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Dissertation
Year: 2021 Publisher: Liège Université de Liège (ULiège)
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Résumé : Il existe de nombreuses méthodes pour éditer les gènes dont CRISPR Cas 9 qui est une nouvelle technologie génétique innovante et très prometteuse, elle fait l’objet de nombreuses études. Cette méthode a vu le jour en 2012 et depuis il a été développé par de nombreux chercheurs partout dans le monde. C’était à l’origine un système bactérien, utilisé par le système immunitaire adaptatif des pathogènes. Le plus étudié est celui de S. thermophilus et S pyogène. Le but de CRISPR Cas 9 est d’introduire une coupure à un endroit précis de l’ADN afin d’induire une réparation dans un gène muté ou non, le rendant ainsi fonctionnel ou à l’inverse inactif. Cette technologie n’est pas encore utilisée chez les humains in vivo, mais c’est le cas sur les cellules humaines in vitro et les animaux, notamment la souris et le chien. Dans ce TFe, nous allons détailler ce qu’est la technologie CRISPR Cas 9, puis nous verrons un exemple de cette technique utilisé dans le cadre d’une maladie génétique, la maladie de Duchenne. Et enfin, nous discuterons des perspectives de cette technique. Summary : There are several methods to edit genes including CRISPR Cas 9, which is a new innovative and very promising genetic technology, which is the subject of numerous studies. This method saw the light in 2012 and since then it has been used by many researchers all over the world. It is derived from a bacterial adaptive immune system against pathogens. The most studied are those of S. thermophilus and S pyogenes. The effect of CRISPR Cas 9 is to introduce a cut at a specific location in DNA in order to induce repair which may result in a mutated or repaired gene, thus making it functional or conversely inactive. This technology is not yet used in humans in vivo, but it is in human cells in vitro and in animals, especially mice and dogs. In this TFe, we will detail how the CRISPR Cas 9 technology works. Then we will see an example of this technique used in the context of a genetic disease, Duchenne's disease. And finally, we will discuss the prospects of futur for this technique.
CRISPR-Cas 9 --- Ingénierie génétique --- ADN --- Chiens --- Souris --- technologie génétique --- édition génomique --- correction mutation --- CRISPR --- Cas 9 --- génétique --- Dystrophie musculaire de duchenne --- genetic editing --- base editing --- dogs --- mouses --- genetic technology --- DMD --- dystrophy --- mutation --- Sciences du vivant > Médecine vétérinaire & santé animale
Book
ISBN: 1282772457 9786612772450 0520942620 9780520942622 9780520255746 0520255747 9780520255753 0520255755 9781282772458 661277245X Year: 2008 Publisher: Berkeley University of California Press
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In the aftermath of the 1992-1995 Bosnian war, the discovery of unmarked mass graves revealed Europe's worst atrocity since World War II: the genocide in the UN "safe area" of Srebrenica. To Know Where He Lies provides a powerful account of the innovative genetic technology developed to identify the eight thousand Bosnian Muslim (Bosniak) men and boys found in those graves and elsewhere, demonstrating how memory, imagination, and science come together to recover identities lost to genocide. Sarah E. Wagner explores technology's import across several areas of postwar Bosnian society-for families of the missing, the Srebrenica community, the Bosnian political leadership (including Serb and Muslim), and international aims of social repair-probing the meaning of absence itself.
Yugoslav War, 1991-1995 --- Missing persons --- DNA fingerprinting --- War in former Yugoslavia, 1991-1995 --- Yugoslav Conflict, 1991-1995 --- Yugoslav Wars of Secession, 1991-1995 --- Yugoslav War Crime Trials, Hague, Netherlands, 1994 --- -DNA fingerprints --- DNA identification --- DNA profiles --- DNA profiling --- Genetic fingerprinting --- Genetic fingerprints --- Forensic genetics --- Identification --- Persons --- Atrocities --- Technique --- DNA fingerprints --- -Atrocities --- accountability. --- armed conflict. --- bosnia. --- bosniak. --- bosnian muslim. --- bosnian war. --- breakup of yugoslavia. --- ethnicity cleansing. --- europe. --- genetic technology. --- genocide. --- herzegovina. --- identification. --- imagination. --- islam. --- meaning of absence. --- memory. --- personalized loss. --- political leadership. --- postwar bosnian society. --- postwar srebrenica. --- potocari. --- safe area. --- science. --- social repair. --- socialist federal republic of yugoslavia. --- srebrenica. --- technology of repair. --- unmarked mass graves. --- violence.
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