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Brown algae comprise approx. 2040 species grown in various climatic conditions. They represent a reservoir of various bioactive compounds, including fucoidan, alginate, phlorotannins, and fucoxanthins. They have shown an array of applications in pharmaceutical and medical fields. Hence, the Guest Editor invites all interested authors to submit their contributions to the current issue in Marine Drugs entitled “Bioactive Compounds from Brown Algae”. It aims to highlight different aspects of bioactive compounds found in brown algae, in either research or review articles. Specifically, we are interested in downstream processes, chemistry, biotechnology, and applications of, for example, heteropolysaccharides and other brown algae bioactives. In addition, the structure elucidation and enzymatic modification of these components are also within the scope of the present Issue.

hepatic steatosis --- lipogenesis --- seaweed --- polyphenol --- fucoidans --- fucoidanases --- glycosidic linkages --- molecular masses --- NMR --- structure–activity relationships --- fucoidan --- cancer --- VEGF --- gene expression --- toxicity --- Dictyosiphon foeniculaceus --- retinal pigment epithelium --- glioblastoma --- astrocytes --- uveal melanoma --- 7-phloro-eckol --- HepG2/CYP2E1 cells --- oxidative stress --- apoptosis --- anti-lung cancer --- brown algae --- human lung carcinoma A-549 cells --- oversulfation --- Sargassum aquifolium --- phlorotannins --- antifungal --- larvicidal --- brown seaweeds --- biological activities --- anti-inflammatory --- antioxidant --- coastal area --- crude lipid extract --- Sargassum ilicifolium --- gut microbiota --- bioaccessibility --- short-chain fatty acids --- prebiotics --- gastrointestinal tract --- noise --- hearing loss --- dieckol --- PFF-A --- alginate --- laminarin --- bioactivity

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Fucoidans are a group of fucose-containing sulfated polysaccharides found in many species of brown seaweeds, with numerous bioactive properties. As a highly bioactive seaweed substance with many promising physiological activities, fucoidans have attracted attention from many industries all over the world. Even though fucoidans are a rich source of bioactive properties, the structural properties and bioactive mechanisms of fucoidans are poorly understood. Therefore, novel studies that either characterize the physical properties or biological activities of fucoidans will fill the knowledge gap between industrial applications and the scientific background of those applications. Both purified and partially purified fucoidans isolated from brown seaweeds present high potential as preventative and therapeutic agents against number of chronic diseases, due to their anti-inflammatory, antioxidant, anticancer, neuroprotective, antiviral, antimicrobial, and anticoagulative properties. This Special Issue is aimed at presenting updated information on well-documented studies of the structural characterization and major biological actions relevant for medical, cosmeceutical, and pharmaceutical applications that fucoidans isolated from brown seaweed can offer.

Medicine --- fucoidan --- low-molecular-weight fucoidan --- adriamycin --- nephrotic syndrome --- psoriasis --- Traf3ip2 --- microbiota --- mucin --- IgA --- fucoidans --- extraction --- brown algae --- production --- bioactivities --- Sri Lankan algae --- anticancer --- sulfated polysaccharide --- Celluclast --- sargassum --- antioxidant --- Maldives --- Padina boryana --- zebrafish --- apoptosis --- DR4 --- mitochondrial pathway --- cancer --- metastasis --- epithelial mesenchymal transition --- nanoparticles --- Helicobacter pylori --- mozuku --- Cladosiphon okamuranus Tokida --- urinalysis --- fucose --- enzymatic purification --- age-related macular degeneration --- VEGF --- oxidative stress --- Laminaria digitata --- Fucus distichus subsp. evanescens --- Saccharina latissima --- retinal pigment epithelium --- ROS --- Phaeophyta --- carbohydrate --- UVB irradiation --- HaCaT cells --- sulfated heterosaccharide --- dopamine neurons apoptosis --- PI3K–Akt --- ascorbic acid --- anti-lung cancer --- human lung carcinoma A-549 cells --- hydrogen peroxide --- Sargassum crassifolium --- fucoidan from Ascophyllum nodosum --- postprandial hyperglycemia --- in vitro and in vivo evaluation --- SGLT1 --- chitosan --- fibroblast growth factor-2 --- polyelectrolyte multilayer --- infrared spectroscopy --- quartz crystal microbalance --- sulfated polysaccharides --- natural defenses --- phenolic metabolism --- phenylalanine ammonia-lyase --- n/a --- PI3K-Akt

