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Le but de ce travail est d’étudier et d’analyser les différents éléments à considérer pour
l’élaboration d’une ou de plusieurs stratégie(s) marketing et commerciale(s) en fonction du ou
des marché(s) ciblé(s). Ce travail étudie ces éléments pour le projet Noeud-Pap’.

bow tie --- acrylic glas --- acrylic glas bow ties --- personnalisation --- customized product --- B2B strategy --- B2C strategy --- product launch --- product commercialization --- Sciences économiques & de gestion > Marketing

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This Special Issue book covers a wide scope in the research field of 3D-printing, including: the use of 3D printing in system design; AM with binding jetting; powder manufacturing technologies in 3D printing; fatigue performance of additively manufactured metals, such as the Ti-6Al-4V alloy; 3D-printing methods with metallic powder and a laser-based 3D printer; 3D-printed custom-made implants; laser-directed energy deposition (LDED) process of TiC-TMC coatings; Wire Arc Additive Manufacturing; cranial implant fabrication without supports in electron beam melting (EBM) additive manufacturing; the influence of material properties and characteristics in laser powder bed fusion; Design For Additive Manufacturing (DFAM); porosity evaluation of additively manufactured parts; fabrication of coatings by laser additive manufacturing; laser powder bed fusion additive manufacturing; plasma metal deposition (PMD); as-metal-arc (GMA) additive manufacturing process; and spreading process maps for powder-bed additive manufacturing derived from physics model-based machine learning.

Technology: general issues --- History of engineering & technology --- powder-bed additive manufacturing (AM) --- powder spreading --- spreading process map --- discrete element method (DEM) --- machine learning --- GMA additive manufacturing --- weld reinforcement --- visual features --- neural network --- selective laser melting --- magnesium alloys --- properties --- plasma metal deposition --- additive manufacturing --- 316L --- processing conditions --- mechanical properties --- microstructure --- virgin --- recycled --- metal powders --- laser powder bed fusion --- laser additive manufacturing --- 316l ss --- nickel alloy --- tribological behavior --- porosity --- rough surface --- ultrasonic testing --- convolutional neural network --- deep neural network --- multi-layer perceptron --- key performance indicators --- topology optimization --- design for additive manufacturing --- design for additive manufacturing services --- selective laser melting (SLM) --- laser powder bed fusion (LPBF) --- powder --- particle size distribution --- particle morphology --- powder layer density --- part density --- flowability --- Hausner ratio --- electron beam melting --- customized implant --- cost analysis --- fitting accuracy --- cranial reconstruction --- thin wall manufacturing --- process modelling --- ultrasonic vibration --- laser directed energy deposition --- coating --- TiC-TMC --- extremity --- revision --- limb salvage surgery --- 3D printing --- customized --- implant --- powder metallurgy --- simulated body fluid --- biomaterial --- fatigue --- titanium --- direct laser deposition --- Inconel 625 --- parametrisation --- microhardness --- preheating --- binder jetting --- sand casting --- aluminum alloy --- corrosion --- pressure drop --- heat exchanger --- surface textures --- dimples --- drag reduction --- powder-bed additive manufacturing (AM) --- powder spreading --- spreading process map --- discrete element method (DEM) --- machine learning --- GMA additive manufacturing --- weld reinforcement --- visual features --- neural network --- selective laser melting --- magnesium alloys --- properties --- plasma metal deposition --- additive manufacturing --- 316L --- processing conditions --- mechanical properties --- microstructure --- virgin --- recycled --- metal powders --- laser powder bed fusion --- laser additive manufacturing --- 316l ss --- nickel alloy --- tribological behavior --- porosity --- rough surface --- ultrasonic testing --- convolutional neural network --- deep neural network --- multi-layer perceptron --- key performance indicators --- topology optimization --- design for additive manufacturing --- design for additive manufacturing services --- selective laser melting (SLM) --- laser powder bed fusion (LPBF) --- powder --- particle size distribution --- particle morphology --- powder layer density --- part density --- flowability --- Hausner ratio --- electron beam melting --- customized implant --- cost analysis --- fitting accuracy --- cranial reconstruction --- thin wall manufacturing --- process modelling --- ultrasonic vibration --- laser directed energy deposition --- coating --- TiC-TMC --- extremity --- revision --- limb salvage surgery --- 3D printing --- customized --- implant --- powder metallurgy --- simulated body fluid --- biomaterial --- fatigue --- titanium --- direct laser deposition --- Inconel 625 --- parametrisation --- microhardness --- preheating --- binder jetting --- sand casting --- aluminum alloy --- corrosion --- pressure drop --- heat exchanger --- surface textures --- dimples --- drag reduction

