Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Foodborne pathogens represent a major burden on society as they are the cause of high numbers of illnesses, hospitalizations, and deaths each year. In addition to their detrimental impact on human health, these microorganisms, which include pathogenic bacteria, viruses, fungi, and a range of parasites, also represent a significant economic cost to food companies in the implementation and constant oversight of food hygiene and safety programs, product recalls, and potential litigation if outbreaks occur. Advancing our current knowledge of the food processing chain and its vulnerabilities to the many factors related to foodborne pathogens (e.g., their stress response, survival and persistence in processing environments, acquisition of virulence factors and antimicrobial drug resistance) is paramount to the development of effective strategies for early detection and control of pathogens, thereby improving food safety.This Special Issue compiled original research articles contributing to a better understanding of the impact of all aspects of foodborne pathogens on food safety.

Listeria monocytogenes --- growth potential --- ready-to-eat --- iceberg lettuce --- rocket --- spinach --- rucola --- arugula --- antimicrobial blue light --- pathogenic bacteria --- food-borne bacteria --- endogenous photosensitizers --- porphyrins --- food safety --- food handling --- food hygiene --- Salmonella --- Salmonellosis --- foodborne illness --- whole papaya --- Salmonella Typhimurium --- survival --- aqueous chlorine dioxide --- malic acid --- shelf-life --- Listeria spp. --- prevalence --- detection --- monitoring --- smear --- benzalkonium chloride --- thymol --- ampicillin --- sublethal antimicrobial exposure --- gene expression --- stress response --- virulence --- foodborne pathogen --- salmonellosis --- chicken --- antibiotic resistance --- microbial contamination --- multidrug-resistant bacteria --- milk alternatives --- Salmonella Enteritidis --- egg white --- AcrD --- stress resistance --- cell invasion --- pathogenic mechanism --- foodborne bacteria --- in vitro cell models --- organoids --- enteroids --- Bacillus cereus group --- chromogenic media --- performance testing --- toxin gene profiling --- panC sequencing --- food-borne salmonellosis --- multi-drug resistance --- invasion genes bacterial virulence --- poultry bio-mapping --- chemical interventions --- Salmonella enumeration --- Campylobacter enumeration --- bacteriophage --- endolysin --- amidase --- bionanoparticles --- BNPs --- enterohemorrhagic Escherichia coli --- yogurt --- quantitative microbial risk assessment

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The aim of this Special Issue is to collect reports regarding all the recent strategies, directed at the improvement of antineoplastic activity of drugs in cancer progression, engaging all the expertise needed for the development of new anticancer drugs: medicinal chemistry, pharmacology, molecular biology, and computational and drug delivery studies.

Research & information: general --- Biology, life sciences --- EGR-1 --- flavonoid --- (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile --- MDA-MB-231 --- MMP9 --- TNFα --- pancreatic ductal adenocarcinoma --- cyclodextrin inclusion complex --- phase solubility studies --- preformulation studies --- biphenylnicotinamide derivatives --- dual inhibitor --- EGFR --- VEGFR2 --- ligand-based pharmacophore --- molecular docking --- molecular dynamics --- leukemias --- doxorubicin --- inflammation --- drug delivery --- tumor targeting --- elastin-like polypeptide --- cell penetrating peptide --- matrix metalloproteinase --- doxorubicin resistance --- photosensitizer delivery system --- PAMAM dendrimer --- photodynamic therapy --- cytotoxicity --- phototoxicity --- colorectal adenocarcinoma --- dicarboximides --- chemical synthesis --- apoptosis --- kinases --- anticancer --- gene profiling --- SAR --- biomarkers --- colorectal cancer --- early detection examination --- liquid biopsy --- personalized medicine --- tumor treatment --- exosomes --- ctDNA --- CTC --- cytotoxic activity --- pyrazole derivatives --- MTT assay --- ADMET analysis --- single-crystal diffraction --- FTIR spectroscopy --- NMR spectroscopy thermogravimetric analysis --- acute myelogenous leukemia --- platelets --- microparticles --- γδ T cells --- immunotherapy --- tumor resistance --- combination therapy --- tumor microenvironment --- immune checkpoint inhibitor --- neuroblastoma --- molecular iodine --- cyclophosphamide --- xenografts --- metronomic therapy --- tamoxifen --- CYP2D6 --- MCF-7 --- Ishikawa cells --- SERM --- TNBC --- uterotrophic --- α-mangostin --- poly(amidoamine) dendrimer --- targeted drug delivery --- biotin targeting --- glioblastoma multiforme --- squamous cell carcinoma --- antiparasitic therapy --- diclofenac --- indomethacin --- oleanolic acid derivative conjugates --- NF-κB --- Nrf2 --- MAPKs --- PSN-1 cells --- reactive oxygen species --- glioblastoma --- brain tumor --- extracellular vesicles --- pancreatic cancer --- paclitaxel --- clathrin --- endocytosis --- sulforaphane --- nicotine --- metalloproteinase-9 --- gastric cancer --- cell invasion --- Arylquin 1 --- colon cancer --- tumor progression --- azelastine --- oxidative stress --- autophagy --- mitotic catastrophe --- chronic myeloid leukemia --- imatinib --- tyrosine kinase --- ketoconazole --- P-glycoprotein --- drug efflux transporter --- non-small-cell lung cancer --- cisplatin resistance --- aldehyde dehydrogenase --- isothiocyanates --- disulfiram --- epithelial to mesenchymal transition --- aminopeptidase N --- acetamidophenones --- Schiff bases --- semicarbazones --- thiosemicarbazones --- inhibition of proliferation

