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Book
Plasma based Synthesis and Modification of Nanomaterials
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ISBN: 3039213962 3039213954 Year: 2020 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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This book, entitled “Plasma-Based Synthesis and Modification of Nanomaterials” is a collection of nine original research articles devoted to the application of different atmospheric pressure (APPs) and low-pressure (LPPs) plasmas for the synthesis or modification of various nanomaterials (NMs) of exceptional properties. These articles also show the structural and morphological characterization of the synthesized NMs and their further interesting and unique applications in different areas of science and technology. The readers interested in the capabilities of plasma-based treatments will quickly be convinced that APPs and LPPs enable one to efficiently synthesize or modify differentiated NMs using a minimal number of operations. Indeed, the presented procedures are eco-friendly and usually involve single-step processes, thus considerably lowering labor investment and costs. As a result, the production of new NMs and their functionalization is more straightforward and can be carried out on a much larger scale compared to other methods and procedures involving complex chemical treatments and processes. The size and morphology, as well as the structural and optical properties of the resulting NMs are tunable and tailorable. In addition to the desirable and reproducible physical dimensions, crystallinity, functionality, and spectral properties of the resultant NMs, the NMs fabricated and/or modified with the aid of APPs are commonly ready-to-use prior to their specific applications, without any initial pre-treatments.


Book
Biomaterial-Related Infections
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Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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The use of medical devices (e.g., catheters, implants, and probes) is a common and essential part of medical care for both diagnostic and therapeutic purposes. However, these devices quite frequently lead to the incidence of infections due to the colonization of their abiotic surfaces by biofilm-growing microorganisms, which are progressively resistant to antimicrobial therapies. Several methods based on anti-infective biomaterials that repel microbes have been developed to combat device-related infections. Among these strategies, surface coating with antibiotics (e.g., beta-lactams), natural compounds (e.g., polyphenols), or inorganic elements (e.g., silver and copper nanoparticles) has been widely recognized as exhibiting broad-spectrum bactericidal or bacteriostatic activity. So, in order to achieve a better therapeutic response, it is crucial to understand how these infections are different from others. This will allow us to find new biomaterials characterized by antifouling coatings with repellent properties or low adhesion towards microorganisms, or antimicrobial coatings that are capable of killing microbes approaching the surface, improving biomaterial functionalization strategies and supporting tissues’ bio-integration.


Book
Biomaterial-Related Infections
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Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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The use of medical devices (e.g., catheters, implants, and probes) is a common and essential part of medical care for both diagnostic and therapeutic purposes. However, these devices quite frequently lead to the incidence of infections due to the colonization of their abiotic surfaces by biofilm-growing microorganisms, which are progressively resistant to antimicrobial therapies. Several methods based on anti-infective biomaterials that repel microbes have been developed to combat device-related infections. Among these strategies, surface coating with antibiotics (e.g., beta-lactams), natural compounds (e.g., polyphenols), or inorganic elements (e.g., silver and copper nanoparticles) has been widely recognized as exhibiting broad-spectrum bactericidal or bacteriostatic activity. So, in order to achieve a better therapeutic response, it is crucial to understand how these infections are different from others. This will allow us to find new biomaterials characterized by antifouling coatings with repellent properties or low adhesion towards microorganisms, or antimicrobial coatings that are capable of killing microbes approaching the surface, improving biomaterial functionalization strategies and supporting tissues’ bio-integration.


Book
Biomaterial-Related Infections
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

The use of medical devices (e.g., catheters, implants, and probes) is a common and essential part of medical care for both diagnostic and therapeutic purposes. However, these devices quite frequently lead to the incidence of infections due to the colonization of their abiotic surfaces by biofilm-growing microorganisms, which are progressively resistant to antimicrobial therapies. Several methods based on anti-infective biomaterials that repel microbes have been developed to combat device-related infections. Among these strategies, surface coating with antibiotics (e.g., beta-lactams), natural compounds (e.g., polyphenols), or inorganic elements (e.g., silver and copper nanoparticles) has been widely recognized as exhibiting broad-spectrum bactericidal or bacteriostatic activity. So, in order to achieve a better therapeutic response, it is crucial to understand how these infections are different from others. This will allow us to find new biomaterials characterized by antifouling coatings with repellent properties or low adhesion towards microorganisms, or antimicrobial coatings that are capable of killing microbes approaching the surface, improving biomaterial functionalization strategies and supporting tissues’ bio-integration.

