancer --- solid-phase synthesis --- targeting --- acrylamide --- enteric nervous system --- galanin --- pig --- stomach --- formyl peptide receptors --- ligands --- diseases --- polymicrobial biofilms --- intragenic antimicrobial peptide --- Hs02 --- Pseudomonas aeruginosa --- Staphylococcus aureus --- osteostatin --- arthritis --- inflammation --- immune response --- cartilage destruction --- bone erosion --- collagen --- hydrolysis --- enzyme --- molecular weight --- sheepskin --- NF-κB --- dry-cured pork ham --- angiotensin I converting enzyme --- endothelial dysfunction --- molecular blind docking --- Lactoferricin B (Lfcin B) --- Histatin-5 --- antimicrobial peptides (AMPs) --- antifungal activity --- proteome microarray --- synergy --- temporin --- MRSA --- antimicrobial peptide --- human keratinocytes --- pseudin-2 --- antisepsis, peptide antibiotics --- neurotensin --- asthma --- T cells --- In situ tetramer staining --- MHC tetramer --- antigen-specific --- confocal microscopy --- fresh tissue --- velvet antler --- alcalase hydrolysate --- antioxidant peptide --- protection ability --- oxidative stress --- Crassostrea angulata --- pidotimod --- CXCR3 --- monocyte --- migration --- PI3K/Akt pathway --- T cell --- immunomodulant --- host defense peptides --- membrane activity --- copper --- piscidins --- Clostridioides difficile --- prolactin-releasing peptide --- GPR10 --- RF-amide peptides --- food intake regulation --- energy expenditure --- neuroprotection --- signaling --- gender differences --- dyslipidemia --- obesity --- hyperglycemia --- pulmonary emphysema --- endothelial progenitor cells --- angiogenic precursor cells --- pegylated glucagon-like peptide 1 --- and endothelial regeneration --- miiuy croaker (Miichthys miiuy) --- swim bladder --- FPYLRH --- antioxidant activity --- cytoprotective effect --- antimicrobial peptides --- antimicrobial resistance --- AMP identification and design --- biosynthesis --- mode of action --- physico-chemical properties --- therapeutic potential --- insects --- Cecropins --- Cec-analogs --- MDR infectious diseases --- airway inflammation --- non-atopic asthma --- hybrid peptide --- pro-inflammatory cytokines --- sPLA2 --- MDA --- database --- proteolysis --- SMILES code --- foods --- nutrition --- chronic diseases --- nutraceuticals --- peptide vaccine --- immune checkpoint inhibitor --- humanized mouse --- cancer antigen --- immune suppression --- vasoactive intestinal peptide --- VPAC1 receptor --- VPAC2 receptor --- rheumatic diseases --- inflammatory bowel disease --- central nervous system diseases --- type 1 diabetes --- Sjögren's syndrome --- biomarkers --- human antimicrobial peptides --- defensins --- cathelicidins --- anti-inflammatory --- pro-inflammatory --- peptide --- combinatorial library --- library design --- screening --- mutagenesis --- prolyl-hydroxyproline (Pro-Hyp) --- hydroxyprolyl-glycine (Hyp-Gly) --- collagen peptide --- fibroblasts --- fetal bovine serum (FBS) --- AMD --- CNV --- VEGFR1 --- multimeric peptides --- oral delivery --- colorectal cancer --- cancer stem cells --- chemoprevention --- bioactive peptide --- lunasin --- ACE-inhibitory activity --- whey peptides --- molecular docking --- hypertension --- antibiotic resistance --- cystic fibrosis --- cryptides --- anti-biofilm peptides --- synergistic effects --- antihypertensive peptides --- functional food --- food-derived --- fermentation --- Chlorella sorokiniana --- in silico --- BIOPEP-UWM database --- proteomics --- bioactive peptides --- nano liquid chromatography tandem mass spectrometry (nanoLC-nanoESI MS/MS) --- apolipoprotein