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We live in a constantly changing society, in which life expectancy has continuously increased, and, therefore, important health issues need to be solved. The development of nanotechnology with applications in the medical field—nanomedicine—has been proven to have strong therapeutic potential, especially by combining drugs with natural polymers, polysaccharides being most commonly used in the development of sustained and controlled release systems of biologically active principles. Polymeric nanoparticles loaded with drugs can actively target various diseases, being able to penetrate cells more effectively or succeed in overcoming some physiological barriers such as the blood–brain barrier. Drug-loaded hydrogels are used to treat dermal and dental conditions, and can act as scaffolds for the development of cell cultures with applications in tissue engineering. The recent literature abounds with articles discussing aspects of obtaining new polymer drug systems and their use in various biomedical applications. The editors of this Special Issue of the journal Molecules, entitled Drug Delivery Systems Based on Polysaccharides, are researchers with decades of experience in this field, and they consider justified and useful these several articles which report recent results of drug delivery systems based on polysaccharides and derivatives, respectively, and their biomedical applications. The authors of the articles are experts in the field, and the editors express their gratitude for the kindness and promptness with which they responded to the call to contribute the recently obtained results of their research to this specific edition of the journal Molecules.

chitin --- polymorphs --- chitin sources --- chitin characterization --- disintegration --- dissolution --- crushing strength --- compression analysis --- graft polymerization --- N-vinylimidazole --- gellan gum --- betaine structure --- mathematical model --- chitosan --- bioactive aldehyde release --- Scale Relativity Theory --- multifractal --- Riccati gauge --- joint invariant function --- SL(2R)-type group --- oxidized carboxymethyl cellulose --- hydrogel film --- curcumin immobilization --- delivery system --- periodontitis --- antibacterial properties --- polysaccharides --- drug delivery systems --- hydrogels --- microparticles --- nanoparticles --- films --- electrospun fibers --- gels --- transdermal drug delivery --- transdermal nanocarrier --- surface modification --- enhanced penetration efficiency --- controlled release --- targeting delivery --- brushite --- calcium phosphate cements --- physical-chemical properties --- mechanical properties --- microbiological properties --- cell viability --- grafted copolymer --- triazole derivative --- adsorption studies

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In 2019, we sent out a call for submissions to a Special Issue of Marine Drugs entitled “Marine Chitin 2019”, and we are pleased that this issue has now been published. Over 16 high-impact papers were included in this issue, which we now plan to publish as a book. In addition, we now seek to publish a further Special Issue of Marine Drugs, “Marine Chitin 2020–2021”. As before, we plan to produce an authoritative and exciting issue that will encompass breakthroughs in scientific and industrial chitin and chitosan research. Significant advances in chitin and chitosan research have been made since the 1970s, and current overviews in recent publications involving chitin and chitosan research advances are in need of an update.

chitosan hydrogel --- chitosan --- biotechnology --- RAW264.7 macrophage --- ?-glucosidase inhibitor --- bromotyrosines --- layer-by-layer film --- amphiphilic polymer --- conjugation --- marine resources --- antioxidant activity --- chitooligosaccharides --- methylene blue --- nanoparticles --- bulk density --- Eudragit® S100 --- lytic polysaccharide monooxygenase --- chitosan oleate salt --- curcumin --- RAW 264.7 cells --- antioxidant --- crude oil --- ball milling --- anti-inflammatory action --- enzymatic modification --- dissolution --- vaginal infections --- Hausner ratio --- crushing strength --- Staphylococcus epidermidis --- mucoadhesive film --- Caco-2 cell culture --- chitosan lactate --- 2D correlation spectroscopy --- chitosan citrate --- direct compression --- chitosan oligomers --- chitin deacetylase --- Pseudomonas aeruginosa --- collagen --- blood --- express method --- sodium carbonate --- HIV sexual transmission --- streptomycin --- antibacterial activity --- pork sausage --- nanocomposites --- chitosanase --- Clostridium perfringens --- chitinase --- mucoadhesion --- chitosan oligosaccharides --- chitosan tartrate --- Staphylococcus aureus --- immunostimulatory activity --- derivatization --- pH responsive release --- soluble chitosan complex --- chitin --- polymer film --- compression work --- wound treatment --- biofilms --- roller compaction --- mitogen-activated protein kinases (MAPK) --- Paenibacillus --- chitooligosaccharide --- mechanical property --- protease --- Polybius henslowii --- scaffolds --- electrospinning --- chitosan-coated liposomes --- phosphoinositide 3-kinases (PI3K)/Akt --- cytotoxicity --- polymorph --- vaginal preexposure prophylaxis --- Aplysina archeri --- antifungal activity --- PLGA --- Kawakita analysis --- marine sponges --- Tenofovir controlled release --- nile red