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Over the years, there has been increasing interest into the public health impact of cannabis use, especially by young adults. This follows the evidence of a growing prevalence of regular cannabis use worldwide, with approximately 200 million users. Recreational cannabis use, especially a frequent use of products with high levels of its main psychoactive ingredient delta-9-tetrahydrocannabinol (Δ 9-THC), can cause dependence and have transient and long-lasting detrimental mental health effects, also negatively impacting cognitive processing and brain function and metabolism. In regular users, the development of tolerance to some of the effects of cannabis, especially the pleasurable ones, may lead to progressively heavier use in order to obtain the same effects in terms of their intensity, with higher health risks. However, the Cannabis Sativa plant contains different chemicals with different potential effects. In this regard, cannabidiol has gained interest because of its potential therapeutic properties, in line with evidence that CBD and Δ9-THC may exhibit opposite effects at the cannabinoid receptor type 1 (CB1), Δ9-THC being a partial agonist and CBD an antagonist/inverse agonist. Different cannabinoids may modulate human brain function and behavior in different ways, with different risk–benefit profiles.

delta-9-tetrahydrocannabinol --- placebo --- cannabis-associated psychosis --- schizophrenia --- BDNF --- CB1 --- CB2 --- episodic memory --- exercise --- African American --- black --- older adult --- marijuana use --- cannabis use disorder --- cue reactivity --- craving --- inhibitory control --- frontal alpha asymmetry --- EEG --- cannabinoids --- cannabis use --- psychotic disorder --- genetics --- age of onset --- clinical high risk --- cannabis --- memory --- functional magnetic resonance imaging --- THC --- systematic review --- gyrification --- surface area --- cortical surface structure --- aerobic fitness --- gender --- endocannabinoid system --- executive functions --- problematic cannabis use --- triple network --- EEG functional connectivity --- eLORETA --- resting state --- Delta-9-tetrahydrocannabinol --- dronabinol --- marijuana --- randomized controlled trial --- opioids --- traumatic injury --- alcohol --- adolescents --- fMRI --- interoception --- negative reinforcement --- migraine: chronic pain --- triptans --- disability --- n/a

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The prevalence of obesity and its comorbidities, particularly type 2 diabetes, cardiovascular and hepatic disease and certain cancers, continues to rise worldwide. Paradoxically, despite an increasingly obesogenic environment, particularly in Western societies, undernutrition is also extremely common. The application of novel, sophisticated techniques, particularly related to imaging and molecular biology, has substantially advanced our understanding of the mechanisms controlling appetite and energy intake. This has led to a redefinition of many concepts, including the relative importance of central versus peripheral mechanisms, recognising that the gastrointestinal (GI) tract, particularly gut hormones, plays a critical role. Given the major advance in knowledge in the field, this Special Issue provides a comprehensive overview of the GI mechanisms underlying the regulation of appetite and energy intake, as a series of definitive reviews by international authorities. The reviews address gut-related mechanisms, including nutrient sensing, gut hormones and GI motility, gut-brain communication, including the roles of the vagus and the modulation of reward perception, the roles of diet and the microbiota, as well as the abnormalities associated with eating disorders, specifically obesity and anorexia of ageing, and the beneficial effects of bariatric surgery. The reviews cover both preclinical research and studies in humans, and are complemented by a number of important original papers.