Keywords

Medicine --- Candida --- biofilms --- diabetes --- medical devices --- candidiasis --- metabolic disorder --- hyperglycemia --- infection --- Candida glabrata --- candidemia --- echinocandins --- resistance --- micafungin --- caspofungin --- in vivo --- titanium dioxide --- nanotubes --- autoclaving --- titanium alloy --- biocompatibility --- wettability --- mechanical properties --- silver nanoparticles --- titanium dioxide nanotubes --- silver ions release --- biointegration --- antimicrobial activity --- polyethylene terephthalate --- PET --- electrospinning --- nanofibers --- antimicrobial agents --- Taguchi method --- antimicrobial efficiency --- cold atmospheric-pressure plasma jet (CAPJ) --- Escherichia coli --- DNA double-strand breaks --- scanning electron microscopy --- Ti6Al4V implants --- anodization process --- XPS --- genotoxicity assessment --- anti-inflammatory properties --- oral biofilm --- infection control --- Streptococcus mutans --- Candida spp. --- natural compounds --- antimicrobial resistance --- Candida --- biofilms --- diabetes --- medical devices --- candidiasis --- metabolic disorder --- hyperglycemia --- infection --- Candida glabrata --- candidemia --- echinocandins --- resistance --- micafungin --- caspofungin --- in vivo --- titanium dioxide --- nanotubes --- autoclaving --- titanium alloy --- biocompatibility --- wettability --- mechanical properties --- silver nanoparticles --- titanium dioxide nanotubes --- silver ions release --- biointegration --- antimicrobial activity --- polyethylene terephthalate --- PET --- electrospinning --- nanofibers --- antimicrobial agents --- Taguchi method --- antimicrobial efficiency --- cold atmospheric-pressure plasma jet (CAPJ) --- Escherichia coli --- DNA double-strand breaks --- scanning electron microscopy --- Ti6Al4V implants --- anodization process --- XPS --- genotoxicity assessment --- anti-inflammatory properties --- oral biofilm --- infection control --- Streptococcus mutans --- Candida spp. --- natural compounds --- antimicrobial resistance


Book
Frontiers in Atmospheric Pressure Plasma Technology
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Year: 2022 Publisher: Basel MDPI Books

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Atmospheric pressure plasma discharges have grown rapidly in importance in recent decades, due to the ease in handling and operation, plus their eco-friendly applications, for agriculture, food, medicine, materials and even the automotive and aerospace industries. In this context, the need for a collection of results based on plasma technologies is justified. Moreover, at the international level, the increased number of projects that translated to publications and patents in the multidisciplinary field of plasma-based technology gives researchers the opportunity to challenge their knowledge and contribute to a new era of green services and products that society demands. Therefore, this book, based on the Special Issue of “Frontiers in Atmospheric Pressure Plasma Technology” in the “Applied Physics” section of the journal Applied Sciences, provides results on some plasma-based methods and technologies for novel and possible future applications of plasmas in life sciences, biomedicine, agriculture, and the automotive industry.This book, entitled “Frontiers in Atmospheric Pressure Plasma Technology”, consists of 8 research articles, 2 review articles and 1 editorial. We know that we are only managing to address a small part of what plasma discharge can be used for, but we hope that the readers will enjoy this book and, therefore, be inspired with new ideas for future research in the field of plasma.

