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Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research.
Epigenetics. --- DNA damage. --- Damage, DNA --- Biochemical genetics --- Mutation (Biology) --- Genetics --- DNA Damage --- Chromatin Assembly and Disassembly --- Epigenesis, Genetic --- genetics --- genetics (DNLM)D042002Q000235 --- Epigenesis, Genetic. --- genetics. --- genetics (DNLM)D042002Q000235.
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Un nouveau paradigme architectural ?! Nos modes de constructions actuels dits « fixes », devenus pour le moins obsolescents, cherchent des réponses émanant de l’économie circulaire. Cette myopie actuelle de la notion de déchet semble alors détrôner tout le principe de démontabilité. Durabilité, flexibilité, désassemblage, adaptabilité, déconstruction, réversibilité… sont tant de termes qui doivent s’imposer à notre nouvelle culture de la conception et construction dite « cradle to cradle ». Traversant les échelles, du plus fixe (structure, site) au plus flexible (spatialité, enveloppe), le bâtiment se résume alors par une superposition de strates indépendantes les unes des autres. En bout de chaîne, le cycle de vie du bâtiment se referme ; les matériaux devenus alors source directe de réemploi : ablation de la démolition en résulte. L’objectif de ce travail est de sensibiliser et d’informer les architectes et autres acteurs de la construction des opportunités qu’offrent de telles pratiques. Une approche systémique qui semble soutenir de grands concepts architecturaux dépassant la théorie vers une pratique, encore qualifiée de science jeune mais illustrant pour autant des résultats prometteurs. Additionnels au cycle de vie fermé, comment quantifier cette approche circulaire, sur quels critères s’appuyer ? A new architectural paradigm ?! Our current so-called "fixed" modes of construction, which have become obsolete to say the least, are looking for answers emanating from the circular economy. This current short-sightedness of the notion of waste seems to dethrone the whole principle of demountability. Durability, flexibility, disassembly, adaptability, deconstruction, reversibility... are so many terms that must be imposed on our new culture of design and construction known as "cradle to cradle". Crossing the scales, from the most fixed (structure, site) to the most flexible (spatiality, envelope), the building is then summed up by a superimposition of layers independent of each other. At the end of the chain, the life cycle of the building closes; the materials then become a direct source of reuse: resulting in the removal of the demolition. The aim of this work is to raise awareness and inform architects and other construction actors of the opportunities offered by such practices. A systemic approach that seems to support great architectural concepts that go beyond theory towards a practice, still qualified as a young science but nevertheless illustrating promising results. In addition to the closed life cycle, how can this circular approach be quantified, which criteria should be used ?
Economie circulaire --- Obsolescence --- Flexibilité --- Durabilité --- Cycle de vie --- Désassemblage --- Réemploi --- Réversibilité --- Circular economy --- Obsolescence --- Flexibility --- Durability --- Lifecycle --- Disassembly --- Reuse --- Reversibility --- Ingénierie, informatique & technologie > Architecture
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Chromatin. --- Nervous System Diseases --- Chromatin --- Histones --- Signal Transduction --- Chromatin Assembly and Disassembly. --- Gene Expression Regulation. --- Epigenesis, Genetic. --- genetics. --- metabolism. --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Epigenome --- DNA Methylation --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- RNAi Therapeutics --- Gene Regulatory Networks --- Chromatin Assembly --- Chromatin Disassembly --- Chromatin Modeling --- Chromatin Remodeling --- Chromatin Disassemblies --- Disassembly, Chromatin --- Remodeling, Chromatin --- Histone Code --- Chromosomes --- Nucleoproteins --- Genetic regulation. --- Nervous system --- Diseases --- Medical neurology --- Nerves --- Neurologic disorders --- Neurological disorders --- Neuropathology --- Neurology --- Gene expression --- Gene expression regulation --- Gene regulation --- Biosynthesis --- Cellular control mechanisms --- Molecular genetics --- Regulation --- Diseases.
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Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.
embryologie (geneeskunde) --- histologie --- Histology. Cytology --- Pathological endocrinology --- Gynaecology. Obstetrics --- General embryology. Developmental biology --- perinatale sterfte --- obstetrie --- urologie --- endocrinologie --- cytologie --- Urology. Andrology --- Chromatin --- Spermatozoa --- Chromatin Assembly and Disassembly. --- DNA Damage --- Infertility, Male --- Chromatin. --- DNA damage. --- Chromatine --- Spermatozoïdes --- ADN --- Stérilité masculine --- pathology. --- physiology. --- etiology. --- Etiology --- Lésions --- Etiologie --- EPUB-LIV-FT LIVMEDEC SPRINGER-B --- Etiology.
