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Contexte : La transplantation cardiaque demeure, encore aujourd’hui, le traitement de choix pour les patients en insuffisance cardiaque terminale. Cependant, certains receveurs décèdent précocement malgré les progrès médicaux et scientifiques.&#13;Objectifs : Ce mémoire a pour but premier de mettre en évidence les facteurs pronostiques de survie chez les 89 patients ayant bénéficié d’une transplantation cardiaque au CHU de Liège entre 2010 et 2022. L’objectif final est de mettre en évidence les actions et mesures qui permettraient d’augmenter le taux de survie des patients bénéficiant d’une transplantation cardiaque.&#13;Méthode : L’interface R Commander a été utilisée afin d’étudier de manière univariée par régression de Cox (P<0.05) l’influence de chaque variable sur la survie des receveurs. Les plus pertinentes ont été représentées graphiquement par l’estimateur de Kaplan-Meyer et analysées par un test de Log Rank. Enfin, une analyse multivariée par modèle linéaire généralisé a été appliquée afin de développer une formule de prédiction de la mortalité des transplantés.&#13;Résultats : La survie des receveurs pourrait être augmentée si les greffons cardiaques provenaient de donneurs âgés de moins de 46 ans (p=0,01) et dont l’indice de masse corporelle est inférieur à 23 kg/m² (p=0,001). Les prélèvements de type « Heart Donation after Circulatory Death » (HDCD)(p=0,91), le temps d’ischémie totale du greffon lorsqu’il reste dans des valeurs acceptables (p=0,45) et la distance séparant le centre de prélèvement du centre de transplantation (p=0,81) n’ont pas d’impact sur la survie des receveurs. L’offre en greffons pourrait être augmentée grâce au développement des prélèvements HDCD et par le recours à des greffons plus éloignés voire inaccessibles géographiquement, solution rendue possible par les technologies de conservation par hypothermie. Context : Heart transplantation remains the best treatment for patients with terminal heart failure. However, some recipients die early despite medical and scientific advances.&#13;Objectives : The primary objective of this study is to highlight the prognostic factors of survival of the 89 patients who underwent a heart transplant at the Liège University Hospital between 2010 and 2022. The final objective is to highlight actions and measures that would increase the survival rate of patients undergoing heart transplantation.&#13;Method : the R Commander interface was used to study by univariate Cox regression (P<0.05) the influence of each variable on recipient survival. The most relevant were graphically represented by the Kaplan-Meyer estimator and analyzed by a Log Rank test. Finally, a multivariate analysis by generalized linear model was applied to develop a prediction formula for transplant mortality.&#13;Results : The survival of recipients could be increased if the heart grafts came from donors under 46 years of age (p=0,01) and whose body mass index is less than 23 kg/m² (p=0,001). Heart Donation after Circulatory Death (HDCD)(p=0,91), the total ischemia time of the graft when it remains within acceptable values (p=0,45) and the distance between the procurement centre and the transplant centre (p=0,81) have no impact on recipient survival. The supply of grafts could be increased by the development of HDCD samples and the use of more distant or geographically inaccessible grafts, a solution made possible by hypothermic preservation technologies.

transplantation cardiaque --- greffon --- survie --- donneur --- receveur --- heart transplant --- graft --- survival --- donor --- recipient --- Sciences de la santé humaine > Chirurgie --- Sciences de la santé humaine > Systèmes cardiovasculaire & respiratoire --- Sciences de la santé humaine > Anesthésie & soins intensifs --- Sciences de la santé humaine > Santé publique, services médicaux & soins de santé

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Heart failure prevalence continues to rise globally. Regardless of the underlying etiology, heart failure remains a progressive disease, largely irreversible and end-stage heart failure requires transplantation. Book focuses on the challenges and recent advances of diagnosis, treatment and prevention of heart failure with or without associated comorbidities. We hope that readers will appreciate the wide breadth of topics and clinical utility of the articles and reviews included to this book collection.