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With the advent of disruptive digital technologies, companies are facing unprecedented challenges and opportunities. Advanced manufacturing systems are of paramount importance in making key enabling technologies and new products more competitive, affordable, and accessible, as well as for fostering their economic and social impact. The manufacturing industry also serves as an innovator for sustainability since automation coupled with advanced manufacturing technologies have helped manufacturing practices transition into the circular economy. To that end, this Special Issue of the journal Applied Sciences, devoted to the broad field of Smart Sustainable Manufacturing Systems, explores recent research into the concepts, methods, tools, and applications for smart sustainable manufacturing, in order to advance and promote the development of modern and intelligent manufacturing systems. In light of the above, this Special Issue is a collection of the latest research on relevant topics and addresses the current challenging issues associated with the introduction of smart sustainable manufacturing systems. Various topics have been addressed in this Special Issue, which focuses on the design of sustainable production systems and factories; industrial big data analytics and cyberphysical systems; intelligent maintenance approaches and technologies for increased operating life of production systems; zero-defect manufacturing strategies, tools and methods towards online production management; and connected smart factories.

n/a --- sensitivity analysis --- customized demand --- dynamic supply chain design --- additive manufacturing --- sensor function --- deteriorating systems --- big data --- connected smart factories --- operations management --- kernel density estimation --- development --- efficiency --- hybrid laminate --- managerial commitment --- productivity benefits --- particle map --- pace --- car-sharing --- particle defect management --- case study --- quality --- semiconductor manufacturing process --- open innovation --- circular economy --- remanufacturing --- sustainability evaluation --- multi-usable cloud service platform --- knowledge-based engineering --- sustainable manufacturing --- Dempster–Shafer evidence theory --- Transport Sustainability Index --- Industry 4.0 --- knowledge management --- collective intelligence --- analytic hierarchy process --- TPM --- flexibility --- manufacturing process innovation --- data collection and analytics --- smart factory --- intelligent machining --- computer-aided innovation --- implementation --- improvement --- piezoceramic compound --- sheet metal forming --- production planning --- impact detection --- maintenance --- Dempster-Shafer evidence theory

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In the first contribution, Morbiducci and co-workers discuss the theoretical and methodological bases supporting the Lagrangian- and Euler-based methods, highlighting their application to cardiovascular flows. The second contribution, by the Ansón and van Lenthe groups, proposes an automated virtual bench test for evaluating the stability of custom shoulder implants without the necessity of mechanical testing. Urdeitx and Doweidar, in the third paper, also adopt the finite element method for developing a computational model aim to study cardiac cell behavior under mechano-electric stimulation. In the fourth contribution, Ayensa-Jiménez et al. develop a methodology to approximate the multidimensional probability density function of the parametric analysis obtained developing a mathematical model of the cancer evolution. The fifth paper is oriented to the topological data analysis; the group of Cueto and Chinesta designs a predictive model capable of estimating the state of drivers using the data collected from motion sensors. In the sixth contribution, the Ohayon and Finet group uses wall shear stress-derived descriptors to study the role of recirculation in the arterial restenosis due to different malapposed and overlapping stent conditions. In the seventh contribution, the research group of Antón demonstrates that the simulation time can be reduced for cardiovascular numerical analysis considering an adequate geometry-reduction strategy applicable to truncated patient specific artery. In the eighth paper, Grasa and Calvo present a numerical model based on the finite element method for simulating extraocular muscle dynamics. The ninth paper, authored by Kahla et al., presents a mathematical mechano-pharmaco-biological model for bone remodeling. Martínez, Peña, and co-workers propose in the tenth paper a methodology to calibrate the dissection properties of aorta layer, with the aim of providing useful information for reliable numerical tools. In the eleventh contribution, Martínez-Bocanegra et al. present the structural behavior of a foot model using a detailed finite element model. The twelfth contribution is centered on the methodology to perform a finite, element-based, numerical model of a hydroxyapatite 3D printed bone scaffold. In the thirteenth paper, Talygin and Gorodkov present analytical expressions describing swirling jets for cardiovascular applications. In the fourteenth contribution, Schenkel and Halliday propose a novel non-Newtonian particle transport model for red blood cells. Finally, Zurita et al. propose a parametric numerical tool for analyzing a silicone customized 3D printable trachea-bronchial prosthesis.

