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Once upon a time, gluten was not part of the human diet, and therefore, there were no gluten-related disorders. With the advent of agriculture 10,000 years ago, the introduction of gluten-containing grains in the human diet created conditions for human diseases related to gluten exposure. These diseases, including celiac disease, non-celiac gluten sensitivity, and wheat allergy, have distinct pathophysiological mechanisms, serological markers, and long-term treatments, but similar, often overlapping clinical presentations. Though current research strives to clarify the boundaries between these entities, their differences can be difficult to distinguish. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders has been a “work in progress”. New epidemiological studies have revealed that gluten-related disorders are not limited to European regions; rather, they are present worldwide. After centuries of neglected attention to celiac disease and other forms of gluten reaction, now we are observing another interesting phenomenon that is generating great confusion among health care professionals. Nearly 25% of Americans (many more than the projected 3 million celiac disease (CD) patients in the U.S.) are reducing or cutting gluten from their diets. This remarkable trend in the general population reflects the misconception that gluten can be harmful for everybody and, therefore, should be avoided to stay healthy, to lose weight, or even to prevent severe diseases. This Special Issue Book of Nutrients contains contributions from leading experts in the field of gluten-related disorders that will help dissipate this confusion by sharing their evidence-based science, which will help the reader to distinguish facts from fantasies.
Non Celiac Gluten Sensitivity --- Food Sensitivities --- Celiac Disease --- Gluten Related Disorders --- Gluten-Free Diet
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The incidence of gluten-related disorders (GRDs) continues to increase and its global prevalence is estimated affect to 5% of the population. s. Celiac disease (CD), Dermatitis Herpetiformis (DH), Gluten Ataxia (GA), wheat allergy (WA), and Non-Celiac Gluten Sensitivity (NCGS) are the five major GRDs that present with a wide range of clinical manifestations. They are manifested by symptoms of gastrointestinal tract disorders, as well as hematological, dermatological endocrinological, gynecological, rheumatological and nervous system. NCGS is a term that is used to describe individuals who are not affected by celiac disease or wheat allergy, yet they have intestinal and/or extra-intestinal symptoms related to gluten ingestion with improvement of their symptoms upon withdrawing gluten from their diet. It is believed that represents some heterogeneous groups with different subgroups characterized by different etiologies, clinical histories and clinical courses. There also appears to be an overlap between NCGS and irritable bowel syndrome (IBS). There is a need for establishing strict criteria for diagnosing NCGS. The absence of validated biomarkers remains a significant limitation for research studies on NCGS. New evidence shows that a gluten-free diet may be beneficial for some patients with gastrointestinal symptoms, such as those symptoms commonly found in patients with IBS.
Medicine --- celiac disease --- children --- HLA-DQ --- prevalence --- Asia --- wheat --- gluten --- non-celiac gluten-sensitivity --- diagnosis --- dermatitis herpetiformis --- anti-tTG --- anti-DGP --- AAA --- AGA --- IL-17A --- HLA-DQB1*02 --- screening --- first-degree relatives --- non-celiac gluten sensitivity --- irritable bowel disease --- FODMAP --- wheat allergy --- vitamin B12 --- iron --- folic acid --- vitamin D --- long-term GFD therapy (LTGFD) --- LTGFD with good compliance (LTGFDWGC) --- anemia --- lymphoma --- IgA deficiency --- gut --- enteropathy --- gluten-free diet --- level of evidences --- gluten-related disorders --- NCGS --- self-report --- survey studies --- celiac disease --- children --- HLA-DQ --- prevalence --- Asia --- wheat --- gluten --- non-celiac gluten-sensitivity --- diagnosis --- dermatitis herpetiformis --- anti-tTG --- anti-DGP --- AAA --- AGA --- IL-17A --- HLA-DQB1*02 --- screening --- first-degree relatives --- non-celiac gluten sensitivity --- irritable bowel disease --- FODMAP --- wheat allergy --- vitamin B12 --- iron --- folic acid --- vitamin D --- long-term GFD therapy (LTGFD) --- LTGFD with good compliance (LTGFDWGC) --- anemia --- lymphoma --- IgA deficiency --- gut --- enteropathy --- gluten-free diet --- level of evidences --- gluten-related disorders --- NCGS --- self-report --- survey studies