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Fucoidans are a group of fucose-containing sulfated polysaccharides found in many species of brown seaweeds, with numerous bioactive properties. As a highly bioactive seaweed substance with many promising physiological activities, fucoidans have attracted attention from many industries all over the world. Even though fucoidans are a rich source of bioactive properties, the structural properties and bioactive mechanisms of fucoidans are poorly understood. Therefore, novel studies that either characterize the physical properties or biological activities of fucoidans will fill the knowledge gap between industrial applications and the scientific background of those applications. Both purified and partially purified fucoidans isolated from brown seaweeds present high potential as preventative and therapeutic agents against number of chronic diseases, due to their anti-inflammatory, antioxidant, anticancer, neuroprotective, antiviral, antimicrobial, and anticoagulative properties. This Special Issue is aimed at presenting updated information on well-documented studies of the structural characterization and major biological actions relevant for medical, cosmeceutical, and pharmaceutical applications that fucoidans isolated from brown seaweed can offer.

Medicine --- fucoidan --- low-molecular-weight fucoidan --- adriamycin --- nephrotic syndrome --- psoriasis --- Traf3ip2 --- microbiota --- mucin --- IgA --- fucoidans --- extraction --- brown algae --- production --- bioactivities --- Sri Lankan algae --- anticancer --- sulfated polysaccharide --- Celluclast --- sargassum --- antioxidant --- Maldives --- Padina boryana --- zebrafish --- apoptosis --- DR4 --- mitochondrial pathway --- cancer --- metastasis --- epithelial mesenchymal transition --- nanoparticles --- Helicobacter pylori --- mozuku --- Cladosiphon okamuranus Tokida --- urinalysis --- fucose --- enzymatic purification --- age-related macular degeneration --- VEGF --- oxidative stress --- Laminaria digitata --- Fucus distichus subsp. evanescens --- Saccharina latissima --- retinal pigment epithelium --- ROS --- Phaeophyta --- carbohydrate --- UVB irradiation --- HaCaT cells --- sulfated heterosaccharide --- dopamine neurons apoptosis --- PI3K-Akt --- ascorbic acid --- anti-lung cancer --- human lung carcinoma A-549 cells --- hydrogen peroxide --- Sargassum crassifolium --- fucoidan from Ascophyllum nodosum --- postprandial hyperglycemia --- in vitro and in vivo evaluation --- SGLT1 --- chitosan --- fibroblast growth factor-2 --- polyelectrolyte multilayer --- infrared spectroscopy --- quartz crystal microbalance --- sulfated polysaccharides --- natural defenses --- phenolic metabolism --- phenylalanine ammonia-lyase --- fucoidan --- low-molecular-weight fucoidan --- adriamycin --- nephrotic syndrome --- psoriasis --- Traf3ip2 --- microbiota --- mucin --- IgA --- fucoidans --- extraction --- brown algae --- production --- bioactivities --- Sri Lankan algae --- anticancer --- sulfated polysaccharide --- Celluclast --- sargassum --- antioxidant --- Maldives --- Padina boryana --- zebrafish --- apoptosis --- DR4 --- mitochondrial pathway --- cancer --- metastasis --- epithelial mesenchymal transition --- nanoparticles --- Helicobacter pylori --- mozuku --- Cladosiphon okamuranus Tokida --- urinalysis --- fucose --- enzymatic purification --- age-related macular degeneration --- VEGF --- oxidative stress --- Laminaria digitata --- Fucus distichus subsp. evanescens --- Saccharina latissima --- retinal pigment epithelium --- ROS --- Phaeophyta --- carbohydrate --- UVB irradiation --- HaCaT cells --- sulfated heterosaccharide --- dopamine neurons apoptosis --- PI3K-Akt --- ascorbic acid --- anti-lung cancer --- human lung carcinoma A-549 cells --- hydrogen peroxide --- Sargassum crassifolium --- fucoidan from Ascophyllum nodosum --- postprandial hyperglycemia --- in vitro and in vivo evaluation --- SGLT1 --- chitosan --- fibroblast growth factor-2 --- polyelectrolyte multilayer --- infrared spectroscopy --- quartz crystal microbalance --- sulfated polysaccharides --- natural defenses --- phenolic metabolism --- phenylalanine ammonia-lyase