Keywords

Technology: general issues --- cold atmospheric pressure plasma --- antimicrobial agent --- plasma medicine --- dentistry --- atmospheric pressure plasma jet (APPJ) --- optical emission spectroscopy (OES) --- plasma-surface interactions --- local surface modification --- polymers --- functionalization --- atmospheric pressure plasma --- transdermal permeability --- transdermal delivery --- nitric oxide --- wounds --- biofilm --- plasma jet --- DBD plasma --- plasma jets --- plasma properties --- reactive species --- RONS --- non-thermal plasma --- transient spark --- electrospray --- plasma-activated water --- nitrous acid --- nitrites --- atmospheric pressure plasma jet --- plasma-wine making --- plasma treatment --- UV-Vis spectroscopy --- ATR-FTIR spectroscopy --- bio-medicine application --- cold gas-discharge plasma --- digital holography --- digital holographic interferometry --- plasma diagnostics --- CAP --- electric diagnosis --- E-field measurements --- vacuum-ultraviolet spectroscopy --- patient leakage current --- power measurement --- voltage-charge plot --- OES --- bio-medical plasma applications --- surface-wave-sustained discharge --- microwave discharge --- cold atmospheric plasma --- microwave plasma torch --- cold atmospheric pressure plasma --- antimicrobial agent --- plasma medicine --- dentistry --- atmospheric pressure plasma jet (APPJ) --- optical emission spectroscopy (OES) --- plasma-surface interactions --- local surface modification --- polymers --- functionalization --- atmospheric pressure plasma --- transdermal permeability --- transdermal delivery --- nitric oxide --- wounds --- biofilm --- plasma jet --- DBD plasma --- plasma jets --- plasma properties --- reactive species --- RONS --- non-thermal plasma --- transient spark --- electrospray --- plasma-activated water --- nitrous acid --- nitrites --- atmospheric pressure plasma jet --- plasma-wine making --- plasma treatment --- UV-Vis spectroscopy --- ATR-FTIR spectroscopy --- bio-medicine application --- cold gas-discharge plasma --- digital holography --- digital holographic interferometry --- plasma diagnostics --- CAP --- electric diagnosis --- E-field measurements --- vacuum-ultraviolet spectroscopy --- patient leakage current --- power measurement --- voltage-charge plot --- OES --- bio-medical plasma applications --- surface-wave-sustained discharge --- microwave discharge --- cold atmospheric plasma --- microwave plasma torch


Book
Promising Detoxification Strategies to Mitigate Mycotoxins in Food and Feed
Author:
ISBN: 3038970271 303897028X Year: 2018 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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This book is a printed edition of the Special Issue Promising Detoxification Strategies to Mitigate Mycotoxins in Food and Feed that was published in Toxins

Keywords

Trichoderma --- n/a --- photodegradation product --- physical decontamination --- growth performance --- toxigenic Fusarium --- curcumin --- mitigation --- Aspergillus flavus --- food and beverage --- ascladiol --- biological control --- antioxidant capability --- trichothecene --- bioprospecting --- turkey --- processing --- chicks --- Sporobolomyces sp. IAM 13481 --- mycotoxins --- epimer --- Tri101 --- enzymes --- neutral electrolyzed water --- antioxidant function --- purification --- ameliorating effects --- aflatoxin-degrading enzyme --- chemical decontamination --- desoxypatulinic acid --- furan rings --- maize --- atmospheric pressure --- biotransformation --- estrogen receptor (ER) --- oxidative stress --- decontamination --- Bacillus shackletonii --- hyssop --- DBD --- degradation --- TQEF-MS/MS --- CYP450 --- enzymatic detoxification --- low temperature plasma --- Fusarium --- AFBO–DNA --- modified mycotoxin --- Bacillus subtilis ANSB060 --- polarity --- thermal treatment --- serum hormones --- mycotoxins mitigation --- mycotoxin --- zearalenone (ZEA) --- cell viability --- detoxification --- patulin --- biodegradation --- interactions --- intracellular and extracellular enzymes --- Bacillus licheniformis CK1 --- deoxynivalenol --- aflatoxins --- aflatoxin B1 --- biological decontamination --- Corylus avellana --- molecular --- Pichia caribbica --- mild technologies --- microbial patulin degradation --- enzyme --- proteomics --- fatty acids --- spores of Ganoderma lucidum --- inhibition --- residue --- food safety --- cold atmospheric pressure plasma technology --- application --- post-weaning female piglets --- laccase --- aflatoxin biodegradation preparation --- Aflatoxin B1 --- microorganism identification --- AFBO-DNA


Book
Frontiers in Atmospheric Pressure Plasma Technology
Author:
Year: 2022 Publisher: Basel MDPI Books

