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La panleucopénie féline est une maladie systémique grave touchant surtout les chatons et jeunes chats, causée par le parvovirus félin de la famille des Parvoviridae. Sa structure lui confère une grande résistance dans l’environnement, et la concentration élevée du virus dans les matières fécales d’animaux infectés explique son extrême contagiosité. Les signes cliniques communs d’une infection sont : anorexie, vomissements, diarrhée, leucopénie et hypoplasie cérébelleuse. Une haute fréquence de détection du parvovirus chez des chats cliniquement sains est rapportée. Ces chats cliniquement sains forment donc un potentiel réservoir pour le maintien de l’infection. En routine, des tests rapides permettent d’établir le diagnostic. Cependant le taux de faux positifs n’est pas négligeable puisque ces tests ne font pas la différence entre les souches vaccinales et les souches de terrain. La PCR en revanche, permet le séquençage et le typage des souches afin de confirmer le diagnostic et devrait donc être plus systématisée. La pathogénie du parvovirus est basée sur son tropisme pour les cellules à division active tels que le tissu lymphoïde, la moelle osseuse, l’épithélium intestinal ainsi que les tissus du nouveau-né en division. Cependant des études récentes montrent un tropisme inhabituel puisque le FPV a été trouvé dans des neurones de chat adulte et de nouvelles lésions telle que la vacuolisation des neurones ont été démontrées.

Panleucopénie féline, parvovirus --- Sciences du vivant > Médecine vétérinaire & santé animale

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Viruses of the Parvoviridae family constitute a most diverse and intriguing field of research. Parvoviruses can differ widely in their structure, genome organization and expression, virus–cell interactions, and impact on hosts. The translational implication of research on parvoviruses is relevant, since many viruses are important human and veterinary pathogens, while other viruses can be engineered as tools for oncolytic therapy or as sophisticated gene delivery vectors. Exploring the diversity and inherent complexity in the biology of these apparently simple viruses is a still challenging topic for the scientific community. The Special Issue of Viruses is a collection of recent contributions in the field of parvovirus research, encompassing many aspects of basic and translational research on viruses of the family Parvoviridae, including on their structure, replication, and gene expression in addition to virus–host interactions and the development of vaccines and viral vectors.

Public health & preventive medicine --- feline parvovirus --- virus-like particles --- VP2 protein --- antibodies --- AAV --- neuro-degenerative disease --- gene therapy --- antigenicity --- sequencing --- virus --- canine parvovirus --- peri-urban --- wild dogs --- disease transmission --- Australia --- parvovirus B19 --- G-quadruplex --- bioinformatics --- antivirals --- BRACO-19 --- pyridostatin --- oncolytic viruses --- rodent protoparvovirus H-1PV --- virus entry --- clathrin-mediated endocytosis --- parvovirus --- minute virus of mice --- RNA processing --- gene expression --- canine --- COVID-19 --- veterinary epidemiology --- B19V --- VP1u --- receptor --- PLA2 --- erythroid cells --- biomarker --- drug delivery --- nanocarrier --- B19 parvovirus --- detection --- cell cycle --- permissivity --- serotype --- capsid --- cryo-EM --- genome packaging --- gene delivery --- bocavirus --- Caribbean region --- new CPV-2a --- outbreak --- endemic --- nearly complete genomes --- virus evolution --- parvoviruses --- nucleus --- imaging of viral interactions and dynamics --- analysis of protein–protein interactions --- analysis of virus–chromatin interactions --- AMDV --- Aleutian disease --- mink parvovirus --- Aleutian mink disease virus --- vaccine --- feline parvovirus --- virus-like particles --- VP2 protein --- antibodies --- AAV --- neuro-degenerative disease --- gene therapy --- antigenicity --- sequencing --- virus --- canine parvovirus --- peri-urban --- wild dogs --- disease transmission --- Australia --- parvovirus B19 --- G-quadruplex --- bioinformatics --- antivirals --- BRACO-19 --- pyridostatin --- oncolytic viruses --- rodent protoparvovirus H-1PV --- virus entry --- clathrin-mediated endocytosis --- parvovirus --- minute virus of mice --- RNA processing --- gene expression --- canine --- COVID-19 --- veterinary epidemiology --- B19V --- VP1u --- receptor --- PLA2 --- erythroid cells --- biomarker --- drug delivery --- nanocarrier --- B19 parvovirus --- detection --- cell cycle --- permissivity --- serotype --- capsid --- cryo-EM --- genome packaging --- gene delivery --- bocavirus --- Caribbean region --- new CPV-2a --- outbreak --- endemic --- nearly complete genomes --- virus evolution --- parvoviruses --- nucleus --- imaging of viral interactions and dynamics --- analysis of protein–protein interactions --- analysis of virus–chromatin interactions --- AMDV --- Aleutian disease --- mink parvovirus --- Aleutian mink disease virus --- vaccine

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Viruses of the Parvoviridae family constitute a most diverse and intriguing field of research. Parvoviruses can differ widely in their structure, genome organization and expression, virus–cell interactions, and impact on hosts. The translational implication of research on parvoviruses is relevant, since many viruses are important human and veterinary pathogens, while other viruses can be engineered as tools for oncolytic therapy or as sophisticated gene delivery vectors. Exploring the diversity and inherent complexity in the biology of these apparently simple viruses is a still challenging topic for the scientific community. The Special Issue of Viruses is a collection of recent contributions in the field of parvovirus research, encompassing many aspects of basic and translational research on viruses of the family Parvoviridae, including on their structure, replication, and gene expression in addition to virus–host interactions and the development of vaccines and viral vectors.

feline parvovirus --- virus-like particles --- VP2 protein --- antibodies --- AAV --- neuro-degenerative disease --- gene therapy --- antigenicity --- sequencing --- virus --- canine parvovirus --- peri-urban --- wild dogs --- disease transmission --- Australia --- parvovirus B19 --- G-quadruplex --- bioinformatics --- antivirals --- BRACO-19 --- pyridostatin --- oncolytic viruses --- rodent protoparvovirus H-1PV --- virus entry --- clathrin-mediated endocytosis --- parvovirus --- minute virus of mice --- RNA processing --- gene expression --- canine --- COVID-19 --- veterinary epidemiology --- B19V --- VP1u --- receptor --- PLA2 --- erythroid cells --- biomarker --- drug delivery --- nanocarrier --- B19 parvovirus --- detection --- cell cycle --- permissivity --- serotype --- capsid --- cryo-EM --- genome packaging --- gene delivery --- bocavirus --- Caribbean region --- new CPV-2a --- outbreak --- endemic --- nearly complete genomes --- virus evolution --- parvoviruses --- nucleus --- imaging of viral interactions and dynamics --- analysis of protein–protein interactions --- analysis of virus–chromatin interactions --- AMDV --- Aleutian disease --- mink parvovirus --- Aleutian mink disease virus --- vaccine