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La cardiomyopathie hypertrophique correspond à la cardiopathie la plus prévalente chez le chat, incitant les vétérinaires à accorder une importance particulière à sa gestion thérapeutique. Pourtant, une étude réalisée il y’a dix ans soulignait un déficit de littérature concernant l’approche médicale de cette pathologie, imposant aux vétérinaires de réaliser leur prise de décision pharmacothérapeutique sur base d’effets théoriques probablement bénéfiques, de leurs expériences personnelles favorables ou de simples transpositions d’effets bénéfiques observés chez l’homme ou chez le chien. Le but de ce travail est de dresser un nouvel état des lieux, dix ans plus tard, des avancées de la communauté scientifique concernant la prise en charge de cette pathologie très fréquente dans l’espèce féline.
Pour cela, nous commencerons par rappeler brièvement la pathophysiologie de cette maladie de façon à mettre en lumière les objectifs thérapeutiques et ainsi les familles pharmacologiques pouvant théoriquement être envisagées pour répondre à ceux-ci. Par la suite, nous passerons en revue la bibliographie relative à chacune de ces familles, en abordant pour chacune leur impact sur l’amélioration de la durée de vie et de la qualité de vie, puis nous soulèverons les questions relatives aux aspects pratiques de leur utilisation (possibilités d’optimisation de la compliance des propriétaires par le biais d’une adaptation de la posologie ou de la forme galénique). Enfin, nous conclurons en résumant les données disponibles au sein de la littérature et en proposant un schéma global de gestion thérapeutique pour chacun des stades de cette pathologie, incluant les aspects théoriques, bibliographiques et pratiques permettant d’optimiser la durée de vie et la qualité de vie des chats atteints de cardiomyopathie hypertrophique féline primaire. Hypertrophic cardiomyopathy is the most prevalent cardiac disease in cats, prompting veterinarians to take a close look at its therapeutic management. A study carried out ten years ago revealed however an important lack of information in the scientific literature concerning the medical approach of this pathology. This deficiency left veterinarians to rely solely on the supposedly positive effects of certain medicines, personal experience or extrapolations from human or dog therapy to make their pharmacotherapeutic decision when dealing with hypertrophic cardiomyopathy in cats. In this paper, we draw up the current state of play, ten years later, on the advances of the scientific community regarding the treatment of this frequent disease in feline species.
To achieve this, we will begin by briefly recalling the pathophysiology of this disease to highlight the therapeutic goals and pharmacological families that could be theoretically efficient in the case of hypertrophic cardiomyopathy. We will then make a review of the existing bibliography for each of these families by addressing their impact on the improvement of lifespan and quality of life, and by raising questions about the practicalities of their use (opportunities for optimizing the owners’ compliance through an adaptation of the dosage or the galenic formulation). Finally, we will conclude by summarizing the available data in the literature and we will suggest a comprehensive therapeutic management scheme for each stage of this pathology, including the theoretical, bibliographic and practical aspects allowing for the optimization of the lifespan and quality of life of cats with primary feline hypertrophic cardiomyopathy.

cardiomyopathie --- hypertrophique --- chat --- décompensation --- hypertrophic --- cardiomyopathy --- cat --- heart failure --- Sciences du vivant > Médecine vétérinaire & santé animale

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Heart Failure --- Congestive heart failure --- Heart Failure. --- Congestive Heart Failure --- Heart Failure, Congestive --- Heart Failure, Left-Sided --- Heart Failure, Right-Sided --- Left-Sided Heart Failure --- Myocardial Failure --- Right-Sided Heart Failure --- Cardiac Failure --- Heart Decompensation --- Decompensation, Heart --- Heart Failure, Left Sided --- Heart Failure, Right Sided --- Left Sided Heart Failure --- Right Sided Heart Failure --- Congestive heart failure. --- Heart failure

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Heart failure --- Heart Failure. --- Heart failure. --- Cardiac failure --- Cardiac insufficiency --- Failure, Heart --- Insufficiency, Cardiac --- Heart --- Cardiac arrest --- Congestive Heart Failure --- Heart Failure, Congestive --- Heart Failure, Left-Sided --- Heart Failure, Right-Sided --- Left-Sided Heart Failure --- Myocardial Failure --- Right-Sided Heart Failure --- Cardiac Failure --- Heart Decompensation --- Decompensation, Heart --- Heart Failure, Left Sided --- Heart Failure, Right Sided --- Left Sided Heart Failure --- Right Sided Heart Failure --- Diseases

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Heart failure --- Heart Failure. --- Heart failure. --- Cardiac failure --- Cardiac insufficiency --- Failure, Heart --- Insufficiency, Cardiac --- Heart --- Cardiac arrest --- Congestive Heart Failure --- Heart Failure, Congestive --- Heart Failure, Left-Sided --- Heart Failure, Right-Sided --- Left-Sided Heart Failure --- Myocardial Failure --- Right-Sided Heart Failure --- Cardiac Failure --- Heart Decompensation --- Decompensation, Heart --- Heart Failure, Left Sided --- Heart Failure, Right Sided --- Left Sided Heart Failure --- Right Sided Heart Failure --- Diseases --- heart failure --- cardiology --- cardiovascular research --- acute heart failure --- congenital heart disease --- arrhythmia --- Pathology of the circulatory system

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Heart failure --- Heart failure. --- Heart Failure --- Cardiac failure --- Cardiac insufficiency --- Failure, Heart --- Insufficiency, Cardiac --- Heart --- Cardiac arrest --- Congestive Heart Failure --- Heart Failure, Congestive --- Heart Failure, Left-Sided --- Heart Failure, Right-Sided --- Left-Sided Heart Failure --- Myocardial Failure --- Right-Sided Heart Failure --- Cardiac Failure --- Heart Decompensation --- Decompensation, Heart --- Heart Failure, Left Sided --- Heart Failure, Right Sided --- Left Sided Heart Failure --- Right Sided Heart Failure --- Diseases --- Periodicals. --- Heart Failure.