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Electrospray ionization mass spectrometry --- Biomolecules --- Analysis

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Comprehensive, up-to-date coverage of a revolutionary technique Electrospray ionization mass spectrometry (ESI-MS) has completely changed the way physicists, chemists, and biologists view the study of large molecules. The technique derives detailed information about molecular weights and structures from extremely small sample quantities. ESI-MS can create highly charged forms of very high molecular weight compounds, it is naturally compatible with many types of separation techniques, and it allows noncovalent interactions between molecules in solution to be preserved in the gas phase. But many researchers may not use the technique to its full potential because they are unfamiliar with the different perspectives of its underlying processes, the varied approaches to implementation, and the wide-ranging utility of the technique.In this book, Richard B. Cole and an assemblage of leading researchers present a single-volume compilation of different approaches to the understanding and exploitation of ESI-MS. This comprehensive guide:* Examines the physical and chemical aspects of the electrospray process and describes the events involved in ion formation as well as the electro-chemical phenomena that are central to charged droplet formation during the process* Explores the coupling of electrospray ionization to various mass spectrometers, including quadrupole, magnetic, time-of-flight, quadrupole ion trap, and Fourier transform ion cyclotron resonance instruments* Describes recent progress in interfacing ESI with solution-based separation techniques, including liquid chromatography and capillary electrophoresis* Charts the rapid development of ESI applications and categorizes them by compound type: peptides and proteins, nucleic acids and their constituents, carbohydrates and lipids, small molecules related to pharmacology and drug metabolism, and organometallics and inorganic compoundsElectrospray Ionization Mass Spectrometry is the indispensable handbook and refer

Spectrometric and optical chemical analysis --- fysicochemie --- Electrospray ionization mass spectrometry. --- Biomolecules --- Analysis. --- 543.51 --- -Electrospray ionization mass spectrometry --- #WSCH:MACC --- ESIMS (Spectrum analysis) --- Ionization mass spectrometry, Electrospray --- Mass spectrometry --- Biological molecules --- Molecules --- Molecular biology --- Positive ray analysis. Mass spectrometry --- Analysis --- Basic Sciences. Chemistry --- Biochemistry --- Proteins and Enzymes --- Proteins and Enzymes. --- 543.51 Positive ray analysis. Mass spectrometry --- Electrospray ionization mass spectrometry --- Biomolecules - Analysis

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Electrospray ionization mass spectrometry --- Spectrum Analysis, Mass. --- Biomolecules --- Chromatography, Liquid. --- Analysis --- Mass spectrometry --- Congresses --- Ionization --- Electrospray ionization mass spectrometry - Congresses. --- Biomolecules - Analysis - Congresses. --- Ionization. Congresses --- Mass spectrometry. Congresses --- Biomolecules. Analysis. Congresses --- Spectrum Analysis, Mass --- Chromatography, Liquid

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Recent advances in large-scale DNA sequencing technology have made it possible to sequence the entire genome of an organism. Attention is now turning to the analysis of the product of the genome, the proteome, which is the set of proteins being expressed by a cell. Two-dimensional gel electrophoresis can be used to create cellular protein maps which give a quantitative and qualitative picture of the proteome. Mass spectrometry is the method of choice for the rapid large-scale idenfification of these proteomes and their modifications. An understanding of these methods is critical for scientists in the "Post-Genome" era.

Proteins --- Analysis --- Cancer research. --- Cell biology. --- Human Genetics. --- Cancer Research. --- Spectrometric and optical chemical analysis --- fysicochemie --- Analytical biochemistry --- Mass spectrometry. --- Analysis. --- Proteomics. --- Human genetics. --- Biotechnology. --- Molecular biology. --- Cell Biology. --- Molecular Medicine. --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Chemical engineering --- Genetic engineering --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Cell biology --- Cellular biology --- Biology --- Cells --- Molecular biology --- Proteins - Analysis --- PROTEOME --- QUADRUPOLE MASS SPECTROMETRY --- ION TRAP MASS SPECTROMETRY --- ELECTROSPRAY IONIZATION MASS SPECTROMETRY --- TIME-OF-FLIGHT MASS SPECTROMETRY --- LASER DESORPTION MASS SPECTROMETRY --- MATRIX-ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY --- PROTEINS --- PEPTIDES --- TANDEM MASS SPECTROMETRY --- ANALYSIS

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Beauty masks, diapers, wound dressings, wipes, protective clothes and biomedical products: all these high-value and/or large-volume products must be highly compatible with human skin and they should have specific functional properties, such as anti-microbial, anti-inflammatory and anti-oxidant properties. They are currently partially or totally produced using fossil-based sources, with evident issues linked to their end of life, as their waste generates an increasing environmental concern. On the contrary, biopolymers and active biomolecules from biobased sources could be used to produce new materials that are highly compatible with the skin and also biodegradable. The final products can be obtained by exploiting safe and smart nanotechnologies such as the extrusion of bionanocomposites and electrospinning/electrospray, as well as innovative surface modification and control methodologies. For all these reasons, recently, many researchers, such as those involved in the European POLYBIOSKIN project activities, have been working in the field of biomaterials with anti-microbial, anti-inflammatory and anti-oxidant properties, as well as biobased materials which are renewable and biodegradable. The present book gathered research and review papers dedicated to materials and technologies for high-performance products where the attention paid to health and environmental impact is efficiently integrated, considering both the skin-compatibility of the selected materials and their source/end of life.

pullulan --- biopolymers --- exopolysaccharides --- biodegradation --- biocompatibility --- poly(lactic acid) --- poly(butylene succinate) --- chitin nanofibrils --- starch --- skin compatibility --- anti-microbial --- poly(hydroxyalkanoate) --- biopolyesters --- beauty masks --- releasing --- skin compatible --- polyhydroxyalkanotes --- sugarcane molasses --- antibacterial materials --- essential oils --- coating --- poly(lactide) --- chitin–lignin nanocomplex --- grafting from --- lactide oligomers --- platelet-rich fibrin --- wound healing --- skin wounds --- wound dressing --- hyperspectral imaging --- principal component analysis --- spectroscopy --- chitosan --- partial least squares regression --- nir --- actives substances --- cn-nl/ga --- skin --- antifouling --- antimicrobial --- antiviral --- electrospinning --- breast implant --- ear prosthesis --- biomedical device --- chronic wound --- biopolymer --- bio-based --- surface modification --- nanolignin --- electrospray --- anti-inflammatory --- blends --- PLA --- PHBV --- nanocomposite --- tissue engineering --- biodegradable --- nanofiber --- n/a --- chitin-lignin nanocomplex