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Book
Instruments and Methods for Cyclotron Produced Radioisotopes
Authors: ---
ISBN: 3039282034 3039282026 Year: 2020 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

The focus of this Special Issue is aimed at enhancing the discussion of Engineering Education, particularly related to technological and professional learning. In the 21st century, students face a challenging demand: they are expected to have the best scientific expertise, but also highly developed social skills and qualities like teamwork, creativity, communication, or leadership. Even though students and teachers are becoming more aware of this necessity, there is still a gap between academic life and the professional world. In this Special Edition Book, the reader can find works tackling interesting topics such as educational resources addressing students’ development of competencies, the importance of final year projects linked to professional environments, and multicultural or interdisciplinary challenges.

Keywords

thick target yield --- 52Mn --- radioisotope production --- magnetron sputtering --- thorium --- theranostics --- molecular sieve desiccant --- medical radioisotope production --- vortex target --- radioisotope target processing --- gamma spectroscopy --- solid --- azeotropic mixtures --- disposable kit --- filament --- targetry --- radiopharmaceuticals --- medical cyclotrons --- unconventional radionuclides --- radioisotope targetry --- thermal study --- recycling of [18O]-water --- medical radioisotopes --- powder target --- metal 3D-printing --- medical cyclotron --- cyclotron --- stacked-foils --- copper-64 --- stack-foil --- targets --- SPECT --- monitor reaction --- purification --- numerical analysis --- carbon-11 --- copper-61 --- boron nitride nanotubes --- radiometals --- radioactive impurities --- solid target system --- Ga-68 --- BNNTs --- spallation --- recoil escape --- cyclotron target --- target stations --- 70 MeV cyclotron --- irradiation --- liquid targets --- target temperature --- separation --- solid target --- enrichment grade --- Molybdenum-100 --- cyclotron solid target --- radionuclides --- ion accelerator --- heavy Rare Earth Elements (hREE) --- molybdenum material recovery --- beam energy --- cyclotrons --- resin --- medical isotopes --- target chemistry --- solid radioisotope targets --- 165Er --- targeted alpha therapy --- gallium-68 --- radionuclide production --- titanium-45 --- medical Sc radioisotopes --- radioisotopes --- liquid and gas targets --- ion source --- actinium-225 --- ANSYS --- cross-section reconstruction --- thick target yield measurements --- cross-section --- Technetium-99m --- fractional distillation --- Radionuclide Yield Calculator --- Gallium-68 --- proton target --- PET --- thick film deposition


Book
Targets, Tracers and Translation - Novel Radiopharmaceuticals Boost Nuclear Medicine
Author:
ISBN: 3039213148 303921313X Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This is the fourth Special Issue in Pharmaceuticals within the last six years dealing with aspects of radiopharmaceutical sciences. It demonstrates the significant interest and increasing relevance to ameliorate nuclear medicine imaging with PET or SPECT, and also radiotherapeutical procedures.Numerous targets and mechanisms have been identified and have been under investigation over the previous years, covering many fields of medical and clinical research. This development is well illustrated by the articles in the present issue, including 13 original research papers and one review, covering a broad range of actual research topics in the field of radiopharmaceutical sciences.

