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Neonatal (early) handling (EH) and environmental enrichment (EE) of laboratory rodents have been the two most commonly used methods of providing supplementary environmental stimulation in order to study behavioral and neurobiological plasticity. A large body of research has been generated since the 1950s, unequivocally showing that both treatments induce profound and long-lasting behavioral and neural consequences while also inducing plastic brain effects and being "protective" against some age-related deficits. The present work is aimed at reviewing the main neurobehavioral effects of both manipulations, with the final purpose of comparing them and trying to find out to what extent the effects of both treatments may share (or not) possible neural mechanisms. (C) 2002 Published by Elsevier Science Inc
2-way active-avoidance. --- Adult-rats. --- Benzodiazepine receptor. --- Brain cortical membranes. --- Brain. --- Consequences. --- Deficits. --- Early experience,neonatal handling,environmental enrichment,stress,anxiety,learning,memory,neural plasticity,hippocampus,age-related deficits. --- Enrichment. --- Environmental enrichment. --- Handling. --- Infantile stimulation. --- Laboratory. --- Low-avoidance rats. --- Mechanisms. --- Method. --- Neonatal. --- Nerve growth-factor. --- Novelty-seeking. --- Perinatal flumazenil. --- Plasticity. --- Purpose. --- Research. --- Rodent. --- Rodents. --- Roman high-avoidance. --- Stimulation. --- Treatment. --- Work.
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In the landscape of the design of carbon nanomaterials, the fine-tuning of their functionalities and physico-chemical properties has increased their potential for therapeutic, diagnostic, and biosensing applications. In this editorial, we will provide a brief overview of the contents of this Special Issue. In particular, nanoplatforms originating from the synergistic combination of carbon-based nanomaterials (i.e., nanotubes, graphene, graphene oxide, carbon quantum dots, nanodiamond, etc.) with various functional molecules such as drugs, natural compounds, biomolecules, polymers, metal nanoparticles, and macrocycles that have useful applications in drug delivery, multi-targeted therapies, theranostic as well as scaffolds in tissue engineering, and as sensing materials have been selected for publication as Articles or Mini Reviews. The variety of applications covered by the nine articles published in this Special Issue of Nanomaterials are proof of the growing attention that the use of carbon nanomaterials in the biomedical/pharmaceutical field has received in recent years. We hope that readers find the contents of this Special Issue useful for their research, which is aimed to advance carbon nanomaterials from the laboratory to clinical nanomedicine.
graphene oxide --- covalent functionalization --- cortical membranes --- calcium phosphate deposition --- graphene/gold nanocomposite --- SERS --- Dopamine --- Rhodamine 6G --- nanodiamond --- tritium --- biodistribution --- Ewing sarcoma --- drug delivery --- siRNA --- nanomedicine --- porphyrin --- J-aggregates --- carbon nanotubes --- nanohybrids --- graphene --- liquid biopsy --- circulating tumor cells --- exosomes --- circulating nucleic acids --- COVID-19 --- pyrrole --- cancer --- doxorubicin --- drug delivery systems --- nanoparticles --- carbon dots --- platelet aggregation --- arterial thrombosis --- signaling molecules --- bleeding disorder --- cytotoxicity --- carbon nanomaterials --- camptothecin --- Caco-2 --- MCF-7 --- NanoHy-GPS --- antibacterial nanosystems --- one-pot microwave-assisted reaction --- silver nanoparticles --- polyvinyl alcohol --- n/a
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In the landscape of the design of carbon nanomaterials, the fine-tuning of their functionalities and physico-chemical properties has increased their potential for therapeutic, diagnostic, and biosensing applications. In this editorial, we will provide a brief overview of the contents of this Special Issue. In particular, nanoplatforms originating from the synergistic combination of carbon-based nanomaterials (i.e., nanotubes, graphene, graphene oxide, carbon quantum dots, nanodiamond, etc.) with various functional molecules such as drugs, natural compounds, biomolecules, polymers, metal nanoparticles, and macrocycles that have useful applications in drug delivery, multi-targeted therapies, theranostic as well as scaffolds in tissue engineering, and as sensing materials have been selected for publication as Articles or Mini Reviews. The variety of applications covered by the nine articles published in this Special Issue of Nanomaterials are proof of the growing attention that the use of carbon nanomaterials in the biomedical/pharmaceutical field has received in recent years. We hope that readers find the contents of this Special Issue useful for their research, which is aimed to advance carbon nanomaterials from the laboratory to clinical nanomedicine.