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The incidence of gluten-related disorders (GRDs) continues to increase and its global prevalence is estimated affect to 5% of the population. s. Celiac disease (CD), Dermatitis Herpetiformis (DH), Gluten Ataxia (GA), wheat allergy (WA), and Non-Celiac Gluten Sensitivity (NCGS) are the five major GRDs that present with a wide range of clinical manifestations. They are manifested by symptoms of gastrointestinal tract disorders, as well as hematological, dermatological endocrinological, gynecological, rheumatological and nervous system. NCGS is a term that is used to describe individuals who are not affected by celiac disease or wheat allergy, yet they have intestinal and/or extra-intestinal symptoms related to gluten ingestion with improvement of their symptoms upon withdrawing gluten from their diet. It is believed that represents some heterogeneous groups with different subgroups characterized by different etiologies, clinical histories and clinical courses. There also appears to be an overlap between NCGS and irritable bowel syndrome (IBS). There is a need for establishing strict criteria for diagnosing NCGS. The absence of validated biomarkers remains a significant limitation for research studies on NCGS. New evidence shows that a gluten-free diet may be beneficial for some patients with gastrointestinal symptoms, such as those symptoms commonly found in patients with IBS.
Medicine --- celiac disease --- children --- HLA-DQ --- prevalence --- Asia --- wheat --- gluten --- non-celiac gluten-sensitivity --- diagnosis --- dermatitis herpetiformis --- anti-tTG --- anti-DGP --- AAA --- AGA --- IL-17A --- HLA-DQB1*02 --- screening --- first-degree relatives --- non-celiac gluten sensitivity --- irritable bowel disease --- FODMAP --- wheat allergy --- vitamin B12 --- iron --- folic acid --- vitamin D --- long-term GFD therapy (LTGFD) --- LTGFD with good compliance (LTGFDWGC) --- anemia --- lymphoma --- IgA deficiency --- gut --- enteropathy --- gluten-free diet --- level of evidences --- gluten-related disorders --- NCGS --- self-report --- survey studies --- n/a
Choose an application
The incidence of gluten-related disorders (GRDs) continues to increase and its global prevalence is estimated affect to 5% of the population. s. Celiac disease (CD), Dermatitis Herpetiformis (DH), Gluten Ataxia (GA), wheat allergy (WA), and Non-Celiac Gluten Sensitivity (NCGS) are the five major GRDs that present with a wide range of clinical manifestations. They are manifested by symptoms of gastrointestinal tract disorders, as well as hematological, dermatological endocrinological, gynecological, rheumatological and nervous system. NCGS is a term that is used to describe individuals who are not affected by celiac disease or wheat allergy, yet they have intestinal and/or extra-intestinal symptoms related to gluten ingestion with improvement of their symptoms upon withdrawing gluten from their diet. It is believed that represents some heterogeneous groups with different subgroups characterized by different etiologies, clinical histories and clinical courses. There also appears to be an overlap between NCGS and irritable bowel syndrome (IBS). There is a need for establishing strict criteria for diagnosing NCGS. The absence of validated biomarkers remains a significant limitation for research studies on NCGS. New evidence shows that a gluten-free diet may be beneficial for some patients with gastrointestinal symptoms, such as those symptoms commonly found in patients with IBS.
celiac disease --- children --- HLA-DQ --- prevalence --- Asia --- wheat --- gluten --- non-celiac gluten-sensitivity --- diagnosis --- dermatitis herpetiformis --- anti-tTG --- anti-DGP --- AAA --- AGA --- IL-17A --- HLA-DQB1*02 --- screening --- first-degree relatives --- non-celiac gluten sensitivity --- irritable bowel disease --- FODMAP --- wheat allergy --- vitamin B12 --- iron --- folic acid --- vitamin D --- long-term GFD therapy (LTGFD) --- LTGFD with good compliance (LTGFDWGC) --- anemia --- lymphoma --- IgA deficiency --- gut --- enteropathy --- gluten-free diet --- level of evidences --- gluten-related disorders --- NCGS --- self-report --- survey studies --- n/a
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