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This book is a collection of papers published in the Special Issue of Pharmaceutics, entitled "Pharmaceutical Particulates and Membranes for Delivery of Drugs and Bioactive Molecules". A drug release profile is a consequential factor for nanoparticle application, directly related to drug stability and therapeutic results, as well as formulation development. Pharmaceutical particulates of different sizes and shapes (e.g., liposomes, oil-in-water emulsions, polymeric nano- and microspheres, metallic nanoparticles (NPs) such as gold, silver and iron oxide crystals, and core-shell hybrid NPs) offer many diagnostic and therapeutic applications. Membranes are also extensively utilized in many applications. They are especially beneficial to the distribution of macromolecular drugs and biopharmaceutical drugs (peptides, proteins, antibodies, oligonucleotides, plasmids, and viruses) with physicochemical and pharmacokinetic vulnerability. The delivery of drugs and bioactive molecules using particulates and membranes has gained a great deal of attention for various applications, such as the treatment of secondary infections, cancer treatment, skin regeneration, orthopaedic applications, and antimicrobial drug delivery. In addition, several production techniques have been utilized for the fabrication of particulates and membranes in the last decade, which include lyophilisation, micro-emulsion, nano-spray dryer, nano-electrospinning, slip casting and 3D printers. Therefore, pharmaceutical particulates and membranes possess excellent prospects to deliver drugs and bioactive molecules with the potential to improve new delivery strategies like sustained and controlled release.

alginate gelispheres --- textural analysis --- crosslinked matrices --- PLGA discs --- prolonged release --- powder flow properties --- microfluidics --- coculture --- HER2 --- polystyrene µPs --- biofunctionalization --- coaxial electrospraying --- polymeric nanoparticles --- spreading angle --- process-property-performance relationship --- nanoemulsion --- mixture design --- aqueous humor --- antimicrobial activity --- sustained release pellets --- double coating layer --- loxoprofen --- citric acid --- pharmacokinetic studies --- biomimetic magnetite --- drug delivery --- magnetic hyperthermia --- magnetite --- MamC --- nanoparticles stability --- pharmaceutical particulates --- membranes --- drug delivery systems --- bio-imaging --- bioactive molecules --- composite --- N-hydroxyphthalimide --- carbon dots --- polymer gels --- antitumoral activity --- wound dressing --- polymeric membrane --- nanoparticles --- curcumin --- alginate --- pluronic F68 --- drug skin permeation --- Franz cells --- tape stripping --- wound infection --- biofilm --- pseudomonas aeruginosa --- antimicrobial delivery --- polyvinylpyrrolidone --- nanofibers --- red blood cells membrane --- arsenic trioxide --- sodium alginate nanoparticles --- reduce toxicity --- anti-tumor --- pediatric drug delivery --- tuberculosis --- reconstitutable dry suspension --- isoniazid --- polymer-lipid --- microparticulate --- direct emulsification --- n/a

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The food packaging industry is experiencing one of the most relevant revolutions associated with the transition from fossil-based polymers to new materials of renewable origin. However, high production costs, low performance, and ethical issues still hinder the market penetration of bioplastics. Recently, coating technology was proposed as an additional strategy for achieving a more rational use of the materials used within the food packaging sector. According to the packaging optimization concept, the use of multifunctional thin layers would enable the replacement of multi-layer and heavy structures, thus reducing the upstream amount of packaging materials while maintaining (or even improving) the functional properties of the final package to pursue the goal of overall shelf life extension. Concurrently, the increasing requirements among consumers for convenience, smaller package sizes, and for minimally processed, fresh, and healthy foods have necessitated the design of highly sophisticated and engineered coatings. To this end, new chemical pathways, new raw materials (e.g., biopolymers), and non-conventional deposition technologies have been used. Nanotechnology, in particular, paved the way for the development of new architectures and never-before-seen patterns that eventually yielded nanostructured and nanocomposite coatings with outstanding performance. This book covers the most recent advances in the coating technology applied to the food packaging sector, with special emphasis on active coatings and barrier coatings intended for the shelf life extension of perishable foods.

