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Thromboembolism is a compelling challenge in cancer care because of its life-threatening nature as well as its impact on specific treatments. Current guidelines do not generally recommend antithrombotic prophylaxis, except in selected categories of patients at high risk of thrombosis. Accordingly, several clinical decision models have been developed to guide the oncologist in thromboembolic risk assessment and targeted prophylaxis. Low-molecular-weight heparins (LMWH) are currently considered as the standard approach in clinical practice guidelines, but recent randomized controlled trials (RCT) indicate that direct oral anticoagulants (DOACs) are effective for the treatment/prophylaxis of cancer-associated thromboembolism. However, many unanswered questions remain on the efficacy and safety of anticoagulants in selected cancer subgroups, and in primary and secondary prevention settings, where anticoagulation needs to be balanced on the risk of bleeding complications. Presently, patient selection remains the main challenge. Improvement in existing VTE risk models or the construction of alternative risk assessment tools are needed in order to ameliorate the risk stratification of cancer patients. This reprint will cover the current clinical evidence supporting the standard of care and emerging treatment/prophylactic options for cancer-associated thromboembolism during both active treatment and simultaneous/palliative care. Tailored approaches based on the use of individualized factors to stratify the thrombotic/bleeding risk in each individual patient are discussed.

Medicine --- Oncology --- multiple myeloma --- venous thromboembolism --- risk assessment models --- thromboprophylaxis --- direct oral anticoagulants --- cancer-associated venous thromboembolism --- thrombosis --- pulmonary embolism --- neoplasms --- anticoagulants --- coumarins --- low molecular weight heparins --- cancer --- endogenous heparin --- heparanase --- heparan sulfate --- hospice --- palliative care units --- low molecular weight heparin --- deep vein thrombosis --- cancer associated thrombosis --- VTE --- malignancy --- direct oral anticoagulant --- pancreatic cancer --- low-molecular weight heparin --- survival --- coagulation activation --- locally advanced breast cancer --- prognostic model --- pCR --- treatment --- prophylaxis --- DOAC --- simultaneous care --- integrated care --- lymphoma --- Non-Hodgkin lymphoma --- Hodgkin lymphoma --- risk factors --- molecular subtype --- arterial thrombosis --- ALK --- ROS1 --- KRAS --- chemotherapy --- low-molecular-weight heparin (LMWH) --- VKA --- UFH --- DOACs --- n/a

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• Reference Manager
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Thromboembolism is a compelling challenge in cancer care because of its life-threatening nature as well as its impact on specific treatments. Current guidelines do not generally recommend antithrombotic prophylaxis, except in selected categories of patients at high risk of thrombosis. Accordingly, several clinical decision models have been developed to guide the oncologist in thromboembolic risk assessment and targeted prophylaxis. Low-molecular-weight heparins (LMWH) are currently considered as the standard approach in clinical practice guidelines, but recent randomized controlled trials (RCT) indicate that direct oral anticoagulants (DOACs) are effective for the treatment/prophylaxis of cancer-associated thromboembolism. However, many unanswered questions remain on the efficacy and safety of anticoagulants in selected cancer subgroups, and in primary and secondary prevention settings, where anticoagulation needs to be balanced on the risk of bleeding complications. Presently, patient selection remains the main challenge. Improvement in existing VTE risk models or the construction of alternative risk assessment tools are needed in order to ameliorate the risk stratification of cancer patients. This reprint will cover the current clinical evidence supporting the standard of care and emerging treatment/prophylactic options for cancer-associated thromboembolism during both active treatment and simultaneous/palliative care. Tailored approaches based on the use of individualized factors to stratify the thrombotic/bleeding risk in each individual patient are discussed.

