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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Endocrinology --- intrauterine growth restriction --- fetal growth restriction --- IUGR --- FGR --- pathology --- placenta --- brain injury --- intrauterine growth restriction --- fetal growth restriction --- IUGR --- FGR --- pathology --- placenta --- brain injury

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

intrauterine growth restriction --- fetal growth restriction --- IUGR --- FGR --- pathology --- placenta --- brain injury

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It is well known that pregnancy complications, including preeclampsia, preterm birth, stillbirth, and intrauterine growth restriction affect over 12% of all pregnancies worldwide. These complications negatively impact both maternal and neonatal health and have short- and long-term effects such as an increased risk of neurodevelopmental and cardiovascular diseases. Over the past decade, numerous groups have investigated the use of new and/or existing drugs to either prolong gestation, such as in cases of threatened preterm labour; alleviate hypertension in preeclampsia; or promote adequate blood flow and nutrient delivery to the placenta to facilitate growth in IUGR. The overarching goal has been to promote healthier pregnancies and neonatal health, but it has been difficult to translate this work into the clinical setting, with problems in terms of drug delivery, specificity, and importantly, the early diagnostic capacities for complications in pregnancy. This book focuses on the early detection, potential novel therapeutic targets, risk factors, maternal outcomes, and long-term consequences of this critical problem.

Medicine --- ultrasonography --- elastography --- uterine cervix --- term pregnancy --- parturition --- genotyping --- preeclampsia --- MMP-9 --- MMP-2 --- SNPs --- tocolytic --- preterm birth --- preterm labor --- neonate --- prematurity --- pregnancy --- therapeutic --- progesterone --- fetus --- sex as a biological variable --- sex differences --- pregnancy complications --- placenta --- prenatal diagnosis --- fetal growth restriction --- miscarriage --- chorio-deciduitis --- grade --- amnionitis --- acute histologic chorioamnionitis --- intra-amniotic inflammatory response --- beta-blocker --- endothelial dysfunction --- cardiovascular disease --- pregnancy loss --- immunology --- vascular endothelial growth factor --- galectin-9 --- interleukin-4 --- proteomics --- urine --- biomarkers --- IBP4 --- SHBG --- RPL --- NK cells --- sildenafil --- PDE5A --- VEGF-A --- angiotensin --- infant --- newborn --- female --- abruptio placentae --- Apgar score --- pregnant women --- gestational age --- IL-1 blockade --- anakinra --- canakinumab --- human --- inflammation --- fetal growth restriction (FGR) --- intra-uterine growth restriction (IUGR) --- SPINT1 --- HAI-1 --- stillbirth --- placental insufficiency --- histopathology --- cardiovascular risk --- postpartum screening --- ultrasonography --- elastography --- uterine cervix --- term pregnancy --- parturition --- genotyping --- preeclampsia --- MMP-9 --- MMP-2 --- SNPs --- tocolytic --- preterm birth --- preterm labor --- neonate --- prematurity --- pregnancy --- therapeutic --- progesterone --- fetus --- sex as a biological variable --- sex differences --- pregnancy complications --- placenta --- prenatal diagnosis --- fetal growth restriction --- miscarriage --- chorio-deciduitis --- grade --- amnionitis --- acute histologic chorioamnionitis --- intra-amniotic inflammatory response --- beta-blocker --- endothelial dysfunction --- cardiovascular disease --- pregnancy loss --- immunology --- vascular endothelial growth factor --- galectin-9 --- interleukin-4 --- proteomics --- urine --- biomarkers --- IBP4 --- SHBG --- RPL --- NK cells --- sildenafil --- PDE5A --- VEGF-A --- angiotensin --- infant --- newborn --- female --- abruptio placentae --- Apgar score --- pregnant women --- gestational age --- IL-1 blockade --- anakinra --- canakinumab --- human --- inflammation --- fetal growth restriction (FGR) --- intra-uterine growth restriction (IUGR) --- SPINT1 --- HAI-1 --- stillbirth --- placental insufficiency --- histopathology --- cardiovascular risk --- postpartum screening