Keywords

n/a --- pretargeting --- radioiodination --- neurodegeneration --- phosphoramidon --- GRPR --- molecular imaging --- allosteric modulator --- radiosynthesis --- separation --- ?-CIT. --- PET/CT imaging --- technetium-99m --- gastrin-releasing peptide receptor --- metabotropic glutamate receptor subtype 5 --- glutamate --- oncogenic fusions --- Fusarinine C --- hypoxia --- tirapazamine (TPZ) --- 68Ga --- sentinel lymph node --- 99mTc-radioligand --- iodine-131 --- electrophilic radioiodination --- 4-dioxide (BTDO) --- minigastrin --- ceftriaxone --- tropomyosin receptor kinase --- carbonic anhydrase IX --- ABP688 --- NPY(Y1)R --- MMPEP --- radiosensitizer --- neprilysin-inhibition --- radiochemistry --- girentuximab --- benzotriazine-1 --- gallium-68 --- cholecystokinin-2 receptor --- tumor targeting --- radioimmunotherapy --- salivary gland uptake --- metabolic stability --- tumor hypoxia --- multimerization --- oxidizing agent --- neuroinflammation --- gastrin-releasing peptide --- dextran --- carbon-11 --- peptide heterodimers --- apparent molar activity --- radiometals --- microglia --- rituximab --- [18F]FMISO --- [11C]meta-hydroxyephedrine --- Iodo-Gen® --- mannose --- 177Lu-radiopharmaceuticals --- azomycin nucleosides --- breast cancer --- click chemistry --- small animal imaging --- SR 4317 --- benzotriazine-1-monoxide (BTMO) --- bombesin --- prostate cancer --- Chloramine T --- 99mTc-radiopharmaceuticals --- ketamine --- PSMA-617 --- positron emission tomography --- hydrazinonicotinic acid (HYNIC) --- renal cell carcinomas --- [18F]PSS232 --- PET --- endoradiotherapy


Book
Radiopharmaceuticals for PET Imaging - Issue A
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Positron emission tomography (PET) is a very useful technique for medical diagnosis and drug development. Radiopharmaceuticals are a key element in PET techniques and one of the pivotal factors influencing the applications of PET. The aim of this Special Issue of Molecules is to report on the recent research work on a number of aspects of PET radiopharmaceuticals and their preclinical and clinical use. More specifically, the content of this Special Issue includes but is not limited to radiolabeling design, radiosynthesis, synthesis techniques, quality control methodologies, GMP production methods, product formulation, in vitro and in vivo preclinical PET evaluations, clinical evaluations, dosimetry, stability study and metabolite analysis, and modeling.

Keywords

Medicine --- kinetic analysis --- Siglec-9 --- gallium-68 --- vascular adhesion protein --- VAP-1 --- infection --- inflammation --- osteomyelitis --- animal model --- Staphylococcus aureus --- multiple myeloma --- positron emission tomography/computed tomography --- radiopharmaceuticals --- 18F-fluorodeoxyglucose --- tetrazine ligation --- PET --- SPECT --- indium-11 --- fluorine-18 --- positron emission tomography (PET), defluorination --- isotopic exchange --- silicon-based fluoride acceptor --- bioorthogonal chemistry --- tetrazine --- inverse electron-demand Diels-Alder ligation --- opioid --- naloxone --- overdose --- fentanyl --- carfentanil --- [11C]carfentanil --- positron emission tomography --- receptor occupancy --- pharmacokinetics --- [18F]AlF --- NOTA --- NODAGA --- PODS --- thiol-reactive --- linker --- affibody molecule --- bioconjugation --- EGFR --- tumor imaging --- vulnerable plaque --- molecular imaging --- PET imaging --- nanobody --- single-domain antibody --- sub-millimetre resolution --- AlF-radiolabelling --- preclinical radiopharmaceutical dosimetry --- image-based internal dosimetry --- OLINDA --- MCT1/MCT4 lactate transporter inhibitor --- [18F]FACH --- radiation safety --- sigma-1 receptor availability --- orthotopic xenograft of glioblastoma in mouse --- small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) --- (S)-(−)-[18F]fluspidine --- imaging-based biomarker --- SV2A protein --- PET radiotracers --- synaptic loss --- radiochemistry --- preclinical development --- clinical outcomes --- monocarboxylate transporters (MCTs) --- FACH --- 18F-labeled analog of FACH --- α-CCA --- blood-brain barrier (BBB) --- positron emission tomography (PET) imaging --- peptides --- proteolysis --- metabolic stability --- kinetic analysis --- Siglec-9 --- gallium-68 --- vascular adhesion protein --- VAP-1 --- infection --- inflammation --- osteomyelitis --- animal model --- Staphylococcus aureus --- multiple myeloma --- positron emission tomography/computed tomography --- radiopharmaceuticals --- 18F-fluorodeoxyglucose --- tetrazine ligation --- PET --- SPECT --- indium-11 --- fluorine-18 --- positron emission tomography (PET), defluorination --- isotopic exchange --- silicon-based fluoride acceptor --- bioorthogonal chemistry --- tetrazine --- inverse electron-demand Diels-Alder ligation --- opioid --- naloxone --- overdose --- fentanyl --- carfentanil --- [11C]carfentanil --- positron emission tomography --- receptor occupancy --- pharmacokinetics --- [18F]AlF --- NOTA --- NODAGA --- PODS --- thiol-reactive --- linker --- affibody molecule --- bioconjugation --- EGFR --- tumor imaging --- vulnerable plaque --- molecular imaging --- PET imaging --- nanobody --- single-domain antibody --- sub-millimetre resolution --- AlF-radiolabelling --- preclinical radiopharmaceutical dosimetry --- image-based internal dosimetry --- OLINDA --- MCT1/MCT4 lactate transporter inhibitor --- [18F]FACH --- radiation safety --- sigma-1 receptor availability --- orthotopic xenograft of glioblastoma in mouse --- small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) --- (S)-(−)-[18F]fluspidine --- imaging-based biomarker --- SV2A protein --- PET radiotracers --- synaptic loss --- radiochemistry --- preclinical development --- clinical outcomes --- monocarboxylate transporters (MCTs) --- FACH --- 18F-labeled analog of FACH --- α-CCA --- blood-brain barrier (BBB) --- positron emission tomography (PET) imaging --- peptides --- proteolysis --- metabolic stability


