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"Primary Progressive Aphasia and Other Frontotemporal Dementias: Diagnosis and Treatment of Associated Communication Disorders is the second volume in the "Medical Speech-Language Pathology" book series. It is intended to fill an unmet need to assist clinicians, students, and related healthcare professionals in the diagnosis and treatment of the title disorders. There is a growing population of individuals diagnosed with various forms of Frontotemporal Dementia (FTD) and Primary Progressive Aphasia (PPA), and this number is likely to increase as medical practitioners and speech-language pathologists (SLPs) become more expert at identifying these conditions. More clinicians will be seeing, and treating, patients with a diagnosis of FTD or PPA. Toward that end, the goal of this book is to expand this clinical knowledge base and support the development of skills in diagnosis, but also in clinical management. Within each chapter is a concise presentation of available evidence-based practice and research findings, with a focus on sharing information that is clinically applicable and digestible for non-researchers. Each chapter provides a comprehensive outline of testing that will assist in the diagnosis of the cognitive-communication disorders associated with FTD, PPAs, and primary progressive apraxia of speech (PPAOS). Primary Progressive Aphasia and Other Frontotemporal Dementias is targeted toward practicing clinicians, graduate students, and clinical researchers who are interested in the latest conceptualization of FTD spectrum disorders. The intent is that this book provides clinical pearls to assist in diagnostic assessments and treatment planning. The book also comes with a PluralPlus companion website containing full color images from the text and supplementary videos"--

Aphasia --- Frontotemporal dementia --- Aphasia, Primary Progressive --- Frontotemporal Dementia --- Diagnosis. --- diagnosis --- therapy

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The world has a rapidly ageing population. Neurodegenerative diseases (ND) are strongly linked with age, with older citizens more at risk. Therefore the prevalence of ND is increasing dramatically. The major problem with ND is its difficulty to be diagnosed early. The goal of biomarker characterization is to increase certainty that a person has or does not have underlying pathology. During last decades, many research projects where focused on research on biomarkers for ND and this research has blasted into hundreds of scientific articles. However, few studies assessed their use in real clinical practice conditions. This Frontiers Research Topic is focused in the use of biomarkers for neurodegenerative disorders in the clinical setting. Topics include the use of biomarkers in the differential diagnosis of ND, the use of biomarkers to assess the risk of conversion from preclinical conditions, the use of biomarkers to follow up of clinical conditions and studies comparing biomarkers. We challenge to publish studies not only for the more frequent and more studied ND (Alzheimer’s and Parkinson’s diseases), but also for other less known ND such as prion diseases, motor neurone diseases, Huntington’s disease, spinocerebellar ataxia or spinal muscular atrophy among others. Biomarkers are very different in nature - from neuroimaging techniques to molecular parameters to be determined in the biochemical laboratory-. We welcome manuscripts reporting all kind of biomarkers since we wish to join and show together studies from different domains and thus give a perspective throughout the whole spectrum of research on biomarkers for ND.

Neurology. --- Neurodegenerative Diseases --- neurodegenerative disease --- Parkinson's disease --- MTAi --- biomarker --- Huntington's disease --- CSF biomarkers --- Frontotemporal dementia (FTD)

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The world has a rapidly ageing population. Neurodegenerative diseases (ND) are strongly linked with age, with older citizens more at risk. Therefore the prevalence of ND is increasing dramatically. The major problem with ND is its difficulty to be diagnosed early. The goal of biomarker characterization is to increase certainty that a person has or does not have underlying pathology. During last decades, many research projects where focused on research on biomarkers for ND and this research has blasted into hundreds of scientific articles. However, few studies assessed their use in real clinical practice conditions. This Frontiers Research Topic is focused in the use of biomarkers for neurodegenerative disorders in the clinical setting. Topics include the use of biomarkers in the differential diagnosis of ND, the use of biomarkers to assess the risk of conversion from preclinical conditions, the use of biomarkers to follow up of clinical conditions and studies comparing biomarkers. We challenge to publish studies not only for the more frequent and more studied ND (Alzheimer’s and Parkinson’s diseases), but also for other less known ND such as prion diseases, motor neurone diseases, Huntington’s disease, spinocerebellar ataxia or spinal muscular atrophy among others. Biomarkers are very different in nature - from neuroimaging techniques to molecular parameters to be determined in the biochemical laboratory-. We welcome manuscripts reporting all kind of biomarkers since we wish to join and show together studies from different domains and thus give a perspective throughout the whole spectrum of research on biomarkers for ND.

