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Book
Therapeutic Potential of Plant Secondary Metabolites in the Treatment of Diseases and Drug Development
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Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

The importance of natural products, and especially plant secondary metabolites, for the treatment of diseases and drug development has already been obvious in medicine for several thousand years. Thus, this Special Issue of MDPI Biomedicines collects eight top articles from the field as regular full papers in addition to five reviews. All of the published papers are a vibrant source of information on the therapeutic potential of plant secondary metabolites in the treatment of diseases and drug development.

Keywords

Cannabis sativa (Cannabis) --- cannabinoids --- tetrahydrocannabinol (THC) --- cannabidiol (CBD) --- cannabinoid receptors (CB1 and CB2) --- Papaver somniferum (opium poppy) --- secondary metabolites --- ursolic acid --- NSCLC --- tumorsphere --- EGFR --- STAT3 --- MMP2 --- PD-L1 --- MAFLD --- tanshinone IIA --- phytochemical --- lipogenesis --- lipid accumulation --- LXRα --- malaria --- quinine --- chloroquine --- artemisinin --- onchocerciasis --- ivermectin --- moxidectin --- cancer --- vincristine --- vinblastine --- anabolic --- diabetes --- Duchenne muscular dystrophy --- β-ecdysone --- ecdysteroid --- ecdysterone --- Mas1 --- osteoporosis --- sarcopenia --- COVID-19 --- cardiometabolic diseases --- respiratory diseases --- natural product --- SARS-CoV-2 --- lung cancer --- United States Food and Drug Administration-approved drug --- natural remedy --- triterpenoid --- molecular ribbon --- Huisgen 1,3-dipolar cycloaddition --- amide bond --- multifunctional PEG3 derivative --- antimicrobial activity --- anti-HIV activity --- cytotoxicity --- supramolecular self-assembly --- phytocannabinoids --- cannabichromene --- thermos-TRPs --- TRPA1 --- α,α-dimethylheptyl effect --- betulinic acid --- BODIPY --- bevirimat --- cell-cycle --- fluorescent microscopy --- maturation inhibitor --- capsaicinoids --- endocannabinoidome --- microbiota --- overweight --- obesity --- food intake --- lipidomics --- metabolism --- alkaloids --- membrane fusion --- viral fusion inhibitor --- antiviral therapy --- curcumin --- cancer cells --- bioavailability --- curcumin derivatives --- curcumin analogues --- curcumin delivery systems --- natural product synthesis --- lignans --- inflammation --- NF-κB inhibition --- n/a


Book
Therapeutic Potential of Plant Secondary Metabolites in the Treatment of Diseases and Drug Development
Author:
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

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Bookmark

Abstract

The importance of natural products, and especially plant secondary metabolites, for the treatment of diseases and drug development has already been obvious in medicine for several thousand years. Thus, this Special Issue of MDPI Biomedicines collects eight top articles from the field as regular full papers in addition to five reviews. All of the published papers are a vibrant source of information on the therapeutic potential of plant secondary metabolites in the treatment of diseases and drug development.

