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For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
Medicine --- tissue barrier --- tight junction --- claudins --- tricellulin --- tight junctions --- organ preservation --- intestine --- transplantation --- ischemia --- intestinal mucosa --- lung --- epithelia --- interleukin 13 --- UBE2Z --- ubiquitin --- osmolality --- hydrostatic pressure --- cancer --- sensor --- tricellular tight junctions --- endometrial cancer --- epithelial barrier dysfunction --- Claudin-7 --- permeability --- WNK4 --- epithelial sodium channel (ENaC), collecting duct cells --- claudin-1 --- hydrogen peroxide --- phosphorylation --- claudin --- angulin --- drug development --- angubindin-1 --- Clostridium perfringens enterotoxin --- Clostridium perfringens iota-toxin --- antibody --- Mz-ChA-1 cells --- biliary epithelial cells --- phosphatidylcholine --- mucus --- paracellular transport --- atopic dermatitis --- cytokines --- STAT3 --- ZO-2 --- cholestasis --- gene transcription --- hypertrophy --- tumor suppressor --- NLS --- NES --- CaSR --- RhoA --- barrier function --- paracellular permeability --- antidiuretic hormone --- Claudin-14 --- CLDN14 --- hearing loss --- vestibular function --- cochlear implantation --- Hepatitis C Virus --- viral entry --- epidermal barrier --- reconstructed human epidermis --- claudin targeting --- Campylobacter jejuni --- curcumin --- apoptosis --- co-culture --- mouse colon --- TNF --- NFκB --- lipolysis-stimulated lipoprotein receptor (LSR) --- epithelial barrier --- cell–cell contact --- caspase --- kidney stones --- ion reabsorption --- quercetin --- brain barriers --- blood-brain barrier --- neurovascular unit --- blood-cerebrospinal fluid barrier --- arachnoid barrier --- glia limitans --- adherens junctions --- paracellular sodium transport --- thick ascending limb --- nephropathy --- HELIX syndrome --- hypokalemia --- hypermagnesemia --- anhidrosis --- gland dysfunction --- aging --- blood–brain barrier --- mutations --- kidney --- liver --- skin --- human --- mice --- disease --- in silico --- drug discovery --- membrane proteins --- protein interactions --- molecular dynamics --- antibiotic-associated hemorrhagic colitis --- Klebsiella oxytoca --- tight junction assembly --- monocytes --- celiac disease --- claudin-2 --- epithelium --- inflammation --- fibrosis --- proliferation --- migration --- tricellular tight junction --- paracellular water transport --- tight epithelium --- MDCK C7 cells --- cell growth --- endothelia --- adherens junction --- apical junctional complex --- AMP-activated protein kinase (AMPK) --- paracellular barrier --- protein structure --- protein domain --- occludin --- junctional adhesion molecule --- zonula occludens --- MAGUK proteins --- PDZ domain --- stem cell --- chemoresistance --- retinal pigment epithelium --- retinopathy --- barrier formation --- collecting duct --- claudin-5 --- neuropathic pain --- nerve injury --- dorsal root ganglion --- enteropathogenic E. coli (EPEC) --- tight junctions (TJ) --- polarity --- atypical aPKCζ --- transepithelial electrical resistance (TER) --- sorting nexin 9 (SNX9) --- EspF --- claudin 1 --- tumor --- metastasis --- epithelial to mesenchymal transition --- cerebral cavernous malformation --- endothelial barrier --- Rho --- ROCK --- MEKK3 --- ion transport --- ion channel --- super-resolution microscopy --- structured illumination microscopy --- stimulated emission depletion --- single molecule localization microscopy --- Claudin --- blood-biliary barrier --- chronic liver disease --- hepatocellular carcinoma --- cholangiocellular carcinoma --- NISCH syndrome --- repair --- NHE2 --- ClC-2 --- inflammatory bowel disease --- mucosal immunology --- ZO-1 --- actomyosin --- aquaporin --- drinking rate --- epithelial fluid transport --- enterocyte --- osmoregulation --- paracellular --- proximal tubule --- calcium permeability --- claudin-12 --- paracellular channels and barriers --- cell polarity --- pathogens --- immune cells --- environmental sensors
Choose an application
For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
Medicine --- tissue barrier --- tight junction --- claudins --- tricellulin --- tight junctions --- organ preservation --- intestine --- transplantation --- ischemia --- intestinal mucosa --- lung --- epithelia --- interleukin 13 --- UBE2Z --- ubiquitin --- osmolality --- hydrostatic pressure --- cancer --- sensor --- tricellular tight junctions --- endometrial cancer --- epithelial barrier dysfunction --- Claudin-7 --- permeability --- WNK4 --- epithelial sodium channel (ENaC), collecting duct cells --- claudin-1 --- hydrogen peroxide --- phosphorylation --- claudin --- angulin --- drug development --- angubindin-1 --- Clostridium perfringens enterotoxin --- Clostridium perfringens iota-toxin --- antibody --- Mz-ChA-1 cells --- biliary epithelial cells --- phosphatidylcholine --- mucus --- paracellular transport --- atopic dermatitis --- cytokines --- STAT3 --- ZO-2 --- cholestasis --- gene transcription --- hypertrophy --- tumor suppressor --- NLS --- NES --- CaSR --- RhoA --- barrier function --- paracellular permeability --- antidiuretic hormone --- Claudin-14 --- CLDN14 --- hearing loss --- vestibular function --- cochlear implantation --- Hepatitis C Virus --- viral entry --- epidermal barrier --- reconstructed human epidermis --- claudin targeting --- Campylobacter jejuni --- curcumin --- apoptosis --- co-culture --- mouse colon --- TNF --- NFκB --- lipolysis-stimulated lipoprotein receptor (LSR) --- epithelial barrier --- cell–cell contact --- caspase --- kidney stones --- ion reabsorption --- quercetin --- brain barriers --- blood-brain barrier --- neurovascular unit --- blood-cerebrospinal fluid barrier --- arachnoid barrier --- glia limitans --- adherens junctions --- paracellular sodium transport --- thick ascending limb --- nephropathy --- HELIX syndrome --- hypokalemia --- hypermagnesemia --- anhidrosis --- gland dysfunction --- aging --- blood–brain barrier --- mutations --- kidney --- liver --- skin --- human --- mice --- disease --- in silico --- drug discovery --- membrane proteins --- protein interactions --- molecular dynamics --- antibiotic-associated hemorrhagic colitis --- Klebsiella oxytoca --- tight junction assembly --- monocytes --- celiac disease --- claudin-2 --- epithelium --- inflammation --- fibrosis --- proliferation --- migration --- tricellular tight junction --- paracellular water transport --- tight epithelium --- MDCK C7 cells --- cell growth --- endothelia --- adherens junction --- apical junctional complex --- AMP-activated protein kinase (AMPK) --- paracellular barrier --- protein structure --- protein domain --- occludin --- junctional adhesion molecule --- zonula occludens --- MAGUK proteins --- PDZ domain --- stem cell --- chemoresistance --- retinal pigment epithelium --- retinopathy --- barrier formation --- collecting duct --- claudin-5 --- neuropathic pain --- nerve injury --- dorsal root ganglion --- enteropathogenic E. coli (EPEC) --- tight junctions (TJ) --- polarity --- atypical aPKCζ --- transepithelial electrical resistance (TER) --- sorting nexin 9 (SNX9) --- EspF --- claudin 1 --- tumor --- metastasis --- epithelial to mesenchymal transition --- cerebral cavernous malformation --- endothelial barrier --- Rho --- ROCK --- MEKK3 --- ion transport --- ion channel --- super-resolution microscopy --- structured illumination microscopy --- stimulated emission depletion --- single molecule localization microscopy --- Claudin --- blood-biliary barrier --- chronic liver disease --- hepatocellular carcinoma --- cholangiocellular carcinoma --- NISCH syndrome --- repair --- NHE2 --- ClC-2 --- inflammatory bowel disease --- mucosal immunology --- ZO-1 --- actomyosin --- aquaporin --- drinking rate --- epithelial fluid transport --- enterocyte --- osmoregulation --- paracellular --- proximal tubule --- calcium permeability --- claudin-12 --- paracellular channels and barriers --- cell polarity --- pathogens --- immune cells --- environmental sensors
Choose an application
For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
tissue barrier --- tight junction --- claudins --- tricellulin --- tight junctions --- organ preservation --- intestine --- transplantation --- ischemia --- intestinal mucosa --- lung --- epithelia --- interleukin 13 --- UBE2Z --- ubiquitin --- osmolality --- hydrostatic pressure --- cancer --- sensor --- tricellular tight junctions --- endometrial cancer --- epithelial barrier dysfunction --- Claudin-7 --- permeability --- WNK4 --- epithelial sodium channel (ENaC), collecting duct cells --- claudin-1 --- hydrogen peroxide --- phosphorylation --- claudin --- angulin --- drug development --- angubindin-1 --- Clostridium perfringens enterotoxin --- Clostridium perfringens iota-toxin --- antibody --- Mz-ChA-1 cells --- biliary epithelial cells --- phosphatidylcholine --- mucus --- paracellular transport --- atopic dermatitis --- cytokines --- STAT3 --- ZO-2 --- cholestasis --- gene transcription --- hypertrophy --- tumor suppressor --- NLS --- NES --- CaSR --- RhoA --- barrier function --- paracellular permeability --- antidiuretic hormone --- Claudin-14 --- CLDN14 --- hearing loss --- vestibular function --- cochlear implantation --- Hepatitis C Virus --- viral entry --- epidermal barrier --- reconstructed human epidermis --- claudin targeting --- Campylobacter jejuni --- curcumin --- apoptosis --- co-culture --- mouse colon --- TNF --- NFκB --- lipolysis-stimulated lipoprotein receptor (LSR) --- epithelial barrier --- cell–cell contact --- caspase --- kidney stones --- ion reabsorption --- quercetin --- brain barriers --- blood-brain barrier --- neurovascular unit --- blood-cerebrospinal fluid barrier --- arachnoid barrier --- glia limitans --- adherens junctions --- paracellular sodium transport --- thick ascending limb --- nephropathy --- HELIX syndrome --- hypokalemia --- hypermagnesemia --- anhidrosis --- gland dysfunction --- aging --- blood–brain barrier --- mutations --- kidney --- liver --- skin --- human --- mice --- disease --- in silico --- drug discovery --- membrane proteins --- protein interactions --- molecular dynamics --- antibiotic-associated hemorrhagic colitis --- Klebsiella oxytoca --- tight junction assembly --- monocytes --- celiac disease --- claudin-2 --- epithelium --- inflammation --- fibrosis --- proliferation --- migration --- tricellular tight junction --- paracellular water transport --- tight epithelium --- MDCK C7 cells --- cell growth --- endothelia --- adherens junction --- apical junctional complex --- AMP-activated protein kinase (AMPK) --- paracellular barrier --- protein structure --- protein domain --- occludin --- junctional adhesion molecule --- zonula occludens --- MAGUK proteins --- PDZ domain --- stem cell --- chemoresistance --- retinal pigment epithelium --- retinopathy --- barrier formation --- collecting duct --- claudin-5 --- neuropathic pain --- nerve injury --- dorsal root ganglion --- enteropathogenic E. coli (EPEC) --- tight junctions (TJ) --- polarity --- atypical aPKCζ --- transepithelial electrical resistance (TER) --- sorting nexin 9 (SNX9) --- EspF --- claudin 1 --- tumor --- metastasis --- epithelial to mesenchymal transition --- cerebral cavernous malformation --- endothelial barrier --- Rho --- ROCK --- MEKK3 --- ion transport --- ion channel --- super-resolution microscopy --- structured illumination microscopy --- stimulated emission depletion --- single molecule localization microscopy --- Claudin --- blood-biliary barrier --- chronic liver disease --- hepatocellular carcinoma --- cholangiocellular carcinoma --- NISCH syndrome --- repair --- NHE2 --- ClC-2 --- inflammatory bowel disease --- mucosal immunology --- ZO-1 --- actomyosin --- aquaporin --- drinking rate --- epithelial fluid transport --- enterocyte --- osmoregulation --- paracellular --- proximal tubule --- calcium permeability --- claudin-12 --- paracellular channels and barriers --- cell polarity --- pathogens --- immune cells --- environmental sensors
Choose an application
For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
tissue barrier --- tight junction --- claudins --- tricellulin --- tight junctions --- organ preservation --- intestine --- transplantation --- ischemia --- intestinal mucosa --- lung --- epithelia --- interleukin 13 --- UBE2Z --- ubiquitin --- osmolality --- hydrostatic pressure --- cancer --- sensor --- tricellular tight junctions --- endometrial cancer --- epithelial barrier dysfunction --- Claudin-7 --- permeability --- WNK4 --- epithelial sodium channel (ENaC), collecting duct cells --- claudin-1 --- hydrogen peroxide --- phosphorylation --- claudin --- angulin --- drug development --- angubindin-1 --- Clostridium perfringens enterotoxin --- Clostridium perfringens iota-toxin --- antibody --- Mz-ChA-1 cells --- biliary epithelial cells --- phosphatidylcholine --- mucus --- paracellular transport --- atopic dermatitis --- cytokines --- STAT3 --- ZO-2 --- cholestasis --- gene transcription --- hypertrophy --- tumor suppressor --- NLS --- NES --- CaSR --- RhoA --- barrier function --- paracellular permeability --- antidiuretic hormone --- Claudin-14 --- CLDN14 --- hearing loss --- vestibular function --- cochlear implantation --- Hepatitis C Virus --- viral entry --- epidermal barrier --- reconstructed human epidermis --- claudin targeting --- Campylobacter jejuni --- curcumin --- apoptosis --- co-culture --- mouse colon --- TNF --- NFκB --- lipolysis-stimulated lipoprotein receptor (LSR) --- epithelial barrier --- cell–cell contact --- caspase --- kidney stones --- ion reabsorption --- quercetin --- brain barriers --- blood-brain barrier --- neurovascular unit --- blood-cerebrospinal fluid barrier --- arachnoid barrier --- glia limitans --- adherens junctions --- paracellular sodium transport --- thick ascending limb --- nephropathy --- HELIX syndrome --- hypokalemia --- hypermagnesemia --- anhidrosis --- gland dysfunction --- aging --- blood–brain barrier --- mutations --- kidney --- liver --- skin --- human --- mice --- disease --- in silico --- drug discovery --- membrane proteins --- protein interactions --- molecular dynamics --- antibiotic-associated hemorrhagic colitis --- Klebsiella oxytoca --- tight junction assembly --- monocytes --- celiac disease --- claudin-2 --- epithelium --- inflammation --- fibrosis --- proliferation --- migration --- tricellular tight junction --- paracellular water transport --- tight epithelium --- MDCK C7 cells --- cell growth --- endothelia --- adherens junction --- apical junctional complex --- AMP-activated protein kinase (AMPK) --- paracellular barrier --- protein structure --- protein