Neurology. --- Neurology --- Medicine --- Health & Biological Sciences --- Neurodegenerative Diseases --- neurodegenerative disease --- Parkinson's disease --- MTAi --- biomarker --- Huntington's disease --- CSF biomarkers --- Frontotemporal dementia (FTD)

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In this special issue of Diagnostics, expert contributors have produced up-to-date research studies and reviews on various topics related to the diagnosis of dementia and cognitive impairment. The methods of the assessments discussed extend from simple neurological signs, which may be elicited in the clinical encounter, through cognitive screening instruments, to sophisticated analyses of neuroimaging and cerebrospinal fluid biomarkers of disease. It is hoped that these various methods may facilitate earlier diagnosis of dementia and its subtypes, and provide differential diagnosis of depression and functional cognitive disorders, as a prelude to meaningful interventions.

screening --- MoCA --- neurodegeneration --- accuracy --- frontotemporal dementia --- cognitive assessment --- Free-Cog --- molecular imaging --- Alzheimer’s --- standardised mini-mental state examination --- decision tree --- differential diagnosis depression vs. MCI/dementia --- computerized cognitive assessment --- quantification --- Alzheimer’s disease --- functional cognitive disorder --- diagnosis --- Triple Test --- diagnostic imaging --- neurocognitive disorder --- feasibility --- TYM-MCI --- amyloid --- cerebrospinal fluid --- dementia --- precision medicine --- Mini-Addenbrooke’s Cognitive Examination --- memory --- depression in old age --- quick mild cognitive impairment screen --- cognition --- nuclear medicine --- TYM --- Rapid Cognitive Screen --- 18F-FDG --- functional neurological disorder cognition --- stroke --- sensitivity and specificity --- Codex --- mortality --- mild cognitive impairment --- cognitive screening instruments --- cognitive impairment --- aging --- SKT (Syndrom-Kurztest) --- PET --- executive function --- Cognition disorders --- Dementia --- Diagnosis. --- SKT (Syndrome-Kurztest)

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Primary progressive aphasia is a clinical syndrome that includes a group of neurodegenerative disorders characterized by progressive language impairment. Our knowledge about this disorder has evolved significantly in recent years. Notably, correlations between clinical findings and pathology have improved, and main clinical, neuroimaging, and genetic features have been described. Furthermore, primary progressive aphasia is a good model for the study of brain–behavior relationships, and has contributed to the knowledge of the neural basis of language functioning. However, there are many open questions remaining. For instance, classification into three variants (non-fluent, semantic, and logopenic) is under debate; further data about epidemiology and natural history of the diseases are needed; and, as in other neurodegenerative disorders, successful therapies are lacking. The Guest Editors expect that this book can be very useful for scholars.

Research & information: general --- Biology, life sciences --- primary progressive aphasia --- informativeness --- speech production --- assessment --- diagnosis --- cognitive approach --- dementia --- frontotemporal dementia --- Alzheimer's disease --- neuropsychology --- span --- sentence repetition --- working memory --- phonological --- visuospatial --- natural history --- mortality --- survival --- memory clinic --- graphical markers --- graphical parameters --- writing pressure --- differential diagnosis --- longitudinal assessment --- cognitive changes --- behavioural and psychological symptoms of dementia --- level of functioning --- electroencephalography --- resting-state --- biomarkers machine learning --- K-Nearest Neighbors --- graph theory --- treatment --- speech and language therapy --- intervention --- cognitive rehabilitation --- bilingualism --- semantic dementia --- semantic variant primary progressive aphasia --- word finding --- language therapy --- behavioural therapy --- electroencephalography (EEG) --- network analysis --- progressive apraxia of speech --- primary progressive aphasia --- informativeness --- speech production --- assessment --- diagnosis --- cognitive approach --- dementia --- frontotemporal dementia --- Alzheimer's disease --- neuropsychology --- span --- sentence repetition --- working memory --- phonological --- visuospatial --- natural history --- mortality --- survival --- memory clinic --- graphical markers --- graphical parameters --- writing pressure --- differential diagnosis --- longitudinal assessment --- cognitive changes --- behavioural and psychological symptoms of dementia --- level of functioning --- electroencephalography --- resting-state --- biomarkers machine learning --- K-Nearest Neighbors --- graph theory --- treatment --- speech and language therapy --- intervention --- cognitive rehabilitation --- bilingualism --- semantic dementia --- semantic variant primary progressive aphasia --- word finding --- language therapy --- behavioural therapy --- electroencephalography (EEG) --- network analysis --- progressive apraxia of speech