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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Psychiatry --- addiction --- concomitant disorders --- community-based treatment models --- recovery --- paradigm change

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Child. --- Eye Diseases. --- Infant. --- Strabismus. --- Convergent Comitant Strabismus --- Mechanical Strabismus --- Hypertropia --- Phorias --- Squint --- Strabismus, Comitant --- Strabismus, Noncomitant --- Comitant Strabismus --- Comitant Strabismus, Convergent --- Hypertropias --- Noncomitant Strabismus --- Phoria --- Strabismus, Convergent Comitant --- Strabismus, Mechanical --- Orthoptics --- Infants --- Disease, Eye --- Diseases, Eye --- Eye Disease --- Ophthalmology --- Children --- Minors --- Periodicals --- Ophthalmology. --- Pediatrics. --- Health Sciences. --- Pediatrics --- Surgery. --- Health Sciences --- Surgery --- Child --- Eye Diseases --- Infant --- Strabismus --- Concomitant Strabismus --- Dissociated Vertical Deviation --- Non-Concomitant Strabismus --- Nonconcomitant Strabismus --- Dissociated Vertical Deviations --- Non Concomitant Strabismus --- Strabismus, Concomitant --- Strabismus, Non-Concomitant --- Strabismus, Nonconcomitant --- Eye Disorders --- Eye Disorder --- Dissociated Horizontal Deviation --- Heterophoria --- Heterotropias --- Deviation, Dissociated Horizontal --- Dissociated Horizontal Deviations --- Heterophorias --- Heterotropia --- Horizontal Deviation, Dissociated

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to the Second Edition here have been significant changes in pediatric Chapter 56 by Maya Eibschitz-Tsimhoni, MD, is a T ophthalmology and strabismus since the first wonderful contribution to the literature, as it reviews edition. Great effort has gone into incorporat­ 235 important ocular disorders that have systemic ing recent advances into this second edition. Each manifestations, and it includes a detailed glossary of chapter in the book has been revised, and over half of terms. them have been completely rewritten. In addition to As with the first edition, our goal is to present a updating and revising the entire book, we have added comprehensive textbook of pediatric ophthalmology three new chapters: Chapter 7 on electrophysiology and strabismus written in a clear, reader-friendly style. and the eye, Chapter 1 7 on strabismus surgery, and Our hope is that the readerwill find the second edi­ Chapter 56 on congenital syndromes with ocular man­ tion of Pediatric Ophthalmology and Strabismus to ifestations. Chapter 17 is the definitive work on pedi­ be scientifically informative, clinically useful, and en­ atric ocular electrophysiology, bar none, and was fin­ joyable to read. ished just weeks before the untimely death of its author, Dr. Tony Kriss (see tribute in Chapter 17).

Eye Diseases --- Pediatric ophthalmology. --- Strabismus --- Strabismus. --- Child. --- Infant. --- Pediatric ophthalmology --- Child --- Infant --- Infants --- Children --- Minors --- Convergent Comitant Strabismus --- Mechanical Strabismus --- Concomitant Strabismus --- Dissociated Vertical Deviation --- Hypertropia --- Non-Concomitant Strabismus --- Nonconcomitant Strabismus --- Phorias --- Squint --- Strabismus, Comitant --- Strabismus, Noncomitant --- Comitant Strabismus --- Comitant Strabismus, Convergent --- Dissociated Vertical Deviations --- Hypertropias --- Non Concomitant Strabismus --- Noncomitant Strabismus --- Phoria --- Strabismus, Concomitant --- Strabismus, Convergent Comitant --- Strabismus, Mechanical --- Strabismus, Non-Concomitant --- Strabismus, Nonconcomitant --- Orthoptics --- Eye Disorders --- Eye Disease --- Eye Disorder --- Ophthalmology --- Heterotropia --- Squinting --- Walleye (Ophthalmology) --- Eye --- Movement disorders --- Ophthalmology. --- Medicine --- Diseases --- Dissociated Horizontal Deviation --- Heterophoria --- Heterotropias --- Deviation, Dissociated Horizontal --- Dissociated Horizontal Deviations --- Heterophorias --- Horizontal Deviation, Dissociated

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Ever since its appearance in Europe five centuries ago, the rosary has been a widespread, highly visible devotion among Roman Catholics. Its popularity has persisted despite centuries of often seismic social upheaval, cultural change, and institutional reform. In form, the rosary consists of a ritually repeated sequence of prayers accompanied by meditations on episodes in the lives of Christ and Mary. As a devotional object of round beads strung on cord or wire, the rosary has changed very little since its introduction centuries ago. Today, the rosary can be found on virtually every continent, and in the hands of hard-line traditionalists as well as progressive Catholics. It is beloved by popes, professors, protesters, commuters on their way to work, children learning their “first prayers,” and homeless persons seeking shelter and safety.Why has this particular devotional object been so ubiquitous and resilient, especially in the face of Catholicism’s reinvention in the Early Modern, or “Counter-Reformation,” Era? Nathan D. Mitchell argues in lyric prose that to understand the rosary’s adaptability, it is essential to consider the changes Catholicism itself began to experience in the aftermath of the Reformation.Unlike many other scholars of this period, Mitchell argues that after the Reformation Catholicism actually became more innovative and diversified rather than retrenched and monolithic. This innovation was especially evident in the sometimes “subversive”; visual representations of sacred subjects, such as in the paintings of Caravaggio, and in new ways of perceiving the relation between Catholic devotion and the liturgy&#8217s ritual symbols. The rosary was thus involved not only in how Catholics gave flesh to their faith, but in new ways of constructing their personal and collective identity. Ultimately, Mitchell employs the history of the rosary, and the concomitant devotion to the Virgin Mary with which it is associated, as a lens through which to better understand early modern Catholic history.

