Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Le hérisson d’Europe (Erinaceus europaeus ) est un petit mammifère sauvage commun, présent partout en Belgique. Aussi bien présent en campagne que dans les milieux plus urbains, il est très apprécié de la population. Parmi les agents pathogènes zoonotiques dont il peut être porteur, une bactérie a récemment été mise en évidence : Corynebacterium ulcerans. Certaines souches de C. ulcerans produisent la toxine diphtérique, responsable de lésions respiratoires et/ou cutanées de type diphtérique. Cette étude s’est concentrée sur 74 hérissons morts dans des Centres de Revalidation des Espèces Animales Vivants à l'Etat Sauvage en Région Wallonne. Ces animaux ont été autopsiés par le Service Faune sauvage (FMV, ULiège) et plusieurs analyses de laboratoires ont été effectuées (cultures bactériennes, qPCR, spectrométrie de masse MALDI-TOF, ELEK test). C. ulcerans a pu être isolé par qPCR sur 47 des 74 hérissons analysés. Parmi les cadavres positifs, on observe une majorité de hérissons présentant des lésions cutanées en accord avec les descriptions de Martel et collaborateurs (2020) et Berger et collaborateurs (2019). Cependant, il n’y a pas de différence observée selon le sexe ou l’âge, contrairement aux observations faites par ces mêmes auteurs. Des analyses sont toujours en cours et visent à déterminer si une infection systémique existe. Les premiers résultats indiquent une tendance allant vers une localisation majoritairement cutanée avec cependant des détections au niveau des organes internes indiquant une possible dissémination de C. ulcerans. En ce qui concerne la santé publique, les résultats de cette étude montrent que C. ulcerans est fréquemment isolé chez le hérisson. Le potentiel zoonotique de cette bactérie doit inciter les centres de revalidation à renforcer les bonnes pratiques d’hygiène lors de la manipulation des hérissons qui y sont soignés.

Hedgehog --- Corynebacterium ulcerans --- zoonoses --- Sciences du vivant > Médecine vétérinaire & santé animale

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, multiple cancers’ drug resistance, and survival rates. This book focuses on several aspects of Hedgehog signaling in organogenesis and the tumor microenvironment, and presents reviews and original papers on recent efforts in the field of Hedgehog signaling.

Medicine --- Cyp26 enzymes --- congenital anomalies --- CRE/LoxP --- hedgehog signaling --- mouse models --- retinoic acid --- smoothened --- sonic hedgehog --- sonic hedgehog (SHH) --- oral squamous cell carcinoma (OSCC) --- tumor microenvironment (TME) --- tumor-associated macrophages (TAMs) --- cancer-associated fibroblasts (CAFs) --- tumor-associated angiogenesis --- hedgehog --- growth plate --- endochondral ossification --- chondrocyte --- osteoblast --- bone disease --- TMJ --- synovial joint --- articular disc --- Ihh --- PTHrP --- osteoarthritis --- epithelial-mesenchymal interaction (EMI) --- prostate cancer --- external genitalia --- androgen --- basement membrane --- bone morphogenetic protein --- stem cell --- animal experiment --- fracture healing --- cancer stem cells --- hypospadias --- urethra --- penis --- bone --- hedgehog signalling --- tooth development --- epithelial and mesenchymal interaction --- Gli1 --- mesenchymal stem cell --- lineage tracing analysis --- stem cell marker --- Cyp26 enzymes --- congenital anomalies --- CRE/LoxP --- hedgehog signaling --- mouse models --- retinoic acid --- smoothened --- sonic hedgehog --- sonic hedgehog (SHH) --- oral squamous cell carcinoma (OSCC) --- tumor microenvironment (TME) --- tumor-associated macrophages (TAMs) --- cancer-associated fibroblasts (CAFs) --- tumor-associated angiogenesis --- hedgehog --- growth plate --- endochondral ossification --- chondrocyte --- osteoblast --- bone disease --- TMJ --- synovial joint --- articular disc --- Ihh --- PTHrP --- osteoarthritis --- epithelial-mesenchymal interaction (EMI) --- prostate cancer --- external genitalia --- androgen --- basement membrane --- bone morphogenetic protein --- stem cell --- animal experiment --- fracture healing --- cancer stem cells --- hypospadias --- urethra --- penis --- bone --- hedgehog signalling --- tooth development --- epithelial and mesenchymal interaction --- Gli1 --- mesenchymal stem cell --- lineage tracing analysis --- stem cell marker

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The book is devoted to the design, application and characterization of thin films and structures, with special emphasis on optical applications. It comprises ten papers—five featured and five regular—authored by scientists all over the world. Diverse materials are studied and their possible applications are demonstrated and discussed—transparent conductive coatings and structures from ZnO doped with Al and Ga and Ti-doped SnO2, polymers and nanosized zeolite thin films for optical sensing, TiO2 with linear and nonlinear optical properties, organic diamagnetic materials, broadband optical coatings, CrWN glass molding coatings, and silicon on insulator waveguides.

