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Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.
glucose-6-phosphate dehydrogenase --- hydroxyurea/hydroxycarbamide --- n/a --- cord blood --- screening --- hemoglobin pattern --- capillary electrophoresis --- sickle cell disease --- (recommended) screening panel --- vaso-occlusive crisis --- Guthrie spots --- newborn screening) --- foetal haemoglobin --- harmonisation --- review --- birth prevalence --- G6PD deficiency --- prevention --- end-organ damage --- thalassemia --- MALDI-TOF --- IEF --- acute chest syndrome --- India --- sickle cell and thalassaemia screening programme --- ‘Getting to Outcomes’ --- newborn screening --- hemoglobinopathy --- service users --- public health engagement --- automated HPLC --- Kaduna State --- gene therapy for haemoglobinopathies --- ?-globin gene --- methods --- neonatal screening program --- malaria --- Plasmodium vivax --- sub-Saharan Africa --- patient organisations --- health policy --- pathophysiology --- Sickle Cell Disease --- mass spectrometry --- sickle cell disorder --- neonatal screening --- non-tribal --- Nigeria --- point-of-care --- HPLC --- laboratory methods --- registry --- patient advocacy --- bone marrow transplant --- anaemia --- hemoglobinopathies --- tribal --- newborn --- burden of disease --- patient representatives --- diagnostics --- policy making --- haemolysis --- Caribbean --- high performance liquid chromatography (HPLC) --- sickle cell disease (SCD) --- implementation science --- 'Getting to Outcomes'
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Babesiosis, caused by tick-transmitted intraerythrocytic parasites (Babesia spp.), occurs worldwide. The disease mainly affects livestock, but records of infections in humans are increasing, and the disease is considered to be emerging worldwide. This book provides a comprehensive and holistic view of Babesia species that can infect humans. Numerous experts analyze, in detail, basic aspects of the biology of Babesia, the pathology of the babesiosis highlighting the pathogenesis of babesiosis in sickle cell, the eco-epidemiology of tick vectors and the impact of climate change on them, the current status, and future prospects for laboratory diagnosis and measures to prevent transfusion transmission. The book also focused on unidentified Babesia parasites that continue to emerge, most likely from wildlife, for which neither tick vector species nor vertebrate reservoir host species are currently known. Lastly, current and new therapies for infected patients, in vitro and in vivo culture systems for antibabesial evaluation and measures to prevent infections are also considered.
Medicine --- Epidemiology & medical statistics --- babesiosis --- Babesia microti --- Babesia duncani --- parasite --- therapy --- atovaquone --- endochin-like quinolones (ELQs) --- human babesiosis --- Nantucket Island --- epidemiology --- ecology --- human risk --- European babesiosis --- Babesia divergens --- Babesia venatorum --- Ixodes ricinus --- parasite identity --- clinical cases --- diagnosis --- treatment --- Babesia --- diversity --- phylogenetic analysis --- blood transfusion --- prevention --- screening --- aspartyl protease --- plasmepsin --- apicomplexa --- piroplasmida --- BmIPA48 --- BMR1_03g00960 --- piroplasmid rhoptry-associated protein-1 (pRAP-1) --- ticks --- Babesia sp. --- biological cycle --- experimental transmission --- experimental models --- Ixodes scapularis --- climate --- global warming --- Babesia sp. MO1 --- Babesia capreoli --- rap-1a --- ama-1 --- phylogeny --- sickle-cell anemia --- hemolysis --- haemoglobinopathies --- immunoepidemiology --- case surveillance --- therapeutic drugs --- peptidases --- antibody-based assays --- nucleic acid tests --- multiplex detection --- next generation sequencing --- glycosylphosphatidylinositol --- protein structure --- antigen --- host blood analysis --- fallow deer --- ixodid ticks --- piroplasm --- red deer --- Theileria --- Babesia bovis --- Babesia bigemina --- Colombia --- n/a --- in vitro culture --- erythrocytes --- DMEM-F12 --- virulence
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Babesiosis, caused by tick-transmitted intraerythrocytic parasites (Babesia spp.), occurs worldwide. The disease mainly affects livestock, but records of infections in humans are increasing, and the disease is considered to be emerging worldwide. This book provides a comprehensive and holistic view of Babesia species that can infect humans. Numerous experts analyze, in detail, basic aspects of the biology of Babesia, the pathology of the babesiosis highlighting the pathogenesis of babesiosis in sickle cell, the eco-epidemiology of tick vectors and the impact of climate change on them, the current status, and future prospects for laboratory diagnosis and measures to prevent transfusion transmission. The book also focused on unidentified Babesia parasites that continue to emerge, most likely from wildlife, for which neither tick vector species nor vertebrate reservoir host species are currently known. Lastly, current and new therapies for infected patients, in vitro and in vivo culture systems for antibabesial evaluation and measures to prevent infections are also considered.