biomarkers --- ST-segment elevation myocardial infarction --- preserved left ventricular ejection fraction --- reduced left ventricular ejection fraction --- heart failure --- NT-proBNP --- soluble ST2 --- galectin-3 --- matrix metalloproteinases --- tissue inhibitors of metalloproteinases --- mortality --- ejection fraction --- cardiopulmonary exercise test --- ventilatory inefficiency --- angiotensin receptor–neprilysin inhibitor --- echocardiography --- HFrEF --- risk stratification --- left ventricle end-diastolic diameter --- E/e’ ratio --- left ventricle outflow tract velocity-time integral --- hospitalization predictor --- short-term prognosis --- heart failure readmission --- acute myocardial infarction --- blood biomarkers --- diagnosis --- congestion --- clinical assessment --- preserved ejection fraction --- type 2 diabetes mellitus --- myocardial infarction --- chronic heart failure --- heart rate variability --- 2D echocardiography --- 24-h ECG monitoring --- chronic kidney disease --- pulmonary hypertension --- arteriovenous fistulas --- overhydration --- heart transplant --- cardiac allograft vasculopathy --- heart transplant rejection --- transthoracic echocardiography --- longitudinal strain --- sensing parameters --- pacing parameters --- adverse left ventricular remodeling --- left ventricular-arterial coupling --- fatty liver --- cardiovascular disease --- fibrosis --- epicardial fat --- left atrial strain --- edema --- dilated cardiomyopathy --- fluid management --- endothelial dysfunction --- n/a --- angiotensin receptor-neprilysin inhibitor --- E/e' ratio

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Perioperative care practices worldwide are in the midst of a seeing change with the implementation of multidisciplinary processes that improve surgical outcomes through (1) better patient education, engagement, and participation; (2) enhanced pre-operative, intra-operative, and post-operative care bundles; and (3) interactive audit programs that provide feedback to the surgical team. These improved outcomes include reductions in the frequency and severity of complications and improved throughput, which ultimately reduce operative stress. Practices in theatre as well as ward are becoming more collaborative and evidence-driven.This book is best utilized by perioperative care team members engaged in quality improvement, collaborative practice, and application of innovations in surgical care.

Medicine --- Surgery --- colorectal surgery --- pediatric --- surgical prophylaxis --- antibiotic prophylaxis --- surgical site infections --- collaboration --- enhanced recovery --- infection, surgical wound --- perioperative care --- pharmacy, clinical --- post-operative nausea and vomiting --- prophylaxis --- surgeon --- surgery --- colorectal --- gynecological --- thromboembolism --- venous --- anesthesiology --- COVID-19 --- nursing --- pediatrics --- pharmacy --- surgical home --- perioperative --- team-based care --- malignant hyperthermia --- collaborative practice --- heart transplant --- tricuspid annuloplasty --- tricuspid regurgitation --- prophylactic --- meta-analysis --- pain management --- opioid stewardship --- postoperative pain --- multimodal analgesia --- regional anesthesia --- preemptive analgesia --- perioperative medication management --- transitions of care --- opioid-related adverse effects --- wearable biosensors --- critical care --- vital sign monitoring --- bio-monitoring system --- technology acceptance --- integration --- implementation --- surgical care --- quality improvement --- n/a

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Perioperative care practices worldwide are in the midst of a seeing change with the implementation of multidisciplinary processes that improve surgical outcomes through (1) better patient education, engagement, and participation; (2) enhanced pre-operative, intra-operative, and post-operative care bundles; and (3) interactive audit programs that provide feedback to the surgical team. These improved outcomes include reductions in the frequency and severity of complications and improved throughput, which ultimately reduce operative stress. Practices in theatre as well as ward are becoming more collaborative and evidence-driven.This book is best utilized by perioperative care team members engaged in quality improvement, collaborative practice, and application of innovations in surgical care.