basal cell carcinoma --- diagnostic test accuracy --- in vivo --- reflectance confocal microscopy --- systematic review --- meta-analysis --- photochemotherapy --- methylaminolevulinate --- actinic keratosis --- vitamin d --- calcitriol --- vitamin d receptor --- skin cancer --- diagnosis --- cytology --- actinic cheilitis --- squamous cell carcinoma --- lip neoplasms --- cutaneous squamous cell carcinoma --- ultraviolet radiation --- genes --- microRNAs --- lncRNAs --- novel therapeutic approaches --- non-melanoma skin cancer --- Merkel cell carcinoma --- telomeres --- telomerase --- epigenetics --- miRNA --- Hedgehog pathway --- signaling pathways --- carcinogenesis

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This Special Issue contributes original research and review articles on the role of new protein, molecular, and genetic markers used for the diagnosis and progression of civilization diseases, as well as biomarkers useful in the monitoring the effects of the implemented treatment.

Medicine --- pharmacogenomics --- NGS variants --- personalized medicine --- FSHR --- personalized drug therapy --- hedgehog-interacting protein --- impaired fasting glucose --- impaired glucose tolerance --- newly diagnosed diabetes --- normal glucose tolerance --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- extracellular matrix components --- hyaluronan --- inflammatory bowel diseases (IBD) --- Crohn’s disease (CD) --- ulcerative colitis (UC) --- sulfated glycosaminoglycans (sGAG) --- hyaluronan (HA) --- soluble part of syndecan-1 (sCD138) --- microRNA --- cardiovascular disease --- diabetes --- mortality --- antiplatelet therapy --- platelet reactivity --- Let-7e --- miR-126 --- miR-223 --- miR-125a-3p --- CCL11 --- CCL24 --- CCL26 --- CCR3 --- CRC --- adiponectin --- adipokines --- rheumatology --- obesity --- overweight --- case control study --- rheumatoid arthritis --- TNF-α inhibitors --- bone turnover markers --- PINP --- PICP --- NTX-I --- CTX-I --- RANKL/OPG --- ovarian cancer --- interleukin 21 --- interleukin 22 --- lymphocytes --- macrophages --- dendritic cells --- innate lymphoid cells --- breast cancer --- extracellular matrix --- proteins --- tumorigenesis --- tumor microenvironment --- pharmacogenomics --- NGS variants --- personalized medicine --- FSHR --- personalized drug therapy --- hedgehog-interacting protein --- impaired fasting glucose --- impaired glucose tolerance --- newly diagnosed diabetes --- normal glucose tolerance --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- extracellular matrix components --- hyaluronan --- inflammatory bowel diseases (IBD) --- Crohn’s disease (CD) --- ulcerative colitis (UC) --- sulfated glycosaminoglycans (sGAG) --- hyaluronan (HA) --- soluble part of syndecan-1 (sCD138) --- microRNA --- cardiovascular disease --- diabetes --- mortality --- antiplatelet therapy --- platelet reactivity --- Let-7e --- miR-126 --- miR-223 --- miR-125a-3p --- CCL11 --- CCL24 --- CCL26 --- CCR3 --- CRC --- adiponectin --- adipokines --- rheumatology --- obesity --- overweight --- case control study --- rheumatoid arthritis --- TNF-α inhibitors --- bone turnover markers --- PINP --- PICP --- NTX-I --- CTX-I --- RANKL/OPG --- ovarian cancer --- interleukin 21 --- interleukin 22 --- lymphocytes --- macrophages --- dendritic cells --- innate lymphoid cells --- breast cancer --- extracellular matrix --- proteins --- tumorigenesis --- tumor microenvironment

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This Special Issue contributes original research and review articles on the role of new protein, molecular, and genetic markers used for the diagnosis and progression of civilization diseases, as well as biomarkers useful in the monitoring the effects of the implemented treatment.

Medicine --- pharmacogenomics --- NGS variants --- personalized medicine --- FSHR --- personalized drug therapy --- hedgehog-interacting protein --- impaired fasting glucose --- impaired glucose tolerance --- newly diagnosed diabetes --- normal glucose tolerance --- inflammatory bowel disease --- ulcerative colitis --- Crohn’s disease --- extracellular matrix components --- hyaluronan --- inflammatory bowel diseases (IBD) --- Crohn’s disease (CD) --- ulcerative colitis (UC) --- sulfated glycosaminoglycans (sGAG) --- hyaluronan (HA) --- soluble part of syndecan-1 (sCD138) --- microRNA --- cardiovascular disease --- diabetes --- mortality --- antiplatelet therapy --- platelet reactivity --- Let-7e --- miR-126 --- miR-223 --- miR-125a-3p --- CCL11 --- CCL24 --- CCL26 --- CCR3 --- CRC --- adiponectin --- adipokines --- rheumatology --- obesity --- overweight --- case control study --- rheumatoid arthritis --- TNF-α inhibitors --- bone turnover markers --- PINP --- PICP --- NTX-I --- CTX-I --- RANKL/OPG --- ovarian cancer --- interleukin 21 --- interleukin 22 --- lymphocytes --- macrophages --- dendritic cells --- innate lymphoid cells --- breast cancer --- extracellular matrix --- proteins --- tumorigenesis --- tumor microenvironment