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Several species of Dinophysis produce one or two groups of lipophilic toxins: okadaic acid (OA) and its derivatives; or the dinophysistoxins (DTXs) (also known as diarrhetic shellfish poisons or DSP toxins) and pectenotoxins (PTXs). DSP toxins are potent inhibitors of protein phosphatases, causing gastrointestinal intoxication in consumers of contaminated seafood. Forty years after the identification of Dinophysis as the causative agent of DSP in Japan, contamination of filter feeding shellfish exposed to Dinophysis blooms is recognized as a problem worldwide. DSP events affect public health and cause considerable losses to the shellfish industry. Costly monitoring programs are implemented in regions with relevant shellfish production to prevent these socioeconomic impacts. Harvest closures are enforced whenever toxin levels exceed regulatory limits (RLs). Dinophysis species are kleptoplastidic dinoflagellates; they feed on ciliates (Mesodinium genus) that have previously acquired plastids from cryptophycean (genera Teleaulax, Plagioselmis, and Geminigera) nanoflagellates. The interactions of Dinophysis with different prey regulate their growth and toxin production. When Dinophysis cells are ingested by shellfish, their toxins are partially biotransformed and bioaccumulated, rendering the shellfish unsuitable for human consumption. DSP toxins may also affect shellfish metabolism. This book covers diverse aspects of the abovementioned topics—from the laboratory culture of Dinophysis and the kinetics of uptake, transformation, and depuration of DSP toxins in shellfish to Dinophysis population dynamics, the monitoring and regulation of DSP toxins, and their impact on the shellfish industry in some of the aquaculture regions that are traditionally most affected, namely, northeastern Japan, western Europe, southern Chile, and New Zealand.

WitOMI analysis --- n/a --- DST accumulation --- mussel --- dinophysistoxins --- depuration --- human health --- pectenotoxins (PTXs) --- cryptophytes --- Mesodinium --- dinophysis --- compartmentalization --- resistance --- Japanese scallop --- surf clam --- HAB monitoring --- toxins --- organic matter --- OMI analysis --- PTXs --- time-series --- Diarrhetic shellfish toxins --- predator-prey preferences --- immunity --- okadaic acid --- physical–biological interactions --- defense --- digestion --- Dinophysis --- harmful algal blooms --- pectenotoxin --- El Niño Southern Oscillation --- lysate --- suspended particulate matter (SPM) --- D. caudata --- mixotrophic cultures --- Mytilus galloprovincialis --- bivalves --- diarrhetic shellfish poisoning --- biotransformation --- Mesodinium cf. rubrum --- RNA-Seq --- DST esterification --- Mesodinium rubrum --- statistical analysis --- seasonality --- mass culture conditions --- D. acuminata-complex --- Argopecten purpuratus --- harmful algal bloom --- pipis (Plebidonax deltoides) --- DTX-2 --- Reloncaví Fjord --- pectenotoxins --- deep sequencing --- climatic anomaly --- Brazil --- qPCR --- high throughput sequencing --- DSP --- accumulation --- LC/MS/MS --- Protoceratium reticulatum --- shellfish toxicity --- transcriptomic response --- New Zealand --- blooms --- trophic transfer --- metabolism --- bacterial community --- kinetics --- marine biotoxins --- diarrhetic shellfish toxins --- bivalve shellfish --- Diarrhetic Shellfish Toxins (DST) --- diarrhetic shellfish toxins (DST) --- Scotland --- Dinophysis acuminata --- DSP toxins --- toxin accumulation --- Southern Annual Mode --- Diarrheic Shellfish Poisoning --- Dinophysis toxins --- OA --- marine toxins --- toxin vectors --- wild harvest --- Dinophysis acuta --- Sydney rock oyster (Saccostrea glomerata) --- Argopecten irradians --- dinophysistoxin --- Port Underwood --- aquaculture --- niche partitioning --- Dinoflagellates. --- Dinoflagellata --- Dinoflagellida --- Dinophyceae --- Dinophyta --- Pyrrophycophyta --- Pyrrophyta --- Phytoflagellates --- physical-biological interactions --- El Niño Southern Oscillation --- Reloncaví Fjord