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Mechanisms of Adiponectin Action
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ISBN: 303921246X 3039212451 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions.


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Renal and adrenal tumors
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ISBN: 1417599510 9781417599516 1383021872 Year: 2003 Publisher: Oxford New York Oxford University Press

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Written by an international group of high-profile contributors, this text provides a single, comprehensive source of information on renal and adrenal tumors.

Keywords

Kidney Diseases --- Urologic Neoplasms --- Endocrine Gland Neoplasms --- Adrenal Gland Diseases --- Urogenital Neoplasms --- Endocrine System Diseases --- Neoplasms by Site --- Urologic Diseases --- Female Urogenital Diseases --- Male Urogenital Diseases --- Diseases --- Neoplasms --- Female Urogenital Diseases and Pregnancy Complications --- Kidney Neoplasms --- Adrenal Gland Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Adrenal Gland Cancer --- Adrenal Neoplasm --- Cancer of the Adrenal Gland --- Neoplasms, Adrenal Gland --- Adrenal Cancer --- Adrenal Cancers --- Adrenal Gland Cancers --- Adrenal Gland Neoplasm --- Adrenal Neoplasms --- Cancer, Adrenal --- Cancer, Adrenal Gland --- Cancers, Adrenal --- Cancers, Adrenal Gland --- Neoplasm, Adrenal --- Neoplasm, Adrenal Gland --- Neoplasms, Adrenal --- Male Genitourinary Diseases --- Genitourinary Disease, Male --- Genitourinary Diseases, Male --- Male Genitourinary Disease --- Male Urogenital Disease --- Urogenital Disease, Male --- Urogenital Diseases, Male --- Female Genitourinary Diseases --- Female Genitourinary Disease --- Female Urogenital Disease --- Genitourinary Disease, Female --- Genitourinary Diseases, Female --- Urogenital Disease, Female --- Urogenital Diseases, Female --- Urological Diseases --- Urinary Tract Diseases --- Disease, Urinary Tract --- Disease, Urologic --- Disease, Urological --- Diseases, Urinary Tract --- Diseases, Urologic --- Diseases, Urological --- Urinary Tract Disease --- Urologic Disease --- Urological Disease --- Urology --- Neoplasms by Sites --- Site, Neoplasm --- Sites, Neoplasm --- Neoplasm Site --- Neoplasm Sites --- Diseases of Endocrine System --- Endocrine Diseases --- Disease, Endocrine --- Disease, Endocrine System --- Diseases, Endocrine --- Diseases, Endocrine System --- Endocrine Disease --- Endocrine System Disease --- System Disease, Endocrine --- System Diseases, Endocrine --- Endocrinology --- Genito-urinary Cancer --- Genito-urinary Neoplasm --- Neoplasms, Genitourinary --- Neoplasms, Urogenital --- Genitourinary Cancer --- Genitourinary Neoplasms --- Urogenital Cancer --- Cancer, Genito-urinary --- Cancer, Genitourinary --- Cancer, Urogenital --- Cancers, Genito-urinary --- Cancers, Genitourinary --- Cancers, Urogenital --- Genito urinary Cancer --- Genito-urinary Cancers --- Genito-urinary Neoplasms --- Genitourinary Cancers --- Genitourinary Neoplasm --- Neoplasm, Genito-urinary --- Neoplasm, Genitourinary --- Neoplasm, Urogenital --- Neoplasms, Genito-urinary --- Urogenital Cancers --- Urogenital Neoplasm --- Adrenal Gland Disease --- Disease, Adrenal Gland --- Diseases, Adrenal Gland --- Gland Disease, Adrenal --- Gland Diseases, Adrenal --- Cancer of the Endocrine Gland --- Carcinoma of Endocrine Gland --- Endocrine Gland Carcinoma --- Neoplasms, Endocrine Gland --- Cancer of Endocrine Gland --- Endocrine Cancer --- Endocrine Gland Cancer --- Cancer, Endocrine --- Cancer, Endocrine Gland --- Cancers, Endocrine --- Carcinoma, Endocrine Gland --- Endocrine Cancers --- Endocrine Gland Neoplasm --- Neoplasm, Endocrine Gland --- Cancer of the Kidney --- Neoplasms, Kidney --- Renal Neoplasms --- Cancer of Kidney --- Kidney Cancer --- Renal Cancer --- Cancer, Kidney --- Cancer, Renal --- Cancers, Kidney --- Cancers, Renal --- Kidney Cancers --- Kidney Neoplasm --- Neoplasm, Kidney --- Neoplasm, Renal --- Neoplasms, Renal --- Renal Cancers --- Renal Neoplasm --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Cancer of the Urinary Tract --- Neoplasms, Urologic --- Urinary Tract Neoplasms --- Urological Cancer --- Urological Neoplasms --- Cancer of Urinary Tract --- Urinary Tract Cancer --- Urologic Cancer --- Cancer, Urinary Tract --- Cancer, Urologic --- Cancer, Urological --- Cancers, Urinary Tract --- Cancers, Urologic --- Cancers, Urological --- Neoplasm, Urinary Tract --- Neoplasm, Urologic --- Neoplasm, Urological --- Neoplasms, Urinary Tract --- Neoplasms, Urological --- Tract Neoplasm, Urinary --- Tract Neoplasms, Urinary --- Urinary Tract Cancers --- Urinary Tract Neoplasm --- Urologic Cancers --- Urologic Neoplasm --- Urological Cancers --- Urological Neoplasm --- Disease, Kidney --- Diseases, Kidney --- Kidney Disease --- Nephrology --- Renal Replacement Therapy --- Kidneys --- Adrenal glands --- Tumors.

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