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This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design.

Medicine --- hydrochlorothiazide --- cyclodextrins --- sepiolite --- nanoclay --- dissolution rate --- tablet --- electrospinning --- chitosan --- chondroitin sulfate --- scaffolds --- montmorillonite --- halloysite --- fibroblasts proliferation --- immune response --- glycosaminoglycans --- antimicrobial properties --- palygorskite --- spring water --- hydrogel --- fibroblast --- biocompatibility --- wound healing --- mesoporous clay --- Neusilin --- aeroperl --- liquisolid technique --- glyburide --- dissolution improvement --- hydrotalcite --- ketoprofen --- hybrid --- photostability --- hydrogel film --- bioadhesion --- heavy metal --- hazardous element --- element mobility --- clay minerals --- toxicity --- palygorksite --- proliferation --- Franz cell --- bioactive elements --- praziquantel --- drug --- organic solvents --- in vitro dissolution tests --- cytotoxicity --- targeted drug delivery --- halloysite nanotube --- osteosarcoma --- methotrexate --- surface modification --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design.

Medicine --- hydrochlorothiazide --- cyclodextrins --- sepiolite --- nanoclay --- dissolution rate --- tablet --- electrospinning --- chitosan --- chondroitin sulfate --- scaffolds --- montmorillonite --- halloysite --- fibroblasts proliferation --- immune response --- glycosaminoglycans --- antimicrobial properties --- palygorskite --- spring water --- hydrogel --- fibroblast --- biocompatibility --- wound healing --- mesoporous clay --- Neusilin --- aeroperl --- liquisolid technique --- glyburide --- dissolution improvement --- hydrotalcite --- ketoprofen --- hybrid --- photostability --- hydrogel film --- bioadhesion --- heavy metal --- hazardous element --- element mobility --- clay minerals --- toxicity --- palygorksite --- proliferation --- Franz cell --- bioactive elements --- praziquantel --- drug --- organic solvents --- in vitro dissolution tests --- cytotoxicity --- targeted drug delivery --- halloysite nanotube --- osteosarcoma --- methotrexate --- surface modification

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This book focuses on fundamental and applied research on polymer processing and its effect on the final surface as the optimization of polymer surface properties results in the unique applicability of these over other materials. The development and testing of the next generation of polymeric and composite materials is of particular interest. Special attention is given to polymer surface modification, external stimuli-responsive surfaces, coatings, adhesion, polymer and composites fatigue analysis, evaluation of the surface quality and microhardness, processing parameter optimization, characterization techniques, among others.

Research & information: general --- Biology, life sciences --- thermoplastic polyurethanes blends --- pressure sensitive adhesives --- viscoelastic properties --- adhesion properties --- tack --- creep --- cohesion properties --- nano-structure functional film --- magnetron sputtering --- cellulose insulation polymer --- space charge --- hydrophobicity --- zinc oxide --- polytetrafluoroethylene --- bromoisobutyryl esterification --- cornstarch --- synthesis process --- past stability --- adhesion --- film properties --- mullite --- whiskers --- nonaqueous precipitation method --- aluminum fluoride --- polar transformation --- screw --- aspect ratio --- carbon nanotube --- dispersion --- masterbatch --- nanocomposite --- polyamide --- polyamide 6 --- halloysite nanotube --- functionalizing agent --- in situ polymerization --- melt blending --- polymorphism --- hydrothermal ageing --- polymers --- octaglycidyl-POSS --- DGEBA --- dicyandiamide --- accelerators --- corrosion --- protective coatings --- infrared spectroscopy --- rheology --- poplar wood --- waterborne UV lacquer product --- wood modification --- contact angle --- spectroscopy --- super-hydrophobic coating --- elastic sensor --- carbon nanotubes --- wearable electronics --- monitoring of breathing --- strain sensor --- polymer composite --- CNTs --- construction composite --- friction resistance --- surface state --- low dielectric constant --- PI --- irradiation --- dielectric loss --- tin compounds --- valsartan --- poly(vinyl chloride) --- additives --- average molecular weight --- weight loss --- functional group index --- PET --- polymer --- plasma jet --- tilted application --- ROS distribution --- UV --- VUV --- epoxy --- Joule heating --- fast curing --- accelerated forming --- shape memory --- Acrylonitrile Butadiene Styrene --- sound absorption --- 3D printing technology --- frequency --- thickness --- air gap --- polyvinyl alcohol --- cationic polyacrylamide --- polyvinyl chloride --- azodicarbonamide --- micro-structure --- diffusion plate --- micro injection molding --- grinding --- ethylene-octene-copolymer --- carbon fibers --- polyaniline --- polypyrrole --- thermoelectric composites --- surface coating --- dopamine hydrochloride --- graphene oxide --- surgical suture --- friction --- Poly(vinylidene chloride-co-acrylonitrile) (P(VDC-co-AN )) --- thermo-dynamic surface characterization --- surface free energy --- inverse gas chromatography --- visual traits --- computer vision and image processing --- basalt fiber --- epoxy composite --- glass transition temperature --- DMA --- TMA --- creep recovery --- stress-relaxation --- heterogeneous nucleation --- cell morphology --- injection molding foaming --- composite materials --- visualization --- gloss transition defect --- surface defect --- surface gloss --- shrinkage --- mold surface replication --- surface analysis --- injection molding --- polymer surface modification --- hydrophobic properties --- optimization --- mathematical modeling --- poly(ethylene glycol) (PEG) --- conjugation --- N,N′-disuccinimidyl carbonate (DSC) --- immobilization --- surface modification --- ultra-high molecular weight polyethylene --- cellulose nanofiber --- bionanocomposite --- melt-blending --- ethanol mixing