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Ultrasound techniques offer many advantages, in terms of ease of realization and patients' safety. The availability of suitable hardware and software tools is condicio sine qua non for new methods testing. This PhD project addresses medical ultrasound signal processing and seeks to achieve two scientific goals: the first is to contribute to the development of an ultrasound research platform, while the second is introducing and validating, through this platform, non-standard methods. During the thesis, the capabilities of the system were improved by creating advanced software tools, such as acoustic field simulators, and by developing echo-signals elaboration programs. In particular, a novel technique for quasi-static elastography was developed, in-vitro tested and implemented in real-time.

Ultrasonic imaging. --- Elastography.

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Ultrasound techniques offer many advantages, in terms of ease of realization and patients' safety. The availability of suitable hardware and software tools is condicio sine qua non for new methods testing. This PhD project addresses medical ultrasound signal processing and seeks to achieve two scientific goals: the first is to contribute to the development of an ultrasound research platform, while the second is introducing and validating, through this platform, non-standard methods. During the thesis, the capabilities of the system were improved by creating advanced software tools, such as acoustic field simulators, and by developing echo-signals elaboration programs. In particular, a novel technique for quasi-static elastography was developed, in-vitro tested and implemented in real-time.

Ultrasonic imaging. --- Elastography.

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The comparison between methods, evaluation of portal hypertension and many other questions are still open issues in liver elastography. New elastographic applications are under evaluation and close to being used in clinical practice. Strain imaging has been incorporated into many disciplines and EFSUMB guidelines are under preparation. More research is necessary for improved evidence for clinical applications in daily practice. The Special Issue published papers on recent advances in development and application of Ultrasound Elastography.

ultrasonography --- elastography --- anti-HBV therapy --- pediatric --- WFUMB --- measurement variability --- tendon stiffness --- pancreas --- patellar positions --- point of care ultrasound --- time of day --- chronic hepatitis B --- quantification --- chronic hepatitis C --- EFSUMB --- stiffness --- liver cirrhosis --- liver fibrosis --- computer-aided diagnosis (CAD) --- guideline --- liver stiffness --- Achilles tendon --- bending energy --- ultrasound elastography --- acoustic radiation force impulse --- tendinopathy --- texture analysis --- power spectrum --- magnetic resonance imaging --- strain ratio --- thyroid cancer --- prior activity --- direct acting antivirals --- strain quantification --- patellar tendon --- shear wave elastography (SWE) --- cine-tagging --- cirrhosis --- health care --- shear wave elastography --- Crohn’s disease --- contrast enhanced ultrasound --- HCV core antigen --- shear modulus --- therapy --- ultrasound --- supersonic shear imaging --- carcinoma --- quantitative --- leg dominance --- viral hepatitis C --- strain elastography --- endoscopic ultrasound (EUS)

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Thyroid nodular disease is one of the most frequent endocrine diseases. The prevalence of thyroid focal lesions detected by imaging techniques, according to studies on different populations, ranges from 10 to 70%. In a population of women over 50 years of age, approximately half of them will have a thyroid focal lesion. However, only 18% of thyroid nodules are diagnosed as malignant. Thyroid nodular disease is the most frequently diagnosed endocrine pathology, while thyroid cancer constitues the most common endocrine malignancy and is reponsible for about 67% of deaths due to neoplasms derived from endocrine organs. The incidence of thyroid cancer has risen by about 240% in the last three decades. Due to the increased availability of imaging techniques, recently, a rise in the detectability of thyroid cancer at the stage of microcarcinoma has been observed. Diagnostic and therapeutic decisions in patients with thyroid nodules require an interdisciplinary consensus between endocrinologists and physicians of other specialities (radiologists, pathologists, surgeons, oncologists). This book focuses on current trends in novel techniques of thyroid nodule diagnostics before they are implemented in the current guidelines on the management of thyroid nodular disease.

thyroid nodule --- care pathway --- guidelines --- fine-needle aspiration cytology --- thyroid cancer --- COLD-PCR --- digital PCR --- BRAFV600E --- papillary thyroid cancer --- liquid biopsy --- thyroid nodules --- ultrasound --- computer-aided diagnosis --- S-Detect --- EU-TIRADS --- PTC --- thyroid --- metastasis --- Snail-1 --- primary hyperparathyroidism --- parathyroidectomy --- remedial surgery --- ectopic mediastinal localization --- persistent hypercalcemia --- ectopic thymus --- shear wave sonoelastography --- strain elastography --- metastatic lymph nodes --- shear wave elastography --- interobserver variability --- tissue aspirate parathyroid hormone assay --- recurrent renal hyperparathyroidism --- persistent renal hyperparathyroidism --- parathyroid sonography --- parathyroid scintigraphy --- thyroid surgery --- vocal cord dysfunction --- vocal cord palsy --- loss of signal --- complications --- parathyroid adenoma --- hyperparathyroidism --- PET-CT --- FEC --- FCH --- n/a --- postsurgical hypoparathyroidism --- risk-factor analysis --- time course

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Diagnostic ultrasonic imaging. --- Elastography. --- Elasticty imaging --- Elastic analysis (Engineering) --- Three-dimensional imaging --- Diagnosis, Ultrasonic --- Diagnostic sonography --- Diagnostic ultrasonics --- Diagnostic ultrasonography --- Diagnostic ultrasound --- Medical diagnostic ultrasonic imaging --- Medical ultrasonography --- Ultrasonic diagnosis --- Ultrasonic diagnostic imaging --- Ultrasonic imaging --- Ultrasonic waves --- Diagnostic imaging --- Ultrasonics in medicine --- Diagnostic use