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Recent advances in epigenetic research as well as the development of exciting new technologies have helped greatly in unraveling the many mysteries of nontraditional genetic processes. In Epigenetics Protocols, hands-on researchers describe state-of-the-art methods for epigenetic analysis, including recent breakthrough techniques that have great potential in the rapidly expanding field of non-Mendelian genetics. The authors provide techniques for the analysis of chromatin remodeling, such as histone acetylation and methylation. In addition, methods in newly developed and especially promising areas of epigenetics, such as telomere position effects, quantitative epigenetics, and ADP ribosylation are covered. There is also an updated analysis of techniques involving DNA methylation and its role in the modification, as well as the maintenance, of chromatin structure. Of special interest are potentially revolutionary techniques. These include methods for determining changes in native chromatin, methods of microarray analysis applied to epigenetics, and methylation-sensitive single-strand conformation techniques. The methods are suitable not only for studying fundamental biological processes, but also for investigating possible therapeutic interventions and such diseases as cancer. The protocols follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and easy to use, Epigenetics Protocols offers investigators readily reproducible techniques that will further promote progress in this critically important field.
Human genetics. --- Human Genetics. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Chromatin Assembly and Disassembly --- Chromosome Structures --- DNA Methylation. --- Epigenesis, Genetic. --- Histone Code --- Histones --- genetics. --- metabolism. --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Epigenome --- DNA Methylation --- DNA Methylations --- Methylation, DNA --- Methylations, DNA --- Methyl CpG Binding Domain --- Genomic Imprinting --- Gene Silencing --- Epigenesis, Genetic
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This volume includes timely reviews of several aspects of chromatin biology written by scientists at the forefront of this rapidly moving field. Topics covered include the structure and function of protein modules within chromatin-remodeling proteins, newly characterized histone modifications (methylation, ubiquitylation) and their functional consequences, transcription and histone dynamics, roles of chromatin remodeling factors in DNA replication and repair, and current models of nucleosome-remodeling mechanisms.
Chromatin Assembly and Disassembly. --- Cell Physiology. --- Histones. --- Chromatin. --- Chromatine --- Life sciences. --- Biochemistry. --- Cytology. --- Life Sciences. --- Cell Biology. --- Biochemistry, general. --- Chromatin --- Histones --- Chromatin Assembly and Disassembly --- Cell Physiological Phenomena --- DNA Packaging --- Gene Expression Regulation --- Nuclear Proteins --- Nucleoproteins --- Chromosome Structures --- Phenomena and Processes --- Proteins --- Genetic Structures --- Genetic Processes --- Cell Physiological Processes --- Chromosomes --- Amino Acids, Peptides, and Proteins --- Intranuclear Space --- Genetic Phenomena --- Chemicals and Drugs --- Cell Nucleus Structures --- Cell Nucleus --- Intracellular Space --- Cellular Structures --- Cells --- Anatomy --- Cytology --- Biology --- Health & Biological Sciences --- Biosciences --- Sciences, Life --- Anatomies --- Cell --- Cell Components --- Cell Component --- Cellular Structure --- Component, Cell --- Components, Cell --- Structure, Cellular --- Structures, Cellular --- Cell Nuclei --- Nuclei, Cell --- Nucleus, Cell --- Cell Nucleus Structure --- Structure, Cell Nucleus --- Structures, Cell Nucleus --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Chromosome --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Genetic Structure --- Structure, Genetic --- Structures, Genetic --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Chromosome Structure --- Structure, Chromosome --- Structures, Chromosome --- Nucleoprotein --- Nuclear Protein --- Nucleolar Proteins --- Protein, Nuclear --- Proteins, Nuclear --- Proteins, Nucleolar --- Expression Regulation, Gene --- Regulation, Gene Action --- Regulation, Gene Expression --- Gene Action Regulation --- Regulation of Gene Expression --- Packaging, DNA --- Chromatin Assembly --- Chromatin Disassembly --- Chromatin Modeling --- Chromatin Remodeling --- Chromatin Disassemblies --- Disassembly, Chromatin --- Remodeling, Chromatin --- Chromatins --- Histone --- Histone H1 --- Histone H1(s) --- Histone H2a --- Histone H2b --- Histone H3 --- Histone H3.3 --- Histone H4 --- Histone H5 --- Histone H7 --- Cell biology --- Cellular biology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- physiology --- Composition --- Subcellular Space --- Intracellular Spaces --- Space, Intracellular --- Space, Subcellular --- Spaces, Intracellular --- Spaces, Subcellular --- Subcellular Spaces --- Subnuclear Space --- Intranuclear Spaces --- Space, Intranuclear --- Space, Subnuclear --- Spaces, Intranuclear --- Spaces, Subnuclear --- Subnuclear Spaces --- Cell biology. --- Cytologists --- Chemistry --- Medical sciences
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The field of epigenetics has played a major role at the forefront not only of molecular biology, but also of medical genetics and clinical medicine. Few disciplines have experienced growth comparable to that which we have witnessed for epigenetics in the past decade. The goal of Epigenetics Protocols, Second Edition is to highlight select techniques that have been mainstays in the field as well as to cover methods that are especially relevant to extant discoveries in epigenetics. This volume focuses on the two broad areas of epigenetics: DNA methylation and chromatin modifications, and also covers the complex topic of computational methods for epigenetic analyses which is essential to a complete understanding of the vast body of information that is being derived with the use of these newly-developed tools. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Epigenetics Protocols, Second Edition serves as an ideal guide to advanced students, basic scientists and clinical researchers as well as clinicians and biotechnology investigators who wish to continue exploring this exciting and progressive research field.