Research & information: general --- active food packaging --- antimicrobial --- antioxidant --- biocatalytic --- surface modification --- pectin --- edible films --- biopolymer coatings --- fruits --- vegetables --- agricultural wastes --- revalorisation --- fresh-cut --- conditioning liquid --- coatings --- spoiling microorganisms --- probiotics --- Citrus spp. --- postharvest --- disease control --- fruit quality --- fungicide alternatives --- edible coatings --- chitosan --- antifungal ingredients --- gas barrier --- coating --- thin film --- PET bottle --- DLC --- SiOx --- SiOC --- isotactic polypropylene --- zinc oxide --- properties --- active packaging --- composites --- carvacrol --- coextrusion --- lysozyme --- lactoferrin --- salmon --- food coatings --- food preservation --- biopolymers --- antioxidant and antimicrobial agents --- burrata cheese --- shelf life --- antimicrobial coating --- packaging design --- bilayer films --- strawberry --- packaging --- chitosan hydrochloride --- edible film --- food safety --- antimicrobial properties --- Botrytis cinerea --- Pectobacterium carotovorum subsp. carotovorum --- rotting --- cellulose nanocrystals (CNC) --- starch nanoparticles (SNP) --- barrier films --- nanomaterials --- nanocomposites --- bio-coatings --- oxygen barrier --- water vapor barrier --- paper --- surface --- Raman --- microscopy --- mapping --- barrier coating --- paper-based food packaging material --- alginate --- water vapor transmission rate --- MOSH/MOAH migration --- permeation --- grease barrier --- water absorptiveness --- HPLC-GC coupled with a flame ionization detector (FID) --- structural changes --- egg preservation --- Carica papaya L. --- starch --- image analysis --- porphyrin --- chlorophyllin --- active coating --- photoactivation --- self-sanitizing --- bologna --- electrospinning --- electrospraying --- superhydrophobicity --- polyethylene terephthalate (PET) --- polylactide (PLA) --- active films --- thermogravimetric analysis --- UV protection --- X-ray diffraction --- PET --- lamination --- nanoindentation --- interface --- edible coating --- hairy fig fruits --- navel oranges --- physicochemical responses --- active food packaging --- antimicrobial --- antioxidant --- biocatalytic --- surface modification --- pectin --- edible films --- biopolymer coatings --- fruits --- vegetables --- agricultural wastes --- revalorisation --- fresh-cut --- conditioning liquid --- coatings --- spoiling microorganisms --- probiotics --- Citrus spp. --- postharvest --- disease control --- fruit quality --- fungicide alternatives --- edible coatings --- chitosan --- antifungal ingredients --- gas barrier --- coating --- thin film --- PET bottle --- DLC --- SiOx --- SiOC --- isotactic polypropylene --- zinc oxide --- properties --- active packaging --- composites --- carvacrol --- coextrusion --- lysozyme --- lactoferrin --- salmon --- food coatings --- food preservation --- biopolymers --- antioxidant and antimicrobial agents --- burrata cheese --- shelf life --- antimicrobial coating --- packaging design --- bilayer films --- strawberry --- packaging --- chitosan hydrochloride --- edible film --- food safety --- antimicrobial properties --- Botrytis cinerea --- Pectobacterium carotovorum subsp. carotovorum --- rotting --- cellulose nanocrystals (CNC) --- starch nanoparticles (SNP) --- barrier films --- nanomaterials --- nanocomposites --- bio-coatings --- oxygen barrier --- water vapor barrier --- paper --- surface --- Raman --- microscopy --- mapping --- barrier coating --- paper-based food packaging material --- alginate --- water vapor transmission rate --- MOSH/MOAH migration --- permeation --- grease barrier --- water absorptiveness --- HPLC-GC coupled with a flame ionization detector (FID) --- structural changes --- egg preservation --- Carica papaya L. --- starch --- image analysis --- porphyrin --- chlorophyllin --- active coating --- photoactivation --- self-sanitizing --- bologna --- electrospinning --- electrospraying --- superhydrophobicity --- polyethylene terephthalate (PET) --- polylactide (PLA) --- active films --- thermogravimetric analysis --- UV protection --- X-ray diffraction --- PET --- lamination --- nanoindentation --- interface --- edible coating --- hairy fig fruits --- navel oranges --- physicochemical responses