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Breast cancer is acknowledged as an international priority in healthcare. It is currently the most common cancer in women worldwide, with demographic trends indicating a continuous increase in incidence. Over the years, increasing efforts and resources have been devoted to the search for a systematic and optimized strategy in breast cancer diagnosis and treatment. Today, the Breast Unit model is considered the gold standard in order to ensure optimal patient-centered and research-based clinical services through multidisciplinary and integrated management.Surgical treatment has gradually evolved toward less aggressive approaches with the adoption of new therapeutic strategies. The evolution of evidence-based guidelines in such leading disciplines as radiation and medical oncology has led to a steady improvement in survival rates. This Special Issue will highlight innovations in the integrated management of breast cancer, their potential advantages, and the many open issues that still need to be properly defined and addressed.

metastatic breast cancer --- breast surgery --- immune system --- metabolic derangements --- precision medicine --- integrated therapies --- advanced breast cancer --- mTOR inhibitor --- CDK4/6 inhibitor --- endocrine resistance --- breast cancer --- pregnancy --- chemotherapy --- tailoring --- personalization --- DataMart --- real world data --- predictive model --- healthcare --- breast-conserving surgery --- non-palpable breast lesions --- image-guided localization --- preoperative breast localization --- breast ultrasound --- large database --- standardized data collection --- networks --- nipple-sparing mastectomy --- immediate breast reconstruction --- acellular dermal matrix (ADM) --- aesthetic and oncological outcomes --- quality of life --- rare breast cancer --- osteoclast-like giant cells --- gene profiling --- Oncotype Dx --- adjuvant treatment --- neoadjuvant chemotherapy --- sentinel lymph node --- systemic treatment --- locally advanced breast cancer --- mini-invasive treatment --- liver metastases --- hepatic surgery --- personalized medicine --- sarcopenia --- physical performance --- frailty --- older cancer patients --- clinical trial --- patient enrollment --- artificial intelligence --- machine learning --- lung cancer --- oncology --- web app --- conventional CT and CT angiography --- DIEP flap planning --- multidisciplinary treatment --- evidence-based medicine --- personalized treatment --- oncological outcomes --- patient quality of life --- normal breast --- breast pathology --- hormone receptor --- hormone expression --- lymphedema --- lymphaticovenous anastomosis --- vascularized lymph node transfer --- lymphatic microsurgery --- radiotherapy --- oligometastatic breast cancer --- locoregional therapy --- CDK4/6 inhibitors --- multidisciplinary --- AMH --- ovarian reserve --- pregnancy desire --- subtypes breast cancer --- miRNAs --- breast cancer treatment --- next-generation-sequencing --- target therapy --- old age --- survival --- vitamin D --- ductal breast cancer --- in situ breast cancer --- lobular breast cancer --- histology --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Health is defined as “the state of the organism when it functions optimally without evidence of disease”. Surprisingly, the words “microbes” or “microorganism” are missing in this definition. The regulation of gut microbiota is mediated by an enormous quantity of aspects, such as microbiological factors, host characteristics, diet patterns, and environmental variables. Some protective, structural, and metabolic functions have been reported for gut microbiota, and these functions are related to the regulation of homeostasis and host health. Host defense against pathogens is, in part, mediated through gut microbiota action and requires intimate interpretation of the current microenvironment and discrimination between commensal and occasional bacteria. The present Special Issue provides a summary of the progress on the topic of intestinal microbiota and its important role in human health in different populations. This Special Issue will be of great interest from a clinical and public health perspective. Nevertheless, more studies with more samples and comparable methods are necessary to understand the actual function of intestinal microbiota in disease development and health maintenance.