Keywords

Technology: general issues --- Chemical engineering --- Cannabis sativa (Cannabis) --- cannabinoids --- tetrahydrocannabinol (THC) --- cannabidiol (CBD) --- cannabinoid receptors (CB1 and CB2) --- Papaver somniferum (opium poppy) --- secondary metabolites --- ursolic acid --- NSCLC --- tumorsphere --- EGFR --- STAT3 --- MMP2 --- PD-L1 --- MAFLD --- tanshinone IIA --- phytochemical --- lipogenesis --- lipid accumulation --- LXRα --- malaria --- quinine --- chloroquine --- artemisinin --- onchocerciasis --- ivermectin --- moxidectin --- cancer --- vincristine --- vinblastine --- anabolic --- diabetes --- Duchenne muscular dystrophy --- β-ecdysone --- ecdysteroid --- ecdysterone --- Mas1 --- osteoporosis --- sarcopenia --- COVID-19 --- cardiometabolic diseases --- respiratory diseases --- natural product --- SARS-CoV-2 --- lung cancer --- United States Food and Drug Administration-approved drug --- natural remedy --- triterpenoid --- molecular ribbon --- Huisgen 1,3-dipolar cycloaddition --- amide bond --- multifunctional PEG3 derivative --- antimicrobial activity --- anti-HIV activity --- cytotoxicity --- supramolecular self-assembly --- phytocannabinoids --- cannabichromene --- thermos-TRPs --- TRPA1 --- α,α-dimethylheptyl effect --- betulinic acid --- BODIPY --- bevirimat --- cell-cycle --- fluorescent microscopy --- maturation inhibitor --- capsaicinoids --- endocannabinoidome --- microbiota --- overweight --- obesity --- food intake --- lipidomics --- metabolism --- alkaloids --- membrane fusion --- viral fusion inhibitor --- antiviral therapy --- curcumin --- cancer cells --- bioavailability --- curcumin derivatives --- curcumin analogues --- curcumin delivery systems --- natural product synthesis --- lignans --- inflammation --- NF-κB inhibition --- Cannabis sativa (Cannabis) --- cannabinoids --- tetrahydrocannabinol (THC) --- cannabidiol (CBD) --- cannabinoid receptors (CB1 and CB2) --- Papaver somniferum (opium poppy) --- secondary metabolites --- ursolic acid --- NSCLC --- tumorsphere --- EGFR --- STAT3 --- MMP2 --- PD-L1 --- MAFLD --- tanshinone IIA --- phytochemical --- lipogenesis --- lipid accumulation --- LXRα --- malaria --- quinine --- chloroquine --- artemisinin --- onchocerciasis --- ivermectin --- moxidectin --- cancer --- vincristine --- vinblastine --- anabolic --- diabetes --- Duchenne muscular dystrophy --- β-ecdysone --- ecdysteroid --- ecdysterone --- Mas1 --- osteoporosis --- sarcopenia --- COVID-19 --- cardiometabolic diseases --- respiratory diseases --- natural product --- SARS-CoV-2 --- lung cancer --- United States Food and Drug Administration-approved drug --- natural remedy --- triterpenoid --- molecular ribbon --- Huisgen 1,3-dipolar cycloaddition --- amide bond --- multifunctional PEG3 derivative --- antimicrobial activity --- anti-HIV activity --- cytotoxicity --- supramolecular self-assembly --- phytocannabinoids --- cannabichromene --- thermos-TRPs --- TRPA1 --- α,α-dimethylheptyl effect --- betulinic acid --- BODIPY --- bevirimat --- cell-cycle --- fluorescent microscopy --- maturation inhibitor --- capsaicinoids --- endocannabinoidome --- microbiota --- overweight --- obesity --- food intake --- lipidomics --- metabolism --- alkaloids --- membrane fusion --- viral fusion inhibitor --- antiviral therapy --- curcumin --- cancer cells --- bioavailability --- curcumin derivatives --- curcumin analogues --- curcumin delivery systems --- natural product synthesis --- lignans --- inflammation --- NF-κB inhibition


Book
Metabolic Syndrome : From Etiology to Prevention and Clinical Management
Authors: ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Metabolic syndrome has been the topic of countless publications. It still remains a subject of debate and some experts have even questioned its clinical relevance. Its diagnosis is nevertheless predictive of an increased risk of type 2 diabetes and cardiovascular disease even in the absence of traditional risk factors. Many years ago, our team made the point that the most prevalent form of metabolic syndrome was linked to abdominal obesity, which can be found even among individuals who are not considered obese by body weight standards. Imaging techniques such as computed tomography and magnetic resonance imaging have revealed the link between regional body fat partitioning and cardiometabolic risk. Visceral obesity is the most dangerous form of obesity, with subcutaneous obesity being associated with lower health risk. We have proposed that excess visceral fat may be a marker of subcutaneous adipose tissue dysfunction not being able to serve as a metabolic sink, causing lipid accumulation at undesired sites, a condition described as ectopic fat deposition. Among the effective approaches to prevent, delay, or manage metabolic syndrome, lifestyle changes are the key elements, with an emphasis on the importance of healthy global dietary patterns, regular physical activity, and adequate sleep quality.

