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This dissertation by Mikael Chéramy investigates the effects and immunological mechanisms of aluminum-formulated Glutamic Acid Decarboxylase 65 (GAD-alum) treatment in Type 1 Diabetes (T1D) patients. The work focuses on clinical trials aimed at preserving β-cell function, particularly during Phase II and III trials. The study evaluates the immune response to GAD-alum treatment, including changes in GADA levels and IgG subclasses. Results indicate a Th2-associated immune response and elevated GADA levels, with prolonged effects observed in some patients. The research aims to enhance understanding of immune responses to autoantigens and identify biomarkers for optimizing future T1D interventions.

Glutamate decarboxylase. --- Immunotherapy.

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This book covedered high-quality contributions (original research articles or review papers) providing a picture on innovations in microbial fermentative processes, including improvements of quality/safety of fermented foods and beverages, production of high added-values products, and valorization/recovery of agro-food wastes.

Technology: general issues --- Biotechnology --- simultaneous saccharification and cultivation (SSC) --- intensive multiple sequential batch cultivation --- thermotolerant yeast --- Kluyveromyces marxianus --- ethanol production --- smoking with open fire --- PAH --- industrial smoking --- clavulanic acid --- Streptomyces clavuligerus --- cell morphology --- shear stress --- high cell density cultivation (HCDC) --- intensive multiple sequential batch (IMSB) --- cell cultivation --- fed-batch at cell level (FBC) --- S. cerevisiae --- dextrin --- bioreactor --- chain elongation --- carboxylate platform --- medium-chain fatty acids --- carboxylic acids --- mixed culture fermentation --- biocontrol --- Bacillus velezensis --- volatile organic compounds --- vascular wilt pathogens --- GABA --- Indonesian fermented foods --- glutamate decarboxylase --- lactic acid bacteria --- L. plantarum --- feast/famine conditions --- industrial-scale bioreactor --- metabolomics --- metabolic response --- penicillin --- Penicillium chrysogenum --- scale-down --- children --- double fortification --- fermented milk --- iron and zinc --- stunting --- synbiotic --- wine --- HS-SPME-GC/MS --- multivariate statistical analysis --- calibration --- whole-plant corn silage --- bacterial community --- fungal community --- metabolites --- fermentation quality --- aerobic stability --- succession pattern --- fermentation process --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book covedered high-quality contributions (original research articles or review papers) providing a picture on innovations in microbial fermentative processes, including improvements of quality/safety of fermented foods and beverages, production of high added-values products, and valorization/recovery of agro-food wastes.

Technology: general issues --- Biotechnology --- simultaneous saccharification and cultivation (SSC) --- intensive multiple sequential batch cultivation --- thermotolerant yeast --- Kluyveromyces marxianus --- ethanol production --- smoking with open fire --- PAH --- industrial smoking --- clavulanic acid --- Streptomyces clavuligerus --- cell morphology --- shear stress --- high cell density cultivation (HCDC) --- intensive multiple sequential batch (IMSB) --- cell cultivation --- fed-batch at cell level (FBC) --- S. cerevisiae --- dextrin --- bioreactor --- chain elongation --- carboxylate platform --- medium-chain fatty acids --- carboxylic acids --- mixed culture fermentation --- biocontrol --- Bacillus velezensis --- volatile organic compounds --- vascular wilt pathogens --- GABA --- Indonesian fermented foods --- glutamate decarboxylase --- lactic acid bacteria --- L. plantarum --- feast/famine conditions --- industrial-scale bioreactor --- metabolomics --- metabolic response --- penicillin --- Penicillium chrysogenum --- scale-down --- children --- double fortification --- fermented milk --- iron and zinc --- stunting --- synbiotic --- wine --- HS-SPME-GC/MS --- multivariate statistical analysis --- calibration --- whole-plant corn silage --- bacterial community --- fungal community --- metabolites --- fermentation quality --- aerobic stability --- succession pattern --- fermentation process