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The word "cancer" is associated with at least 100 different pathologies, depending on the organ involved and the type of tumor developed. Cancer is a complex disease involving multiple pathogenetic mechanisms. Characterization of different types of cancers, which distinguishes them from healthy cells and other cancers, allows for the identification of specific targets for each individual tumor. The principle of chemotherapy is based on interference with the mechanisms that regulate the life and proliferation of cancer cells, causing their death. In recent years, there has been continuous progress in the development of therapeutic agents against cancer, which is ongoing.The Anticancer Inhibitors Special Issue focuses on new target-based anticancer agents that inhibit a specific target involved in the suppression of various types of cancer and the control of their chemoresistance.There is a collection of research and review articles on advances in drug discovery, design, and development of new inhibitor compounds with potency against various cancer types.

breast cancer --- tamoxifen --- LY294002 --- synergism --- apoptosis --- cell cycle --- tea (Camellia sinensis) flowers --- BTFS --- A2780/CP70 ovarian cancer cells --- S phase cell cycle arrest --- nicotinamide phosphoribosyltransferase --- NAD+ biosynthesis --- inhibitor --- azacyclohexane --- anticancer drug --- drug design --- enthalpy effect --- NSCLC --- Cathepsin K --- cell proliferation --- cell migration --- cell invasion --- mTOR --- isatin-hydrazones --- cytotoxicity --- CDK2 inhibitor --- ATP competitive inhibitor --- ADME analysis --- receptor tyrosine kinases --- protein-protein interactions --- protein engineering --- directed evolution --- angiogenesis --- binding affinity --- agonistic activity --- saponins --- phytochemicals --- tea (Camellia sinensis) flower --- ovarian cancer --- autophagy --- ZMYND8 --- tumorigenesis --- epigenetic regulation --- pro-oncogenic effects --- tumor suppression --- tacrine-coumarin derivatives --- DNA --- topoisomerases I, II --- lung carcinoma cells --- A549 --- chemotherapy --- prodrug --- drug targeting --- overexpressed enzymes --- ADC --- ADEPT --- GDEPT --- LEAPT --- PROTAC --- cyclin-dependent kinase --- cancer --- resistance --- small molecule inhibitors --- PROTACs --- statins --- pancreatic cancer --- DNA microarray --- pitavastatin --- cerivastatin --- simvastatin --- fluvastatin --- atorvastatin --- pravastatin --- HMG-CoA reductase inhibitors --- n/a

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Biotechnology --- Genetic engineering --- Biochemical engineering --- Biomedical Engineering. --- Environmental Microbiology. --- Genetic Engineering. --- Microbiological Techniques. --- Technology. --- Génie biochimique --- Biotechnologie. --- Génie génétique. --- Annuaires. --- Biochemical engineering. --- Biotechnology. --- Genetic engineering. --- Periodicals. --- Arts, Industrial --- Industrial Arts --- Microbiologic Technic --- Microbiologic Technics --- Microbiologic Technique --- Microbiological Technics --- Technic, Microbiologic --- Technics, Microbiological --- Technique, Microbiologic --- Techniques, Microbiologic --- Microbiologic Techniques --- Microbiological Technic --- Microbiological Technique --- Technic, Microbiological --- Technics, Microbiologic --- Technique, Microbiological --- Techniques, Microbiological --- Microbiology --- Engineering, Genetic --- Intervention, Genetic --- Genetic Intervention --- Genetic Interventions --- Interventions, Genetic --- Microbiology, Environmental --- Environment --- Engineering, Biomedical --- Clinical Engineering --- Engineering, Clinical --- Designed genetic change --- Gene splicing --- Genetic intervention --- Genetic surgery --- Bio-process engineering --- Bioprocess engineering --- methods --- microbiology --- Cloud Computing --- Cloning, Molecular --- DNA, Recombinant --- Industrial Microbiology --- Artificial Gene Fusion --- Organisms, Genetically Modified --- Animals, Genetically Modified --- Plants, Genetically Modified --- Biomedical Technology --- Genetic recombination --- Transgenic organisms --- Chemical engineering --- Biochemistry --- Génie biochimique --- Génie génétique. --- genetic manipulation --- genetic modification --- Breeding and Genetic Improvement --- molecular genetics --- antibody engineering --- cisgenesis --- directed evolution --- DNA shuffling --- gene editing --- genetically engineered traits --- intragenesis --- nuclear transplantation --- paratransgenesis --- protein engineering --- sex preselection --- transgenesis --- bioengineering --- bioethics --- biopharmaceuticals --- biotechnology --- food biotechnology --- gene therapy --- genetic improvement --- genetic techniques and protocols --- genetically modified foods --- genetically modified organisms --- genetically modified plants --- metabolic engineering --- molecular farming --- reverse genetics --- Serials --- Biomedical engineering. --- Microbial ecology. --- Biomedical Engineering --- Environmental Microbiology --- Genetic Engineering --- Microbiological Techniques --- Technology --- Biotechnologie --- Génie biomédical. --- Écologie microbienne. --- Technologie. --- biomedical engineering. --- Environmental microbiology --- Microorganisms --- Ecology --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Applied science --- Arts, Useful --- Science, Applied --- Useful arts --- Science --- Industrial arts --- Material culture --- genetic engineering

