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This Special Issue is result of a call for papers of the Section Industrial Crystallization of MDPI’s scientific journal Crystals. It addresses scientists and engineers active in research and process & product development in life-science industries (e.g. pharmaceuticals, fine chemicals and biotechnology products) and bulk chemical applications (e.g. desalination) as well. The contributions comprise several fundamental and application-oriented facets of crystallization providing an overview of industrially relevant subjects in the field. Main issues cover phase equilibria and solid-state behavior of crystalline compounds, crystal shape and size and related measurement techniques. Melt and solution crystallization are considered specifically addressing contemporary aspects of continuous crystallization and process intensification.

K-MER zeolite --- synthesis parameter --- morphology --- cyanoethylation of methanol --- catalyst --- multi-dendrite motion --- CA-LBM model --- dendritic growth --- natural convection --- numerical simulation --- melt crystallization --- freeze crystallization (FC) --- recycling --- ionic liquid (IL) --- solid–liquid equilibrium --- cellulose --- nanocrystals --- modification --- poly(butylene succinate) --- crystallization --- kinetics --- chirality --- deracemization --- preferential crystallization --- racemic conglomerate --- phase behavior --- polymorphism --- aryl glycerol ethers --- spherical BaTiO3 nanoparticle --- hydrothermal synthesis --- nanoscale TiO2 seed --- crystal growth --- dielectric property --- curcumin --- purification --- ternary mixture of curcuminoids --- reverse osmosis --- membrane fouling --- gypsum scaling --- fluorescent-tagged polyacrylate --- fluorescence --- scale inhibition mechanisms --- solvent effect --- crystal habit --- aspect ratio --- molecular dynamics (MD) --- surface structure --- amine --- biocatalysis --- enzyme --- process intensification --- enantioselective --- fluidized bed --- continuous --- chiral separation --- racemate resolution --- enantiomer --- asparagine monohydrate --- fine chemicals --- continuous crystallization --- crystal shape --- process design --- DTB crystallizer --- scale up --- L-serine --- L-alanine --- enantiomers --- isomorphic miscibility --- thermal expansion --- PXRD --- TRPXRD --- optical measurement techniques --- crystal size measurement --- inline probe --- crystal needles --- microcrystals --- microplate --- grid scanning --- in situ data collection --- n/a --- solid-liquid equilibrium

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A total of 16 original research articles. Contributions from 10 countries from 3 continents. Organic synthesis towards novel heterocyclic compounds. Fully characterized inorganic and organic molecules including X-ray crystallographic analysis. Cyclization reactions, reactivity of aromatic compounds and improved synthetic methodologies of important intermediate compounds.

heterocycle --- piperazine --- pyrimidine --- DABCO --- nucleophilic displacement --- chlorination --- [1,3]-H shift --- aza-Michael addition --- DFT calculations --- dimethyl acetylenedicarboxylate --- isoxazolo[3,4-b]quinolin-3(1H)-one --- pyrazolines --- curcuminoids --- nitrogen heterocycles --- cytotoxic --- DNA binding --- MDR reversal --- oxygen-nitrogen heterocycles --- 11a,12-dihydrobenzo[b]benzo[5,6][1,4]oxazino[2,3-e][1,4]oxazine --- disulfur dichloride --- o-aminophenol --- condensation --- 4-anilino-quin(az)olines --- hinge binder --- conformational flexibility --- kinase inhibitor design --- imine --- Schiff base --- X-ray crystallographic analysis --- Cu(II) complex --- gamma-amino acid --- ruthenium --- carbonyl complex --- azopyridine --- anion radical --- electronic structure --- magnetic properties --- chalcogenophene --- heterocycles --- ligands --- pyridine derivatives --- thiophene derivatives --- aminocyclopentitol --- bicyclic aziridine --- water chemistry --- nucleophilic substitution --- homopiperazine --- X-ray structure --- C–C bond length --- 15N-NMR --- catechol --- alkyne --- thiol-alkyne click reaction --- domino reactions --- bromination --- intramolecular SN displacement --- carbocyclic hydantoins --- N-1 substituted hydantoin --- spiro hydantoins --- imidazolidine-2,4-diones --- stereochemistry --- NMR --- HRMS --- GIAO --- ring closing --- Au-nanoparticles --- NaBH4 --- amino-substituted fused oxazolocoumarin --- fused oxazolocoumarins --- chemoselective reduction --- o-hydroxynitrocoumarins --- benzimidazole --- nucleophilic aromatic substitution --- thiosemicarbazone --- n/a --- C-C bond length