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Abstract

Atmospheric pressure plasma discharges have grown rapidly in importance in recent decades, due to the ease in handling and operation, plus their eco-friendly applications, for agriculture, food, medicine, materials and even the automotive and aerospace industries. In this context, the need for a collection of results based on plasma technologies is justified. Moreover, at the international level, the increased number of projects that translated to publications and patents in the multidisciplinary field of plasma-based technology gives researchers the opportunity to challenge their knowledge and contribute to a new era of green services and products that society demands. Therefore, this book, based on the Special Issue of “Frontiers in Atmospheric Pressure Plasma Technology” in the “Applied Physics” section of the journal Applied Sciences, provides results on some plasma-based methods and technologies for novel and possible future applications of plasmas in life sciences, biomedicine, agriculture, and the automotive industry.This book, entitled “Frontiers in Atmospheric Pressure Plasma Technology”, consists of 8 research articles, 2 review articles and 1 editorial. We know that we are only managing to address a small part of what plasma discharge can be used for, but we hope that the readers will enjoy this book and, therefore, be inspired with new ideas for future research in the field of plasma.


Book
Frontiers in Atmospheric Pressure Plasma Technology
Author:
Year: 2022 Publisher: Basel MDPI Books

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Abstract

Atmospheric pressure plasma discharges have grown rapidly in importance in recent decades, due to the ease in handling and operation, plus their eco-friendly applications, for agriculture, food, medicine, materials and even the automotive and aerospace industries. In this context, the need for a collection of results based on plasma technologies is justified. Moreover, at the international level, the increased number of projects that translated to publications and patents in the multidisciplinary field of plasma-based technology gives researchers the opportunity to challenge their knowledge and contribute to a new era of green services and products that society demands. Therefore, this book, based on the Special Issue of “Frontiers in Atmospheric Pressure Plasma Technology” in the “Applied Physics” section of the journal Applied Sciences, provides results on some plasma-based methods and technologies for novel and possible future applications of plasmas in life sciences, biomedicine, agriculture, and the automotive industry.This book, entitled “Frontiers in Atmospheric Pressure Plasma Technology”, consists of 8 research articles, 2 review articles and 1 editorial. We know that we are only managing to address a small part of what plasma discharge can be used for, but we hope that the readers will enjoy this book and, therefore, be inspired with new ideas for future research in the field of plasma.


Book
Plasma Biology
Authors: ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Irving Langmuir coined the name “plasma” to describe an ionized gas back in 1927. Just over 90 years later, plasma technology is becoming increasingly important in our daily life. For example, in the medical field and dentistry, plasma is used as a method of disinfection and sterilization. Moreover, additional potential novel applications of this technology in different forms of therapy have been proposed. In the agricultural sector, plasma technology could contribute to higher crop yields by enhancing seed germination and the growth of plants, as well as the preservation of foods by disinfection. Plasma technology could also be utilized in environmental applications, including water treatment and remediation, as well as treatment of exhaust gases. Although recent extensive studies have uncovered the broad potential of plasma technology, its mechanisms of action remain unclear. Therefore, further studies aimed at elucidating the molecular mechanisms of plasma technology are required. This book is composed of original articles and reviews investigating the molecular mechanisms of plasma biology. Relevant areas of study include applications in plasma medicine, plasma agriculture, as well as plasma chemistry. Studies on potential therapeutic approaches using plasma itself and plasma-treated solutions are also included.