finite element analysis --- shoulder implant stability --- implant design --- reverse shoulder arthroplasty --- micromotion --- in-silico --- 3D model --- cardiac cell --- cardiac muscle tissue --- cardiomyocyte --- electrical stimulation --- copulas --- design of experiments --- glioblastoma multiforme --- mathematical modelling --- Morse theory --- topological data analysis --- machine learning --- time series --- smart driving --- fixed points --- manifolds --- divergence --- hemodynamics --- computational fluid dynamics --- overlap --- malapposition --- stent --- stenosis --- thrombosis --- radioembolization --- liver cancer --- hepatic artery --- computational cost analysis --- personalized medicine --- patient specific --- finite element method --- implicit FEM --- explicit FEM --- skeletal muscle --- biomechanics --- mathematical model --- cell dynamics --- bone physiology --- bone disorders --- aortic dissection --- delamination tests --- cohesive zone model --- porcine aorta --- vascular mechanics --- foot finite element method --- foot and ankle model --- shared nodes --- separated mesh --- plantar pressure --- finite element modelling --- bone tissue engineering --- 3D scaffold --- additive manufacturing --- potential swirling flow --- Navier–Stokes equations --- unsteady swirling flow --- tornado-like jets --- haemorheology --- blood flow modelling --- particle transport --- numerical fluid mechanics --- tracheobronchial stent --- parametric model --- 3D printing --- customized prosthesis

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America has a long history of drug panics in which countless social problems have been blamed on the devastating effects of some harmful substance. In the last forty years, such panics have often focused on synthetic or designer drugs, like methamphetamine, PCP, Ecstasy, methcathinone, and rave drugs like ketamine, and GHB. Fear of these substances has provided critical justification for the continuing "war on drugs." Synthetic Panics traces the history of these anti-drug movements, demonstrating that designer chemicals inspire so much fear not because they are uniquely dangerous, but because they bring into focus deeply rooted public concerns about social and cultural upheaval. Jenkins highlights the role of the mass media in spreading anti-drug hysteria and shows how proponents of the war on drugs use synthetic panics to scapegoat society's "others" and exacerbate racial, class, and intergenerational conflict.