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It is well known that pregnancy complications, including preeclampsia, preterm birth, stillbirth, and intrauterine growth restriction affect over 12% of all pregnancies worldwide. These complications negatively impact both maternal and neonatal health and have short- and long-term effects such as an increased risk of neurodevelopmental and cardiovascular diseases. Over the past decade, numerous groups have investigated the use of new and/or existing drugs to either prolong gestation, such as in cases of threatened preterm labour; alleviate hypertension in preeclampsia; or promote adequate blood flow and nutrient delivery to the placenta to facilitate growth in IUGR. The overarching goal has been to promote healthier pregnancies and neonatal health, but it has been difficult to translate this work into the clinical setting, with problems in terms of drug delivery, specificity, and importantly, the early diagnostic capacities for complications in pregnancy. This book focuses on the early detection, potential novel therapeutic targets, risk factors, maternal outcomes, and long-term consequences of this critical problem.

ultrasonography --- elastography --- uterine cervix --- term pregnancy --- parturition --- genotyping --- preeclampsia --- MMP-9 --- MMP-2 --- SNPs --- tocolytic --- preterm birth --- preterm labor --- neonate --- prematurity --- pregnancy --- therapeutic --- progesterone --- fetus --- sex as a biological variable --- sex differences --- pregnancy complications --- placenta --- prenatal diagnosis --- fetal growth restriction --- miscarriage --- chorio-deciduitis --- grade --- amnionitis --- acute histologic chorioamnionitis --- intra-amniotic inflammatory response --- beta-blocker --- endothelial dysfunction --- cardiovascular disease --- pregnancy loss --- immunology --- vascular endothelial growth factor --- galectin-9 --- interleukin-4 --- proteomics --- urine --- biomarkers --- IBP4 --- SHBG --- RPL --- NK cells --- sildenafil --- PDE5A --- VEGF-A --- angiotensin --- infant --- newborn --- female --- abruptio placentae --- Apgar score --- pregnant women --- gestational age --- IL-1 blockade --- anakinra --- canakinumab --- human --- inflammation --- fetal growth restriction (FGR) --- intra-uterine growth restriction (IUGR) --- SPINT1 --- HAI-1 --- stillbirth --- placental insufficiency --- histopathology --- cardiovascular risk --- postpartum screening --- n/a

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Most complex respiratory conditions invoke interactions between genetic and environmental factors, such as smoking, pollution, and diet. There is increasing evidence that diet and nutrition are important factors, not only in disease prevention, but also in their contribution to the chronicity and heterogeneity of lung disorders. Nutrients exert potent effects on metabolism through a variety of regulatory mechanisms, resulting in local and systemic changes in metabolite levels. In this issue of Nutrients, we would like to bring together papers dealing with the topic of “Respiratory Diseases and Nutrition”. We welcome manuscripts detailing human and animal studies focused on the roles of dietary and metabolic factors in the initiation and progression of respiratory diseases, including, but not limited to, chronic obstructive pulmonary disease (COPD) and asthma. In vitro studies aimed at elucidating the potential molecular mechanisms of diet–metabolic interactions are also invited. We welcome different types of manuscript submissions, including original research articles and up-to-date reviews and commentaries.

Research & information: general --- Biology, life sciences --- Food & society --- antioxidant --- chronic obstructive pulmonary disease --- dietary pattern --- inflammation --- lung function --- Mediterranean diet --- nutrition --- oxidative stress --- polyphenol --- polyunsaturated fatty acid --- black ginseng --- oral administration --- influenza A virus --- cytokines --- antiviral --- lung development --- undernutrition --- lung diseases --- ghrelin --- leptin --- GLP-1 --- retinoids --- cholecalciferol --- fetal growth restriction --- respiratory distress syndrome --- lung transplantation --- body mass index --- body composition --- lean body mass --- muscle mass --- sarcopenia --- creatinine-height index --- obesity --- pregnancy --- allergic airway disease --- offspring --- high fat diet --- omega-3 index --- asthma --- fatty acids --- nutritional biomarkers --- pulmonary hypertension --- microbiota --- vitamin C --- vitamin D --- iron --- diet --- bisphenol A --- estrogen --- xenoestrogens --- para-inflammation --- endocrine --- alarmins --- allergy --- microbiome --- nutrients --- prematurity --- bronchopulmonary dysplasia --- weight loss --- children