Keywords

Humanities --- Social interaction --- trimethylamine N-oxide (TMAO) --- obesity --- visceral adiposity index (VAI) --- fatty liver index (FLI) --- metabolic syndrome (MetS) --- healthy lifestyle score --- metabolic syndrome --- SUN cohort --- branched-chain amino acids --- acylcarnitines --- dietary protein sources --- meat --- metabolite profiling --- diet --- pediatric obesity --- nonalcoholic fatty liver disease --- saliva --- metabolomics --- gas-chromatography mass spectrometry --- anthropometric indexes --- diagnosis criteria --- adolescents --- bone mineral density --- insulin resistance --- bone health --- osteoporosis --- atherosclerotic cardiovascular disease --- visceral fat accumulation --- universal public health screening program --- health check-up --- health guidance --- city planning --- carbohydrate --- polyunsaturated fat --- monounsaturated fat --- saturated fat --- fish oil --- meta-analyses --- lipids --- glucose --- blood pressure --- breastfeeding duration --- birth weight --- cardiorespiratory fitness --- cardiovascular disease --- exercise training --- linseed --- secoisolariciresinol diglucoside --- high-carbohydrate --- high-fat diet --- anthropometric indices --- cardiometabolic risk --- elderly --- risk --- pediatric --- adolescent --- sugar-sweetened beverages --- weight gain --- type 2 diabetes --- older adults --- macronutrient intake --- dietary intake --- fat intake --- endocannabinoids --- endocannabinoidome --- microbiome --- fructose --- hypertriglyceridemia --- metabolism --- sleep --- sleep apnea --- sleep habit --- sleep duration --- chronotype --- social jetlag --- ethnicity --- prevention --- lifestyle --- cardiometabolic --- exercise --- abdominal obesity --- energy balance --- caloric restriction --- non-alcoholic fatty liver disease --- physical activity --- saturated fatty acids --- diet quality --- dietary guidelines --- trimethylamine N-oxide (TMAO) --- obesity --- visceral adiposity index (VAI) --- fatty liver index (FLI) --- metabolic syndrome (MetS) --- healthy lifestyle score --- metabolic syndrome --- SUN cohort --- branched-chain amino acids --- acylcarnitines --- dietary protein sources --- meat --- metabolite profiling --- diet --- pediatric obesity --- nonalcoholic fatty liver disease --- saliva --- metabolomics --- gas-chromatography mass spectrometry --- anthropometric indexes --- diagnosis criteria --- adolescents --- bone mineral density --- insulin resistance --- bone health --- osteoporosis --- atherosclerotic cardiovascular disease --- visceral fat accumulation --- universal public health screening program --- health check-up --- health guidance --- city planning --- carbohydrate --- polyunsaturated fat --- monounsaturated fat --- saturated fat --- fish oil --- meta-analyses --- lipids --- glucose --- blood pressure --- breastfeeding duration --- birth weight --- cardiorespiratory fitness --- cardiovascular disease --- exercise training --- linseed --- secoisolariciresinol diglucoside --- high-carbohydrate --- high-fat diet --- anthropometric indices --- cardiometabolic risk --- elderly --- risk --- pediatric --- adolescent --- sugar-sweetened beverages --- weight gain --- type 2 diabetes --- older adults --- macronutrient intake --- dietary intake --- fat intake --- endocannabinoids --- endocannabinoidome --- microbiome --- fructose --- hypertriglyceridemia --- metabolism --- sleep --- sleep apnea --- sleep habit --- sleep duration --- chronotype --- social jetlag --- ethnicity --- prevention --- lifestyle --- cardiometabolic --- exercise --- abdominal obesity --- energy balance --- caloric restriction --- non-alcoholic fatty liver disease --- physical activity --- saturated fatty acids --- diet quality --- dietary guidelines


Book
Metabolic Syndrome : From Etiology to Prevention and Clinical Management
Authors: ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