domain --- occludin --- junctional adhesion molecule --- zonula occludens --- MAGUK proteins --- PDZ domain --- stem cell --- chemoresistance --- retinal pigment epithelium --- retinopathy --- barrier formation --- collecting duct --- claudin-5 --- neuropathic pain --- nerve injury --- dorsal root ganglion --- enteropathogenic E. coli (EPEC) --- tight junctions (TJ) --- polarity --- atypical aPKCζ --- transepithelial electrical resistance (TER) --- sorting nexin 9 (SNX9) --- EspF --- claudin 1 --- tumor --- metastasis --- epithelial to mesenchymal transition --- cerebral cavernous malformation --- endothelial barrier --- Rho --- ROCK --- MEKK3 --- ion transport --- ion channel --- super-resolution microscopy --- structured illumination microscopy --- stimulated emission depletion --- single molecule localization microscopy --- Claudin --- blood-biliary barrier --- chronic liver disease --- hepatocellular carcinoma --- cholangiocellular carcinoma --- NISCH syndrome --- repair --- NHE2 --- ClC-2 --- inflammatory bowel disease --- mucosal immunology --- ZO-1 --- actomyosin --- aquaporin --- drinking rate --- epithelial fluid transport --- enterocyte --- osmoregulation --- paracellular --- proximal tubule --- calcium permeability --- claudin-12 --- paracellular channels and barriers --- cell polarity --- pathogens --- immune cells --- environmental sensors
Choose an application
Discovered over 40 years ago, the annexin proteins were found to be a structurally conserved subgroup of Ca2+-binding proteins. While the initial research on annexins focused on their signature feature of Ca2+-dependent binding to membranes, over the years, the biennial “Annexin” conference series has highlighted additional diversity in the functions attributed to the annexin family of proteins. The roles of these proteins now extend from basic science to biomedical research, and are being translated into clinical settings. Research on annexins involves a global network of researchers and the 10th biennial Annexin conference brought together over 80 researchers from ten European countries, USA, Brazil, Singapore, Japan, and Australia for 3 days in September 2019. In this conference, the discussions focused on two distinct themes — the role of annexins in cellular organization and health and disease. The articles published in this Special Issue cover these two main themes discussed at the conference, offering a glimpse into some of the notable findings in the field of annexin biology
Research & information: general --- inflammation --- nigericin --- pyroptosis --- mass spectrometry --- lipidomics --- anxA2 --- Birbeck granules --- Langerhans cell --- A2t --- annexin --- plasma membrane repair --- membrane curvature --- membrane curvature sensing --- membrane shaping --- interdisciplinary research --- cell rupture --- membrane damage --- bias analysis --- G protein-coupled receptor (GPCR) --- formyl peptide receptor 1 --- danger-associated molecular pattern (DAMP) --- pathogen-associated molecular pattern (PAMP) --- annexin A1 peptide Ac2-26 --- cholesterol --- AnxA6 --- chaperone-mediated autophagy --- endolysosomes --- NPC1 --- Lamp2A --- annexin A2 --- microdomain --- cross-linker --- quartz crystal microbalance with dissipation monitoring (QCM-D) --- mucin-1 --- claudin-1 --- zona occludens --- ERK1/2 pathway --- angiogenesis --- F-actin polymerization --- BeWo spheroids --- Ishikawa cells --- influenza --- RNA-sequencing --- transcriptomics --- autophagy --- Annexin-A1 --- infection --- adherens junction --- macroautophagy --- breast cancer --- estrogen receptor negative --- Annexin A2 --- metastasis --- annexin-A6 --- membrane repair --- human skeletal muscle --- cap subdomain --- fluorescence --- electron microscopy --- CLEM --- annexin A6 --- RasGRF2 --- EGFR --- cell growth --- cell motility --- acquired resistance --- tyrosine kinase inhibitors --- muscle injury --- plasma membrane --- vesicle --- muscular dystrophy --- annexinA2 egress --- exocytosis --- chromaffin cells --- thrombosis --- Annexin A1 --- formyl peptide receptors --- sickle cell disease --- sepsis --- Annexin --- membrane --- injury --- virus --- lipid --- cancer --- inflammation --- nigericin --- pyroptosis --- mass spectrometry --- lipidomics --- anxA2 --- Birbeck granules --- Langerhans cell --- A2t --- annexin --- plasma membrane repair --- membrane curvature --- membrane curvature sensing --- membrane shaping --- interdisciplinary research --- cell rupture --- membrane damage --- bias analysis --- G protein-coupled receptor (GPCR) --- formyl peptide receptor 1 --- danger-associated molecular pattern (DAMP) --- pathogen-associated molecular pattern (PAMP) --- annexin A1 peptide Ac2-26 --- cholesterol --- AnxA6 --- chaperone-mediated autophagy --- endolysosomes --- NPC1 --- Lamp2A --- annexin A2 --- microdomain --- cross-linker --- quartz crystal microbalance with dissipation monitoring (QCM-D) --- mucin-1 --- claudin-1 --- zona occludens --- ERK1/2 pathway --- angiogenesis --- F-actin polymerization --- BeWo spheroids --- Ishikawa cells --- influenza --- RNA-sequencing --- transcriptomics --- autophagy --- Annexin-A1 --- infection --- adherens junction --- macroautophagy --- breast cancer --- estrogen receptor negative --- Annexin A2 --- metastasis --- annexin-A6 --- membrane repair --- human skeletal muscle --- cap subdomain --- fluorescence --- electron microscopy --- CLEM --- annexin A6 --- RasGRF2 --- EGFR --- cell growth --- cell motility --- acquired resistance --- tyrosine kinase inhibitors --- muscle injury --- plasma membrane --- vesicle --- muscular dystrophy --- annexinA2 egress --- exocytosis --- chromaffin cells --- thrombosis --- Annexin A1 --- formyl peptide receptors --- sickle cell disease --- sepsis --- Annexin --- membrane --- injury --- virus --- lipid --- cancer
Choose an application
Discovered over 40 years ago, the annexin proteins were found to be a structurally conserved subgroup of Ca2+-binding proteins. While the initial research on annexins focused on their signature feature of Ca2+-dependent binding to membranes, over the years, the biennial “Annexin” conference series has highlighted additional diversity in the functions attributed to the annexin family of proteins. The roles of these proteins now extend from basic science to biomedical research, and are being translated into clinical settings. Research on annexins involves a global network of researchers and the 10th biennial Annexin conference brought together over 80 researchers from ten European countries, USA, Brazil, Singapore, Japan, and Australia for 3 days in September 2019. In this conference, the discussions focused on two distinct themes — the role of annexins in cellular organization and health and disease. The articles published in this Special Issue cover these two main themes discussed at the conference, offering a glimpse into some of the notable findings in the field of annexin biology
inflammation --- nigericin --- pyroptosis --- mass spectrometry --- lipidomics --- anxA2 --- Birbeck granules --- Langerhans cell --- A2t --- annexin --- plasma membrane repair --- membrane curvature --- membrane curvature sensing --- membrane shaping --- interdisciplinary research --- cell rupture --- membrane damage --- bias analysis --- G protein-coupled receptor (GPCR) --- formyl peptide receptor 1 --- danger-associated molecular pattern (DAMP) --- pathogen-associated molecular pattern (PAMP) --- annexin A1 peptide Ac2-26 --- cholesterol --- AnxA6 --- chaperone-mediated autophagy --- endolysosomes --- NPC1 --- Lamp2A --- annexin A2 --- microdomain --- cross-linker --- quartz crystal microbalance with dissipation monitoring (QCM-D) --- mucin-1 --- claudin-1 --- zona occludens --- ERK1/2 pathway --- angiogenesis --- F-actin polymerization --- BeWo spheroids --- Ishikawa cells --- influenza --- RNA-sequencing --- transcriptomics --- autophagy --- Annexin-A1 --- infection --- adherens junction --- macroautophagy --- breast cancer --- estrogen receptor negative --- Annexin A2 --- metastasis --- annexin-A6 --- membrane repair --- human skeletal muscle --- cap subdomain --- fluorescence --- electron microscopy --- CLEM --- annexin A6 --- RasGRF2 --- EGFR --- cell growth --- cell motility --- acquired resistance --- tyrosine kinase inhibitors --- muscle injury --- plasma membrane --- vesicle --- muscular dystrophy --- annexinA2 egress --- exocytosis --- chromaffin cells --- thrombosis --- Annexin A1 --- formyl peptide receptors --- sickle cell disease --- sepsis --- Annexin --- membrane --- injury --- virus --- lipid --- cancer
Choose an application
For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
Medicine --- tissue barrier --- tight junction --- claudins --- tricellulin --- tight junctions --- organ preservation --- intestine --- transplantation --- ischemia --- intestinal mucosa --- lung --- epithelia --- interleukin 13 --- UBE2Z --- ubiquitin --- osmolality --- hydrostatic pressure --- cancer --- sensor --- tricellular tight junctions --- endometrial cancer --- epithelial barrier dysfunction --- Claudin-7 --- permeability --- WNK4 --- epithelial sodium channel (ENaC), collecting duct cells --- claudin-1 --- hydrogen peroxide --- phosphorylation --- claudin --- angulin --- drug development --- angubindin-1 --- Clostridium perfringens enterotoxin --- Clostridium perfringens iota-toxin --- antibody --- Mz-ChA-1 cells --- biliary epithelial cells --- phosphatidylcholine --- mucus --- paracellular transport --- atopic dermatitis --- cytokines --- STAT3 --- ZO-2 --- cholestasis --- gene transcription --- hypertrophy --- tumor suppressor --- NLS --- NES --- CaSR --- RhoA --- barrier function --- paracellular permeability --- antidiuretic hormone --- Claudin-14 --- CLDN14 --- hearing loss --- vestibular function --- cochlear implantation --- Hepatitis