Human genetics. --- Gene expression. --- Human Genetics. --- Gene Expression. --- Genes --- Genetic regulation --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Expression --- Chromatin Assembly and Disassembly --- Chromosome Structures --- DNA Methylation. --- Epigeneis, Genetic. --- Histone Code --- Histones --- genetics. --- metabolism. --- DNA Methylations --- Methylation, DNA --- Methylations, DNA --- Methyl CpG Binding Domain --- Genomic Imprinting --- Gene Silencing --- Epigenesis, Genetic --- Epigenetic Process --- Epigenetics Processes --- Epigenetic Processes --- Genetic Epigenesis --- Process, Epigenetic --- Processes, Epigenetic --- Processes, Epigenetics --- Epigenome --- DNA Methylation
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Sustainability Delivered was written to help supply chain managers, entrepreneurs, executives, and stakeholders develop the awareness and skills needed to support sustainable supply chain management in their firms. The book introduces the many ways that social and environmental responsibility can be integrated into supply chain management, from sustainable product and process design to programs and techniques that support product end-of-life management. The book also explores how sustainable supply chain management can be a key contributor to a firm's competitive advantage. With case examples, workshops, and step-by-step instruction in how to create a sustainable supply chain, Sustainability Delivered is the most practical and usable book on the market for helping business leaders authentically pursue and deliver on sustainability ideals.
Business logistics. --- Sustainability. --- Green products. --- Biomimicry --- Certification programs --- Cradle to Cradle (C2C) --- Design for Disassembly (DfD) --- Design for the Environment --- Ecoefficiency --- End-of- life management (EOL) --- Environmental management system (EMS) --- Environmentally responsible supply chain management --- Extended product responsibility --- Industrial ecology --- ISO 14000 --- ISO 26000 --- Life Cycle Analysis --- Life Cycle Assessment --- Natural Step --- Process design --- Product design --- Product end-of-life management (EOL) --- Purchasing scorecards --- Socially responsible supply chain management --- Supplier assessment --- Supplier scorecards --- Sustainable supply chain management --- Value stream mapping
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Currently, the transition from using the combustion engine to electrified vehicles is a matter of time and drives the demand for compact, high-energy-density rechargeable lithium ion batteries as well as for large stationary batteries to buffer solar and wind energy. The future challenges, e.g., the decarbonization of the CO2-intensive transportation sector, will push the need for such batteries even more. The cost of lithium ion batteries has become competitive in the last few years, and lithium ion batteries are expected to dominate the battery market in the next decade. However, despite remarkable progress, there is still a strong need for improvements in the performance of lithium ion batteries. Further improvements are not only expected in the field of electrochemistry but can also be readily achieved by improved manufacturing methods, diagnostic algorithms, lifetime prediction methods, the implementation of artificial intelligence, and digital twins. Therefore, this Special Issue addresses the progress in battery and energy storage development by covering areas that have been less focused on, such as digitalization, advanced cell production, modeling, and prediction aspects in concordance with progress in new materials and pack design solutions.