Metabolic syndrome has been the topic of countless publications. It still remains a subject of debate and some experts have even questioned its clinical relevance. Its diagnosis is nevertheless predictive of an increased risk of type 2 diabetes and cardiovascular disease even in the absence of traditional risk factors. Many years ago, our team made the point that the most prevalent form of metabolic syndrome was linked to abdominal obesity, which can be found even among individuals who are not considered obese by body weight standards. Imaging techniques such as computed tomography and magnetic resonance imaging have revealed the link between regional body fat partitioning and cardiometabolic risk. Visceral obesity is the most dangerous form of obesity, with subcutaneous obesity being associated with lower health risk. We have proposed that excess visceral fat may be a marker of subcutaneous adipose tissue dysfunction not being able to serve as a metabolic sink, causing lipid accumulation at undesired sites, a condition described as ectopic fat deposition. Among the effective approaches to prevent, delay, or manage metabolic syndrome, lifestyle changes are the key elements, with an emphasis on the importance of healthy global dietary patterns, regular physical activity, and adequate sleep quality.

Keywords

Humanities --- Social interaction --- trimethylamine N-oxide (TMAO) --- obesity --- visceral adiposity index (VAI) --- fatty liver index (FLI) --- metabolic syndrome (MetS) --- healthy lifestyle score --- metabolic syndrome --- SUN cohort --- branched-chain amino acids --- acylcarnitines --- dietary protein sources --- meat --- metabolite profiling --- diet --- pediatric obesity --- nonalcoholic fatty liver disease --- saliva --- metabolomics --- gas-chromatography mass spectrometry --- anthropometric indexes --- diagnosis criteria --- adolescents --- bone mineral density --- insulin resistance --- bone health --- osteoporosis --- atherosclerotic cardiovascular disease --- visceral fat accumulation --- universal public health screening program --- health check-up --- health guidance --- city planning --- carbohydrate --- polyunsaturated fat --- monounsaturated fat --- saturated fat --- fish oil --- meta-analyses --- lipids --- glucose --- blood pressure --- breastfeeding duration --- birth weight --- cardiorespiratory fitness --- cardiovascular disease --- exercise training --- linseed --- secoisolariciresinol diglucoside --- high-carbohydrate --- high-fat diet --- anthropometric indices --- cardiometabolic risk --- elderly --- risk --- pediatric --- adolescent --- sugar-sweetened beverages --- weight gain --- type 2 diabetes --- older adults --- macronutrient intake --- dietary intake --- fat intake --- endocannabinoids --- endocannabinoidome --- microbiome --- fructose --- hypertriglyceridemia --- metabolism --- sleep --- sleep apnea --- sleep habit --- sleep duration --- chronotype --- social jetlag --- ethnicity --- prevention --- lifestyle --- cardiometabolic --- exercise --- abdominal obesity --- energy balance --- caloric restriction --- non-alcoholic fatty liver disease --- physical activity --- saturated fatty acids --- diet quality --- dietary guidelines --- n/a


Book
Therapeutic Potential of Plant Secondary Metabolites in the Treatment of Diseases and Drug Development
Author:
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

The importance of natural products, and especially plant secondary metabolites, for the treatment of diseases and drug development has already been obvious in medicine for several thousand years. Thus, this Special Issue of MDPI Biomedicines collects eight top articles from the field as regular full papers in addition to five reviews. All of the published papers are a vibrant source of information on the therapeutic potential of plant secondary metabolites in the treatment of diseases and drug development.