multiple myeloma --- venous thromboembolism --- risk assessment models --- thromboprophylaxis --- direct oral anticoagulants --- cancer-associated venous thromboembolism --- thrombosis --- pulmonary embolism --- neoplasms --- anticoagulants --- coumarins --- low molecular weight heparins --- cancer --- endogenous heparin --- heparanase --- heparan sulfate --- hospice --- palliative care units --- low molecular weight heparin --- deep vein thrombosis --- cancer associated thrombosis --- VTE --- malignancy --- direct oral anticoagulant --- pancreatic cancer --- low-molecular weight heparin --- survival --- coagulation activation --- locally advanced breast cancer --- prognostic model --- pCR --- treatment --- prophylaxis --- DOAC --- simultaneous care --- integrated care --- lymphoma --- Non-Hodgkin lymphoma --- Hodgkin lymphoma --- risk factors --- molecular subtype --- arterial thrombosis --- ALK --- ROS1 --- KRAS --- chemotherapy --- low-molecular-weight heparin (LMWH) --- VKA --- UFH --- DOACs --- n/a

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• Reference Manager
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• RefWorks (Direct export to RefWorks)

Thromboembolism is a compelling challenge in cancer care because of its life-threatening nature as well as its impact on specific treatments. Current guidelines do not generally recommend antithrombotic prophylaxis, except in selected categories of patients at high risk of thrombosis. Accordingly, several clinical decision models have been developed to guide the oncologist in thromboembolic risk assessment and targeted prophylaxis. Low-molecular-weight heparins (LMWH) are currently considered as the standard approach in clinical practice guidelines, but recent randomized controlled trials (RCT) indicate that direct oral anticoagulants (DOACs) are effective for the treatment/prophylaxis of cancer-associated thromboembolism. However, many unanswered questions remain on the efficacy and safety of anticoagulants in selected cancer subgroups, and in primary and secondary prevention settings, where anticoagulation needs to be balanced on the risk of bleeding complications. Presently, patient selection remains the main challenge. Improvement in existing VTE risk models or the construction of alternative risk assessment tools are needed in order to ameliorate the risk stratification of cancer patients. This reprint will cover the current clinical evidence supporting the standard of care and emerging treatment/prophylactic options for cancer-associated thromboembolism during both active treatment and simultaneous/palliative care. Tailored approaches based on the use of individualized factors to stratify the thrombotic/bleeding risk in each individual patient are discussed.

Medicine --- Oncology --- multiple myeloma --- venous thromboembolism --- risk assessment models --- thromboprophylaxis --- direct oral anticoagulants --- cancer-associated venous thromboembolism --- thrombosis --- pulmonary embolism --- neoplasms --- anticoagulants --- coumarins --- low molecular weight heparins --- cancer --- endogenous heparin --- heparanase --- heparan sulfate --- hospice --- palliative care units --- low molecular weight heparin --- deep vein thrombosis --- cancer associated thrombosis --- VTE --- malignancy --- direct oral anticoagulant --- pancreatic cancer --- low-molecular weight heparin --- survival --- coagulation activation --- locally advanced breast cancer --- prognostic model --- pCR --- treatment --- prophylaxis --- DOAC --- simultaneous care --- integrated care --- lymphoma --- Non-Hodgkin lymphoma --- Hodgkin lymphoma --- risk factors --- molecular subtype --- arterial thrombosis --- ALK --- ROS1 --- KRAS --- chemotherapy --- low-molecular-weight heparin (LMWH) --- VKA --- UFH --- DOACs --- multiple myeloma --- venous thromboembolism --- risk assessment models --- thromboprophylaxis --- direct oral anticoagulants --- cancer-associated venous thromboembolism --- thrombosis --- pulmonary embolism --- neoplasms --- anticoagulants --- coumarins --- low molecular weight heparins --- cancer --- endogenous heparin --- heparanase --- heparan sulfate --- hospice --- palliative care units --- low molecular weight heparin --- deep vein thrombosis --- cancer associated thrombosis --- VTE --- malignancy --- direct oral anticoagulant --- pancreatic cancer --- low-molecular weight heparin --- survival --- coagulation activation --- locally advanced breast cancer --- prognostic model --- pCR --- treatment --- prophylaxis --- DOAC --- simultaneous care --- integrated care --- lymphoma --- Non-Hodgkin lymphoma --- Hodgkin lymphoma --- risk factors --- molecular subtype --- arterial thrombosis --- ALK --- ROS1 --- KRAS --- chemotherapy --- low-molecular-weight heparin (LMWH) --- VKA --- UFH --- DOACs