Medicine --- lixisenatide --- intragastric meal retention --- energy intake --- type 2 diabetes --- obesity --- amino acid --- isoleucine --- chronic supplementation --- energy expenditure --- oral glucose tolerance test --- glycaemic control --- gastric emptying breath test --- endocannabinoid --- cannabinoid CB1 receptor --- gut-brain --- intestine --- western diet --- preference --- whey protein --- gastric emptying --- appetite --- lifecourse --- gut hormones --- hunger --- protein --- TAS2R5 --- TAS2R39 --- TAS2R14 --- agonist --- food intake --- GLP1 --- CCK --- PYY --- miniature pig --- pig model --- functional brain imaging --- molecular imaging --- vagal afferents --- single fiber recording --- insulin resistance --- GLP-1r --- gastric barostat --- scintigraphy --- meal ingestion --- postprandial responses --- hedonic sensations --- homeostatic sensations --- abdominal wall activity --- abdominal distension --- taste --- fat --- carbohydrate --- bariatric surgery --- GLP-1 --- ghrelin --- Roux-en-Y gastric bypass --- gastric band --- sleeve gastrectomy --- circadian --- gastrointestinal tract --- enteroendocrine cells --- chemosensory --- GIP --- nutrients --- hormones --- food ingestion --- digestion --- satiety --- digestive well-being --- functional gastrointestinal disorders --- postprandial symptoms --- brainstem --- vagus --- feeding --- gastrointestinal --- cue reactivity --- meal anticipation --- motivation --- nutrient preference --- flavor --- aversion --- bile acids --- TGR-5 --- FXR --- gastrointestinal hormones --- body weight --- gastric accommodation --- satiation --- CB1 receptor --- gut-brain --- reward --- aging --- whey --- anorexia --- supplements --- sarcopenia --- nutrient sensing --- enteroendocrine cells (EECs) --- appetite regulation --- G-protein coupled receptors (GPCRs) --- bitter substances --- gastric motor function --- postprandial blood glucose --- preclinical studies --- human studies --- texture --- oro-sensory exposure --- sensory science --- cephalic responses --- brain areas --- brain stem --- weight management --- intestinal brake --- duodenal jejunal and ileal brake --- tastants --- circadian clock --- gastric bypass surgery --- microbiome --- hypothalamus --- lixisenatide --- intragastric meal retention --- energy intake --- type 2 diabetes --- obesity --- amino acid --- isoleucine --- chronic supplementation --- energy expenditure --- oral glucose tolerance test --- glycaemic control --- gastric emptying breath test --- endocannabinoid --- cannabinoid CB1 receptor --- gut-brain --- intestine --- western diet --- preference --- whey protein --- gastric emptying --- appetite --- lifecourse --- gut hormones --- hunger --- protein --- TAS2R5 --- TAS2R39 --- TAS2R14 --- agonist --- food intake --- GLP1 --- CCK --- PYY --- miniature pig --- pig model --- functional brain imaging --- molecular imaging --- vagal afferents --- single fiber recording --- insulin resistance --- GLP-1r --- gastric barostat --- scintigraphy --- meal ingestion --- postprandial responses --- hedonic sensations --- homeostatic sensations --- abdominal wall activity --- abdominal distension --- taste --- fat --- carbohydrate --- bariatric surgery --- GLP-1 --- ghrelin --- Roux-en-Y gastric bypass --- gastric band --- sleeve gastrectomy --- circadian --- gastrointestinal tract --- enteroendocrine cells --- chemosensory --- GIP --- nutrients --- hormones --- food ingestion --- digestion --- satiety --- digestive well-being --- functional gastrointestinal disorders --- postprandial symptoms --- brainstem --- vagus --- feeding --- gastrointestinal --- cue reactivity --- meal anticipation --- motivation --- nutrient preference --- flavor --- aversion --- bile acids --- TGR-5 --- FXR --- gastrointestinal hormones --- body weight --- gastric accommodation --- satiation --- CB1 receptor --- gut-brain --- reward --- aging --- whey --- anorexia --- supplements --- sarcopenia --- nutrient sensing --- enteroendocrine cells (EECs) --- appetite regulation --- G-protein coupled receptors (GPCRs) --- bitter substances --- gastric motor function --- postprandial blood glucose --- preclinical studies --- human studies --- texture --- oro-sensory exposure --- sensory science --- cephalic responses --- brain areas --- brain stem --- weight management --- intestinal brake --- duodenal jejunal and ileal brake --- tastants --- circadian clock --- gastric bypass surgery --- microbiome --- hypothalamus

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The prevalence of obesity and its comorbidities, particularly type 2 diabetes, cardiovascular and hepatic disease and certain cancers, continues to rise worldwide. Paradoxically, despite an increasingly obesogenic environment, particularly in Western societies, undernutrition is also extremely common. The application of novel, sophisticated techniques, particularly related to imaging and molecular biology, has substantially advanced our understanding of the mechanisms controlling appetite and energy intake. This has led to a redefinition of many concepts, including the relative importance of central versus peripheral mechanisms, recognising that the gastrointestinal (GI) tract, particularly gut hormones, plays a critical role. Given the major advance in knowledge in the field, this Special Issue provides a comprehensive overview of the GI mechanisms underlying the regulation of appetite and energy intake, as a series of definitive reviews by international authorities. The reviews address gut-related mechanisms, including nutrient sensing, gut hormones and GI motility, gut-brain communication, including the roles of the vagus and the modulation of reward perception, the roles of diet and the microbiota, as well as the abnormalities associated with eating disorders, specifically obesity and anorexia of ageing, and the beneficial effects of bariatric surgery. The reviews cover both preclinical research and studies in humans, and are complemented by a number of important original papers.