Medicine --- Surgery --- colorectal surgery --- pediatric --- surgical prophylaxis --- antibiotic prophylaxis --- surgical site infections --- collaboration --- enhanced recovery --- infection, surgical wound --- perioperative care --- pharmacy, clinical --- post-operative nausea and vomiting --- prophylaxis --- surgeon --- surgery --- colorectal --- gynecological --- thromboembolism --- venous --- anesthesiology --- COVID-19 --- nursing --- pediatrics --- pharmacy --- surgical home --- perioperative --- team-based care --- malignant hyperthermia --- collaborative practice --- heart transplant --- tricuspid annuloplasty --- tricuspid regurgitation --- prophylactic --- meta-analysis --- pain management --- opioid stewardship --- postoperative pain --- multimodal analgesia --- regional anesthesia --- preemptive analgesia --- perioperative medication management --- transitions of care --- opioid-related adverse effects --- wearable biosensors --- critical care --- vital sign monitoring --- bio-monitoring system --- technology acceptance --- integration --- implementation --- surgical care --- quality improvement --- colorectal surgery --- pediatric --- surgical prophylaxis --- antibiotic prophylaxis --- surgical site infections --- collaboration --- enhanced recovery --- infection, surgical wound --- perioperative care --- pharmacy, clinical --- post-operative nausea and vomiting --- prophylaxis --- surgeon --- surgery --- colorectal --- gynecological --- thromboembolism --- venous --- anesthesiology --- COVID-19 --- nursing --- pediatrics --- pharmacy --- surgical home --- perioperative --- team-based care --- malignant hyperthermia --- collaborative practice --- heart transplant --- tricuspid annuloplasty --- tricuspid regurgitation --- prophylactic --- meta-analysis --- pain management --- opioid stewardship --- postoperative pain --- multimodal analgesia --- regional anesthesia --- preemptive analgesia --- perioperative medication management --- transitions of care --- opioid-related adverse effects --- wearable biosensors --- critical care --- vital sign monitoring --- bio-monitoring system --- technology acceptance --- integration --- implementation --- surgical care --- quality improvement

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On March 11, 2020, the World Health Organization declared COVID-19 a global pandemic and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 presents significant challenges to health systems and public health in both hemispheres as well as to the economies of each country. The morbidity and mortality due to infections caused by SARS-CoV-2 have been significant despite the short duration since its discovery and initially overwhelmed many hospitals and clinics. It influences everyone, and countermeasures have been dramatic in their impact on employment, social systems, and mental health. This Special Issue provides an avenue for authors from various disciplines to provide feedback on our responses and preparedness to COVID-19 globally as well as to disseminate critical information about the SARS-CoV-2 virus and the associated COVID-19 pandemic. It consists of 22 peer-reviewed papers that cover worldwide perspectives encompasses the following: Original articles about COVID-19 (including epidemiology, modelling, clinical data, treatment, prevention, countermeasures, impacts on tropical regions, response, and preparedness);Original articles about SARS-CoV-2 (microbiology, virology, transmission, pathology, and vaccinology);Perspectives about COVID-19 and SARS-CoV-2 (comparisons with past coronavirus outbreaks, impactful local initiatives, novel responses, and commentaries);Reviews on COVID-19 (based on systematic and narrative reviews);and Innovations (vaccine development, drug trials, and original countermeasures).

Medicine --- Environmental medicine --- COVID-19 --- SARS-CoV-2 --- hepatitis B and C --- cirrhosis --- chronic kidney disease --- alcohol-related liver disease --- nonalcoholic steatohepatitis --- necrosis --- MDR-TB --- clinical trials --- IL-6 inhibitors --- tocilizumab --- cytokine release syndrome --- cytokine storm --- operational research --- health systems --- SORT IT --- pandemics --- training --- pandemic --- endemic --- tuberculosis --- impact --- control --- overview --- malaria --- preparedness --- Africa --- emergency --- fecal calprotectin --- bowel perforation --- D-Dimer --- thrombosis --- ischemia --- efficacy --- safety --- kaletra --- lopinavir/ritonavir --- meta-analysis --- coronavirus --- SARS-CoV-1 --- MERS --- SARS --- influenza --- healthcare worker --- healthcare personnel --- general practitioners --- medical doctor --- heart transplant --- CMV --- Chagas disease --- infection --- severity --- respiratory viruses --- coinfections --- health care workers --- Philippines --- rhinovirus --- severe acute respiratory syndrome coronavirus 2 --- plasmodium falciparum --- differential diagnosis --- cognitive bias --- diagnostic reasoning --- recurrence --- reinfection --- Bangladesh --- Kenya --- Nairobi --- presumptive tuberculosis --- TB treatment outcomes --- HIV --- antiretroviral therapy --- EpiCollect5 --- Malawi --- Lilongwe --- Zimbabwe --- Harare --- real-time operational research --- ethics --- research capacity building --- India --- Nepal --- post-acute COVID-19 syndrome --- COVID-19 vaccines --- mortality --- epidemiology --- public health --- healthcare workers --- attitudes --- perceptions --- knowledge --- n/a