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The present special issue will lead you to discover the association between cerebrovascular events, cognitive impairment and atrial fibrillation, through update reviews and original articles exploring the pathophysiological mechanisms underpinning this association and describing the latest results in term of stroke prevention in AF. An interesting scientific journey that reflects the recent advances in pharmacological treatments and interventional procedures involving both mind and heart.

Medicine --- memory loss --- antioxidant --- neuroprotective --- acetylcholinesterase inhibitor --- molecular docking --- atrial --- fibrillation --- venous --- thrombosis --- anticoagulation --- perception --- chronic obstructive pulmonary disease --- atrial fibrillation --- cardiovascular risk --- outcome --- prognosis --- novel oral anticoagulants --- prosthetic valve replacement --- subclinical atrial fibrillation --- stroke --- ischemic cerebral events --- catheter ablation --- screening --- cognitive impairment --- atrial fibrillation ablation --- iatrogenic interatrial septum defect --- paradoxical embolism --- anticoagulant interruption --- cardioversion --- oral anticoagulation therapy --- left atrial appendage thrombosis --- transesophageal echocardiography --- IL1B --- IL1RN --- polymorphism --- inflammation --- cognitive decline --- rhythm control --- microbleeds --- cerebral ischemia --- diabetes mellitus --- metformin --- thiazolidinediones --- GLP-1 receptor agonists --- SGLT-2 inhibitors --- atrial high rate episodes --- NOACs --- non vitamin K oral anticoagulants --- oral anticoagulation --- intracerebral hemorrhage --- cerebral small vessel disease --- brain MRI --- circulating biomarkers --- direct oral anticoagulants (DOACs) --- atrial fibrillation (AF) --- electrical cardioversion (EC) --- surgical cryoablation --- left atrial function --- minimally invasive mitral valve repair --- echocardiography --- aneurysmal subarachnoid hemorrhage --- interdisciplinary setting --- metabolic syndrome --- obesity --- dementia --- memory loss --- antioxidant --- neuroprotective --- acetylcholinesterase inhibitor --- molecular docking --- atrial --- fibrillation --- venous --- thrombosis --- anticoagulation --- perception --- chronic obstructive pulmonary disease --- atrial fibrillation --- cardiovascular risk --- outcome --- prognosis --- novel oral anticoagulants --- prosthetic valve replacement --- subclinical atrial fibrillation --- stroke --- ischemic cerebral events --- catheter ablation --- screening --- cognitive impairment --- atrial fibrillation ablation --- iatrogenic interatrial septum defect --- paradoxical embolism --- anticoagulant interruption --- cardioversion --- oral anticoagulation therapy --- left atrial appendage thrombosis --- transesophageal echocardiography --- IL1B --- IL1RN --- polymorphism --- inflammation --- cognitive decline --- rhythm control --- microbleeds --- cerebral ischemia --- diabetes mellitus --- metformin --- thiazolidinediones --- GLP-1 receptor agonists --- SGLT-2 inhibitors --- atrial high rate episodes --- NOACs --- non vitamin K oral anticoagulants --- oral anticoagulation --- intracerebral hemorrhage --- cerebral small vessel disease --- brain MRI --- circulating biomarkers --- direct oral anticoagulants (DOACs) --- atrial fibrillation (AF) --- electrical cardioversion (EC) --- surgical cryoablation --- left atrial function --- minimally invasive mitral valve repair --- echocardiography --- aneurysmal subarachnoid hemorrhage --- interdisciplinary setting --- metabolic syndrome --- obesity --- dementia