Technology: general issues --- Chemical engineering --- graphene oxide --- covalent functionalization --- cortical membranes --- calcium phosphate deposition --- graphene/gold nanocomposite --- SERS --- Dopamine --- Rhodamine 6G --- nanodiamond --- tritium --- biodistribution --- Ewing sarcoma --- drug delivery --- siRNA --- nanomedicine --- porphyrin --- J-aggregates --- carbon nanotubes --- nanohybrids --- graphene --- liquid biopsy --- circulating tumor cells --- exosomes --- circulating nucleic acids --- COVID-19 --- pyrrole --- cancer --- doxorubicin --- drug delivery systems --- nanoparticles --- carbon dots --- platelet aggregation --- arterial thrombosis --- signaling molecules --- bleeding disorder --- cytotoxicity --- carbon nanomaterials --- camptothecin --- Caco-2 --- MCF-7 --- NanoHy-GPS --- antibacterial nanosystems --- one-pot microwave-assisted reaction --- silver nanoparticles --- polyvinyl alcohol --- n/a
Choose an application
In the landscape of the design of carbon nanomaterials, the fine-tuning of their functionalities and physico-chemical properties has increased their potential for therapeutic, diagnostic, and biosensing applications. In this editorial, we will provide a brief overview of the contents of this Special Issue. In particular, nanoplatforms originating from the synergistic combination of carbon-based nanomaterials (i.e., nanotubes, graphene, graphene oxide, carbon quantum dots, nanodiamond, etc.) with various functional molecules such as drugs, natural compounds, biomolecules, polymers, metal nanoparticles, and macrocycles that have useful applications in drug delivery, multi-targeted therapies, theranostic as well as scaffolds in tissue engineering, and as sensing materials have been selected for publication as Articles or Mini Reviews. The variety of applications covered by the nine articles published in this Special Issue of Nanomaterials are proof of the growing attention that the use of carbon nanomaterials in the biomedical/pharmaceutical field has received in recent years. We hope that readers find the contents of this Special Issue useful for their research, which is aimed to advance carbon nanomaterials from the laboratory to clinical nanomedicine.
Technology: general issues --- Chemical engineering --- graphene oxide --- covalent functionalization --- cortical membranes --- calcium phosphate deposition --- graphene/gold nanocomposite --- SERS --- Dopamine --- Rhodamine 6G --- nanodiamond --- tritium --- biodistribution --- Ewing sarcoma --- drug delivery --- siRNA --- nanomedicine --- porphyrin --- J-aggregates --- carbon nanotubes --- nanohybrids --- graphene --- liquid biopsy --- circulating tumor cells --- exosomes --- circulating nucleic acids --- COVID-19 --- pyrrole --- cancer --- doxorubicin --- drug delivery systems --- nanoparticles --- carbon dots --- platelet aggregation --- arterial thrombosis --- signaling molecules --- bleeding disorder --- cytotoxicity --- carbon nanomaterials --- camptothecin --- Caco-2 --- MCF-7 --- NanoHy-GPS --- antibacterial nanosystems --- one-pot microwave-assisted reaction --- silver nanoparticles --- polyvinyl alcohol --- graphene oxide --- covalent functionalization --- cortical membranes --- calcium phosphate deposition --- graphene/gold nanocomposite --- SERS --- Dopamine --- Rhodamine 6G --- nanodiamond --- tritium --- biodistribution --- Ewing sarcoma --- drug delivery --- siRNA --- nanomedicine --- porphyrin --- J-aggregates --- carbon nanotubes --- nanohybrids --- graphene --- liquid biopsy --- circulating tumor cells --- exosomes --- circulating nucleic acids --- COVID-19 --- pyrrole --- cancer --- doxorubicin --- drug delivery systems --- nanoparticles --- carbon dots --- platelet aggregation --- arterial thrombosis --- signaling molecules --- bleeding disorder --- cytotoxicity --- carbon nanomaterials --- camptothecin --- Caco-2 --- MCF-7 --- NanoHy-GPS --- antibacterial nanosystems --- one-pot microwave-assisted reaction --- silver nanoparticles --- polyvinyl alcohol
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