Rosary. --- Dominican Rosary --- Beads --- Prayer --- Rosaries (Prayer books) --- Religious aspects --- Catholic Church --- Mary, --- ʻAdhrāʼ --- Arogyamata --- Ārōkkiyamāta --- Birhen ng mga Dukha --- Blessed Lady --- Blessed Mother --- Blessed Virgin Mary, --- Hagnē Theotokos --- Madonna, The --- Mama Mary --- Mare de Déu --- Maria, --- Mariam Astuatsatsin --- Marie, --- Marie Théotokos --- Marii︠a︡, --- Maryam, --- Maryja, --- Meryem Ana --- Miryam, --- Mother of God --- Muíre, --- Nossa Senhora --- Our Lady --- Our Lady of Good Health --- Our Lady of Sorrows --- Our Lady of the Blessed Sacrament --- Qiddīsah Maryam --- Theotokos --- Vierge Marie, --- Virgen María --- Virgin Mary, --- Virgin of the Poor --- Ynang Maria --- مريم --- مريم العذراء --- 성모마리아 --- Our Lady of Emmitsburg --- Majka Isusova --- Devotion to. --- History --- Rosary --- 248.159.4 --- 248.159.4 Mariale devotie. Verering van O. L. Vrouw. Mariamaand --- Mariale devotie. Verering van O. L. Vrouw. Mariamaand --- Christian special devotions --- Christian church history --- Mariam Astuatsatsin, --- Meryem Ana, --- Virgen María, --- Ynang Maria, --- Church of Rome --- Roman Catholic Church --- Katholische Kirche --- Katolyt︠s︡ʹka t︠s︡erkva --- Römisch-Katholische Kirche --- Römische Kirche --- Ecclesia Catholica --- Eglise catholique --- Eglise catholique-romaine --- Katolicheskai︠a︡ t︠s︡erkovʹ --- Chiesa cattolica --- Iglesia Católica --- Kościół Katolicki --- Katolicki Kościół --- Kościół Rzymskokatolicki --- Nihon Katorikku Kyōkai --- Katholikē Ekklēsia --- Gereja Katolik --- Kenesiyah ha-Ḳatolit --- Kanisa Katoliki --- כנסיה הקתולית --- כנסייה הקתולית --- 가톨릭교 --- 천주교 --- Catholic. --- Mary. --- Mitchell. --- Virgin. --- associated. --- better. --- concomitant. --- devotion. --- early. --- employs. --- history. --- lens. --- modern. --- rosary. --- through. --- understand. --- which. --- with.

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This collection of articles provides an overview of the current and future methods for applying a personalized medicine approach to the diagnosis, management, and treatment of autism spectrum disorder.

fecal metabolites --- ASD --- microbiome --- gastrointestinal symptoms --- Fisher Discriminant Analysis --- digital biomarkers --- wearables --- time series analysis --- autism --- social dyads --- socio-motor parameters --- network connectivity --- non-linear complex dynamics --- stochastic analysis --- autism spectrum disorders --- copy number variants --- females --- Array-Comparative Genomic Hybridization (Array-CGH) --- autism spectrum disorder --- Ehlers-Danlos syndrome --- hypermobility spectrum disorders --- autonomic disorder --- mast cell activation syndrome --- genetic testing --- chromosomal microarray analysis --- whole exome sequencing --- whole genome sequencing --- clinical utility --- polygenic risk scores --- Temple Grandin --- biomarker --- omics --- precision medicine --- proteomics --- transcriptomics --- epigenetics --- metabolomics --- patient stratification --- mitochondria --- oxidative stress --- prenatal environment --- immune dysfunction --- immunoglobulin G --- intravenous immunoglobulin --- energy metabolism --- fatty acid oxidation --- acyl-carnitines --- resveratrol --- integrative --- model --- concomitant --- condition --- disorder --- autism spectrum disorder (ASD) --- genomics --- personalized treatment strategy --- single nucleotide polymorphisms --- clinical decision support tool --- ADHD --- PANDAS --- OCD --- anxiety --- folate receptor alpha --- folates --- pregnancy --- brain development --- fetal development --- cobalamin --- glutathione --- methylation --- methylcobalamin --- redox metabolism --- locked-in network syndrome --- resting-state functional magnetic resonance imaging --- temporal lobe epilepsy --- amygdala --- brain --- COVID-19 --- children --- cytokines --- flavonoids --- inflammation --- luteolin --- mast cells --- microglia --- SARS-CoV-2 --- stress --- nutraceuticals --- survey --- vitamins --- minerals --- B12 --- folinic acid --- quality of life --- parents --- intervention --- systematic review --- medical claims --- logistic regression analysis --- retrospective analysis --- associated risk --- monoamine neurotransmitters --- neurotransmitter deficiency --- cerebral folate deficiency --- folate receptor alpha autoantibodies --- leucovorin --- α-amylase --- cortisol --- heart rate variability --- neuromodulation --- sleep anxiety --- transdermal electrical neuromodulation --- neurostimulation --- n/a