lixisenatide --- intragastric meal retention --- energy intake --- type 2 diabetes --- obesity --- amino acid --- isoleucine --- chronic supplementation --- energy expenditure --- oral glucose tolerance test --- glycaemic control --- gastric emptying breath test --- endocannabinoid --- cannabinoid CB1 receptor --- gut–brain --- intestine --- western diet --- preference --- whey protein --- gastric emptying --- appetite --- lifecourse --- gut hormones --- hunger --- protein --- TAS2R5 --- TAS2R39 --- TAS2R14 --- agonist --- food intake --- GLP1 --- CCK --- PYY --- miniature pig --- pig model --- functional brain imaging --- molecular imaging --- vagal afferents --- single fiber recording --- insulin resistance --- GLP-1r --- gastric barostat --- scintigraphy --- meal ingestion --- postprandial responses --- hedonic sensations --- homeostatic sensations --- abdominal wall activity --- abdominal distension --- taste --- fat --- carbohydrate --- bariatric surgery --- GLP-1 --- ghrelin --- Roux-en-Y gastric bypass --- gastric band --- sleeve gastrectomy --- circadian --- gastrointestinal tract --- enteroendocrine cells --- chemosensory --- GIP --- nutrients --- hormones --- food ingestion --- digestion --- satiety --- digestive well-being --- functional gastrointestinal disorders --- postprandial symptoms --- brainstem --- vagus --- feeding --- gastrointestinal --- cue reactivity --- meal anticipation --- motivation --- nutrient preference --- flavor --- aversion --- bile acids --- TGR-5 --- FXR --- gastrointestinal hormones --- body weight --- gastric accommodation --- satiation --- CB1 receptor --- gut-brain --- reward --- aging --- whey --- anorexia --- supplements --- sarcopenia --- nutrient sensing --- enteroendocrine cells (EECs) --- appetite regulation --- G-protein coupled receptors (GPCRs) --- bitter substances --- gastric motor function --- postprandial blood glucose --- preclinical studies --- human studies --- texture --- oro-sensory exposure --- sensory science --- cephalic responses --- brain areas --- brain stem --- weight management --- intestinal brake --- duodenal jejunal and ileal brake --- tastants --- circadian clock --- gastric bypass surgery --- microbiome --- hypothalamus --- n/a

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This Special Issue includes original research and reviews of the literature focusing on food labels, which are a tool to promote public health that, at the same time, may represent a marketing tool and may influence consumers’ perception of food quality.

nutritional labelling --- food choices --- comprehension --- perception --- Dutch consumers --- food policies --- front-of-pack nutrition label --- traffic light --- health star --- Nutri-Score --- reference intake --- warning label --- serving size --- portion size --- food labeling --- nutrition facts label --- back of pack --- front of pack --- health framing --- breakfast cereals --- food labelling --- nutrition declaration --- nutritional quality --- gluten free --- nutrition and health claims --- salt information --- salt content --- salt label --- sodium label --- sodium information --- nutritional information --- nutritional labeling --- salt information use --- nutrition knowledge --- nutrition facts --- food cue reactivity --- sugar --- eye tracking --- priming --- color --- nutrition facts panel --- food label --- consumer behavior --- food decision making --- food packaging --- food choice --- nutrition --- front-of-pack labelling --- health star rating --- nutrition labelling --- consumer perception --- qualitative research --- nutrition labeling --- food processing --- nutrition policy --- Spain --- food analysis --- dietary sugars --- reformulation --- organic food --- health food --- nutrient content claims --- health claims --- nutrient profile --- menu labeling --- food and nutrition policy --- restaurant chains --- energy --- obesity --- quality carbohydrate --- dietary fibre --- whole grains --- glycemic index --- latent class modeling --- traditional meat product, mangalica sausage --- online nutrition intervention --- theory of planned behavior --- nutrition labels --- consumer attitude --- perceived healthiness --- product attributes --- healthy food --- consumer choice --- extra virgin olive oil --- hedonic price model --- country of origin --- energy density --- children --- food supply --- front-of-pack label --- discretionary --- entomophagy --- insect-based foods --- edible insects --- food sustainability --- perception of food --- novel food --- disgust --- neophobia --- variety seeking --- food technology neophobia --- consumer studies --- behavior --- labelling --- carbohydrate quality --- ICQC --- consensus --- food label use --- front-of-package (FOP) labels --- back-of-package (BOP) labels --- nutrition claims --- choice experiment --- willingness to pay (WTP) --- consumers’ preferences --- sustainability label --- nutrition and health claim --- fish species --- allergen labelling --- Latin America --- packaged food products --- supermarket circulars --- ultra-processed --- pasta --- nutritional composition --- n/a --- consumers' preferences