Keywords

Technology: general issues --- cold jet atmospheric pressure plasma --- reactive oxygen and nitrogen species --- backbone cleavage --- hydroxylation --- carbonyl formation --- cold atmospheric plasma --- autophagy --- silymarin nanoemulsion --- PI3K/mTOR pathway --- wound healing --- oncology --- regenerative medicine --- plasma --- atmospheric pressure plasma jets --- large-scale imaging --- machine learning --- cancer treatment --- cellular imaging --- reactive oxygen species --- mesoporous silica nanoparticles --- biomaterials --- bone regeneration --- cytotoxicity --- proliferation --- osteogenic differentiation --- plasma-activated medium --- TRAIL --- DR5 --- apoptosis --- ROS/RNS --- atmospheric-pressure plasma --- titanium --- amine --- mesenchymal stem cells --- antibiotic resistant bacteria --- antibiotic resistance gene --- disinfection --- E. coli --- inactivation --- sterilization --- cell migration --- endothelial cells VEGF --- gynaecological oncology --- vulva cancer --- risk factors --- plasma tissue interaction --- premalignant lesions --- cancer development --- patient stratification --- individualised profiling --- predictive preventive personalised medicine (PPPM/3PM) --- treatment --- Candida albicans --- cold plasma treatment --- genome --- hydrolytic enzyme activity --- carbon assimilation --- drug susceptibility --- malignant melanoma --- acidification --- nitrite --- acidified nitrite --- nitration --- membrane damage --- CAP --- cancer --- cold atmospheric pressure plasma --- hydrogen peroxide --- hypochlorous acid --- moDCs --- peroxynitrite --- RNS --- ROS --- non-thermal plasma --- biological activity --- breast cancer --- solution plasma process --- aqueous solutions --- chitin --- chitosan --- degradation --- deacetylation --- non-thermal atmospheric pressure plasma --- Pectobacteriaceae --- Dickeya spp. --- Pectobacterium spp. --- antibacterial --- plant protection --- agriculture --- selective cancer treatment --- reaction network --- mathematical modeling --- Mdm2-p53 --- plasma treatment --- molecular dynamic (MD) simulations --- cold jet atmospheric pressure plasma --- reactive oxygen and nitrogen species --- backbone cleavage --- hydroxylation --- carbonyl formation --- cold atmospheric plasma --- autophagy --- silymarin nanoemulsion --- PI3K/mTOR pathway --- wound healing --- oncology --- regenerative medicine --- plasma --- atmospheric pressure plasma jets --- large-scale imaging --- machine learning --- cancer treatment --- cellular imaging --- reactive oxygen species --- mesoporous silica nanoparticles --- biomaterials --- bone regeneration --- cytotoxicity --- proliferation --- osteogenic differentiation --- plasma-activated medium --- TRAIL --- DR5 --- apoptosis --- ROS/RNS --- atmospheric-pressure plasma --- titanium --- amine --- mesenchymal stem cells --- antibiotic resistant bacteria --- antibiotic resistance gene --- disinfection --- E. coli --- inactivation --- sterilization --- cell migration --- endothelial cells VEGF --- gynaecological oncology --- vulva cancer --- risk factors --- plasma tissue interaction --- premalignant lesions --- cancer development --- patient stratification --- individualised profiling --- predictive preventive personalised medicine (PPPM/3PM) --- treatment --- Candida albicans --- cold plasma treatment --- genome --- hydrolytic enzyme activity --- carbon assimilation --- drug susceptibility --- malignant melanoma --- acidification --- nitrite --- acidified nitrite --- nitration --- membrane damage --- CAP --- cancer --- cold atmospheric pressure plasma --- hydrogen peroxide --- hypochlorous acid --- moDCs --- peroxynitrite --- RNS --- ROS --- non-thermal plasma --- biological activity --- breast cancer --- solution plasma process --- aqueous solutions --- chitin --- chitosan --- degradation --- deacetylation --- non-thermal atmospheric pressure plasma --- Pectobacteriaceae --- Dickeya spp. --- Pectobacterium spp. --- antibacterial --- plant protection --- agriculture --- selective cancer treatment --- reaction network --- mathematical modeling --- Mdm2-p53 --- plasma treatment --- molecular dynamic (MD) simulations


Book
Plasma in Cancer Treatment
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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In the last decade, research on cold atmospheric plasma (CAP) has significantly advanced our understanding of the effect of CAP on cancer cells and their potential for cancer treatment. This effect is due to the reactive oxygen and nitrogen species (RONS) created by plasma. This has been demonstrated for different cancer cell lines and the first clinical trials showed promising results. In addition, plasma could be combined with other treatments—such as immunotherapy—to boost its anticancer activity. The addition of new research tools to study the response of cancer cells to CAP—such as 3D in vitro, in ovo, and in vivo models and in silico approaches—as well as the use of -OMICS technologies could aid in unravelling the underlying mechanisms of CAP in cancer treatment. In order to progress towards widespread clinical application of CAP, an integrated study of the multidimensional effect of CAP in cancer treatment is essential. In this book, reviews and original research papers are published that provide new insights into the mechanisms of cold atmospheric plasma in cancer treatment, based on in vitro and in vivo experiments, clinical studies, as well as computer modeling.

