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Abordar a hepatite C - grave epidemia contemporânea - não só em seus aspectos biomédicos, mas destacando ainda questões psicológicas, sociais e históricas relativas à doença: este é o objetivo desse livro, escrito pelo médico, com pós-doutorado no exterior, Francisco Inácio Bastos. Também pesquisador titular do Instituto de Comunicação e Informação Científica e Tecnológica em Saúde (Icict/Fiocruz), o autor é experiente no trabalho junto a usuários de drogas e portadores do HIV. Muitos de seus pacientes com Aids, atendidos em instituição voltada à população necessitada, têm falecido em decorrência da dupla infecção pelo HIV e pelo vírus da hepatite C. Testemunha das dificuldades enfrentadas pelos pacientes com hepatite C crônica para conseguirem tratamento, Bastos destaca a necessidade de se melhorar a prevenção e a assistência prestada a quem vive com essa doença.

Hepatology

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Hepatology --- Hepatology. --- Gastroenterology. --- Gastroenterology

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Hepatology --- Hepatology. --- Gastroenterology --- hepatology --- liver --- hepatobiliary surgery

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Hepatology. --- Gastroenterology

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The burden of hepatitis C virus (HCV) infection on the public health care system continues to remain significant despite the remarkable progress made in HCV therapeutics in the recent past. There are now almost a dozen oral interferon-free direct-acting antivirals available for the treatment of hepatitis C virus infection. Despite advances in the treatment of HCV, therapeutic gaps remain that are yet to be fully explored. Researchers and scientists still strive to understand virus-host interactions to map the disease's progression along with extrahepatic manifestations and virus invasion strategies impacting the host's immune system. This book briefly discusses the biology of HCV infection, virus-host interactions, molecular epidemiology of the infection, and the full spectrum of immune responses to hepatitis C. It also provides in-depth information about HCV, clinical diagnostics, and therapeutic knowledge to all stakeholders involved in HCV screening, diagnosis, treatment, and management. Topics covered in the chapters include 1) HCV-host interactions leading to asymptomatic acute infection, 2) the progression of acute HCV infection to chronic disease and subsequent extrahepatic comorbidities, 3) Innate and adaptive immune responses in HCV infections, 4) Consensus-based Approaches for Hepatitis C Screening and Diagnosis, 5) advances in hepatitis C therapy and global management of HCV, and 6) the outcomes of Oral Interferon-free Direct-acting Antivirals as Combination Therapies to Cure Hepatitis C. This book is a valuable addition to undergraduate and postgraduate hepatology students and physicians, clinicians, hepatologists, and health care officials involved in HCV clinical diagnosis and therapeutics.

Hepatology --- Medical