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Oncology. Neoplasms --- Toxicology --- Carbolines --- Carcinogens. --- Food Additives --- Imidazoles --- Mycotoxins --- Furocoumarins --- Quinolines --- Ultraviolet Rays --- 547.587.51 --- Oncogens --- Tumor Initiators --- Tumor Promoters --- Initiators, Tumor --- Promoters, Tumor --- Benzidines --- toxicity. --- adverse effects. --- Coumarin. Coumarinic acid. Coumaric acid. Thiocoumarin --- Conferences - Meetings --- 547.587.51 Coumarin. Coumarinic acid. Coumaric acid. Thiocoumarin --- Carcinogen --- Oncogen --- Tumor Initiator --- Tumor Promoter --- Initiator, Tumor --- Promoter, Tumor --- Carcinogens --- toxicity --- adverse effects

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Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers.

coumarin --- hydroxyl-modified coumarin --- photophysical --- thermal and structural characterization --- Glycyrrhiza uralensis --- glycyrol --- liquiritigenin --- cholinesterases --- human monoamine oxidases --- kinetics --- docking simulation --- chalcone --- neurodegenerative diseases --- adenosine receptors --- binding affinity --- docking --- 4-hydroxy-7-methoxycoumarin --- macrophage --- inflammation --- NF-κB --- MAPK --- calanolides --- pseudocalanolides --- calanolide A --- Calophyllum --- Calophyllaceae --- anti-HIV --- reverse transcriptase --- non-nucleoside reverse transcriptase inhibitors (NNRTIs) --- osthole --- umbelliferone --- esculin --- 4-hydroxycoumarin --- sorafenib --- apoptosis --- autophagy --- Yin Chen Hao --- constitutive androstane receptor --- scoparone --- coumarins --- quorum sensing --- QS inhibitors --- plant-derived molecules --- Chromobacterium violaceum --- immunoproteasome --- psoralen core --- non-peptidic --- electrophilic compounds --- warhead scan --- inflammatory bowel disease --- isocoumarin --- Crohn’s disease --- ulcerative colitis --- glutathione --- oxidative stress --- complementary therapies --- intestinal inflammation --- benzopyrones --- five-membered aromatic heterocycles --- furan --- pyrrole --- thiophene --- selenophen --- dihydrocoumarin-fused dihydropyranones --- 3-aroylcoumarines --- benzyl 2,3-butadienoate --- 6’-(4-biphenyl)-β-iso-cinchonine --- biological applications --- drug discovery --- fluorescent probes --- warfarin --- acenocoumarol --- mechanical valve --- time in therapeutic range --- anticoagulation --- Ruta chalepensis --- Rutaceae --- chalepin --- chalepensin --- bioactivity --- biosynthesis --- coumarin3-carboxamides --- pyranocoumarins --- anticancer activity --- antibacterial activity --- free radical polymerization --- LED --- photocomposites --- direct laser write --- analytical methods --- model plant --- natural genetic variation --- natural products --- simple coumarins --- chalcocoumarin --- MAO-B --- molecular dynamics --- in silico studies --- dye-sensitized solar cells --- coumarin dyes --- thieno [3,2-b] thiophene --- charge transfer --- ethynylaryl --- esculetin --- antiplatelet activity --- impedance aggregometry --- COX --- polyphenols --- pyrazole --- imidazole --- thiazole --- oxazole --- triazole --- thiadiazole --- curcumin --- curcumin–coumarin hybrids --- neuroprotection --- monoamine oxidase inhibition --- cholinesterase inhibition --- scavenging activity --- Escherichia coli --- biotransformation --- ferulenol --- structural annotation --- in silico tools --- n/a --- Crohn's disease --- 6'-(4-biphenyl)-β-iso-cinchonine --- curcumin-coumarin hybrids

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Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers.