Keywords

Medicine --- cell adhesion --- plasma medicine --- oncology --- cold atmospheric plasma --- selectivity --- plasma-treated liquid --- dielectric barrier discharge --- pancreatic cancer --- pancreatic stellate cells --- immunogenic cell death --- dendritic cells --- cell communication --- extracellular matrix (ECM) --- reactive oxygen and nitrogen species (ROS) --- tumour microenvironment (TME) --- extracellular vesicles --- communication junctions --- three-dimensional in vitro culture models --- apoptosis --- breast cancer --- genome-wide expression --- reactive oxygen species --- anticancer drugs --- screening --- tumor spheroids --- combination therapy --- kINPen --- reactive oxygen and nitrogen species --- ROS --- cancer --- non-thermal atmospheric pressure plasma (NTP) --- indirect treatment --- plasma-treated phosphate-buffered saline --- electroporation --- electric pulses --- pulsed electric field amplitude --- melanoma --- long-lived reactive species --- bone cancer --- osteosarcoma --- reactive species --- plasma-activated liquid --- Ringer's saline --- organotypic model --- nonthermal biocompatible plasma --- soft jet plasma --- human glioblastoma --- p38/MAPK pathway --- tissue penetration --- non-thermal plasma --- non-invasive plasma treatment (NIPP) --- cervical intraepithelial neoplasia (CIN) --- Raman imaging --- Raman microspectroscopy --- Plasma lipid interactions --- cold physical plasma --- radiation therapy --- radio-frequency discharge --- PARP-inhibitor --- olaparib --- DNA-damage --- gold quantum dots --- plasma --- nanomaterials --- cellular uptake --- invasiveness --- cold atmospheric pressure plasma --- plasma-activated Ringer's lactate solution --- ovarian cancer --- cytotoxicity --- plasma-activated liquids --- multicellular tumor spheroids --- long-lived reactive oxygen and nitrogen species --- high frequency electrosurgery --- plasma treatment --- cold atmospheric plasma (CAP) --- free radicals --- cancer selectivity --- cervical cancer treatment --- cervical intraepithelial neoplasia --- cholangiocarcinoma --- cold plasma --- innovative therapy --- tumor cells --- macrophages --- plasma selectivity --- plasma jet --- cell adhesion --- plasma medicine --- oncology --- cold atmospheric plasma --- selectivity --- plasma-treated liquid --- dielectric barrier discharge --- pancreatic cancer --- pancreatic stellate cells --- immunogenic cell death --- dendritic cells --- cell communication --- extracellular matrix (ECM) --- reactive oxygen and nitrogen species (ROS) --- tumour microenvironment (TME) --- extracellular vesicles --- communication junctions --- three-dimensional in vitro culture models --- apoptosis --- breast cancer --- genome-wide expression --- reactive oxygen species --- anticancer drugs --- screening --- tumor spheroids --- combination therapy --- kINPen --- reactive oxygen and nitrogen species --- ROS --- cancer --- non-thermal atmospheric pressure plasma (NTP) --- indirect treatment --- plasma-treated phosphate-buffered saline --- electroporation --- electric pulses --- pulsed electric field amplitude --- melanoma --- long-lived reactive species --- bone cancer --- osteosarcoma --- reactive species --- plasma-activated liquid --- Ringer's saline --- organotypic model --- nonthermal biocompatible plasma --- soft jet plasma --- human glioblastoma --- p38/MAPK pathway --- tissue penetration --- non-thermal plasma --- non-invasive plasma treatment (NIPP) --- cervical intraepithelial neoplasia (CIN) --- Raman imaging --- Raman microspectroscopy --- Plasma lipid interactions --- cold physical plasma --- radiation therapy --- radio-frequency discharge --- PARP-inhibitor --- olaparib --- DNA-damage --- gold quantum dots --- plasma --- nanomaterials --- cellular uptake --- invasiveness --- cold atmospheric pressure plasma --- plasma-activated Ringer's lactate solution --- ovarian cancer --- cytotoxicity --- plasma-activated liquids --- multicellular tumor spheroids --- long-lived reactive oxygen and nitrogen species --- high frequency electrosurgery --- plasma treatment --- cold atmospheric plasma (CAP) --- free radicals --- cancer selectivity --- cervical cancer treatment --- cervical intraepithelial neoplasia --- cholangiocarcinoma --- cold plasma --- innovative therapy --- tumor cells --- macrophages --- plasma selectivity --- plasma jet

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