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On March 11, 2020, the World Health Organization declared COVID-19 a global pandemic and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 presents significant challenges to health systems and public health in both hemispheres as well as to the economies of each country. The morbidity and mortality due to infections caused by SARS-CoV-2 have been significant despite the short duration since its discovery and initially overwhelmed many hospitals and clinics. It influences everyone, and countermeasures have been dramatic in their impact on employment, social systems, and mental health. This Special Issue provides an avenue for authors from various disciplines to provide feedback on our responses and preparedness to COVID-19 globally as well as to disseminate critical information about the SARS-CoV-2 virus and the associated COVID-19 pandemic. It consists of 22 peer-reviewed papers that cover worldwide perspectives encompasses the following: Original articles about COVID-19 (including epidemiology, modelling, clinical data, treatment, prevention, countermeasures, impacts on tropical regions, response, and preparedness);Original articles about SARS-CoV-2 (microbiology, virology, transmission, pathology, and vaccinology);Perspectives about COVID-19 and SARS-CoV-2 (comparisons with past coronavirus outbreaks, impactful local initiatives, novel responses, and commentaries);Reviews on COVID-19 (based on systematic and narrative reviews);and Innovations (vaccine development, drug trials, and original countermeasures).

Medicine --- Environmental medicine --- COVID-19 --- SARS-CoV-2 --- hepatitis B and C --- cirrhosis --- chronic kidney disease --- alcohol-related liver disease --- nonalcoholic steatohepatitis --- necrosis --- MDR-TB --- clinical trials --- IL-6 inhibitors --- tocilizumab --- cytokine release syndrome --- cytokine storm --- operational research --- health systems --- SORT IT --- pandemics --- training --- pandemic --- endemic --- tuberculosis --- impact --- control --- overview --- malaria --- preparedness --- Africa --- emergency --- fecal calprotectin --- bowel perforation --- D-Dimer --- thrombosis --- ischemia --- efficacy --- safety --- kaletra --- lopinavir/ritonavir --- meta-analysis --- coronavirus --- SARS-CoV-1 --- MERS --- SARS --- influenza --- healthcare worker --- healthcare personnel --- general practitioners --- medical doctor --- heart transplant --- CMV --- Chagas disease --- infection --- severity --- respiratory viruses --- coinfections --- health care workers --- Philippines --- rhinovirus --- severe acute respiratory syndrome coronavirus 2 --- plasmodium falciparum --- differential diagnosis --- cognitive bias --- diagnostic reasoning --- recurrence --- reinfection --- Bangladesh --- Kenya --- Nairobi --- presumptive tuberculosis --- TB treatment outcomes --- HIV --- antiretroviral therapy --- EpiCollect5 --- Malawi --- Lilongwe --- Zimbabwe --- Harare --- real-time operational research --- ethics --- research capacity building --- India --- Nepal --- post-acute COVID-19 syndrome --- COVID-19 vaccines --- mortality --- epidemiology --- public health --- healthcare workers --- attitudes --- perceptions --- knowledge --- n/a

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• Reference Manager
• EndNote
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On March 11, 2020, the World Health Organization declared COVID-19 a global pandemic and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 presents significant challenges to health systems and public health in both hemispheres as well as to the economies of each country. The morbidity and mortality due to infections caused by SARS-CoV-2 have been significant despite the short duration since its discovery and initially overwhelmed many hospitals and clinics. It influences everyone, and countermeasures have been dramatic in their impact on employment, social systems, and mental health. This Special Issue provides an avenue for authors from various disciplines to provide feedback on our responses and preparedness to COVID-19 globally as well as to disseminate critical information about the SARS-CoV-2 virus and the associated COVID-19 pandemic. It consists of 22 peer-reviewed papers that cover worldwide perspectives encompasses the following: Original articles about COVID-19 (including epidemiology, modelling, clinical data, treatment, prevention, countermeasures, impacts on tropical regions, response, and preparedness);Original articles about SARS-CoV-2 (microbiology, virology, transmission, pathology, and vaccinology);Perspectives about COVID-19 and SARS-CoV-2 (comparisons with past coronavirus outbreaks, impactful local initiatives, novel responses, and commentaries);Reviews on COVID-19 (based on systematic and narrative reviews);and Innovations (vaccine development, drug trials, and original countermeasures).