C Virus --- viral entry --- epidermal barrier --- reconstructed human epidermis --- claudin targeting --- Campylobacter jejuni --- curcumin --- apoptosis --- co-culture --- mouse colon --- TNF --- NFκB --- lipolysis-stimulated lipoprotein receptor (LSR) --- epithelial barrier --- cell–cell contact --- caspase --- kidney stones --- ion reabsorption --- quercetin --- brain barriers --- blood-brain barrier --- neurovascular unit --- blood-cerebrospinal fluid barrier --- arachnoid barrier --- glia limitans --- adherens junctions --- paracellular sodium transport --- thick ascending limb --- nephropathy --- HELIX syndrome --- hypokalemia --- hypermagnesemia --- anhidrosis --- gland dysfunction --- aging --- blood–brain barrier --- mutations --- kidney --- liver --- skin --- human --- mice --- disease --- in silico --- drug discovery --- membrane proteins --- protein interactions --- molecular dynamics --- antibiotic-associated hemorrhagic colitis --- Klebsiella oxytoca --- tight junction assembly --- monocytes --- celiac disease --- claudin-2 --- epithelium --- inflammation --- fibrosis --- proliferation --- migration --- tricellular tight junction --- paracellular water transport --- tight epithelium --- MDCK C7 cells --- cell growth --- endothelia --- adherens junction --- apical junctional complex --- AMP-activated protein kinase (AMPK) --- paracellular barrier --- protein structure --- protein domain --- occludin --- junctional adhesion molecule --- zonula occludens --- MAGUK proteins --- PDZ domain --- stem cell --- chemoresistance --- retinal pigment epithelium --- retinopathy --- barrier formation --- collecting duct --- claudin-5 --- neuropathic pain --- nerve injury --- dorsal root ganglion --- enteropathogenic E. coli (EPEC) --- tight junctions (TJ) --- polarity --- atypical aPKCζ --- transepithelial electrical resistance (TER) --- sorting nexin 9 (SNX9) --- EspF --- claudin 1 --- tumor --- metastasis --- epithelial to mesenchymal transition --- cerebral cavernous malformation --- endothelial barrier --- Rho --- ROCK --- MEKK3 --- ion transport --- ion channel --- super-resolution microscopy --- structured illumination microscopy --- stimulated emission depletion --- single molecule localization microscopy --- Claudin --- blood-biliary barrier --- chronic liver disease --- hepatocellular carcinoma --- cholangiocellular carcinoma --- NISCH syndrome --- repair --- NHE2 --- ClC-2 --- inflammatory bowel disease --- mucosal immunology --- ZO-1 --- actomyosin --- aquaporin --- drinking rate --- epithelial fluid transport --- enterocyte --- osmoregulation --- paracellular --- proximal tubule --- calcium permeability --- claudin-12 --- paracellular channels and barriers --- cell polarity --- pathogens --- immune cells --- environmental sensors --- tissue barrier --- tight junction --- claudins --- tricellulin --- tight junctions --- organ preservation --- intestine --- transplantation --- ischemia --- intestinal mucosa --- lung --- epithelia --- interleukin 13 --- UBE2Z --- ubiquitin --- osmolality --- hydrostatic pressure --- cancer --- sensor --- tricellular tight junctions --- endometrial cancer --- epithelial barrier dysfunction --- Claudin-7 --- permeability --- WNK4 --- epithelial sodium channel (ENaC), collecting duct cells --- claudin-1 --- hydrogen peroxide --- phosphorylation --- claudin --- angulin --- drug development --- angubindin-1 --- Clostridium perfringens enterotoxin --- Clostridium perfringens iota-toxin --- antibody --- Mz-ChA-1 cells --- biliary epithelial cells --- phosphatidylcholine --- mucus --- paracellular transport --- atopic dermatitis --- cytokines --- STAT3 --- ZO-2 --- cholestasis --- gene transcription --- hypertrophy --- tumor suppressor --- NLS --- NES --- CaSR --- RhoA --- barrier function --- paracellular permeability --- antidiuretic hormone --- Claudin-14 --- CLDN14 --- hearing loss --- vestibular function --- cochlear implantation --- Hepatitis C Virus --- viral entry --- epidermal barrier --- reconstructed human epidermis --- claudin targeting --- Campylobacter jejuni --- curcumin --- apoptosis --- co-culture --- mouse colon --- TNF --- NFκB --- lipolysis-stimulated lipoprotein receptor (LSR) --- epithelial barrier --- cell–cell contact --- caspase --- kidney stones --- ion reabsorption --- quercetin --- brain barriers --- blood-brain barrier --- neurovascular unit --- blood-cerebrospinal fluid barrier --- arachnoid barrier --- glia limitans --- adherens junctions --- paracellular sodium transport --- thick ascending limb --- nephropathy --- HELIX syndrome --- hypokalemia --- hypermagnesemia --- anhidrosis --- gland dysfunction --- aging --- blood–brain barrier --- mutations --- kidney --- liver --- skin --- human --- mice --- disease --- in silico --- drug discovery --- membrane proteins --- protein interactions --- molecular dynamics --- antibiotic-associated hemorrhagic colitis --- Klebsiella oxytoca --- tight junction assembly --- monocytes --- celiac disease --- claudin-2 --- epithelium --- inflammation --- fibrosis --- proliferation --- migration --- tricellular tight junction --- paracellular water transport --- tight epithelium --- MDCK C7 cells --- cell growth --- endothelia --- adherens junction --- apical junctional complex --- AMP-activated protein kinase (AMPK) --- paracellular barrier --- protein structure --- protein domain --- occludin --- junctional adhesion molecule --- zonula occludens --- MAGUK proteins --- PDZ domain --- stem cell --- chemoresistance --- retinal pigment epithelium --- retinopathy --- barrier formation --- collecting duct --- claudin-5 --- neuropathic pain --- nerve injury --- dorsal root ganglion --- enteropathogenic E. coli (EPEC) --- tight junctions (TJ) --- polarity --- atypical aPKCζ --- transepithelial electrical resistance (TER) --- sorting nexin 9 (SNX9) --- EspF --- claudin 1 --- tumor --- metastasis --- epithelial to mesenchymal transition --- cerebral cavernous malformation --- endothelial barrier --- Rho --- ROCK --- MEKK3 --- ion transport --- ion channel --- super-resolution microscopy --- structured illumination microscopy --- stimulated emission depletion --- single molecule localization microscopy --- Claudin --- blood-biliary barrier --- chronic liver disease --- hepatocellular carcinoma --- cholangiocellular carcinoma --- NISCH syndrome --- repair --- NHE2 --- ClC-2 --- inflammatory bowel disease --- mucosal immunology --- ZO-1 --- actomyosin --- aquaporin --- drinking rate --- epithelial fluid transport --- enterocyte --- osmoregulation --- paracellular --- proximal tubule --- calcium permeability --- claudin-12 --- paracellular channels and barriers --- cell polarity --- pathogens --- immune cells --- environmental sensors
Choose an application
For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
Medicine --- tissue barrier --- tight junction --- claudins --- tricellulin --- tight junctions --- organ preservation --- intestine --- transplantation --- ischemia --- intestinal mucosa --- lung --- epithelia --- interleukin 13 --- UBE2Z --- ubiquitin --- osmolality --- hydrostatic pressure --- cancer --- sensor --- tricellular tight junctions --- endometrial cancer --- epithelial barrier dysfunction --- Claudin-7 --- permeability --- WNK4 --- epithelial sodium channel (ENaC), collecting duct cells --- claudin-1 --- hydrogen peroxide --- phosphorylation --- claudin --- angulin --- drug development --- angubindin-1 --- Clostridium perfringens enterotoxin --- Clostridium perfringens iota-toxin --- antibody --- Mz-ChA-1 cells --- biliary epithelial cells --- phosphatidylcholine --- mucus --- paracellular transport --- atopic dermatitis --- cytokines --- STAT3 --- ZO-2 --- cholestasis --- gene transcription --- hypertrophy --- tumor suppressor --- NLS --- NES --- CaSR --- RhoA --- barrier function --- paracellular permeability --- antidiuretic hormone --- Claudin-14 --- CLDN14 --- hearing loss --- vestibular function --- cochlear implantation --- Hepatitis C Virus --- viral entry --- epidermal barrier --- reconstructed human epidermis --- claudin targeting --- Campylobacter jejuni --- curcumin --- apoptosis --- co-culture --- mouse colon --- TNF --- NFκB --- lipolysis-stimulated lipoprotein receptor (LSR) --- epithelial barrier --- cell–cell contact --- caspase --- kidney stones --- ion reabsorption --- quercetin --- brain barriers --- blood-brain barrier --- neurovascular unit --- blood-cerebrospinal fluid barrier --- arachnoid barrier --- glia limitans --- adherens junctions --- paracellular sodium transport --- thick ascending limb --- nephropathy --- HELIX syndrome --- hypokalemia --- hypermagnesemia --- anhidrosis --- gland dysfunction --- aging --- blood–brain barrier --- mutations --- kidney --- liver --- skin --- human --- mice --- disease --- in silico --- drug discovery --- membrane proteins --- protein interactions --- molecular dynamics --- antibiotic-associated hemorrhagic colitis --- Klebsiella oxytoca --- tight junction assembly --- monocytes --- celiac disease --- claudin-2 --- epithelium --- inflammation --- fibrosis --- proliferation --- migration --- tricellular tight junction --- paracellular water transport --- tight epithelium --- MDCK C7 cells --- cell growth --- endothelia --- adherens junction --- apical junctional complex --- AMP-activated protein kinase (AMPK) --- paracellular barrier --- protein structure --- protein domain --- occludin --- junctional adhesion molecule --- zonula occludens --- MAGUK proteins --- PDZ domain --- stem cell --- chemoresistance --- retinal pigment epithelium --- retinopathy --- barrier formation --- collecting duct --- claudin-5 --- neuropathic pain --- nerve injury --- dorsal root ganglion --- enteropathogenic E. coli (EPEC) --- tight junctions (TJ) --- polarity --- atypical aPKCζ --- transepithelial electrical resistance (TER) --- sorting nexin 9 (SNX9) --- EspF --- claudin 1 --- tumor --- metastasis --- epithelial to mesenchymal transition --- cerebral cavernous malformation --- endothelial barrier --- Rho --- ROCK --- MEKK3 --- ion transport --- ion channel --- super-resolution microscopy --- structured illumination microscopy --- stimulated emission depletion --- single molecule localization microscopy --- Claudin --- blood-biliary barrier --- chronic liver disease --- hepatocellular carcinoma --- cholangiocellular carcinoma --- NISCH syndrome --- repair --- NHE2 --- ClC-2 --- inflammatory bowel disease --- mucosal immunology --- ZO-1 --- actomyosin --- aquaporin --- drinking rate --- epithelial fluid transport --- enterocyte --- osmoregulation --- paracellular --- proximal tubule --- calcium permeability --- claudin-12 --- paracellular channels and barriers --- cell polarity --- pathogens --- immune cells --- environmental sensors --- tissue barrier --- tight junction --- claudins --- tricellulin --- tight junctions --- organ preservation --- intestine --- transplantation --- ischemia --- intestinal mucosa --- lung --- epithelia --- interleukin 13 --- UBE2Z --- ubiquitin --- osmolality --- hydrostatic pressure --- cancer --- sensor --- tricellular tight junctions --- endometrial cancer --- epithelial barrier dysfunction --- Claudin-7 --- permeability --- WNK4 --- epithelial sodium channel (ENaC), collecting duct cells --- claudin-1 --- hydrogen peroxide --- phosphorylation --- claudin --- angulin --- drug development --- angubindin-1 --- Clostridium perfringens enterotoxin --- Clostridium perfringens iota-toxin --- antibody --- Mz-ChA-1 cells --- biliary epithelial cells --- phosphatidylcholine --- mucus --- paracellular transport --- atopic dermatitis --- cytokines --- STAT3 --- ZO-2 --- cholestasis --- gene transcription --- hypertrophy --- tumor suppressor --- NLS --- NES --- CaSR --- RhoA --- barrier function --- paracellular permeability --- antidiuretic hormone --- Claudin-14 --- CLDN14 --- hearing loss --- vestibular function --- cochlear implantation --- Hepatitis C Virus --- viral entry --- epidermal barrier --- reconstructed human epidermis --- claudin targeting --- Campylobacter jejuni --- curcumin --- apoptosis --- co-culture --- mouse colon --- TNF --- NFκB --- lipolysis-stimulated lipoprotein receptor (LSR) --- epithelial barrier --- cell–cell contact --- caspase --- kidney stones --- ion reabsorption --- quercetin --- brain barriers --- blood-brain barrier --- neurovascular unit --- blood-cerebrospinal fluid barrier --- arachnoid barrier --- glia limitans --- adherens junctions --- paracellular sodium transport --- thick ascending limb --- nephropathy --- HELIX syndrome --- hypokalemia --- hypermagnesemia --- anhidrosis --- gland dysfunction --- aging --- blood–brain barrier --- mutations --- kidney --- liver --- skin --- human --- mice --- disease --- in silico --- drug discovery --- membrane proteins --- protein interactions --- molecular dynamics --- antibiotic-associated hemorrhagic colitis --- Klebsiella oxytoca --- tight junction assembly --- monocytes --- celiac disease --- claudin-2 --- epithelium --- inflammation --- fibrosis --- proliferation --- migration --- tricellular tight junction --- paracellular water transport --- tight epithelium --- MDCK C7 cells --- cell growth --- endothelia --- adherens junction --- apical junctional complex --- AMP-activated protein kinase (AMPK) --- paracellular barrier --- protein structure --- protein domain --- occludin --- junctional adhesion molecule --- zonula occludens --- MAGUK proteins --- PDZ domain --- stem cell --- chemoresistance --- retinal pigment epithelium --- retinopathy --- barrier formation --- collecting duct --- claudin-5 --- neuropathic pain --- nerve injury --- dorsal root ganglion --- enteropathogenic E. coli (EPEC) --- tight junctions (TJ) --- polarity --- atypical aPKCζ --- transepithelial electrical resistance (TER) --- sorting nexin 9 (SNX9) --- EspF --- claudin 1 --- tumor --- metastasis --- epithelial to mesenchymal transition --- cerebral cavernous malformation --- endothelial barrier --- Rho --- ROCK --- MEKK3 --- ion transport --- ion channel --- super-resolution microscopy --- structured illumination microscopy --- stimulated emission depletion --- single molecule localization microscopy --- Claudin --- blood-biliary barrier --- chronic liver disease --- hepatocellular carcinoma --- cholangiocellular carcinoma --- NISCH syndrome --- repair --- NHE2 --- ClC-2 --- inflammatory bowel disease --- mucosal immunology --- ZO-1 --- actomyosin --- aquaporin --- drinking rate --- epithelial fluid transport --- enterocyte --- osmoregulation --- paracellular --- proximal tubule --- calcium permeability --- claudin-12 --- paracellular channels and barriers --- cell polarity --- pathogens --- immune cells --- environmental sensors
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