Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This dissertation by Leif B.G. Johansson explores the development and application of luminescent conjugated oligothiophenes (LCOs) as molecular probes for studying protein aggregation diseases, notably amyloid-related conditions. The work highlights the advantages of LCOs over traditional dyes like Congo red and Thioflavin T, emphasizing their ability to detect early-stage protein aggregates and distinguish different aggregate morphologies. The research incorporates novel techniques such as Surface Plasmon Resonance (SPR) and Positron Emission Tomography (PET) to study the interactions between LCOs and amyloid fibrils in real-time. The thesis also discusses the synthesis of asymmetrical LCOs and the role of molecular modifications in enhancing binding specificity and sensitivity. This work is intended for researchers in chemistry and biomedical sciences focusing on molecular diagnostics and therapeutic developments in protein aggregation diseases.

Conjugated oligomers. --- Amyloidosis.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Process monitoring and control are fundamental to all processes; this holds especially for bioprocesses, due to their complex nature. Usually, bioprocesses deal with living cells, which have their own regulatory systems. It helps to adjust the cell to its environmental condition. This must not be the optimal condition that the cell needs to produce whatever is desired. Therefore, a close monitoring of the cell and its environment is essential to provide optimal conditions for production. Without measurement, no information of the current process state is obtained. In this book, methods and techniques are provided for the monitoring and control of bioprocesses. From new developments for sensors, the application of spectroscopy and modelling approaches, the estimation and observer implementation for ethanol production and the development and scale-up of various bioprocesses and their closed loop control information are presented. The processes discussed here are very diverse. The major applications are cultivation processes, where microorganisms were grown, but also an incubation process of bird’s eggs, as well as an indoor climate control for humans, will be discussed. Altogether, in 12 chapters, nine original research papers and three reviews are presented.

Research & information: general --- Biology, life sciences --- bioenvironmental control --- model-predictive controller --- zonal controlling --- dynamic modelling --- flotation --- bioleaching --- frother --- mixed culture --- machine learning --- Raman spectroscopy --- downstream processing --- chromatography --- flow cell --- extended Kalman filter --- biotechnological processes --- bioreactor control --- specific growth rate control --- batch-to-batch reproducibility --- thermal sensation --- thermal comfort --- machine-learning --- prediction --- adaptive controlling --- thermal growth curve --- temperature modeling --- thermoregulation --- monitoring and control --- bioprocess engineering --- calorimetry --- biocontrol agent --- Bacillus subtilis natto --- isolation --- molecular identification --- medium optimization --- antimicrobial activity --- bactericides --- spectral analyses --- biological selenate reduction --- electron donor competition --- nitrate --- perchlorate --- sequencing batch --- Pseudomonas --- siderophores --- antagonism --- batch fermentation --- exponential fed-batch fermentation --- bio-friendly formulations --- biocontrol --- nonlinear state estimation --- geometric observer --- bioreactor --- continuous system --- model-based sensor --- well-defined macromolecules --- sequence-defined macromolecules --- sequence-defined polymers --- conjugated oligomers --- oligo(arylene ethynylene)s --- biosensors --- sensors --- process monitoring --- bioprocess monitoring and control --- signal noise management --- dielectric spectroscopy --- PAT --- microbial bioprocessing --- bioenvironmental control --- model-predictive controller --- zonal controlling --- dynamic modelling --- flotation --- bioleaching --- frother --- mixed culture --- machine learning --- Raman spectroscopy --- downstream processing --- chromatography --- flow cell --- extended Kalman filter --- biotechnological processes --- bioreactor control --- specific growth rate control --- batch-to-batch reproducibility --- thermal sensation --- thermal comfort --- machine-learning --- prediction --- adaptive controlling --- thermal growth curve --- temperature modeling --- thermoregulation --- monitoring and control --- bioprocess engineering --- calorimetry --- biocontrol agent --- Bacillus subtilis natto --- isolation --- molecular identification --- medium optimization --- antimicrobial activity --- bactericides --- spectral analyses --- biological selenate reduction --- electron donor competition --- nitrate --- perchlorate --- sequencing batch --- Pseudomonas --- siderophores --- antagonism --- batch fermentation --- exponential fed-batch fermentation --- bio-friendly formulations --- biocontrol --- nonlinear state estimation --- geometric observer --- bioreactor --- continuous system --- model-based sensor --- well-defined macromolecules --- sequence-defined macromolecules --- sequence-defined polymers --- conjugated oligomers --- oligo(arylene ethynylene)s --- biosensors --- sensors --- process monitoring --- bioprocess monitoring and control --- signal noise management --- dielectric spectroscopy --- PAT --- microbial bioprocessing