Research & information: general --- Biology, life sciences --- coumarin --- hydroxyl-modified coumarin --- photophysical --- thermal and structural characterization --- Glycyrrhiza uralensis --- glycyrol --- liquiritigenin --- cholinesterases --- human monoamine oxidases --- kinetics --- docking simulation --- chalcone --- neurodegenerative diseases --- adenosine receptors --- binding affinity --- docking --- 4-hydroxy-7-methoxycoumarin --- macrophage --- inflammation --- NF-κB --- MAPK --- calanolides --- pseudocalanolides --- calanolide A --- Calophyllum --- Calophyllaceae --- anti-HIV --- reverse transcriptase --- non-nucleoside reverse transcriptase inhibitors (NNRTIs) --- osthole --- umbelliferone --- esculin --- 4-hydroxycoumarin --- sorafenib --- apoptosis --- autophagy --- Yin Chen Hao --- constitutive androstane receptor --- scoparone --- coumarins --- quorum sensing --- QS inhibitors --- plant-derived molecules --- Chromobacterium violaceum --- immunoproteasome --- psoralen core --- non-peptidic --- electrophilic compounds --- warhead scan --- inflammatory bowel disease --- isocoumarin --- Crohn's disease --- ulcerative colitis --- glutathione --- oxidative stress --- complementary therapies --- intestinal inflammation --- benzopyrones --- five-membered aromatic heterocycles --- furan --- pyrrole --- thiophene --- selenophen --- dihydrocoumarin-fused dihydropyranones --- 3-aroylcoumarines --- benzyl 2,3-butadienoate --- 6'-(4-biphenyl)-β-iso-cinchonine --- biological applications --- drug discovery --- fluorescent probes --- warfarin --- acenocoumarol --- mechanical valve --- time in therapeutic range --- anticoagulation --- Ruta chalepensis --- Rutaceae --- chalepin --- chalepensin --- bioactivity --- biosynthesis --- coumarin3-carboxamides --- pyranocoumarins --- anticancer activity --- antibacterial activity --- free radical polymerization --- LED --- photocomposites --- direct laser write --- analytical methods --- model plant --- natural genetic variation --- natural products --- simple coumarins --- chalcocoumarin --- MAO-B --- molecular dynamics --- in silico studies --- dye-sensitized solar cells --- coumarin dyes --- thieno [3,2-b] thiophene --- charge transfer --- ethynylaryl --- esculetin --- antiplatelet activity --- impedance aggregometry --- COX --- polyphenols --- pyrazole --- imidazole --- thiazole --- oxazole --- triazole --- thiadiazole --- curcumin --- curcumin-coumarin hybrids --- neuroprotection --- monoamine oxidase inhibition --- cholinesterase inhibition --- scavenging activity --- Escherichia coli --- biotransformation --- ferulenol --- structural annotation --- in silico tools --- coumarin --- hydroxyl-modified coumarin --- photophysical --- thermal and structural characterization --- Glycyrrhiza uralensis --- glycyrol --- liquiritigenin --- cholinesterases --- human monoamine oxidases --- kinetics --- docking simulation --- chalcone --- neurodegenerative diseases --- adenosine receptors --- binding affinity --- docking --- 4-hydroxy-7-methoxycoumarin --- macrophage --- inflammation --- NF-κB --- MAPK --- calanolides --- pseudocalanolides --- calanolide A --- Calophyllum --- Calophyllaceae --- anti-HIV --- reverse transcriptase --- non-nucleoside reverse transcriptase inhibitors (NNRTIs) --- osthole --- umbelliferone --- esculin --- 4-hydroxycoumarin --- sorafenib --- apoptosis --- autophagy --- Yin Chen Hao --- constitutive androstane receptor --- scoparone --- coumarins --- quorum sensing --- QS inhibitors --- plant-derived molecules --- Chromobacterium violaceum --- immunoproteasome --- psoralen core --- non-peptidic --- electrophilic compounds --- warhead scan --- inflammatory bowel disease --- isocoumarin --- Crohn's disease --- ulcerative colitis --- glutathione --- oxidative stress --- complementary therapies --- intestinal inflammation --- benzopyrones --- five-membered aromatic heterocycles --- furan --- pyrrole --- thiophene --- selenophen --- dihydrocoumarin-fused dihydropyranones --- 3-aroylcoumarines --- benzyl 2,3-butadienoate --- 6'-(4-biphenyl)-β-iso-cinchonine --- biological applications --- drug discovery --- fluorescent probes --- warfarin --- acenocoumarol --- mechanical valve --- time in therapeutic range --- anticoagulation --- Ruta chalepensis --- Rutaceae --- chalepin --- chalepensin --- bioactivity --- biosynthesis --- coumarin3-carboxamides --- pyranocoumarins --- anticancer activity --- antibacterial activity --- free radical polymerization --- LED --- photocomposites --- direct laser write --- analytical methods --- model plant --- natural genetic variation --- natural products --- simple coumarins --- chalcocoumarin --- MAO-B --- molecular dynamics --- in silico studies --- dye-sensitized solar cells --- coumarin dyes --- thieno [3,2-b] thiophene --- charge transfer --- ethynylaryl --- esculetin --- antiplatelet activity --- impedance aggregometry --- COX --- polyphenols --- pyrazole --- imidazole --- thiazole --- oxazole --- triazole --- thiadiazole --- curcumin --- curcumin-coumarin hybrids --- neuroprotection --- monoamine oxidase inhibition --- cholinesterase inhibition --- scavenging activity --- Escherichia coli --- biotransformation --- ferulenol --- structural annotation --- in silico tools