Designer drugs --- Drug abuse --- Drug control --- Government policy --- Drug and Narcotic Control --- Designer Drugs --- Substance-Related Disorders --- Legislation, Drug --- Diseases --- Pharmacy Administration --- Mental Disorders --- Pharmaceutical Preparations --- Chemicals and Drugs --- Organization and Administration --- Social Control, Formal --- Legislation as Topic --- Psychiatry and Psychology --- Health Services Administration --- Sociology --- Social Sciences --- Health Care Economics and Organizations --- Health Care --- Anthropology, Education, Sociology and Social Phenomena --- Substance Abuse --- Social Welfare & Social Work --- Synthetic drugs of abuse --- Drugs --- Drugs of abuse --- Synthetic drugs --- Derivatives --- United States --- Prescription Drug Abuse --- Substance Addiction --- Drug Abuse --- Drug Addiction --- Drug Dependence --- Drug Habituation --- Drug Use Disorders --- Organic Mental Disorders, Substance-Induced --- Substance Dependence --- Substance Use Disorders --- Abuse, Drug --- Abuse, Prescription Drug --- Abuse, Substance --- Abuses, Substance --- Addiction, Drug --- Addiction, Substance --- Dependence, Drug --- Dependence, Substance --- Disorder, Drug Use --- Disorder, Substance Use --- Drug Abuse, Prescription --- Drug Use Disorder --- Habituation, Drug --- Organic Mental Disorders, Substance Induced --- Substance Abuses --- Substance Use Disorder --- Disruptive, Impulse Control, and Conduct Disorders --- Psychoses, Alcoholic --- Social Problems --- Illicit Drugs --- Behavior, Addictive --- Codependency, Psychological --- Alcohol-Related Disorders --- Prescription Drug Misuse --- Customized Drugs --- Drugs, Customized --- Drugs, Designer --- Drug Design --- Drug Control --- Narcotic and Drug Control --- Pharmaceutic Policy --- Drug Regulations --- Narcotic Control --- Pharmaceutical Policy --- Control, Drug --- Control, Narcotic --- Controls, Drug --- Controls, Narcotic --- Drug Controls --- Drug Regulation --- Narcotic Controls --- Pharmaceutical Policies --- Policies, Pharmaceutical --- Policy, Pharmaceutical --- Regulation, Drug --- Regulations, Drug --- E-books --- Chemical Dependence --- Substance Use --- Chemical Dependences --- Dependence, Chemical --- Dependences, Chemical --- Substance Uses --- Use, Substance --- Customized Drug --- Designer Drug --- Drug, Customized --- Drug, Designer --- Drogenpolitik --- Synthetische Droge --- Drug control. --- Drug abuse. --- Substance-Related Disorders. --- Designer Drugs. --- Drug and Narcotic Control. --- Abuse of substances --- Addictive behavior --- Chemical dependence --- Chemical dependency --- Substance addiction --- Substance dependence --- Substance-related disorders --- Substance use disorders --- Psychology, Pathological --- Government policy. --- USA. --- United States. --- Drug use --- Substance abuse --- Drug enforcement --- Drug law enforcement --- Drug policy --- Drug traffic --- Drug traffic control --- Narcotics, Control of --- War on drugs --- Vice control --- ABŞ --- ABSh --- Ameerika Ühendriigid --- America (Republic) --- Amerika Birlăshmish Shtatlary --- Amerika Birlăşmi Ştatları --- Amerika Birlăşmiş Ştatları --- Amerika ka Kelenyalen Jamanaw --- Amerika Qūrama Shtattary --- Amerika Qŭshma Shtatlari --- Amerika Qushma Shtattary --- Amerika (Republic) --- Amerikai Egyesült Államok --- Amerikanʹ Veĭtʹsėndi︠a︡vks Shtattnė --- Amerikări Pĕrleshu̇llĕ Shtatsem --- Amerikas Forenede Stater --- Amerikayi Miatsʻyal Nahangner --- Ameriketako Estatu Batuak --- Amirika Carékat --- AQSh --- Ar. ha-B. --- Arhab --- Artsot ha-Berit --- Artzois Ha'bris --- Bí-kok --- Ē.P.A. --- EE.UU. --- Egyesült Államok --- ĒPA --- Estados Unidos --- Estados Unidos da América do Norte --- Estados Unidos de América --- Estaos Xuníos --- Estaos Xuníos d'América --- Estatos Unitos --- Estatos Unitos d'America --- Estats Units d'Amèrica --- Ètats-Unis d'Amèrica --- États-Unis d'Amérique --- Fareyniḳṭe Shṭaṭn --- Feriene Steaten --- Feriene Steaten fan Amearika --- Forente stater --- FS --- Hēnomenai Politeiai Amerikēs --- Hēnōmenes Politeies tēs Amerikēs --- Hiwsisayin Amerikayi Miatsʻeal Tērutʻiwnkʻ --- Istadus Unidus --- Jungtinės Amerikos valstybės --- Mei guo --- Mei-kuo --- Meiguo --- Mî-koet --- Miatsʻyal Nahangner --- Miguk --- Na Stàitean Aonaichte --- NSA --- S.U.A. --- SAD --- Saharat ʻAmērikā --- SASht --- Severo-Amerikanskie Shtaty --- Severo-Amerikanskie Soedinennye Shtaty --- Si︠e︡vero-Amerikanskīe Soedinennye Shtaty --- Sjedinjene Američke Države --- Soedinennye Shtaty Ameriki --- Soedinennye Shtaty Severnoĭ Ameriki --- Soedinennye Shtaty Si︠e︡vernoĭ Ameriki --- Spojené staty americké --- SShA --- Stadoù-Unanet Amerika --- Stáit Aontaithe Mheiriceá --- Stany Zjednoczone --- Stati Uniti --- Stati Uniti d'America --- Stâts Unîts --- Stâts Unîts di Americhe --- Steatyn Unnaneysit --- Steatyn Unnaneysit America --- SUA (Stati Uniti d'America) --- Sŭedineni amerikanski shtati --- Sŭedinenite shtati --- Tetã peteĩ reko Amérikagua --- U.S. --- U.S.A. --- United States of America --- Unol Daleithiau --- Unol Daleithiau America --- Unuiĝintaj Ŝtatoj de Ameriko --- US --- USA --- Usono --- Vaeinigte Staatn --- Vaeinigte Staatn vo Amerika --- Vereinigte Staaten --- Vereinigte Staaten von Amerika --- Verenigde State van Amerika --- Verenigde Staten --- VS --- VSA --- Wááshindoon Bikéyah Ałhidadiidzooígíí --- Wilāyāt al-Muttaḥidah --- Wilāyāt al-Muttaḥidah al-Amirīkīyah --- Wilāyāt al-Muttaḥidah al-Amrīkīyah --- Yhdysvallat --- Yunaeted Stet --- Yunaeted Stet blong Amerika --- ZDA --- Združene države Amerike --- Zʹi︠e︡dnani Derz︠h︡avy Ameryky --- Zjadnośone staty Ameriki --- Zluchanyi︠a︡ Shtaty Ameryki --- Zlucheni Derz︠h︡avy --- ZSA --- Η.Π.Α. --- Ηνωμένες Πολιτείες της Αμερικής --- Америка (Republic) --- Американь Вейтьсэндявкс Штаттнэ --- Америкӑри Пӗрлешӳллӗ Штатсем --- САЩ --- Съединените щати --- Злучаныя Штаты Амерыкі --- ولايات المتحدة --- ولايات المتّحدة الأمريكيّة --- ولايات المتحدة الامريكية --- 미국 --- Spojené obce severoamerické --- Substance Related Disorder --- Disorder, Substance Related --- Disorders, Substance Related --- Related Disorder, Substance --- Related Disorders, Substance --- États-Unis --- É.-U. --- ÉU --- Designer Droge --- Designerdroge --- Partydroge --- Halluzinogen --- Suchtpolitik --- Prevention --- AB --- Amerikanʹ Veĭtʹsėndi͡avks Shtattn --- Saharat ʻAmērik --- Si͡evero-Amerikanskīe Soedinennye Shtaty --- Soedinennye Shtaty Si͡evernoĭ Ameriki --- Spojené obce severoamerick --- Spojené staty americk --- Stáit Aontaithe Mheirice --- SUA --- Wááshindoon Bikéyah Ałhidadiidzooígí --- Zʹi͡ednani Derz͡havy Ameryky --- Zluchanyi͡a Shtaty Ameryki --- Zlucheni Derz͡havy --- Amerikanʹ Veĭtʹsėndi͡avks Shtattnė