Narrow your search

Library

FARO (3)

KU Leuven (3)

LUCA School of Arts (3)

Odisee (3)

Thomas More Kempen (3)

Thomas More Mechelen (3)

UCLL (3)

ULiège (3)

VIVES (3)

Vlaams Parlement (3)

More...

Resource type

book (6)


Language

English (6)


Year
From To Submit

2022 (1)

2021 (5)

Listing 1 - 6 of 6
Sort by

Book
Paediatric Formulation: Design and Development
Authors: ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.

Keywords

Medicine --- dasatinib --- Duchenne muscular dystrophy --- cyclodextrin inclusion complex --- phase solubility studies --- paediatric age --- liquid formulation --- tumorspheres --- retinoblastoma --- topotecan --- penetration --- confocal microscopy --- poorly water soluble drug --- solubility enhancement --- grinding --- spray congealing --- neglected tropical diseases --- polymorph --- Norvir® --- ritonavir --- poorly soluble compound --- pediatric --- palatability assessment --- bioavailability --- flavor profile --- Interleukin-1 --- anakinra --- canakinumab --- innovative biotechnologies --- autoinflammatory disease --- Kawasaki disease --- systemic juvenile idiopathic arthritis --- personalized medicine --- child --- pediatrics --- neonates --- formulation --- product development --- formulation development --- oral --- parenteral --- topical --- inhaled --- intra nasal --- biopharmaceutics --- administration --- excipient --- NICU --- device --- medication error --- dosage form --- modified release --- drug delivery --- paediatric formulation development --- paediatric dosage forms --- chronic myeloid leukemia --- tyrosine kinase inhibitors --- pediatric age --- imatinib --- nilotinb --- ponatinib --- Orodispersible formulation --- pyrazinamide --- pediatric drug delivery --- tuberculosis --- design of experiments --- children --- edible films --- development --- design --- paediatric --- age-related --- palatable --- taste-masking --- acceptable --- dasatinib --- Duchenne muscular dystrophy --- cyclodextrin inclusion complex --- phase solubility studies --- paediatric age --- liquid formulation --- tumorspheres --- retinoblastoma --- topotecan --- penetration --- confocal microscopy --- poorly water soluble drug --- solubility enhancement --- grinding --- spray congealing --- neglected tropical diseases --- polymorph --- Norvir® --- ritonavir --- poorly soluble compound --- pediatric --- palatability assessment --- bioavailability --- flavor profile --- Interleukin-1 --- anakinra --- canakinumab --- innovative biotechnologies --- autoinflammatory disease --- Kawasaki disease --- systemic juvenile idiopathic arthritis --- personalized medicine --- child --- pediatrics --- neonates --- formulation --- product development --- formulation development --- oral --- parenteral --- topical --- inhaled --- intra nasal --- biopharmaceutics --- administration --- excipient --- NICU --- device --- medication error --- dosage form --- modified release --- drug delivery --- paediatric formulation development --- paediatric dosage forms --- chronic myeloid leukemia --- tyrosine kinase inhibitors --- pediatric age --- imatinib --- nilotinb --- ponatinib --- Orodispersible formulation --- pyrazinamide --- pediatric drug delivery --- tuberculosis --- design of experiments --- children --- edible films --- development --- design --- paediatric --- age-related --- palatable --- taste-masking --- acceptable


Book
Natural Polymers and Biopolymers II
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

BioPolymers could be either natural polymers – polymer naturally occurring in Nature, such as cellulose or starch…, or biobased polymers that are artificially synthesized from natural resources. Since the late 1990s, the polymer industry has faced two serious problems: global warming and anticipation of limitation to the access to fossil resources. One solution consists in the use of sustainable resources instead of fossil-based resources. Hence, biomass feedstocks are a promising resource and biopolymers are one of the most dynamic polymer area. Additionally, biodegradability is a special functionality conferred to a material, bio-based or not. Very recently, facing the awareness of the volumes of plastic wastes, biodegradable polymers are gaining increasing attention from the market and industrial community. This special issue of Molecules deals with the current scientific and industrial challenges of Natural and Biobased Polymers, through the access of new biobased monomers, improved thermo-mechanical properties, and by substitution of harmful substances. This themed issue can be considered as collection of highlights within the field of Natural Polymers and Biobased Polymers which clearly demonstrate the increased interest in this field. We hope that this will inspire researchers to further develop this area and thus contribute to futures more sustainable society.”

Keywords

Research & information: general --- imine --- epoxide --- amine --- thermoset --- bio-based --- biobased epoxy --- cardanol --- cationic photocuring --- microfibrillated cellulose --- biobased composites --- sustainable materials --- biomass --- green chemistry --- mechanims --- humins --- epoxy resins --- thermosets --- kinetics --- ring-opening --- biobased --- polyurethane foam --- catalyst --- polycarbonates --- furan-maleimide --- Diels-Alder --- fatty acids --- melt extrusion --- 3D printing --- cellulose nanofibrils --- biocomposite filaments --- physical property --- drained and undrained peatlands --- peats --- humic acids --- thermal --- paramagnetic and optical properties --- acetylated starch --- etherified starch --- chemical composition --- macromolecular characteristics --- surface characterization --- lignin --- fractionation --- biobased polymers --- solvent extraction --- membrane-assisted ultrafiltration --- plant oil-based monomers --- mixed micelles --- methyl-β-cyclodextrin inclusion complex --- emulsion polymerization --- nanocellulose --- polymer --- coating --- textile --- adhesion --- biobased monomer --- photoinduced-polymerization --- eugenol-derived methacrylate --- bacterial cellulose --- alginate --- gelatin --- curcumin --- biomaterials --- chitosan --- silane coupling agent --- microfiber --- crosslinking --- mechanical strength --- block copolymers --- renewable resources --- RAFT --- alkyl lactate --- PSA --- terpenoid --- exo-methylene --- conjugated diene --- renewable monomer --- biobased polymer --- radical polymerization --- copolymerization --- living radical polymerization --- RAFT polymerization --- heat-resistant polymer --- n/a


Book
Natural Polymers and Biopolymers II
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

BioPolymers could be either natural polymers – polymer naturally occurring in Nature, such as cellulose or starch…, or biobased polymers that are artificially synthesized from natural resources. Since the late 1990s, the polymer industry has faced two serious problems: global warming and anticipation of limitation to the access to fossil resources. One solution consists in the use of sustainable resources instead of fossil-based resources. Hence, biomass feedstocks are a promising resource and biopolymers are one of the most dynamic polymer area. Additionally, biodegradability is a special functionality conferred to a material, bio-based or not. Very recently, facing the awareness of the volumes of plastic wastes, biodegradable polymers are gaining increasing attention from the market and industrial community. This special issue of Molecules deals with the current scientific and industrial challenges of Natural and Biobased Polymers, through the access of new biobased monomers, improved thermo-mechanical properties, and by substitution of harmful substances. This themed issue can be considered as collection of highlights within the field of Natural Polymers and Biobased Polymers which clearly demonstrate the increased interest in this field. We hope that this will inspire researchers to further develop this area and thus contribute to futures more sustainable society.”

Keywords

imine --- epoxide --- amine --- thermoset --- bio-based --- biobased epoxy --- cardanol --- cationic photocuring --- microfibrillated cellulose --- biobased composites --- sustainable materials --- biomass --- green chemistry --- mechanims --- humins --- epoxy resins --- thermosets --- kinetics --- ring-opening --- biobased --- polyurethane foam --- catalyst --- polycarbonates --- furan-maleimide --- Diels-Alder --- fatty acids --- melt extrusion --- 3D printing --- cellulose nanofibrils --- biocomposite filaments --- physical property --- drained and undrained peatlands --- peats --- humic acids --- thermal --- paramagnetic and optical properties --- acetylated starch --- etherified starch --- chemical composition --- macromolecular characteristics --- surface characterization --- lignin --- fractionation --- biobased polymers --- solvent extraction --- membrane-assisted ultrafiltration --- plant oil-based monomers --- mixed micelles --- methyl-β-cyclodextrin inclusion complex --- emulsion polymerization --- nanocellulose --- polymer --- coating --- textile --- adhesion --- biobased monomer --- photoinduced-polymerization --- eugenol-derived methacrylate --- bacterial cellulose --- alginate --- gelatin --- curcumin --- biomaterials --- chitosan --- silane coupling agent --- microfiber --- crosslinking --- mechanical strength --- block copolymers --- renewable resources --- RAFT --- alkyl lactate --- PSA --- terpenoid --- exo-methylene --- conjugated diene --- renewable monomer --- biobased polymer --- radical polymerization --- copolymerization --- living radical polymerization --- RAFT polymerization --- heat-resistant polymer --- n/a


Book
Paediatric Formulation: Design and Development
Authors: ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.