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This Special Issue aims to provide an updated overview of the flourishing ongoing research activity in the field of the chemistry of natural and nature-inspired compounds. Ten of the submitted articles were accepted for publication after peer-review. Interestingly, the published papers cover a wide range of chemical reactions, different scaffolds, and several medicinal chemistry applications. Moreover, this Special Issue gathered contributions from all over the world, testifying the international scientific community’s interest in this topic. I would like to sincerely thank the MDPI staff, particularly Jade Lu and the editorial team of Molbank. I am particularly grateful to the authors that decided to share the results of their research by contributing their manuscript to this Special Issue, and, of course, to the reviewers for their valuable help.

quercetin --- flavonoids --- semi-synthetic --- PDE --- sildenafil --- molecular modeling --- Garcinia porrecta --- Clusiaceae --- xanthone --- Lansium domesticum --- Meliaceae --- MCF-7 --- triterpene onoceranoid --- hydrazone --- (+)-camphor --- valproic acid --- technology --- terpenoid --- anticonvulsant activity --- 1,2,3-triazole --- anticancer --- aminoquinoline --- hybrid compound --- kokosanolide --- tetranortriterpenoid --- C. dichotoma --- antidiabetic --- α-glucosidase --- α-amylase --- docking --- ADMET --- curcumin analog --- organic synthesis --- photophysical properties --- steady-state fluorescence --- DFT calculation --- 7-hydroxy-2H-chromen-2-one --- O-acylation reaction --- coumarin --- lupeol derivative --- benzylidene derivative --- α-glucosidase inhibition --- Oxone® --- n/a

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Biocatalysis, the application of enzymes as catalysts for chemical synthesis, has become an increasingly valuable tool for the synthetic chemist. Enzymatic transformations carried out by enzymes or whole-cell catalysts are used for the production of a wide variety of compounds ranging from bulk to fine chemicals. The primary consideration for the incorporation of biotransformation in a synthetic sequence is regio- and stereocontrol that can be achieved with enzyme-catalyzed reactions. Biotransformations are thus becoming accepted as a method for generating optically pure compounds as well as for developing efficient routes to target compounds. This Special Issue aims to address the main applications of biocatalysts, isolated enzymes, and whole microorganisms in the synthesis of bioactive compounds and their precursors.

Research & information: general --- Biology, life sciences --- 8-hydroxydaidzein --- stable --- soluble --- anti-inflammation --- amylosucrase --- Deinococcus geothermalis --- coumarin --- biotransformation --- filamentous fungi --- selective hydroxylation --- bromination --- chlorination --- pharmaceuticals --- active agent synthesis --- biocatalysis --- haloperoxidase --- halogenase --- glycosyltransferase --- Glycine max (L.) Merr. --- HPLC/MS --- isoflavone aglycone-rich extract --- isoflavone α-glucoside --- alkene cleavage --- aryl alkenes --- basidiomycota --- carotene degradation --- dye-decolorizing peroxidase (DyP) --- manganese --- Komagataella pfaffii --- Pleurotus sapidus --- monoterpenes --- limonene --- glycerol --- mevalonate pathway --- reaction engineering --- bioprocess --- biocatalyst --- two-liquid phase fermentation --- in situ product removal --- lipase --- unsaturated fatty acid --- oxidative cleavage --- oxidation --- adaptation --- UV/NTG mutagenesis --- psychrotrophs --- terpenes