Research & information: general --- battery energy storage --- renewable energy --- distribution network --- genetic algorithm --- particle swarm optimization --- electrolyte --- additive --- interface --- pseudocapacitance --- intercalation --- energy storage --- secondary battery --- sodium-ion --- lithium-ion battery --- traction battery --- waterjet-based recycling --- direct recycling --- life cycle assessment --- global warming potential --- electro-thermal model --- smart cell --- intelligent battery --- neural network --- temperature prediction --- DRT by time domain data --- pulse evaluation --- relaxation voltage --- online diagnosis --- degradation mechanisms --- EIS --- lead batteries --- safety concept --- safety battery --- battery monitoring --- electronic battery sensor --- failure modes --- failure distribution --- failure rates --- field battery investigation --- safe supply --- power supply system --- zinc ion batteries --- stationary energy storage --- polymer binder --- solvent --- doctor blade coating --- manganese dioxide --- mixing ratio --- electrochemical impedance spectroscopy --- SEM+EDX --- electrode fabrication --- lithium ion battery --- AC current injection --- bi-directional control --- charger --- lithium-ion battery cell --- volumetric expansion --- mechanical degradation --- state of charge dependency --- cell thickness --- mechanical aging --- non-uniform volume change --- solar photovoltaic energy --- redox flow battery --- residential load --- renewable energy integration --- battery sizing --- battery efficiency --- lithium battery --- temperature dependency --- ether based electrolyte --- insitu deposited lithium-metal electrode --- Coulombic efficiency --- lithium deposition morphology --- Li-ion battery --- thermal runaway --- model --- post-mortem analysis --- ecofriendly electrolyte for lithium-ion batteries --- increased thermal stability of electrolytes --- enhanced electrolyte safety based on high flash point --- tributylacetylcitrate --- acetyltributylcitrate --- electric vehicle battery --- disassembly --- disassembly planner design --- disassembly strategy optimization --- battery management system --- state monitoring --- state-of-charge --- digital twin --- battery model --- Doyle-Fuller-Newman model --- equivalent circuit model --- parameter estimation --- lithium-ion batteries --- temperature estimation --- sensorless temperature measurement --- artificial intelligence --- artificial neural network --- lithium-ion cells --- battery thermal management systems --- CFD simulations --- liquid cooling
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Currently, the transition from using the combustion engine to electrified vehicles is a matter of time and drives the demand for compact, high-energy-density rechargeable lithium ion batteries as well as for large stationary batteries to buffer solar and wind energy. The future challenges, e.g., the decarbonization of the CO2-intensive transportation sector, will push the need for such batteries even more. The cost of lithium ion batteries has become competitive in the last few years, and lithium ion batteries are expected to dominate the battery market in the next decade. However, despite remarkable progress, there is still a strong need for improvements in the performance of lithium ion batteries. Further improvements are not only expected in the field of electrochemistry but can also be readily achieved by improved manufacturing methods, diagnostic algorithms, lifetime prediction methods, the implementation of artificial intelligence, and digital twins. Therefore, this Special Issue addresses the progress in battery and energy storage development by covering areas that have been less focused on, such as digitalization, advanced cell production, modeling, and prediction aspects in concordance with progress in new materials and pack design solutions.
battery energy storage --- renewable energy --- distribution network --- genetic algorithm --- particle swarm optimization --- electrolyte --- additive --- interface --- pseudocapacitance --- intercalation --- energy storage --- secondary battery --- sodium-ion --- lithium-ion battery --- traction battery --- waterjet-based recycling --- direct recycling --- life cycle assessment --- global warming potential --- electro-thermal model --- smart cell --- intelligent battery --- neural network --- temperature prediction --- DRT by time domain data --- pulse evaluation --- relaxation voltage --- online diagnosis --- degradation mechanisms --- EIS --- lead batteries --- safety concept --- safety battery --- battery monitoring --- electronic battery sensor --- failure modes --- failure distribution --- failure rates --- field battery investigation --- safe supply --- power supply system --- zinc ion batteries --- stationary energy storage --- polymer binder --- solvent --- doctor blade coating --- manganese dioxide --- mixing ratio --- electrochemical impedance spectroscopy --- SEM+EDX --- electrode fabrication --- lithium ion battery --- AC current injection --- bi-directional control --- charger --- lithium-ion battery cell --- volumetric expansion --- mechanical degradation --- state of charge dependency --- cell thickness --- mechanical aging --- non-uniform volume change --- solar photovoltaic energy --- redox flow battery --- residential load --- renewable energy integration --- battery sizing --- battery efficiency --- lithium battery --- temperature dependency --- ether based electrolyte --- insitu deposited lithium-metal electrode --- Coulombic efficiency --- lithium deposition morphology --- Li-ion battery --- thermal runaway --- model --- post-mortem analysis --- ecofriendly electrolyte for lithium-ion batteries --- increased thermal stability of electrolytes --- enhanced electrolyte safety based on high flash point --- tributylacetylcitrate --- acetyltributylcitrate --- electric vehicle battery --- disassembly --- disassembly planner design --- disassembly strategy optimization --- battery management system --- state monitoring --- state-of-charge --- digital twin --- battery model --- Doyle-Fuller-Newman model --- equivalent circuit model --- parameter estimation --- lithium-ion batteries --- temperature estimation --- sensorless temperature measurement --- artificial intelligence --- artificial neural network --- lithium-ion cells --- battery thermal management systems --- CFD simulations --- liquid cooling
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