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There is talk of an upcoming antibiotic armageddon, with untreatable post-operative infections, and similarly untreatable complications after chemotherapy. Indeed, the now famous “O’Neill Report” (https://amr-review.org/) suggests that, by 2050, more people might die from antibiotic-resistant bacterial infections than from cancer. While we are still learning all the subtle drivers of antibiotic resistance, it seems increasingly clear that we need to take a “one health” approach, curtailing the use of antibiotics in both human and veterinary medicine. However, there are no new classes of antibiotics on our horizon. Maybe something that has been around “forever” can come to our rescue—bacteriophages! Nevertheless, it is also necessary to do things differently, and use these new antimicrobials appropriately. Therefore, an in-depth study of bacteriophage biology and case-by-case applications might be required. Whilst by no means comprehensive, this book does cover some of the many topics related to bacteriophages as antimicrobials, including their use in human therapy and aquaculture. It also explores the potential use of phage endolysins as substitutes of antibiotics in two sectors where there is an urgent need—human therapy and the agro-food industry. Last but not least, there is an excellent perspective article on phage therapy implementation.

Medicine --- bacteriophages --- dairy industry --- pathogens --- lactic acid bacteria --- fermentation failure --- biofilms --- antimicrobial resistance --- antimicrobials --- lysins --- horizontal gene transfer, transduction --- biofilm --- phage therapy --- resistance --- bacteriophage --- models --- agent based --- mass action --- bacterial phage resistance --- regression modeling --- MRSA --- Clostridium difficile --- Clostridium difficile infection --- microbiome --- in vitro fermentation model --- marine vibrios --- biological control --- aquaculture --- interactions --- vibriosis --- Aeromonas hydrophila --- Motile Aeromonas Septicemia --- MAS --- multiple-antibiotic-resistance --- striped catfish (Pangasianodon hypophthalmus) --- endolysin --- antibiotics --- one health --- protein engineering --- Aeromonas salmonicida --- furunculosis --- phage-resistant mutants --- proteins --- infrared spectroscopy --- lysin --- lytic enzyme --- peptidoglycan hydrolase --- antimicrobial --- antibacterial --- antibiotic resistance --- bacteriophage therapy --- Nagoya Protocol --- CRISPR CAS --- phage isolation --- phage resistance --- Staphylococcus --- Kayvirus --- Vibrio anguillarum --- fish larvae --- challenge trials --- phage display --- enzybiotics --- Bacteriophages --- diabetic foot ulcer --- osteomyelitis --- Staphylococcus aureus --- Antibiotic-resistant bacteria --- lysogenic conversion --- prophage induction --- read recruitment --- shiga toxin --- American Foulbrood --- phage --- Paenibacillus larvae --- Brevibacillus laterosporus --- treatment --- safety --- bystander phage therapy --- Mycobacterium smegmatis --- mycobacteriophages --- directed evolution --- PlyC CHAP --- protein net charge --- CBD-independent --- FoldX --- STEC-specific bacteriophage --- whole genome sequencing --- STEC O145 strains --- antimicrobial agent --- Pseudomonas aeruginosa --- dual-species --- antibiotic --- synergy --- simultaneous --- sequential --- microbiome therapy --- evolution