babesiosis --- Babesia microti --- Babesia duncani --- parasite --- therapy --- atovaquone --- endochin-like quinolones (ELQs) --- human babesiosis --- Nantucket Island --- epidemiology --- ecology --- human risk --- European babesiosis --- Babesia divergens --- Babesia venatorum --- Ixodes ricinus --- parasite identity --- clinical cases --- diagnosis --- treatment --- Babesia --- diversity --- phylogenetic analysis --- blood transfusion --- prevention --- screening --- aspartyl protease --- plasmepsin --- apicomplexa --- piroplasmida --- BmIPA48 --- BMR1_03g00960 --- piroplasmid rhoptry-associated protein-1 (pRAP-1) --- ticks --- Babesia sp. --- biological cycle --- experimental transmission --- experimental models --- Ixodes scapularis --- climate --- global warming --- Babesia sp. MO1 --- Babesia capreoli --- rap-1a --- ama-1 --- phylogeny --- sickle-cell anemia --- hemolysis --- haemoglobinopathies --- immunoepidemiology --- case surveillance --- therapeutic drugs --- peptidases --- antibody-based assays --- nucleic acid tests --- multiplex detection --- next generation sequencing --- glycosylphosphatidylinositol --- protein structure --- antigen --- host blood analysis --- fallow deer --- ixodid ticks --- piroplasm --- red deer --- Theileria --- Babesia bovis --- Babesia bigemina --- Colombia --- n/a --- in vitro culture --- erythrocytes --- DMEM-F12 --- virulence
Choose an application
Babesiosis, caused by tick-transmitted intraerythrocytic parasites (Babesia spp.), occurs worldwide. The disease mainly affects livestock, but records of infections in humans are increasing, and the disease is considered to be emerging worldwide. This book provides a comprehensive and holistic view of Babesia species that can infect humans. Numerous experts analyze, in detail, basic aspects of the biology of Babesia, the pathology of the babesiosis highlighting the pathogenesis of babesiosis in sickle cell, the eco-epidemiology of tick vectors and the impact of climate change on them, the current status, and future prospects for laboratory diagnosis and measures to prevent transfusion transmission. The book also focused on unidentified Babesia parasites that continue to emerge, most likely from wildlife, for which neither tick vector species nor vertebrate reservoir host species are currently known. Lastly, current and new therapies for infected patients, in vitro and in vivo culture systems for antibabesial evaluation and measures to prevent infections are also considered.
Medicine --- Epidemiology & medical statistics --- babesiosis --- Babesia microti --- Babesia duncani --- parasite --- therapy --- atovaquone --- endochin-like quinolones (ELQs) --- human babesiosis --- Nantucket Island --- epidemiology --- ecology --- human risk --- European babesiosis --- Babesia divergens --- Babesia venatorum --- Ixodes ricinus --- parasite identity --- clinical cases --- diagnosis --- treatment --- Babesia --- diversity --- phylogenetic analysis --- blood transfusion --- prevention --- screening --- aspartyl protease --- plasmepsin --- apicomplexa --- piroplasmida --- BmIPA48 --- BMR1_03g00960 --- piroplasmid rhoptry-associated protein-1 (pRAP-1) --- ticks --- Babesia sp. --- biological cycle --- experimental transmission --- experimental models --- Ixodes scapularis --- climate --- global warming --- Babesia sp. MO1 --- Babesia capreoli --- rap-1a --- ama-1 --- phylogeny --- sickle-cell anemia --- hemolysis --- haemoglobinopathies --- immunoepidemiology --- case surveillance --- therapeutic drugs --- peptidases --- antibody-based assays --- nucleic acid tests --- multiplex detection --- next generation sequencing --- glycosylphosphatidylinositol --- protein structure --- antigen --- host blood analysis --- fallow deer --- ixodid ticks --- piroplasm --- red deer --- Theileria --- Babesia bovis --- Babesia bigemina --- Colombia --- in vitro culture --- erythrocytes --- DMEM-F12 --- virulence --- babesiosis --- Babesia microti --- Babesia duncani --- parasite --- therapy --- atovaquone --- endochin-like quinolones (ELQs) --- human babesiosis --- Nantucket Island --- epidemiology --- ecology --- human risk --- European babesiosis --- Babesia divergens --- Babesia venatorum --- Ixodes ricinus --- parasite identity --- clinical cases --- diagnosis --- treatment --- Babesia --- diversity --- phylogenetic analysis --- blood transfusion --- prevention --- screening --- aspartyl protease --- plasmepsin --- apicomplexa --- piroplasmida --- BmIPA48 --- BMR1_03g00960 --- piroplasmid rhoptry-associated protein-1 (pRAP-1) --- ticks --- Babesia sp. --- biological cycle --- experimental transmission --- experimental models --- Ixodes scapularis --- climate --- global warming --- Babesia sp. MO1 --- Babesia capreoli --- rap-1a --- ama-1 --- phylogeny --- sickle-cell anemia --- hemolysis --- haemoglobinopathies --- immunoepidemiology --- case surveillance --- therapeutic drugs --- peptidases --- antibody-based assays --- nucleic acid tests --- multiplex detection --- next generation sequencing --- glycosylphosphatidylinositol --- protein structure --- antigen --- host blood analysis --- fallow deer --- ixodid ticks --- piroplasm --- red deer --- Theileria --- Babesia bovis --- Babesia bigemina --- Colombia --- in vitro culture --- erythrocytes --- DMEM-F12 --- virulence
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