Keywords

Technology: general issues --- Chemical engineering --- Cannabis sativa (Cannabis) --- cannabinoids --- tetrahydrocannabinol (THC) --- cannabidiol (CBD) --- cannabinoid receptors (CB1 and CB2) --- Papaver somniferum (opium poppy) --- secondary metabolites --- ursolic acid --- NSCLC --- tumorsphere --- EGFR --- STAT3 --- MMP2 --- PD-L1 --- MAFLD --- tanshinone IIA --- phytochemical --- lipogenesis --- lipid accumulation --- LXRα --- malaria --- quinine --- chloroquine --- artemisinin --- onchocerciasis --- ivermectin --- moxidectin --- cancer --- vincristine --- vinblastine --- anabolic --- diabetes --- Duchenne muscular dystrophy --- β-ecdysone --- ecdysteroid --- ecdysterone --- Mas1 --- osteoporosis --- sarcopenia --- COVID-19 --- cardiometabolic diseases --- respiratory diseases --- natural product --- SARS-CoV-2 --- lung cancer --- United States Food and Drug Administration-approved drug --- natural remedy --- triterpenoid --- molecular ribbon --- Huisgen 1,3-dipolar cycloaddition --- amide bond --- multifunctional PEG3 derivative --- antimicrobial activity --- anti-HIV activity --- cytotoxicity --- supramolecular self-assembly --- phytocannabinoids --- cannabichromene --- thermos-TRPs --- TRPA1 --- α,α-dimethylheptyl effect --- betulinic acid --- BODIPY --- bevirimat --- cell-cycle --- fluorescent microscopy --- maturation inhibitor --- capsaicinoids --- endocannabinoidome --- microbiota --- overweight --- obesity --- food intake --- lipidomics --- metabolism --- alkaloids --- membrane fusion --- viral fusion inhibitor --- antiviral therapy --- curcumin --- cancer cells --- bioavailability --- curcumin derivatives --- curcumin analogues --- curcumin delivery systems --- natural product synthesis --- lignans --- inflammation --- NF-κB inhibition --- n/a


Book
Metabolic Syndrome : From Etiology to Prevention and Clinical Management
Authors: ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

Metabolic syndrome has been the topic of countless publications. It still remains a subject of debate and some experts have even questioned its clinical relevance. Its diagnosis is nevertheless predictive of an increased risk of type 2 diabetes and cardiovascular disease even in the absence of traditional risk factors. Many years ago, our team made the point that the most prevalent form of metabolic syndrome was linked to abdominal obesity, which can be found even among individuals who are not considered obese by body weight standards. Imaging techniques such as computed tomography and magnetic resonance imaging have revealed the link between regional body fat partitioning and cardiometabolic risk. Visceral obesity is the most dangerous form of obesity, with subcutaneous obesity being associated with lower health risk. We have proposed that excess visceral fat may be a marker of subcutaneous adipose tissue dysfunction not being able to serve as a metabolic sink, causing lipid accumulation at undesired sites, a condition described as ectopic fat deposition. Among the effective approaches to prevent, delay, or manage metabolic syndrome, lifestyle changes are the key elements, with an emphasis on the importance of healthy global dietary patterns, regular physical activity, and adequate sleep quality.

Keywords

trimethylamine N-oxide (TMAO) --- obesity --- visceral adiposity index (VAI) --- fatty liver index (FLI) --- metabolic syndrome (MetS) --- healthy lifestyle score --- metabolic syndrome --- SUN cohort --- branched-chain amino acids --- acylcarnitines --- dietary protein sources --- meat --- metabolite profiling --- diet --- pediatric obesity --- nonalcoholic fatty liver disease --- saliva --- metabolomics --- gas-chromatography mass spectrometry --- anthropometric indexes --- diagnosis criteria --- adolescents --- bone mineral density --- insulin resistance --- bone health --- osteoporosis --- atherosclerotic cardiovascular disease --- visceral fat accumulation --- universal public health screening program --- health check-up --- health guidance --- city planning --- carbohydrate --- polyunsaturated fat --- monounsaturated fat --- saturated fat --- fish oil --- meta-analyses --- lipids --- glucose --- blood pressure --- breastfeeding duration --- birth weight --- cardiorespiratory fitness --- cardiovascular disease --- exercise training --- linseed --- secoisolariciresinol diglucoside --- high-carbohydrate --- high-fat diet --- anthropometric indices --- cardiometabolic risk --- elderly --- risk --- pediatric --- adolescent --- sugar-sweetened beverages --- weight gain --- type 2 diabetes --- older adults --- macronutrient intake --- dietary intake --- fat intake --- endocannabinoids --- endocannabinoidome --- microbiome --- fructose --- hypertriglyceridemia --- metabolism --- sleep --- sleep apnea --- sleep habit --- sleep duration --- chronotype --- social jetlag --- ethnicity --- prevention --- lifestyle --- cardiometabolic --- exercise --- abdominal obesity --- energy balance --- caloric restriction --- non-alcoholic fatty liver disease --- physical activity --- saturated fatty acids --- diet quality --- dietary guidelines --- n/a

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