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Throughout most of history, medicinal plants and their active metabolites have represented a valuable source of compounds used to prevent and to cure several diseases. Interest in natural compounds is still high as they represent a source of novel biologically/pharmacologically active compounds. Due to their high structural diversity and complexity, they are interesting structural scaffolds that can offer promising candidates for the study of new drugs, functional foods, and food additives.Plant extracts are a highly complex mixture of compounds and qualitative and quantitative analyses are necessary to ensure their quality. Furthermore, greener methods of extraction and analysis are needed today.This book is based on articles submitted for publication in the Special Issue entitled “Qualitative and Quantitative Analysis of Bioactive Natural Products” that collected original research and reviews on these topics.

Scorzonera --- capsaicinoids --- artificial neural network --- cerebral ischemia reperfusion injury --- antioxidant activity --- quality evaluation --- chemometrics --- secondary metabolites --- identification --- antioxidant capacity --- Moroccan region --- volatile compounds --- HPLC-Q-Exactive-Orbitrap-MS --- quantitative analysis --- amino acids content --- HPLC-ELSD --- antioxidant --- autophagy --- quantification --- sugars --- 1-triacontanol --- hemp seed oil --- Alzheimer’s disease --- macrodiolides --- extraction --- recycling preparative high performance liquid chromatography --- HPLC methods --- GC-MS --- Myristica fragrans --- Rossa da inverno sel. Rojo Duro onion cultivar --- fruit powders --- decursin --- food traceability --- ionic liquids --- separation optimisation --- Spondias spp. --- C-glycosylflavone --- wine --- UPLC-MS --- scutellarein --- saffron --- carotenoids --- red cabbage --- hydrodistillation --- Ginkgo biloba Extract (GBE) --- gas chromatography --- organic acids --- olive leaves --- crocins --- CBD oil --- Bolbostemma paniculatum --- UPLC-ESI-MS/MS --- geographical origin --- HPLC --- traditional Chinese medicine decoction --- liquid chromatography --- bioactive natural compounds --- Podospermum --- metabolic profiling --- SPME-GC/MS --- LTQ-Orbitrap --- oral administration --- UPLC --- bioactive compounds --- Erigeron breviscapus extract --- terrain conditions --- nutmeg --- antibacterial activity --- method validation --- ShenFu prescription decoction --- chili --- decursinol angelate --- statistical evaluations --- stereoselective and simultaneous analysis --- curcuminoids --- Talaromyces pinophilus --- talarodiolide --- HPLC-Q-TOF-MS/MS --- Olea europaea L. --- triterpenes --- chromatogram-bioactivity correlation --- essential oil --- stability --- Staphylococcus aureus --- Iris lactea Pall. var. chinensis (Fisch.) Koidz. --- endothelial function --- anthocyanins --- HPLC analysis --- liquid chromatography-mass spectrometry --- nodakenin --- turmerone --- UHPLC-MS/MS --- Quercus acuta leaf --- Curcuma longa --- UHPLC analysis --- ginseng berry extract --- geographical variation --- qualitative analysis --- Sorbus --- free radical-scavenging --- ginsenosides --- flavonoids --- biostimulant --- GC/MS --- terpenes --- aleuritolic acid --- phenolic compounds --- apoptosis --- response surface methodology --- phenolic acids --- pharmacokinetics --- mass spectrometry --- scutellarin --- multivariate statistical analysis --- phenolics --- MODDE experimental design --- proanthocyanidins --- UFLC-QQQ-MS --- rice --- cannabidiol --- odor-activity values --- UPLC-QTOF-MS --- turmeric --- decursinol

