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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Medical genetics --- diet --- metabolism --- epigenetic modification --- programming --- liver diseases

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Glycans (carbohydrate chains) of marine creatures are rich and diverse in polysaccharides, glycoproteins, and glycolipids. The chains that are metabolized by glycan-related enzymes (glycosyltransferases and glycosidases) are recognized by glycan-binding proteins (lectins) which regulate cellular processes such as growth, differentiation, and death. Marine glycomics that involves the genome and transcriptome accelerates our understanding of the evolution of glycans, glycan-related enzymes, and lectins. From 2017 to 2019, the Special Issue “Marine Glycobiology, Glycomics and Lectins” of the journal Marine Drugs published scientific articles and reviews, on the background of “glycobiology”—that is, glycan-based biosciences. The aim was to promote the discovery of novel biomolecules that contribute to drug development and clinical studies. This has great potential for establishing connections between the fields of both human health and marine life sciences.This book contains 11 scientific papers representing current topics in comprehensive glycosciences related to therapeutic agents from marine natural products, as outlined.

toxicity --- anticoagulant activities --- Portunus pelagicus --- complement system --- Fucus distichus subsp. evanescens --- MytiLec-1 --- DNA methyltransferases --- malignant glioma --- heparin --- innate immunity --- polysialic acid (polySia) --- HddSBL --- differentiation induction --- phagocytosis --- fucosylated glycosaminoglycan --- Alzheimer’s disease --- thermostable --- amyloid-? --- lectins --- ?-secretase --- fucoidan --- oncolytic vaccinia virus --- Marinomonas --- viral replication --- BACE1 --- glioblastoma --- bioactivity --- Ehrlich ascites carcinoma --- adverse effects --- therapeutic effects --- ERK --- physicochemical characteristics --- oligo-fucoidan --- tandem duplication --- lectin --- galactooligosaccharides --- recombinant --- TTL --- theoretical model --- fucan sulfate --- retinal pigment epithelium --- glycosaminoglycan --- ?-galactosidase --- apoptosis-related genes --- C1q --- VEGF --- nanomedical devices --- epigenetic modification --- nematocyst discharge process --- Mytilus galloprovincialis --- pattern recognition receptors --- Pattalus mollis --- transglycosylation --- anti-viral --- nematogalectin --- heparan sulphate --- oxidative stress --- bivalve mollusks