Book
Natural Polymers and Biopolymers II
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

BioPolymers could be either natural polymers – polymer naturally occurring in Nature, such as cellulose or starch…, or biobased polymers that are artificially synthesized from natural resources. Since the late 1990s, the polymer industry has faced two serious problems: global warming and anticipation of limitation to the access to fossil resources. One solution consists in the use of sustainable resources instead of fossil-based resources. Hence, biomass feedstocks are a promising resource and biopolymers are one of the most dynamic polymer area. Additionally, biodegradability is a special functionality conferred to a material, bio-based or not. Very recently, facing the awareness of the volumes of plastic wastes, biodegradable polymers are gaining increasing attention from the market and industrial community. This special issue of Molecules deals with the current scientific and industrial challenges of Natural and Biobased Polymers, through the access of new biobased monomers, improved thermo-mechanical properties, and by substitution of harmful substances. This themed issue can be considered as collection of highlights within the field of Natural Polymers and Biobased Polymers which clearly demonstrate the increased interest in this field. We hope that this will inspire researchers to further develop this area and thus contribute to futures more sustainable society.”

Keywords

Research & information: general --- imine --- epoxide --- amine --- thermoset --- bio-based --- biobased epoxy --- cardanol --- cationic photocuring --- microfibrillated cellulose --- biobased composites --- sustainable materials --- biomass --- green chemistry --- mechanims --- humins --- epoxy resins --- thermosets --- kinetics --- ring-opening --- biobased --- polyurethane foam --- catalyst --- polycarbonates --- furan-maleimide --- Diels-Alder --- fatty acids --- melt extrusion --- 3D printing --- cellulose nanofibrils --- biocomposite filaments --- physical property --- drained and undrained peatlands --- peats --- humic acids --- thermal --- paramagnetic and optical properties --- acetylated starch --- etherified starch --- chemical composition --- macromolecular characteristics --- surface characterization --- lignin --- fractionation --- biobased polymers --- solvent extraction --- membrane-assisted ultrafiltration --- plant oil-based monomers --- mixed micelles --- methyl-β-cyclodextrin inclusion complex --- emulsion polymerization --- nanocellulose --- polymer --- coating --- textile --- adhesion --- biobased monomer --- photoinduced-polymerization --- eugenol-derived methacrylate --- bacterial cellulose --- alginate --- gelatin --- curcumin --- biomaterials --- chitosan --- silane coupling agent --- microfiber --- crosslinking --- mechanical strength --- block copolymers --- renewable resources --- RAFT --- alkyl lactate --- PSA --- terpenoid --- exo-methylene --- conjugated diene --- renewable monomer --- biobased polymer --- radical polymerization --- copolymerization --- living radical polymerization --- RAFT polymerization --- heat-resistant polymer --- imine --- epoxide --- amine --- thermoset --- bio-based --- biobased epoxy --- cardanol --- cationic photocuring --- microfibrillated cellulose --- biobased composites --- sustainable materials --- biomass --- green chemistry --- mechanims --- humins --- epoxy resins --- thermosets --- kinetics --- ring-opening --- biobased --- polyurethane foam --- catalyst --- polycarbonates --- furan-maleimide --- Diels-Alder --- fatty acids --- melt extrusion --- 3D printing --- cellulose nanofibrils --- biocomposite filaments --- physical property --- drained and undrained peatlands --- peats --- humic acids --- thermal --- paramagnetic and optical properties --- acetylated starch --- etherified starch --- chemical composition --- macromolecular characteristics --- surface characterization --- lignin --- fractionation --- biobased polymers --- solvent extraction --- membrane-assisted ultrafiltration --- plant oil-based monomers --- mixed micelles --- methyl-β-cyclodextrin inclusion complex --- emulsion polymerization --- nanocellulose --- polymer --- coating --- textile --- adhesion --- biobased monomer --- photoinduced-polymerization --- eugenol-derived methacrylate --- bacterial cellulose --- alginate --- gelatin --- curcumin --- biomaterials --- chitosan --- silane coupling agent --- microfiber --- crosslinking --- mechanical strength --- block copolymers --- renewable resources --- RAFT --- alkyl lactate --- PSA --- terpenoid --- exo-methylene --- conjugated diene --- renewable monomer --- biobased polymer --- radical polymerization --- copolymerization --- living radical polymerization --- RAFT polymerization --- heat-resistant polymer


