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AROMATIC NITROGEN HETEROCYCLES --- AROMATIC NITROGEN HETEROCYCLES

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Marine drugs have drawn considerable attention due to their significant biological and pharmacological properties, such as antimicrobial or antibacterial activities and antitumor effects, among others. The frequent occurrence of heterocyclic motifs in the structure of many of these targets has revealed the key role of these units as promising pharmacophores. In this Special Issue we have gathered several original papers which highlight the isolation, structural elucidation and biological essays of newly isolated heterocyclic marine drugs, as well as reviews which give an overview of the isolation, synthesis and pharmacological activities of different classes of marine heterocycles.

Medicine --- Pharmacology --- Heterocycles --- synthesis --- biosynthesis --- marine drugs --- analogs

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Heterocycles are among the most common scaffolds in many organic molecules, e.g., vitamins, hormones, antibiotics, alkaloids, herbicides, dyes, drugs, and pharmaceutically relevant substances. These molecules are also incorporated in numerous macromolecules such as DNA, polymers, and macrocycles, where their hetero-functional units are often employed to establish supramolecular interaction. It is thus not surprising that—since the 19th century—the synthesis of heterocycles has been constantly blooming, evolving from classic condensation reactions to the development of click reactions and new multicomponent domino synthetic approaches. In the last thirty years, with the ever-growing research developments of new and atom-efficient sustainable synthetic strategies, the field of Green Chemistry has made significant contributions to the development of heterocyclic motifs. The novel methodologies aim at high process performances by means of eco-compatible methodologies, employing non-toxic and biodegradable chemicals.

Science: general issues --- green chemistry --- heterocycles --- cyclic compound --- sustainable --- green principles --- green chemistry --- heterocycles --- cyclic compound --- sustainable --- green principles

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Heterocyclic compounds. --- Cycloids, Mixed (Chemistry) --- Heteroatomic compounds --- Heterocycles --- Mixed cycloids (Chemistry) --- Organic cyclic compounds

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Progress in Heterocyclic Chemistry Volume 5 deals critically with original material selected essentially from the 1992 heterocyclic literature. Chapters 1 and 2 are given over to reviews: in the first, SO2 extrusion from five-membered rings is discussed by R.A. Aitken and colleagues, which completes last year's review on this topic. The second review presents a review of 2-acylamino-3-dimethylaminopropenoates in heterocyclic synthesis. The chapters are arranged according to ring sizes as in the previous volumes and are supported by references, numerous diagrams and a subject index.

Heterocyclic compounds. --- Cycloids, Mixed (Chemistry) --- Heteroatomic compounds --- Heterocycles --- Mixed cycloids (Chemistry) --- Organic cyclic compounds