Research & information: general --- Biology, life sciences --- sperm quality --- probiotics --- zebrafish --- motility --- behavior --- intestinal microbiota --- intestinal Bacteroides --- cardiorespiratory fitness --- trunk muscle training --- aerobic exercise training --- brisk walking --- nutrients --- gut microbiota --- nutrition --- habitual diets --- Western diet --- obesity --- cardiometabolic risk factors --- chronic health conditions --- gastrointestinal disorders --- prebiotics and probiotics --- metabolic syndrome --- gastrointestinal microbiome --- Lactobacillus reuteri V3401 --- sugar alcohol --- prebiotic --- bowel function --- immune function --- respiratory tract infections --- otitis media --- sinusitis --- weight management --- satiety --- bone health --- AMP-activated protein kinase --- butyrate --- developmental origins of health and disease (DOHaD) --- high fat diet --- hypertension --- nutrient-sensing signals --- propionate --- short chain fatty acids --- kefir --- autism spectrum disorders --- oral microbiota --- dysbiosis --- co-occurring conditions --- allergy --- abdominal pain --- biomarker discovery --- anorexia --- food restriction --- ClpB --- microbiota --- Enterobacteriaceae --- inulin --- circadian rhythm --- feeding timing --- choline --- trimethylamine --- trimethylamine n-oxide --- 16S rRNA gene profiling --- qPCR --- linear mixed models --- soy protein --- lipid metabolism --- circadian --- chrono-nutrition --- microbiome --- pregnancy --- fetus --- placenta --- newborn --- infancy --- critical illness --- sepsis --- lipid metabolome --- amlodipine --- corticosterone --- ACTH --- gut bacteriome --- ischemia-reperfusion injury --- nutritional status --- supplemented nutrition --- partial hepatectomy --- liver transplantation --- vaginal microbiome --- bacterial communities --- vaginal dysbiosis --- bacterial vaginosis --- risk factors --- hormone replacement therapy --- cardiovascular diseases --- atherosclerosis --- prebiotics --- alanine aminotransferase --- antibiotic --- Optifast --- gut microbiome --- metronidazole --- nonnutritive sweeteners --- sweetening agents

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The Identification of the Genetic Components of Autism Spectrum Disorders 2019 will serve as a resource for laboratory and clinical scientists as well as translational-based researchers, primary healthcare providers or physicians, psychologists/psychiatrists, neurologists, developmental pediatricians, clinical geneticists, and other healthcare providers, teachers, caregivers and students involved in autism spectrum disorders (ASD) with the goal to translate information directly to the clinic, education and home setting. Other professionals, students and families might find this textbook of value based on better awareness, causes and understanding of genetic components leading to autism and open avenues for treatment. Genetics play a role with up to 90% of autism, with over 800 currently recognized genes contributing to causes, clinical presentation, treatment, and counseling of family members. This textbook includes 13 chapters divided into three sections (clinical, genetics, other) written by experts in the field dedicated to research and clinical care, description, treatment and generating relevant reviews for ASD and related disorders impacting gene expression, profiling, and pathways. Identification of potential risk factors will be discussed, including obesity, microbiota, malignancy, and the immune system, as well as their direct or indirect contribution to ASD treatment and causation.

Research & information: general --- Biology, life sciences --- Genetics (non-medical) --- autism spectrum disorders (ASD) --- cancer --- overlapping genes and gene profiling --- super-pathways --- phenotypes and diseases --- molecular functions and processes --- 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome --- imprinting --- parent-of-origin effects --- phenotype-genotype correlation --- autism --- developmental delays --- motor delays --- microbiome --- gut --- ProSAP2 --- Phelan McDermid Syndrome --- gut–brain interaction --- leaky gut --- IL-6 --- SHANK --- collapsin response mediator protein 4 --- autism spectrum disorder --- neurodevelopmental disorder --- whole-exome sequencing --- animal model --- sex different phenotypes --- 15q11.2 BP1–BP2 microdeletion (Burnside–Butler syndrome) --- NIPA1 --- NIPA2 --- CYFIP1 --- TUBGCP5 genes --- Prader–Willi and Angelman syndromes --- magnesium transporters and supplementation --- potential treatment options --- intellectual disability --- AMPA receptors --- NMDA receptors --- guanine nucleotide exchange factor --- synaptic plasticity --- Autism spectrum disorder --- ASD --- Obesity --- Overweight --- Body mass index --- BMI --- autism candidate genes --- synaptotagmin-like protein 4 (SYTL4) --- transmembrane protein 187 (TMEM187) --- SYTL4-protein structure --- STRING-protein-protein interaction --- expression profile --- microRNA- interactions --- autism spectrum disorders --- biological networks --- genomics --- multi-omics --- network diffusion --- data integration --- genetics --- quantitative traits --- stratification by trait severity --- heterogeneity reduction --- case-control association analysis --- fragile X syndrome --- RNA toxicity --- DNA methylation --- mosaicism --- pediatrics --- MS-QMA --- AmplideX --- cytokine --- monocyte --- β-glucan --- T cell cytokine --- trained immunity --- maternal immune activation --- epigenetics --- mice --- postnatal VPA injection --- SAM --- gene expression --- nanostring