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Throughout most of history, medicinal plants and their active metabolites have represented a valuable source of compounds used to prevent and to cure several diseases. Interest in natural compounds is still high as they represent a source of novel biologically/pharmacologically active compounds. Due to their high structural diversity and complexity, they are interesting structural scaffolds that can offer promising candidates for the study of new drugs, functional foods, and food additives.Plant extracts are a highly complex mixture of compounds and qualitative and quantitative analyses are necessary to ensure their quality. Furthermore, greener methods of extraction and analysis are needed today.This book is based on articles submitted for publication in the Special Issue entitled “Qualitative and Quantitative Analysis of Bioactive Natural Products” that collected original research and reviews on these topics.

Scorzonera --- capsaicinoids --- artificial neural network --- cerebral ischemia reperfusion injury --- antioxidant activity --- quality evaluation --- chemometrics --- secondary metabolites --- identification --- antioxidant capacity --- Moroccan region --- volatile compounds --- HPLC-Q-Exactive-Orbitrap-MS --- quantitative analysis --- amino acids content --- HPLC-ELSD --- antioxidant --- autophagy --- quantification --- sugars --- 1-triacontanol --- hemp seed oil --- Alzheimer’s disease --- macrodiolides --- extraction --- recycling preparative high performance liquid chromatography --- HPLC methods --- GC-MS --- Myristica fragrans --- Rossa da inverno sel. Rojo Duro onion cultivar --- fruit powders --- decursin --- food traceability --- ionic liquids --- separation optimisation --- Spondias spp. --- C-glycosylflavone --- wine --- UPLC-MS --- scutellarein --- saffron --- carotenoids --- red cabbage --- hydrodistillation --- Ginkgo biloba Extract (GBE) --- gas chromatography --- organic acids --- olive leaves --- crocins --- CBD oil --- Bolbostemma paniculatum --- UPLC-ESI-MS/MS --- geographical origin --- HPLC --- traditional Chinese medicine decoction --- liquid chromatography --- bioactive natural compounds --- Podospermum --- metabolic profiling --- SPME-GC/MS --- LTQ-Orbitrap --- oral administration --- UPLC --- bioactive compounds --- Erigeron breviscapus extract --- terrain conditions --- nutmeg --- antibacterial activity --- method validation --- ShenFu prescription decoction --- chili --- decursinol angelate --- statistical evaluations --- stereoselective and simultaneous analysis --- curcuminoids --- Talaromyces pinophilus --- talarodiolide --- HPLC-Q-TOF-MS/MS --- Olea europaea L. --- triterpenes --- chromatogram-bioactivity correlation --- essential oil --- stability --- Staphylococcus aureus --- Iris lactea Pall. var. chinensis (Fisch.) Koidz. --- endothelial function --- anthocyanins --- HPLC analysis --- liquid chromatography-mass spectrometry --- nodakenin --- turmerone --- UHPLC-MS/MS --- Quercus acuta leaf --- Curcuma longa --- UHPLC analysis --- ginseng berry extract --- geographical variation --- qualitative analysis --- Sorbus --- free radical-scavenging --- ginsenosides --- flavonoids --- biostimulant --- GC/MS --- terpenes --- aleuritolic acid --- phenolic compounds --- apoptosis --- response surface methodology --- phenolic acids --- pharmacokinetics --- mass spectrometry --- scutellarin --- multivariate statistical analysis --- phenolics --- MODDE experimental design --- proanthocyanidins --- UFLC-QQQ-MS --- rice --- cannabidiol --- odor-activity values --- UPLC-QTOF-MS --- turmeric --- decursinol