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Nausea is an unpleasant feeling. It can be followed by vomiting which a mechanism is allowing to evacuate the content of the upper part of gastrointestinal tube. Different molecules exist and act on different paths to inhibit those vomiting. Antidopaminergic molecules are frequently used as the domperidone. Domperidone antagonizes dopaminergic receptors which are found in the area postrema but also acts as a gastroprokinetic. Some studies reported a risk of QTc prolongation. This can lead to arrhythmias or sudden cardiac death. The risk of extra-pyramidal side effect exists but more often by children because of their blood-brain barrier which is not totally developed and by old people. Domperidone is also used to raise the production of milk for mothers who can’t produce enough to breastfeed their child. Indeed, secretion of prolactin rises up with domperidone. But this use is still off-label. More studies have to be done to prove the efficacy and the safety for mothers. La nausée est une sensation désagréable qui peut être suivie de vomissements. Ceux-ci permettent d'évacuer le contenu de la partie haute du tube digestif. Différentes molécules agissant sur différentes voies sont disponibles pour les inhiber. Les médicaments anti dopaminergiques sont fréquemment employés comme le dompéridone. Il agit en antagonisant les récepteurs dopaminergiques situés dans l'area postrema et possède également des propriétés gastroprocinétiques. Des études ont été réalisées sur cette molécule mettant en avant un risque d'allongement de l'intervalle QTc pouvant évoluer en torsades de pointe. Ces torsades de pointe sont susceptibles d'induire des syncopes ou peuvent dégénérer en fibrillation ventriculaire menant à un arrêt cardiaque ou provoquer la mort subite. Le dompéridone est aussi associé au risque de développer un syndrome extrapyramidal, plus particulièrement chez les enfants dont la barrière hémato-encéphalique n'est pas encore tout à fait développée et chez les personnes plus âgées. Comme dit précédemment, le dompéridone est utilisé dans le traitement des nausées et vomissements mais un usage en off-label est de plus en plus pratiqué. En effet, un de ses effets secondaires est d'augmenter la production de prolactine par l'antéhypophyse ce qui a pour conséquence une augmentation de la production de lait. Cette propriété est exploitée pour les mères ayant une production lactée insuffisante mais dont le bébé nécessite une alimentation par le lait maternel. Il a été évalué que seule une très petite quantité passait dans le lait maternel et qu'il n'y avait donc pas de danger pour le nouveau-né. Cependant, des études supplémentaires sont nécessaires afin de prouver l'efficacité de la molécule pour cette indication et pour évaluer sa sécurité chez la mère aux posologies prescrites.

Domperidone --- Galactogogues --- Breast Feeding --- Antiemetics --- Nausea

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Lactation --- Lactation. --- Mammary Glands, Animal. --- 591.146 --- 636 --- --- Milk --- Milk secretion --- Milk yield --- Physiology --- Breastfeeding --- Breast milk --- Prolactin --- Animal Mammary Glands --- Mammae --- Udder --- Animal Mammary Gland --- Mammary Gland, Animal --- Udders --- Breast --- Lactation, Prolonged --- Lactations, Prolonged --- Prolonged Lactation --- Prolonged Lactations --- Milk, Human --- Galactogogues --- Secretion --- Mammary Glands, Animal --- Milk Secretion --- Milk Secretions

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Drugs During Pregnancy and Lactation, 3rd Edition is a quick and reliable reference for all those working in disciplines related to fertility, pregnancy, lactation, child health and human genetics who prescribe or deliver medicinal products, and to those who evaluate health and safety risks. Each chapter contains twofold information regarding drugs that are appropriate for prescription during pregnancy and an assessment of the risk of a drug when exposure during pregnancy has already occurred. Thoroughly updated with current regulations, references to the latest pharmacological data, and new medicinal products, this edition is a comprehensive resource covering latest knowledge and findings related to drugs during lactation and pregnancy.

Pharmacology. Therapy --- Gynaecology. Obstetrics --- Pregnant women --- Pregnancy --- Pregnant Women. --- Lactation. --- Drug use. --- Medical care. --- drug effects. --- Milk Secretion --- Lactation, Prolonged --- Lactations, Prolonged --- Milk Secretions --- Prolonged Lactation --- Prolonged Lactations --- Breast --- Milk --- Milk, Human --- Galactogogues --- Pregnant Woman --- Women, Pregnant --- Woman, Pregnant --- Maternal-Fetal Relations --- Gestation --- Pregnancies --- Litter Size --- Pregnant Women --- Expectant mothers --- Gravida --- Mothers --- Women

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Breastfeeding --- Lactation --- Breast Feeding. --- Lactation. --- Breastfeeding. --- Tijdschriften GEZ --- borstvoeding --- lactatiekunde --- vroedkunde --- Borstvoeding --- Lactation, Prolonged --- Lactations, Prolonged --- Prolonged Lactation --- Prolonged Lactations --- Breast --- Milk --- Milk, Human --- Galactogogues --- Breast Feeding, Exclusive --- Breastfeeding, Exclusive --- Exclusive Breast Feeding --- Exclusive Breastfeeding --- Feeding, Breast --- Periodicals --- Health Sciences --- Life Sciences --- General and Others --- Pediatrics --- Immunology --- Milk secretion --- Breast feeding --- Nursing (Breastfeeding) --- Suckling --- Secretion --- Milk yield --- Physiology --- Breast milk --- Prolactin --- Infants --- Wet nurses --- Nutrition --- Milk Secretion --- Milk Secretions --- Breast Feeding --- Breast Fed --- Breastfed --- Milk Sharing --- Wet Nursing --- Sharing, Milk

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For more than 35 years, Dr. Ruth Lawrences landmark reference has been the definitive guide to breastfeeding for the medical profession. The 8th Edition continues to bring together evidence-based clinical information on all aspects of breastfeeding, from the basic science of human lactation to issues of clinical management. Comprehensive, easy to read, and clinically relevant, it provides the most up-to-date information for physicians regarding breastfeeding, issues surrounding breastfeeding, and care of the lactating woman.

Borstvoeding --- Breastfeeding. --- Breast milk. --- Lactation. --- Breast Feeding. --- Milk, Human. --- Lactation, Prolonged --- Lactations, Prolonged --- Prolonged Lactation --- Prolonged Lactations --- Breast --- Milk --- Milk, Human --- Galactogogues --- Human Milk --- Breast Milk --- Breast Milks --- Milk, Breast --- Breast Feeding --- Infant Nutritional Physiological Phenomena --- Lactation --- Breast Feeding, Exclusive --- Breastfeeding --- Breastfeeding, Exclusive --- Exclusive Breast Feeding --- Exclusive Breastfeeding --- Feeding, Breast --- Milk secretion --- Milk yield --- Physiology --- Breast milk --- Prolactin --- Breastmilk --- Human milk --- Mother's milk --- Breast feeding --- Nursing (Breastfeeding) --- Suckling --- Infants --- Wet nurses --- Secretion --- Nutrition --- borstvoeding --- 614.9 --- gynaecologie --- vroedkunde --- Milk Secretion --- Milk Secretions --- Breast Fed --- Breastfed --- Milk Sharing --- Wet Nursing --- Sharing, Milk