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Air --- Atmosfeer. --- Air Pollution --- Pollution --- Pollution. --- Air Pollutions --- Pollution, Air --- Pollutions, Air --- Toxics, Air --- Air contaminants --- Air pollutants --- Air toxics --- Airborne pollutants --- Atmosphere --- Contaminants, Air --- Control of air pollution --- Pollutants, Air --- Air quality --- Atmospheric deposition --- Air Quality --- Aerosols. --- Air Pollution. --- Environmental Health. --- Environmental Health Science --- Health, Environmental --- Environmental Health Sciences --- Environmental Healths --- Health Science, Environmental --- Health Sciences, Environmental --- Healths, Environmental --- Science, Environmental Health --- Sciences, Environmental Health --- Ecology --- Administration, Inhalation --- Nebulizers and Vaporizers --- Aerosol --- Control --- air pollution. --- aerosols. --- environmental health. --- ecological health --- ecosystem health --- environmental health science --- public health --- ecological balance --- ecological resilience --- ecosystem services --- environmental hazards --- environmental management --- health hazards --- One Health initiative --- material forms --- bioaerosols --- mists --- airborne transmission --- biological safety cabinet --- electrospraying --- foggers --- fogs (materials) --- pesticide formulations --- pollution --- indoor air pollution --- aerobiology --- air pollutants --- air pollution control --- air quality --- air sampling --- airshed --- atmospheric chemistry --- atmospheric deposition --- Clean Air Act --- clean energy --- critical load --- Earth atmosphere --- environmental markets --- flue gas --- flue gas desulfurization --- greenhouse gas emissions --- greenhouse gases --- heat island --- nitrogen oxides --- pollen rain --- second hand smoke --- smoke --- time-weighted average --- Aerosols --- Environmental Health

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The food packaging industry is experiencing one of the most relevant revolutions associated with the transition from fossil-based polymers to new materials of renewable origin. However, high production costs, low performance, and ethical issues still hinder the market penetration of bioplastics. Recently, coating technology was proposed as an additional strategy for achieving a more rational use of the materials used within the food packaging sector. According to the packaging optimization concept, the use of multifunctional thin layers would enable the replacement of multi-layer and heavy structures, thus reducing the upstream amount of packaging materials while maintaining (or even improving) the functional properties of the final package to pursue the goal of overall shelf life extension. Concurrently, the increasing requirements among consumers for convenience, smaller package sizes, and for minimally processed, fresh, and healthy foods have necessitated the design of highly sophisticated and engineered coatings. To this end, new chemical pathways, new raw materials (e.g., biopolymers), and non-conventional deposition technologies have been used. Nanotechnology, in particular, paved the way for the development of new architectures and never-before-seen patterns that eventually yielded nanostructured and nanocomposite coatings with outstanding performance. This book covers the most recent advances in the coating technology applied to the food packaging sector, with special emphasis on active coatings and barrier coatings intended for the shelf life extension of perishable foods.

Research & information: general --- active food packaging --- antimicrobial --- antioxidant --- biocatalytic --- surface modification --- pectin --- edible films --- biopolymer coatings --- fruits --- vegetables --- agricultural wastes --- revalorisation --- fresh-cut --- conditioning liquid --- coatings --- spoiling microorganisms --- probiotics --- Citrus spp. --- postharvest --- disease control --- fruit quality --- fungicide alternatives --- edible coatings --- chitosan --- antifungal ingredients --- gas barrier --- coating --- thin film --- PET bottle --- DLC --- SiOx --- SiOC --- isotactic polypropylene --- zinc oxide --- properties --- active packaging --- composites --- carvacrol --- coextrusion --- lysozyme --- lactoferrin --- salmon --- n/a --- food coatings --- food preservation --- biopolymers --- antioxidant and antimicrobial agents --- burrata cheese --- shelf life --- antimicrobial coating --- packaging design --- bilayer films --- strawberry --- packaging --- chitosan hydrochloride --- edible film --- food safety --- antimicrobial properties --- Botrytis cinerea --- Pectobacterium carotovorum subsp. carotovorum --- rotting --- cellulose nanocrystals (CNC) --- starch nanoparticles (SNP) --- barrier films --- nanomaterials --- nanocomposites --- bio-coatings --- oxygen barrier --- water vapor barrier --- paper --- surface --- Raman --- microscopy --- mapping --- barrier coating --- paper-based food packaging material --- alginate --- water vapor transmission rate --- MOSH/MOAH migration --- permeation --- grease barrier --- water absorptiveness --- HPLC–GC coupled with a flame ionization detector (FID) --- structural changes --- egg preservation --- Carica papaya L. --- starch --- image analysis --- porphyrin --- chlorophyllin --- active coating --- photoactivation --- self-sanitizing --- bologna --- electrospinning --- electrospraying --- superhydrophobicity --- polyethylene terephthalate (PET) --- polylactide (PLA) --- active films --- thermogravimetric analysis --- UV protection --- X-ray diffraction --- PET --- lamination --- nanoindentation --- interface --- edible coating --- hairy fig fruits --- navel oranges --- physicochemical responses --- HPLC-GC coupled with a flame ionization detector (FID)