Book
Radiopharmaceuticals for PET Imaging - Issue A
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Positron emission tomography (PET) is a very useful technique for medical diagnosis and drug development. Radiopharmaceuticals are a key element in PET techniques and one of the pivotal factors influencing the applications of PET. The aim of this Special Issue of Molecules is to report on the recent research work on a number of aspects of PET radiopharmaceuticals and their preclinical and clinical use. More specifically, the content of this Special Issue includes but is not limited to radiolabeling design, radiosynthesis, synthesis techniques, quality control methodologies, GMP production methods, product formulation, in vitro and in vivo preclinical PET evaluations, clinical evaluations, dosimetry, stability study and metabolite analysis, and modeling.

Keywords

kinetic analysis --- Siglec-9 --- gallium-68 --- vascular adhesion protein --- VAP-1 --- infection --- inflammation --- osteomyelitis --- animal model --- Staphylococcus aureus --- multiple myeloma --- positron emission tomography/computed tomography --- radiopharmaceuticals --- 18F-fluorodeoxyglucose --- tetrazine ligation --- PET --- SPECT --- indium-11 --- fluorine-18 --- positron emission tomography (PET), defluorination --- isotopic exchange --- silicon-based fluoride acceptor --- bioorthogonal chemistry --- tetrazine --- inverse electron-demand Diels-Alder ligation --- opioid --- naloxone --- overdose --- fentanyl --- carfentanil --- [11C]carfentanil --- positron emission tomography --- receptor occupancy --- pharmacokinetics --- [18F]AlF --- NOTA --- NODAGA --- PODS --- thiol-reactive --- linker --- affibody molecule --- bioconjugation --- EGFR --- tumor imaging --- vulnerable plaque --- molecular imaging --- PET imaging --- nanobody --- single-domain antibody --- sub-millimetre resolution --- AlF-radiolabelling --- preclinical radiopharmaceutical dosimetry --- image-based internal dosimetry --- OLINDA --- MCT1/MCT4 lactate transporter inhibitor --- [18F]FACH --- radiation safety --- sigma-1 receptor availability --- orthotopic xenograft of glioblastoma in mouse --- small animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) --- (S)-(−)-[18F]fluspidine --- imaging-based biomarker --- SV2A protein --- PET radiotracers --- synaptic loss --- radiochemistry --- preclinical development --- clinical outcomes --- monocarboxylate transporters (MCTs) --- FACH --- 18F-labeled analog of FACH --- α-CCA --- blood-brain barrier (BBB) --- positron emission tomography (PET) imaging --- peptides --- proteolysis --- metabolic stability

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