E --- amyloid fibrils --- Alzheimer's disease --- Αβ oligomer --- amyloid --- Aβ peptide --- glioma --- platelets --- antiproliferative assay --- conjugation --- docetaxel --- doxorubicin --- extra domain B --- fibronectin --- Fmoc/tBu --- peptide-drug conjugate --- prostate cancer --- solid-phase synthesis --- targeting --- acrylamide --- enteric nervous system --- galanin --- pig --- stomach --- formyl peptide receptors --- ligands --- diseases --- polymicrobial biofilms --- intragenic antimicrobial peptide --- Hs02 --- Pseudomonas aeruginosa --- Staphylococcus aureus --- osteostatin --- arthritis --- inflammation --- immune response --- cartilage destruction --- bone erosion --- collagen --- hydrolysis --- enzyme --- molecular weight --- sheepskin --- NF-κB --- dry-cured pork ham --- angiotensin I converting enzyme --- endothelial dysfunction --- molecular blind docking --- Lactoferricin B (Lfcin B) --- Histatin-5 --- antimicrobial peptides (AMPs) --- antifungal activity --- proteome microarray --- synergy --- temporin --- MRSA --- antimicrobial peptide --- human keratinocytes --- pseudin-2 --- antisepsis, peptide antibiotics --- neurotensin --- asthma --- T cells --- In situ tetramer staining --- MHC tetramer --- antigen-specific --- confocal microscopy --- fresh tissue --- velvet antler --- alcalase hydrolysate --- antioxidant peptide --- protection ability --- oxidative stress --- Crassostrea angulata --- pidotimod --- CXCR3 --- monocyte --- migration --- PI3K/Akt pathway --- T cell --- immunomodulant --- host defense peptides --- membrane activity --- copper --- piscidins --- Clostridioides difficile --- prolactin-releasing peptide --- GPR10 --- RF-amide peptides --- food intake regulation --- energy expenditure --- neuroprotection --- signaling --- gender differences --- dyslipidemia --- obesity --- hyperglycemia --- pulmonary emphysema --- endothelial progenitor cells --- angiogenic precursor cells --- pegylated glucagon-like peptide 1 --- and endothelial regeneration --- miiuy croaker (Miichthys miiuy) --- swim bladder --- FPYLRH --- antioxidant activity --- cytoprotective effect --- antimicrobial peptides --- antimicrobial resistance --- AMP identification and design --- biosynthesis --- mode of action --- physico-chemical properties --- therapeutic potential --- insects --- Cecropins --- Cec-analogs --- MDR infectious diseases --- airway inflammation --- non-atopic asthma --- hybrid peptide --- pro-inflammatory cytokines --- sPLA2 --- MDA --- database --- proteolysis --- SMILES code --- foods --- nutrition --- chronic diseases --- nutraceuticals --- peptide vaccine --- immune checkpoint inhibitor --- humanized mouse --- cancer antigen --- immune suppression --- vasoactive intestinal peptide --- VPAC1 receptor --- VPAC2 receptor --- rheumatic diseases --- inflammatory bowel disease --- central nervous system diseases --- type 1 diabetes --- Sjögren's syndrome --- biomarkers --- human antimicrobial peptides --- defensins --- cathelicidins --- anti-inflammatory --- pro-inflammatory --- peptide --- combinatorial library --- library design --- screening --- mutagenesis --- prolyl-hydroxyproline (Pro-Hyp) --- hydroxyprolyl-glycine (Hyp-Gly) --- collagen peptide --- fibroblasts --- fetal bovine serum (FBS) --- AMD --- CNV --- VEGFR1 --- multimeric peptides --- oral delivery --- colorectal cancer --- cancer stem cells --- chemoprevention --- bioactive peptide --- lunasin --- ACE-inhibitory activity --- whey peptides --- molecular docking --- hypertension --- antibiotic resistance --- cystic fibrosis --- cryptides --- anti-biofilm peptides --- synergistic effects