COVID-19 --- SARS-CoV-2 --- hepatitis B and C --- cirrhosis --- chronic kidney disease --- alcohol-related liver disease --- nonalcoholic steatohepatitis --- necrosis --- MDR-TB --- clinical trials --- IL-6 inhibitors --- tocilizumab --- cytokine release syndrome --- cytokine storm --- operational research --- health systems --- SORT IT --- pandemics --- training --- pandemic --- endemic --- tuberculosis --- impact --- control --- overview --- malaria --- preparedness --- Africa --- emergency --- fecal calprotectin --- bowel perforation --- D-Dimer --- thrombosis --- ischemia --- efficacy --- safety --- kaletra --- lopinavir/ritonavir --- meta-analysis --- coronavirus --- SARS-CoV-1 --- MERS --- SARS --- influenza --- healthcare worker --- healthcare personnel --- general practitioners --- medical doctor --- heart transplant --- CMV --- Chagas disease --- infection --- severity --- respiratory viruses --- coinfections --- health care workers --- Philippines --- rhinovirus --- severe acute respiratory syndrome coronavirus 2 --- plasmodium falciparum --- differential diagnosis --- cognitive bias --- diagnostic reasoning --- recurrence --- reinfection --- Bangladesh --- Kenya --- Nairobi --- presumptive tuberculosis --- TB treatment outcomes --- HIV --- antiretroviral therapy --- EpiCollect5 --- Malawi --- Lilongwe --- Zimbabwe --- Harare --- real-time operational research --- ethics --- research capacity building --- India --- Nepal --- post-acute COVID-19 syndrome --- COVID-19 vaccines --- mortality --- epidemiology --- public health --- healthcare workers --- attitudes --- perceptions --- knowledge --- n/a

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Phytotherapy is probably the oldest form of medicine; however, it represents a new therapeutic tool for healthcare workers. Indeed plants are an infinite source of novel molecules, with countless possible combinations. This collection of articles (a Special Issue from Molecules) brings together the most up-to-date studies on the use of plant-derived compounds, ranging from their anti-inflammatory, antioxidant, and anticancer effects to the revision of the prominent literature.

Medicine --- natural products --- phenylpropanoids --- phenolic acids --- plants --- depression --- behavioral disorders --- forced swim test --- tail suspension test --- anti-cancer activities --- multifloroside --- 10-oxyderivatives of oleoside secoiridoids --- structure-activity relationship --- flow cytometry --- epigallocatechin-3-gallate --- EGCG --- catechin --- green tea --- cancer preventive --- pharmacological activities --- Amelanchier alnifolia Nutt. --- carriers --- powders --- bioactive compounds --- functional food --- Ageratina havanensis --- flavonoids --- UPLC-ESI-MS/MS --- P-glycoprotein --- antioxidant potential --- nootkatone --- anti-inflammatory --- acute inflammation --- granuloma --- Pharbitis nil --- colorectal cancer --- KRAS --- muscle function --- juglone --- NLRP3 inflammasome --- caspase-1 --- IL-1β --- IL-18 --- plant secondary metabolites --- natural compounds --- biological activity --- phytochemistry --- pharmacological activity --- plant side effects --- Talisia esculenta --- Brosimum gaudichaudii --- Genipa americana --- Bromelia antiacantha --- RA-3 --- nephrotoxicity --- triterpene --- antioxidant --- hyperuricemia --- Hibiscus acetosella --- phenolic compound --- antibacterial --- UPLC --- Tabebuia impetiginosa --- Taheebo --- traditional uses --- immunopharmacology --- immunological disorders --- hesperidin --- new-clean process extraction --- nanocrystals --- anti-ageing --- zingerone --- lipopolysaccharide --- inflammation --- anti-oxidant --- cytokine storm --- procalcitonin --- histopathology --- doxorubicin --- Mahonia aquifolium --- matrix metalloproteinases --- cytotoxicity --- human lung adenocarcinoma --- natural products --- phenylpropanoids --- phenolic acids --- plants --- depression --- behavioral disorders --- forced swim test --- tail suspension test --- anti-cancer activities --- multifloroside --- 10-oxyderivatives of oleoside secoiridoids --- structure-activity relationship --- flow cytometry --- epigallocatechin-3-gallate --- EGCG --- catechin --- green tea --- cancer preventive --- pharmacological activities --- Amelanchier alnifolia Nutt. --- carriers --- powders --- bioactive compounds --- functional food --- Ageratina havanensis --- flavonoids --- UPLC-ESI-MS/MS --- P-glycoprotein --- antioxidant potential --- nootkatone --- anti-inflammatory --- acute inflammation --- granuloma --- Pharbitis nil --- colorectal cancer --- KRAS --- muscle function --- juglone --- NLRP3 inflammasome --- caspase-1 --- IL-1β --- IL-18 --- plant secondary metabolites --- natural compounds --- biological activity --- phytochemistry --- pharmacological activity --- plant side effects --- Talisia esculenta --- Brosimum gaudichaudii --- Genipa americana --- Bromelia antiacantha --- RA-3 --- nephrotoxicity --- triterpene --- antioxidant --- hyperuricemia --- Hibiscus acetosella --- phenolic compound --- antibacterial --- UPLC --- Tabebuia impetiginosa --- Taheebo --- traditional uses --- immunopharmacology --- immunological disorders --- hesperidin --- new-clean process extraction --- nanocrystals --- anti-ageing --- zingerone --- lipopolysaccharide --- inflammation --- anti-oxidant --- cytokine storm --- procalcitonin --- histopathology --- doxorubicin --- Mahonia aquifolium --- matrix metalloproteinases --- cytotoxicity --- human lung adenocarcinoma