Book
Strategies to Improve Antineoplastic Activity of Drugs in Cancer Progression
Author:
ISBN: 3036559272 3036559280 Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

Loading...
Export citation

Choose an application

Bookmark

Abstract

The aim of this Special Issue is to collect reports regarding all the recent strategies, directed at the improvement of antineoplastic activity of drugs in cancer progression, engaging all the expertise needed for the development of new anticancer drugs: medicinal chemistry, pharmacology, molecular biology, and computational and drug delivery studies.

Keywords

Research & information: general --- Biology, life sciences --- EGR-1 --- flavonoid --- (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile --- MDA-MB-231 --- MMP9 --- TNFα --- pancreatic ductal adenocarcinoma --- cyclodextrin inclusion complex --- phase solubility studies --- preformulation studies --- biphenylnicotinamide derivatives --- dual inhibitor --- EGFR --- VEGFR2 --- ligand-based pharmacophore --- molecular docking --- molecular dynamics --- leukemias --- doxorubicin --- inflammation --- drug delivery --- tumor targeting --- elastin-like polypeptide --- cell penetrating peptide --- matrix metalloproteinase --- doxorubicin resistance --- photosensitizer delivery system --- PAMAM dendrimer --- photodynamic therapy --- cytotoxicity --- phototoxicity --- colorectal adenocarcinoma --- dicarboximides --- chemical synthesis --- apoptosis --- kinases --- anticancer --- gene profiling --- SAR --- biomarkers --- colorectal cancer --- early detection examination --- liquid biopsy --- personalized medicine --- tumor treatment --- exosomes --- ctDNA --- CTC --- cytotoxic activity --- pyrazole derivatives --- MTT assay --- ADMET analysis --- single-crystal diffraction --- FTIR spectroscopy --- NMR spectroscopy thermogravimetric analysis --- acute myelogenous leukemia --- platelets --- microparticles --- γδ T cells --- immunotherapy --- tumor resistance --- combination therapy --- tumor microenvironment --- immune checkpoint inhibitor --- neuroblastoma --- molecular iodine --- cyclophosphamide --- xenografts --- metronomic therapy --- tamoxifen --- CYP2D6 --- MCF-7 --- Ishikawa cells --- SERM --- TNBC --- uterotrophic --- α-mangostin --- poly(amidoamine) dendrimer --- targeted drug delivery --- biotin targeting --- glioblastoma multiforme --- squamous cell carcinoma --- antiparasitic therapy --- diclofenac --- indomethacin --- oleanolic acid derivative conjugates --- NF-κB --- Nrf2 --- MAPKs --- PSN-1 cells --- reactive oxygen species --- glioblastoma --- brain tumor --- extracellular vesicles --- pancreatic cancer --- paclitaxel --- clathrin --- endocytosis --- sulforaphane --- nicotine --- metalloproteinase-9 --- gastric cancer --- cell invasion --- Arylquin 1 --- colon cancer --- tumor progression --- azelastine --- oxidative stress --- autophagy --- mitotic catastrophe --- chronic myeloid leukemia --- imatinib --- tyrosine kinase --- ketoconazole --- P-glycoprotein --- drug efflux transporter --- non-small-cell lung cancer --- cisplatin resistance --- aldehyde dehydrogenase --- isothiocyanates --- disulfiram --- epithelial to mesenchymal transition --- aminopeptidase N --- acetamidophenones --- Schiff bases --- semicarbazones --- thiosemicarbazones --- inhibition of proliferation

Listing 1 - 6 of 6
Sort by