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Polymers are the largest and most versatile class of biomaterials, being extensively applied for therapeutic applications. From natural to synthetic polymers, the possibilities to design and modify their physical-chemical properties make these systems of great interest in a wide range of biomedical applications as diverse as drug delivery systems, organ-on-a-chip, diagnostics, tissue engineering, and so on.In recent years, advances in the synthesis and modification of polymers and characterization techniques have allowed the design of novel biomaterials as well as the study of their biological behavior in vitro and in vivo.The purpose of this Special Issue is to highlight recent achievements in the synthesis and modification of polymers for biomedical applications for final applications in the field of biomedicine.

biocomposite --- chitosan --- chlorhexidine --- coating --- hernia --- mesh infection --- nanoparticles --- PLGA --- polypropylene --- rifampicin --- 3D-bioprinting --- static mixer --- reactive hydrogel --- hyaluronic acid --- modified chitosan --- curcumin --- microwave --- interpenetrated polymer network --- semi-IPN --- methacrylated hyaluronic acid --- glycerylphytate --- mesenchymal stem cell --- bioadhesion --- biomaterials --- biomedical application --- healthcare system management --- innovation --- polymer based bioadhesive --- polymers --- magnetite nanoparticles --- Tween 80 --- synthesis --- nanotoxicology --- genotoxicity --- hemotoxicity --- soy protein --- film --- semiconductor --- biomaterial --- additive manufacturing --- sterilization --- medical devices --- bioabsorbable --- polymer --- biopolymer --- hydrogel --- microparticles --- dye release --- drug delivery system --- dual-responsiveness --- dendritic polyglycerol sulfates --- biofabrication --- microfluidics --- electrospinning --- 3D printing --- electrospraying --- natural polymers --- cell encapsulation --- polymeric prodrug --- dual-sensitive --- combination chemotherapy --- drug conjugation --- dextran --- hydrogels --- carboxymethyl cellulose --- succinoglycan --- metal coordination --- drug delivery --- swelling properties --- extracellular matrix --- external stimuli --- tissue maturation --- gelatin --- sodium carboxymethyl cellulose --- scaffold --- A549 cells --- freeze drying --- silicone rubber --- biomechanical --- hyper-elastic --- constitutive model --- FEA --- pH-sensitive hydrogel --- poly(acrylic acid) --- quartz crystal microbalance (QCM) --- ellipsometric measurement --- antibacterial activity --- Ganoderma lucidum --- polysaccharides --- cisplatin --- synergistic effect --- anti-lung cancer --- nanocellulose fiber --- low methoxyl pectin --- sodium alginate --- clindamycin --- pancreatic cancer --- gemcitabine --- controlled release --- non-woven sheet --- chemotherapy --- antitumor efficacy --- poly(L-lactic acid) --- antimicrobials agents --- amphiphilic block copolymer --- quaternized polymer --- hemolysis --- micelle --- black phosphorus --- polyetheretherketone --- lubrication properties --- antibacterial properties --- sensorineural hearing loss --- cochlear implants --- self-bending electrode arrays --- silicone rubber–hydrogel composites --- actuators --- swelling behavior --- curvature --- biocompatibility --- nanofibrous dura mater --- antifibrosis --- neuroprotection --- tetramethylpyrazine